Article
Endocrinology & Metabolism
Yujia Gong, Na Li, Mengyu Lai, Fang Fang, Jiaying Yang, Mei Kang, Tingting Shen, Yongde Peng, Yufan Wang
Summary: This study found that low levels of osteocalcin (OC) during late pregnancy and postpartum were associated with increased risk of abnormal glucose metabolism (AGM) in gestational diabetes mellitus (GDM) patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Food Science & Technology
Yueting Ge, Bowen Li, Yuhui Yang, Chuanxing Feng, Xue Tang, Yonghui Shi, Guowei Le, Jin Sun
Summary: Consumption of pork with high levels of oxidative injury can lead to disorders of glucose metabolism in mice, characterized by hyperglycemia, hypoinsulinemia, impaired glucose tolerance, and impaired pancreatic insulin secretion. Protein oxidation plays a key role in this abnormal glucose metabolism induced by high oxidative injury pork intake.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Cell & Tissue Engineering
Nikolai Jaschke, Wolfgang Sipos, Lorenz C. Hofbauer, Tilman D. Rachner, Martina Rauner
Summary: This article explores how the skeleton regulates whole-body homeostasis by secreting hormones and discusses the origins and functions of two common skeletal mediators in physiology and their potential disease associations. It provides a theoretical framework to explain the evolutionary roles of these hormones in amniote physiology and addresses limitations and challenges in research. Additionally, unresolved questions and potential future studies in this growing field are summarized.
Editorial Material
Endocrinology & Metabolism
Dured Dardari
Summary: The pathophysiology of Charcot neuroarthropathy (CN) involves unclear mechanisms, particularly in terms of the onset of inflammation and bone remodeling factor disruption leading to bone lysis. This study suggests a potential link between this inflammation and the rapid correction of chronic hyperglycemia, which is associated with treatment-induced neuropathy of diabetes (TIND). The findings contribute to a better understanding of the mysterious physiopathology of CN.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Biochemical Research Methods
Marie Heraudeau, Candice M. Roux, Caroline Lahogue, Stacy Largilliere, Stephane Allouche, Veronique Lelong-Boulouard, Thomas Freret
Summary: This study developed a non-invasive oral administration method in male Sprague Dawley rats, as a safe alternative to oral gavage, that is more faithful to clinical reality and reduces biases in pharmacokinetics and/or pharmacodynamics interpretation.
JOURNAL OF NEUROSCIENCE METHODS
(2023)
Article
Nutrition & Dietetics
Eva Hassler, Gunter Almer, Gernot Reishofer, Hannes Deutschmann, Wilfried Renner, Markus Herrmann, Stefan Leber, Alexander Staszewski, Felix Gunzer, Harald Mangge
Summary: This study investigates the association between osteocalcin levels and the distribution of subcutaneous and intermuscular adipose tissue of the mid-thigh, as well as the impact of different training methods on osteocalcin levels. The results show a negative correlation between osteocalcin and the distribution of adipose tissue, as well as muscle area, in the mid-thigh. Additionally, osteocalcin is negatively related to serum insulin. These findings provide further insights into the role of osteocalcin in glucose metabolism.
Article
Endocrinology & Metabolism
Theresia Ziegs, Johanna Dorst, Loreen Ruhm, Nikolai Avdievitch, Anke Henning
Summary: For the first time, labeling effects after oral intake of [1-13C]glucose are observed in the human brain with pure 1H detection at 9.4 T. This study demonstrates that the combination of oral administration of [1-13C]Glc with pure 1H MRS acquisition is a simple and suitable technique to measure metabolic rates in the brain.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Nutrition & Dietetics
Si Chen, Shubo Wang, Shuqiao Ding, Chuan Zhang
Summary: The relationship between glucose metabolism and bone health is not well-studied. This study used OGTT and NIRS to investigate gender-specific disparities in tibial hemodynamic responses among young healthy adults. The results showed that the tibial hemodynamic responses to OGTT were similar between males and females.
Review
Nutrition & Dietetics
Gerard Karsenty
Summary: Together, loss- and gain-of-function experiments have identified osteocalcin as a hormone with wide-ranging effects in rodents and primates. It influences energy metabolism, steroidogenesis, neurotransmitter biosynthesis, male fertility, electrolyte homeostasis, cognition, the stress response, and exercise capacity. This review focuses on the regulation of energy metabolism by osteocalcin, while also touching on its other functions and proposing a potential common theme with bone's structural functions.
