Targeting tumor suppressor genes for cancer therapy

Targeting cancer-specific mutations by T cell receptor gene therapy

(2015) Thomas Blankenstein et al.   CURRENT OPINION IN IMMUNOLOGY

Cancer genomics

(2015) Jeremy Lewin et al.   CURRENT OPINION IN ONCOLOGY

Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure

(2015) R. Pagliarini et al.   EMBO REPORTS

Intravenous Administration of Retroviral Replicating Vector, Toca 511, Demonstrates Therapeutic Efficacy in Orthotopic Immune-Competent Mouse Glioma Model

(2015) Tiffany T. Huang et al.   HUMAN GENE THERAPY

Application of single-cell genomics in cancer: promise and challenges

(2015) Quin F. Wills et al.   HUMAN MOLECULAR GENETICS

Beyond BRAF V600 : Clinical Mutation Panel Testing by Next-Generation Sequencing in Advanced Melanoma

(2015) Alan E. Siroy et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TP53 loss creates therapeutic vulnerability in colorectal cancer

(2015) Yunhua Liu et al.   NATURE

Sequencing small genomic targets with high efficiency and extreme accuracy

(2015) Michael W Schmitt et al.   NATURE METHODS

Opportunities and challenges provided by crosstalk between signalling pathways in cancer

(2015) A Prahallad et al.   ONCOGENE

The origin of breast tumor heterogeneity

(2015) A Skibinski et al.   ONCOGENE

Novel and emerging targeted-based cancer therapy agents and methods

(2015) Mohammad Hojjat-Farsangi   TUMOR BIOLOGY

Quantifying tumor heterogeneity in whole-genome and whole-exome sequencing data

(2014) Layla Oesper et al.   BIOINFORMATICS

Genetic and Pharmacological Strategies to Refunctionalize the von Hippel Lindau R167Q Mutant Protein

(2014) Z. Ding et al.   CANCER RESEARCH

Cancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance

(2014) Hariharan Easwaran et al.   MOLECULAR CELL

ARID1B is a specific vulnerability in ARID1A-mutant cancers

(2014) Katherine C Helming et al.   NATURE MEDICINE

An update on PARP inhibitors—moving to the adjuvant setting

(2014) Amir Sonnenblick et al.   Nature Reviews Clinical Oncology

Expanding the computational toolbox for mining cancer genomes

(2014) Li Ding et al.   NATURE REVIEWS GENETICS

Applying Synthetic Lethality for the Selective Targeting of Cancer

(2014) Donal P. McLornan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanism-based cancer therapy: resistance to therapy, therapy for resistance

(2014) P Ramos et al.   ONCOGENE

Identifying driver mutations in sequenced cancer genomes: computational approaches to enable precision medicine

(2014) Benjamin J Raphael et al.   Genome Medicine

Emerging Understanding of Multiscale Tumor Heterogeneity

(2014) Michael J. Gerdes et al.   Frontiers in Oncology

Predicting the functional consequences of cancer-associated amino acid substitutions

(2013) Hashem A. Shihab et al.   BIOINFORMATICS

OncodriveCLUST: exploiting the positional clustering of somatic mutations to identify cancer genes

(2013) David Tamborero et al.   BIOINFORMATICS

Toca 511 gene transfer and 5-fluorocytosine in combination with temozolomide demonstrates synergistic therapeutic efficacy in a temozolomide-sensitive glioblastoma model

(2013) T T Huang et al.   CANCER GENE THERAPY

MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models

(2013) C. Tovar et al.   CANCER RESEARCH

Gene therapy on the move

(2013) Kerstin B. Kaufmann et al.   EMBO Molecular Medicine

Gene therapy enters the pharma market: The short story of a long journey

(2013) Hildegard Büning   EMBO Molecular Medicine

Mdm2 and MdmX inhibitors for the treatment of cancer: a patent review (2011 – present)

(2013) Krzysztof Zak et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial

(2013) Shahneen K Sandhu et al.   LANCET ONCOLOGY

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Computational approaches to identify functional genetic variants in cancer genomes

(2013)   NATURE METHODS

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia

(2013) R. J. Brentjens et al.   Science Translational Medicine

The Unpluggable in Pursuit of the Undruggable: Tackling the Dark Matter of the Cancer Therapeutics Universe

(2013) Richard J. Epstein   Frontiers in Oncology

Chemical modification allows phallotoxins and amatoxins to be used as tools in cell biology

(2012) Jan Anderl et al.   Beilstein Journal of Organic Chemistry

Cancer Vulnerabilities Unveiled by Genomic Loss

(2012) Deepak Nijhawan et al.   CELL

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

Predicting the Functional, Molecular, and Phenotypic Consequences of Amino Acid Substitutions using Hidden Markov Models

(2012) Hashem A. Shihab et al.   HUMAN MUTATION

Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer

(2012) Sören Lehmann et al.   JOURNAL OF CLINICAL ONCOLOGY

Therapeutic Potential of Amanitin-Conjugated Anti-Epithelial Cell Adhesion Molecule Monoclonal Antibody Against Pancreatic Carcinoma

