Identification of a Small Interface between the Methyltransferase and RNA Polymerase of NS5 that is Essential for Zika Virus Replication

Molecular docking revealed the binding of nucleotide/side inhibitors to Zika viral polymerase solved structures

(2018) A. A. Elfiky et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

The structural model of Zika virus RNA-dependent RNA polymerase in complex with RNA for rational design of novel nucleotide inhibitors

(2018) Jakub Šebera et al.   Scientific Reports

The ProTide Prodrug Technology: From the Concept to the Clinic

(2017) Youcef Mehellou et al.   JOURNAL OF MEDICINAL CHEMISTRY

2016, the year of Zika virus

(2017) Diederik van de Beek et al.   Nature Reviews Neurology

The structure of Zika virus NS5 reveals a conserved domain conformation

(2017) Boxiao Wang et al.   Nature Communications

Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase

(2017) Andre S. Godoy et al.   Nature Communications

Structure and function of the Zika virus full-length NS5 protein

(2017) Baoyu Zhao et al.   Nature Communications

The structure of the binary methyltransferase-SAH complex from Zika virus reveals a novel conformation for the mechanism of mRNA capping

(2017) Chatrin Chatrin et al.   Oncotarget

De novo RNA synthesis catalyzed by the Zika Virus RNA polymerase domain

(2017) Christina Calmels et al.   Scientific Reports

Crystal structure of full-lengthZika virusNS5 protein reveals a conformation similar toJapanese encephalitis virusNS5

(2017) Anup K. Upadhyay et al.   Acta Crystallographica Section F-Structural Biology Communications

Analysis of Ribonucleotide 5′-Triphosphate Analogs as Potential Inhibitors of Zika Virus RNA-Dependent RNA Polymerase by Using Nonradioactive Polymerase Assays

(2016) Gaofei Lu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Zika Virus Causes Testis Damage and Leads to Male Infertility in Mice

(2016) Wenqiang Ma et al.   CELL

An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors

(2016) Chao Shan et al.   Cell Host & Microbe

Zika viral polymerase inhibition using anti-HCV drugs both in market and under clinical trials

(2016) Abdo A. Elfiky   JOURNAL OF MEDICAL VIROLOGY

Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives

(2016) Bruno Coutard et al.   JOURNAL OF VIROLOGY

Structure of transcribing mammalian RNA polymerase II

(2016) Carrie Bernecky et al.   NATURE

The Neurobiology of Zika Virus

(2016) Hongda Li et al.   NEURON

Structures of NS5 Methyltransferase from Zika Virus

(2016) Javier Coloma et al.   Cell Reports

First Locally Transmitted Zika Virus Cases Identified in the United States

(2016) Camila V. Ventura et al.   JAMA Ophthalmology

Male-to-Male Sexual Transmission of Zika Virus — Texas, January 2016

(2016) D. Trew Deckard et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Crystal Structures of the E. coli Transcription Initiation Complexes with a Complete Bubble

(2015) Yuhong Zuo et al.   MOLECULAR CELL

Structural basis for RNA replication by the hepatitis C virus polymerase

(2015) T. C. Appleby et al.   SCIENCE

A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

(2015) Yongqian Zhao et al.   PLoS Pathogens

The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain

(2014) Supanee Potisopon et al.   NUCLEIC ACIDS RESEARCH

The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication

(2014) Xiao-Dan Li et al.   PLoS Neglected Tropical Diseases

A Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability andde NovoInitiation Activities

(2013) Siew Pheng Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

(2013) Lars Petter Jordheim et al.   NATURE REVIEWS DRUG DISCOVERY

Crystal Structure of the Full-Length Japanese Encephalitis Virus NS5 Reveals a Conserved Methyltransferase-Polymerase Interface

(2013) Guoliang Lu et al.   PLoS Pathogens

Structural basis of initial RNA polymerase II transcription

(2011) Alan C M Cheung et al.   EMBO JOURNAL

Characterization of the Elongation Complex of Dengue Virus RNA Polymerase

(2010) Zhinan Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical and genetic characterization of dengue virus methyltransferase

(2010) Hongping Dong et al.   VIROLOGY