ANNUAL REVIEW OF NUTRITION
(2023)
Article
Endocrinology & Metabolism
Alexander N. Comninos, Morten S. Hansen, Alan Courtney, Sirazum Choudhury, Lisa Yang, Edouard G. Mills, Maria Phylactou, Mark Busbridge, Muaza Khir, Thilipan Thaventhiran, Paul Bech, Tricia Tan, Ali Abbara, Morten Frost, Waljit S. Dhillo
Summary: This study aims to assess the effects of kisspeptin on human bone metabolism. In vitro experiments showed that kisspeptin promoted osteoblast differentiation and inhibited osteoclastic resorptive activity. Clinical experiments showed that kisspeptin increased bone formation markers without affecting bone resorption markers.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Neurosciences
Xuzhu Lin, Cassandra Smith, Alba Moreno-Asso, Navabeh Zarekookandeh, Tara C. Brennan-Speranza, Gustavo Duque, Alan Hayes, Itamar Levinger
Summary: This study investigates the protective effects of the combination of undercarboxylated osteocalcin (ucOC) and ibandronate (IBN) against immobilization-induced muscle wasting and insulin resistance. The results show that the combined treatment significantly increases muscle weight and improves glucose tolerance compared to individual treatments.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Endocrinology & Metabolism
Arthe Raajendiran, Christoph Krisp, David P. De Souza, Geraldine Ooi, Paul R. Burton, Renea A. Taylor, Mark P. Molloy, Matthew J. Watt
Summary: Adipose tissue plays a crucial role in energy balance and metabolism regulation, with differences in protein composition leading to metabolic variation in different regions. Upper-body adipocytes are associated with glycolysis, lipogenesis, and oxidative stress, while lower-body adipocytes show enhanced activation of PPARa and mitochondrial oxidative phosphorylation processes.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Chemistry, Multidisciplinary
Qiang Chang, Jie Huang, Liming He, Fengna Xi
Summary: This study demonstrates a simple electrochemical immunosensor based on gold nanoparticles electrodeposited on chitosan-reduced graphene oxide composite modified electrode for sensitive detection of bone metabolism biomarker BGP. The immobilized AuNPs provide binding sites for anti-BGP antibodies, resulting in reduced electrochemical signal when BGP is present. The electrochemical detection is fast and ultrasensitive, with a detection limit of 20 ag ml(-1), and it is also reliable for detecting BGP in human serum.
FRONTIERS IN CHEMISTRY
(2022)
Article
Toxicology
Francisco Alberto Verdin-Betancourt, Mario Figueroa, Alicia Guadalupe Soto-Ramos, Ma de Lourdes Lopez-Gonzalez, Gilberto Castaneda-Hernandez, Yael Yvette Bernal-Hernandez, Aurora Elizabeth Rojas-Garcia, Adolfo Sierra-Santoyo
Summary: The study found that Temephos is well absorbed, extensively metabolized, widely distributed, and preferentially stored in adipose tissue. Among Temephos metabolites, Tem-SO2-OH is the most abundant and could serve as a biomarker for toxicokinetic modeling. These results provide critical insights into the toxicity and dosimetry of Temephos and its metabolites.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Endocrinology & Metabolism
Wen-bin Zheng, Jing Hu, Di-Chen Zhao, Bing-Na Zhou, Ou Wang, Yan Jiang, Wei-Bo Xia, Xiao-ping Xing, Mei Li
Summary: Osteogenesis imperfecta (OI) patients commonly exhibit obesity, glucolipid metabolic abnormalities, and reduced grip strength. Circulating osteocalcin and undercarboxylated osteocalcin may play an important role in regulating glucose metabolism and muscle function in children with OI.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shohei Yoshimoto, Miho Matsuda, Kenichi Kato, Eijiro Jimi, Hiroshi Takeuchi, Shuji Nakano, Shunichi Kajioka, Etsuko Matsuzaki, Takao Hirofuji, Ryuji Inoue, Masato Hirata, Hiromitsu Morita
Summary: The study found that VRAC is highly functional and associated with proliferation in HST-1 cells, but not in HaCaT cells. The pharmacological profile of VRAC in HST-1 was similar to previous reports, and inhibition of VRAC with DCPIB led to apoptosis in HST-1 cells. Knockdown of TMEM16A and LRRC8A attenuated VRAC activity in HST-1 cells.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Satoru Mukai, Akiko Mizokami, Takahito Otani, Tomomi Sano, Miho Matsuda, Sakura Chishaki, Jing Gao, Tomoyo Kawakubo-Yasukochi, Ronghao Tang, Takashi Kanematsu, Hiroshi Takeuchi, Eijiro Jimi, Masato Hirata
Summary: GPRC6A regulates various physiological processes in response to its interaction with multiple ligands and its constitutive activation in adipocytes plays a key role in adipose lipid handling and the prevention of obesity and related metabolic disorders.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Eika Ando, Sen Higashi, Akiko Mizokami, Seiji Watanabe, Masato Hirata, Hiroshi Takeuchi
Summary: Bone matrix protein osteocalcin (OC) is involved in the development of learning and memory, and the prevention of anxiety-like behaviors in mice. This study found that OC can enhance cell proliferation, differentiation, and survival in neurons by binding to its candidate receptor GPR158.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
Tae Hun Hahm, Toshiro Matsui, Mitsuru Tanaka