(2012) Gerhard Moldenhauer et al.   JNCI-Journal of the National Cancer Institute

Design and Selection of Toca 511 for Clinical Use: Modified Retroviral Replicating Vector With Improved Stability and Gene Expression

(2012) Omar D Perez et al.   MOLECULAR THERAPY

Passenger deletions generate therapeutic vulnerabilities in cancer

(2012) Florian L. Muller et al.   NATURE

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

Objective assessment of cancer genes for drug discovery

(2012) Mishal N. Patel et al.   NATURE REVIEWS DRUG DISCOVERY

NLK Is a Novel Therapeutic Target for PTEN Deficient Tumour Cells

(2012) Ana M. Mendes-Pereira et al.   PLoS One

Circumventing Cancer Drug Resistance in the Era of Personalized Medicine

(2012) Levi A. Garraway et al.   Cancer Discovery

ATP Binds to Proteasomal ATPases in Pairs with Distinct Functional Effects, Implying an Ordered Reaction Cycle

(2011) David M. Smith et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

PRIMA-1Met/APR-246 Induces Apoptosis and Tumor Growth Delay in Small Cell Lung Cancer Expressing Mutant p53

(2011) R. Zandi et al.   CLINICAL CANCER RESEARCH

Making sense of cancer genomic data

(2011) Lynda Chin et al.   GENES & DEVELOPMENT

Treatment with olaparib in a patient with PTEN-deficient endometrioid endometrial cancer

(2011) Martin D. Forster et al.   Nature Reviews Clinical Oncology

Believe it or not: how much can we rely on published data on potential drug targets?

(2011) Florian Prinz et al.   NATURE REVIEWS DRUG DISCOVERY

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

(2011) David L. Porter et al.   NEW ENGLAND JOURNAL OF MEDICINE

canSAR: an integrated cancer public translational research and drug discovery resource

(2011) Mark D. Halling-Brown et al.   NUCLEIC ACIDS RESEARCH

Predicting the functional impact of protein mutations: application to cancer genomics

(2011) Boris Reva et al.   NUCLEIC ACIDS RESEARCH

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

(2011) H. W. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploring the Genomes of Cancer Cells: Progress and Promise

(2011) M. R. Stratton   SCIENCE

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

(2011) M. Kalos et al.   Science Translational Medicine

miRNA response to DNA damage

(2011) Guohui Wan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Delivering the goods: viral and non-viral gene therapy systems and the inherent limits on cargo DNA and internal sequences

(2010) Helen Atkinson et al.   GENETICA

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

International network of cancer genome projects

(2010) Thomas J. Hudson (Chairperson) et al.   NATURE

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Translating p53 into the clinic

(2010) Chit Fang Cheok et al.   Nature Reviews Clinical Oncology

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

(2010) S. A. Forbes et al.   NUCLEIC ACIDS RESEARCH

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

Reactivation of p53: from peptides to small molecules

(2010) Christopher J. Brown et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

p53-based Cancer Therapy

(2010) D. P. Lane et al.   Cold Spring Harbor Perspectives in Biology

Nonviral Gene Delivery: Principle, Limitations, and Recent Progress

(2009) Mohammed S. Al-Dosari et al.   AAPS Journal

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

A Phase 2 Trial of Surgery With Perioperative INGN 201 (Ad5CMV-p53) Gene Therapy Followed by Chemoradiotherapy for Advanced, Resectable Squamous Cell Carcinoma of the Oral Cavity, Oropharynx, Hypopharynx, and Larynx

(2009) George H. Yoo et al.   ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY

Phosphorylation and Degradation of MdmX Is Inhibited by Wip1 Phosphatase in the DNA Damage Response

(2009) X. Zhang et al.   CANCER RESEARCH

Cancer-Specific High-Throughput Annotation of Somatic Mutations: Computational Prediction of Driver Missense Mutations

(2009) H. Carter et al.   CANCER RESEARCH

Assembly Pathway of the Mammalian Proteasome Base Subcomplex Is Mediated by Multiple Specific Chaperones

(2009) Takeumi Kaneko et al.   CELL

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

The combined status of ATM and p53 link tumor development with therapeutic response

(2009) H. Jiang et al.   GENES & DEVELOPMENT

Targeting Mdm2 and Mdmx in Cancer Therapy: Better Living through Medicinal Chemistry?

(2009) Mark Wade et al.   MOLECULAR CANCER RESEARCH

Variation of Breast Cancer Risk Among BRCA1/2 Carriers

(2008) Colin B. Begg et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Exposing the fitness contribution of duplicated genes

(2008) Alexander DeLuna et al.   NATURE GENETICS

Widespread conservation of genetic redundancy during a billion years of eukaryotic evolution

(2008) Tanya Vavouri et al.   TRENDS IN GENETICS