Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II

Cancer statistics, 2018

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The Diagnosis and Treatment of Prostate Cancer

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CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2

(2017) Liying Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

(2017) Robert T. Manguso et al.   NATURE

Strategies and challenges for the next generation of antibody–drug conjugates

(2017) Alain Beck et al.   NATURE REVIEWS DRUG DISCOVERY

Drugging the undruggables: exploring the ubiquitin system for drug development

(2016) Xiaodong Huang et al.   CELL RESEARCH

Prostate cancer

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Antibody–drug conjugates for cancer therapy

(2016) Anish Thomas et al.   LANCET ONCOLOGY

Deletions linked to TP53 loss drive cancer through p53-independent mechanisms

(2016) Yu Liu et al.   NATURE

The increasing complexity of the ubiquitin code

(2016) Richard Yau et al.   NATURE CELL BIOLOGY

ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer

(2016) Junjian Wang et al.   NATURE MEDICINE

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

(2016) Varahram Shahryari et al.   Jove-Journal of Visualized Experiments

Clinical Overview of MDM2/X-Targeted Therapies

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Targeting Cullin–RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation

(2015) Emil Bulatov et al.   BIOCHEMICAL JOURNAL

Targeting tumor suppressor genes for cancer therapy

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Integrative Clinical Genomics of Advanced Prostate Cancer

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An emerging playbook for antibody–drug conjugates: lessons from the laboratory and clinic suggest a strategy for improving efficacy and safety

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Amanita phalloides poisoning: Mechanisms of toxicity and treatment

(2015) Juliana Garcia et al.   FOOD AND CHEMICAL TOXICOLOGY

A new way to target p53-defective colorectal cancer

(2015) Yunhua Liu et al.   Future Oncology

TP53 loss creates therapeutic vulnerability in colorectal cancer

(2015) Yunhua Liu et al.   NATURE

Structural basis of transcription initiation by RNA polymerase II

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DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer

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Gene essentiality and synthetic lethality in haploid human cells

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Identification and characterization of essential genes in the human genome

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A novel, non-radioactive eukaryotic in vitro transcription assay for sensitive quantification of RNA polymerase II activity

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Analysis of TP53 Mutation Status in Human Cancer Cell Lines: A Reassessment

(2014) Bernard Leroy et al.   HUMAN MUTATION

Measuring error rates in genomic perturbation screens: gold standards for human functional genomics

(2014) T. Hart et al.   Molecular Systems Biology

Evolution of androgen receptor targeted therapy for advanced prostate cancer

(2014) Yien Ning Sophia Wong et al.   Nature Reviews Clinical Oncology

High-risk prostate cancer—classification and therapy

(2014) Albert J. Chang et al.   Nature Reviews Clinical Oncology

New insights into ubiquitin E3 ligase mechanism

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Phase II Study of Lutetium-177-Labeled Anti-Prostate-Specific Membrane Antigen Monoclonal Antibody J591 for Metastatic Castration-Resistant Prostate Cancer

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Genetic Screens in Human Cells Using the CRISPR-Cas9 System

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Therapeutic Potential of Amanitin-Conjugated Anti-Epithelial Cell Adhesion Molecule Monoclonal Antibody Against Pancreatic Carcinoma

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Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

ROC1/RBX1 E3 Ubiquitin Ligase Silencing Suppresses Tumor Cell Growth via Sequential Induction of G2-M Arrest, Apoptosis, and Senescence

(2009) L. Jia et al.   CANCER RESEARCH

Structural and Functional Insights into the Roles of the Mms21 Subunit of the Smc5/6 Complex

(2009) Xinyuan Duan et al.   MOLECULAR CELL

RBX1/ROC1 disruption results in early embryonic lethality due to proliferation failure, partially rescued by simultaneous loss of p27

(2009) M. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology

Database for mRNA Half-Life of 19 977 Genes Obtained by DNA Microarray Analysis of Pluripotent and Differentiating Mouse Embryonic Stem Cells

(2008) L. V. Sharova et al.   DNA RESEARCH

Exploring RNA transcription and turnover in vivo by using click chemistry

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