Summary: A fluorescence-assisted spraying method was developed to overcome the variability in matrix crystals and improve the reproducibility of analyte intensity in matrix-assisted laser desorption/ionization mass spectrometry imaging. The method utilized a fluorescent reagent, rhodamine 6G, to achieve a constant fluorescence intensity. The proposed method successfully quantified nifedipine and ferulic acid in a rat kidney section and visually determined the accumulation of ferulic acid in the kidney over time.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Hikaru Fukuda, Shinobu Sato, Tingting Zou, Sen Higashi, Osamu Takahashi, Manabu Habu, Masaaki Sasaguri, Kazuhiro Tominaga, Shigeori Takenaka, Hiroshi Takeuchi
Summary: In this study, the interaction of cyclic naphthalene diimide derivatives with G-quartet DNA was investigated under dilute or molecular crowding condition. The results showed that compound 4 exhibited the highest stability towards the TA-core. Additionally, compound 3 demonstrated specific growth inhibition of cancer cell line Ca9-22 at IC50 <0.03 μM, with the highest expression level of telomerase mRNA.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Agriculture, Multidisciplinary
Xiaojing Sheng, Mitsuru Tanaka, Risa Katagihara, Marika Hashimoto, Satoshi Nagaoka, Toshiro Matsui
Summary: The study established a novel analytical assay for peptide metabolites from glycinin, using MALDI-MS combined with amine derivatization with coumarin. The use of coumarin derivatization under specific conditions led to improved MS detection of peptides, allowing for successful characterization of glycinin-derived metabolites in rats.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Agriculture, Multidisciplinary
Tae Hun Hahm, Mitsuru Tanaka, Toshiro Matsui
Summary: Anthocyanins are natural color pigments found in plants, such as berries, vegetables, and grapes. They have various physiological effects and are considered promising functional food ingredients. However, the bioavailability of anthocyanins, especially their absorption behaviors, is still unclear.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Cell Biology
Jing Gao, Akiko Mizokami, Hiroshi Takeuchi, Aonan Li, Fei Huang, Haruki Nagano, Takashi Kanematsu, Eijiro Jimi, Masato Hirata
Summary: PRIP facilitates insulin signaling by modulating the internalization of insulin receptor (IR) in adipocytes, playing an important regulatory role in insulin signaling.
JOURNAL OF CELL SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Mitsuru Tanaka, Keishiro Arima, Tomotaka Takeshita, Yuri Kunitake, Naoto Ohno, Miho Imamura, Toshiro Matsui
Summary: In this study, a GCB-LDI-MS method was developed for the simultaneous detection of taste- and odor-active compounds. This method was able to detect compounds that could not be detected by conventional matrix-assisted-LDI-MS, and it was also capable of detecting a variety of taste-active compounds in liquid samples.
ACS APPLIED NANO MATERIALS
(2022)
Article
Endocrinology & Metabolism
Kayo Mori, Akiko Mizokami, Tomomi Sano, Satoru Mukai, Fumitaka Hiura, Yasunori Ayukawa, Kiyoshi Koyano, Takashi Kanematsu, Eijiro Jimi
Summary: The study suggests that activation of the non-canonical NF-kappa B pathway through elevation of serum RANKL levels contributes to postmenopausal obesity.
JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fumitaka Hiura, Yuko Kawabata, Tsukasa Aoki, Akiko Mizokami, Eijiro Jimi
Summary: The study reveals the importance of ATG4/LC3 in osteoclast maturation and bone resorption. By using a specific inhibitor of ATG4B, NSC185058 (NSC), osteoclastogenesis and maturation can be inhibited, leading to a decrease in alveolar bone resorption in a periodontitis model.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Mayuka Yamagata, Sen Higashi, Noboru Yaida, Akane Ichihara, Manabu Habu, Masaaki Sasaguri, Kazuhiro Tominaga, Hiroshi Takeuchi
Summary: Metformin reduces the expression of EGFR in cancer cells and inhibits cell proliferation by promoting ligand-induced internalization and degradation of EGFR. This finding suggests that the effect of metformin on EGFR may impact therapeutic outcomes when combined with other cancer treatments.
ORAL SCIENCE INTERNATIONAL
(2023)
Article
Food Science & Technology
Yuna Lee, Akihiro Nakano, Saya Nakamura, Kenta Sakai, Mitsuru Tanaka, Keisuke Sanematsu, Noriatsu Shigemura, Toshiro Matsui
Summary: This study aimed to develop a dipeptide with an agonistic effect on AdipoR1 in skeletal muscle, and found that Tyr-Pro was the most effective in promoting glucose uptake, likely through the activation of AMPK/Glut4 pathway in L6 myotubes. This dipeptide may directly interact with AdipoR1 as an agonist, as demonstrated by molecular dynamics simulations.
NPJ SCIENCE OF FOOD
(2021)
Article
Dentistry, Oral Surgery & Medicine
Fumiko Aonuma, Sen Higashi, Shintaro Tsuka, Tomoko Ohsumi, Chihiro Masaki, Ryuji Hosokawa, Hiroshi Takeuchi
Summary: The study found that C1q can affect the differentiation of osteoblasts and osteoclasts, depending on the concentration. C1q does not activate the Wnt/beta-catenin signaling pathway, but can upregulate RANKL-induced phosphorylation of Akt.
JOURNAL OF PROSTHODONTIC RESEARCH
(2021)