Eukaryotic initiation factor 5B (eIF5B) provides a critical cell survival switch to glioblastoma cells via regulation of apoptosis

Oxygen-Sensitive Remodeling of Central Carbon Metabolism by Archaic eIF5B

(2018) J.J. David Ho et al.   Cell Reports

FTY720 inhibits the Nrf2/ARE pathway in human glioblastoma cell lines and sensitizes glioblastoma cells to temozolomide

(2017) Li Zhang et al.   Pharmacological Reports

Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms

(2017) Dae-Sun Kim et al.   Nature Communications

Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma

(2017) Shawn T. Beug et al.   Nature Communications

More than just scanning: the importance of cap-independent mRNA translation initiation for cellular stress response and cancer

(2016) Rafaela Lacerda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The deubiquitinase Usp27x stabilizes the BH3‐only protein Bim and enhances apoptosis

(2016) Arnim Weber et al.   EMBO REPORTS

The Deubiquitinase Inhibitor PR-619 Sensitizes Normal Human Fibroblasts to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-mediated Cell Death

(2016) Roslyn N. Crowder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic Analysis of eIF5B Silencing-Modulated Proteostasis

(2016) Xu Jiang et al.   PLoS One

Systematic discovery of cap-independent translation sequences in human and viral genomes

(2016) Shira Weingarten-Gabbay et al.   SCIENCE

Inhibitor of apoptosis protein expression in glioblastomas and their in vitro and in vivo targeting by SMAC mimetic GDC-0152

(2016) A Tchoghandjian et al.   Cell Death & Disease

EGFR and NF-κB: partners in cancer

(2015) Kateryna Shostak et al.   TRENDS IN MOLECULAR MEDICINE

Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress

(2015) Stacey L. Lehman et al.   PLoS Genetics

Birinapant (TL32711), a Bivalent SMAC Mimetic, Targets TRAF2-Associated cIAPs, Abrogates TNF-Induced NF- B Activation, and Is Active in Patient-Derived Xenograft Models

(2014) C. A. Benetatos et al.   MOLECULAR CANCER THERAPEUTICS

Structure of the mammalian 80S initiation complex with initiation factor 5B on HCV-IRES RNA

(2014) Hiroshi Yamamoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Upregulation of eIF5B controls cell-cycle arrest and specific developmental stages

(2014) S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessment of Selective mRNA Translation in Mammalian Cells by Polysome Profiling

(2014) Mame Daro Faye et al.   Jove-Journal of Visualized Experiments

Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis

(2013) Krishnendu Sinha et al.   ARCHIVES OF TOXICOLOGY

Inhibitor of Apoptosis (IAP) Proteins-Modulators of Cell Death and Inflammation

(2013) J. Silke et al.   Cold Spring Harbor Perspectives in Biology

TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation

(2012) S Jouan-Lanhouet et al.   CELL DEATH AND DIFFERENTIATION

Wilms Tumor Gene on X Chromosome (WTX) Inhibits Degradation of NRF2 Protein through Competitive Binding to KEAP1 Protein

(2012) Nathan D. Camp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level

(2011) V Graupner et al.   CELL DEATH AND DIFFERENTIATION

Bortezomib Sensitizes Malignant Human Glioma Cells to TRAIL, Mediated by Inhibition of the NF- B Signaling Pathway

(2011) E. P. Jane et al.   MOLECULAR CANCER THERAPEUTICS

IRES-mediated translation of cellular messenger RNA operates in eIF2α- independent manner during stress

(2011) Nehal Thakor et al.   NUCLEIC ACIDS RESEARCH

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Down-regulation of c-FLIP Enhances Death of Cancer Cells by Smac Mimetic Compound

(2009) H. H. Cheung et al.   CANCER RESEARCH

NF45 functions as an IRES trans-acting factor that is required for translation of cIAP1 during the unfolded protein response

(2009) T E Graber et al.   CELL DEATH AND DIFFERENTIATION

Akt-dependent and -independent mechanisms of mTOR regulation in cancer

(2009) Regan M. Memmott et al.   CELLULAR SIGNALLING

An internal ribosomal entry site mediates redox-sensitive translation of Nrf2

(2009) Wenge Li et al.   NUCLEIC ACIDS RESEARCH

BH3-only proteins in apoptosis and beyond: an overview

(2009) E Lomonosova et al.   ONCOGENE

eIF2-dependent and eIF2-independent modes of initiation on the CSFV IRES: a common role of domain II

(2008) Tatyana V Pestova et al.   EMBO JOURNAL

Eukaryotic translation initiation machinery can operate in a bacterial-like mode without eIF2

(2008) Ilya M Terenin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Both cIAP1 and cIAP2 regulate TNF -mediated NF- B activation

(2008) D. J. Mahoney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Re-programming of translation following cell stress allows IRES-mediated translation to predominate

(2007) Keith A. Spriggs et al.   BIOLOGY OF THE CELL