Recapitulation of methotrexate hepatotoxicity with induced pluripotent stem cell-derived hepatocytes from patients with rheumatoid arthritis

Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 3 (MODY3) carrying a hepatocyte nuclear factor 1-alpha ( HNF1A ) mutation

(2018) Frank Griscelli et al.   Stem Cell Research

TAT-mediated intracellular delivery of carboxypeptidase G2 protects against methotrexate-induced cell death in HepG2 cells

(2018) Issa Sadeghian et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Generation of Multilayered 3D Structures of HepG2 Cells Using a Bio-printing Technique

(2017) Hyeryeon Jeon et al.   Gut and Liver

Pro-fibrotic compounds induce stellate cell activation, ECM-remodelling and Nrf2 activation in a human 3D-multicellular model of liver fibrosis

(2017) Vincenzo Prestigiacomo et al.   PLoS One

Phenotypic Characterization of Toxic Compound Effects on Liver Spheroids Derived from iPSC Using Confocal Imaging and Three-Dimensional Image Analysis

(2016) Oksana Sirenko et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Induced pluripotent stem cell technology: a decade of progress

(2016) Yanhong Shi et al.   NATURE REVIEWS DRUG DISCOVERY

Adenosine and adenosine receptors in the pathogenesis and treatment of rheumatic diseases

(2016) Bruce N. Cronstein et al.   Nature Reviews Rheumatology

Preventing and Managing Toxicities of High-Dose Methotrexate

(2016) S. C. Howard et al.   ONCOLOGIST

Editor’s Highlight: Modeling Compound-Induced FibrogenesisIn VitroUsing Three-Dimensional Bioprinted Human Liver Tissues

(2016) Leah M. Norona et al.   TOXICOLOGICAL SCIENCES

Three-dimensional Organotypic Culture Models of Human Hepatocellular Carcinoma

(2016) Atsushi Takai et al.   Scientific Reports

Long-term culture and expansion of primary human hepatocytes

(2015) Gahl Levy et al.   NATURE BIOTECHNOLOGY

Small-Molecule-Driven Hepatocyte Differentiation of Human Pluripotent Stem Cells

(2015) Richard Siller et al.   Stem Cell Reports

Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, hepatic cell lines and primary hepatocytes

(2014) Anna-Karin M. Sjogren et al.   ARCHIVES OF TOXICOLOGY

Human Hepatocytes with Drug Metabolic Function Induced from Fibroblasts by Lineage Reprogramming

(2014) Yuanyuan Du et al.   Cell Stem Cell

Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes

(2014) Pengyu Huang et al.   Cell Stem Cell

Combined use of N-acetylcysteine and Liberase improves the viability and metabolic function of human hepatocytes isolated from human liver

(2014) David C. Bartlett et al.   CYTOTHERAPY

A review of methotrexate-associated hepatotoxicity

(2014) Roopjeet K. Bath et al.   Journal of Digestive Diseases

Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant

(2014) Takanori Takebe et al.   Nature Protocols

Vitamin C enhances anticancer activity in methotrexate-treated Hep3B hepatocellular carcinoma cells

(2014) GIOU-TENG YIANG et al.   ONCOLOGY REPORTS

Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells

(2013) Su Mi Choi et al.   HEPATOLOGY

Identification of small molecules for human hepatocyte expansion and iPS differentiation

(2013) Jing Shan et al.   Nature Chemical Biology

Production of hepatocyte-like cells from human pluripotent stem cells

(2013) Nicholas R F Hannan et al.   Nature Protocols

Highly Efficient Differentiation of Functional Hepatocytes From Human Induced Pluripotent Stem Cells

(2013) Xiaocui Ma et al.   Stem Cells Translational Medicine

Accurate Prediction of Drug-Induced Liver Injury Using Stem Cell-Derived Populations

(2013) Dagmara Szkolnicka et al.   Stem Cells Translational Medicine

JAK inhibition for the treatment of rheumatoid arthritis: a new era in oral DMARD therapy

(2012) Kris Vaddi et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Modeling hepatitis C virus infection using human induced pluripotent stem cells

(2012) R. E. Schwartz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determination of Drug Toxicity Using 3D Spheroids Constructed From an Immortal Human Hepatocyte Cell Line

(2012) Stephen J. Fey et al.   TOXICOLOGICAL SCIENCES

In vitro models for liver toxicity testing

(2012) Valerie Y. Soldatow et al.   Toxicology Research

Opportunities for Use of Human iPS Cells in Predictive Toxicology

(2011) B D Anson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Rapid generation of mature hepatocyte-like cells from human induced pluripotent stem cells by an efficient three-step protocol

(2011) Yu-Fan Chen et al.   HEPATOLOGY

Hepatotoxicity related to antirheumatic drugs

(2011) Guruprasad P. Aithal   Nature Reviews Rheumatology

Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells

(2010) S. Tamir Rashid et al.   JOURNAL OF CLINICAL INVESTIGATION

Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver

(2010) Karima Begriche et al.   JOURNAL OF HEPATOLOGY

Current Concepts of Mechanisms in Drug-Induced Hepatotoxicity

(2009) Stefan Russmann et al.   CURRENT MEDICINAL CHEMISTRY

Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells

(2009) Karim Si-Tayeb et al.   HEPATOLOGY