Review
Nutrition & Dietetics
Lu Ding, Jieying Liu, Liyuan Zhou, Xinhua Xiao
Summary: This article systematically reviewed the effects of maternal exercise on offspring obesity outcomes in adulthood. The results showed that maternal exercise contributes to improved glucose tolerance, reduced insulin concentration, and lower total cholesterol and low-density lipoprotein levels in adult offspring in mice. However, in rats, maternal exercise leads to a higher body weight in adult offspring, which might be attributed to the high-fat diet of offspring after weaning. These findings further support the metabolic beneficial role of maternal exercise on offspring in adulthood, although the issue of translating the results to the human population is still yet to be addressed.
Article
Immunology
Yue Sun, Runxiang Xie, Lu Li, Ge Jin, Bingqian Zhou, Huan Huang, Mengfan Li, Yunwei Yang, Xiang Liu, Xiaocang Cao, Bangmao Wang, Wentian Liu, Kui Jiang, Hailong Cao
Summary: Prenatal maternal stress may affect the gut microbiota and neuroimmune network of offspring, resulting in impaired intestinal development and increased susceptibility.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rachel Schroeder, Preethy Sridharan, Lynn Nguyen, Alexandra Loren, Noelle S. Williams, Kavitha P. Kettimuthu, Coral J. Cintron-Perez, Edwin Vazquez-Rosa, Andrew A. Pieper, Hanna E. Stevens
Summary: Prenatal stress affects embryonic brain development by dysregulating NAD(+) synthesis machinery and GABAergic interneuron development, leading to cognitive deficits and depression-like behavior in adulthood. Maternal administration of the NAD(+) modulator, P7C3-A20, protects offspring from the detrimental effects of prenatal stress.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Endocrinology & Metabolism
Holly Hinrichs, Austin Faerber, Monica Young, Samuel J. Ballentine, Michael D. Thompson
Summary: Maternal exercise may protect offspring from progression of NAFLD, according to a study on female mice fed a high fat, fructose, cholesterol (HFFC) diet. The exercise reduced inflammation and fibrosis in the offspring, and also resulted in changes in metabolism. The findings suggest that maternal exercise could be a potential approach to prevent developmentally programmed liver disease in offspring.
Article
Nutrition & Dietetics
Huishi Toh, James A. Thomson, Peng Jiang
Summary: Through a longitudinal study on Nile rats, we found that maternal intake of a high-fiber diet significantly reduces the risk of diet-induced diabetes in offspring, indicating a potential protective effect of a high-fiber diet that can be transmitted through generations.
Article
Nutrition & Dietetics
You-Lin Tain, Chih-Yao Hou, Guo-Ping Chang-Chien, Su-Fan Lin, Chien-Ning Hsu
Summary: Emerging evidence suggests that disturbances in early-life gut microbiota can influence adult disease. In this study, the researchers found that maternal chronic kidney disease (CKD) can lead to offspring hypertension, but perinatal supplementation of propionate can prevent this and reverse established hypertension. This protective effect is associated with increased propionate-generating bacteria, elevated plasma propionate levels, higher expression of the SCFA receptor GPR41, improved gut microbiota diversity, and shifts in composition.
Article
Food Science & Technology
Zulkiflee Kuedo, Lalita Chotphruethipong, Navaneethan Raju, Ratchaneekorn Reudhabibadh, Soottawat Benjakul, Pennapa Chonpathompikunlert, Wanwimol Klaypradit, Pilaiwanwadee Hutamekalin
Summary: This study found that the ethanolic extract-loaded liposome from white shrimp shells had neuroprotective effects on Aβ-induced memory impairment in rats. It improved memory ability through the regulation of memory-related proteins and activation of signaling pathways.
Article
Immunology
Chien-Wen Su, Chih-Yu Chen, Tangyou Mao, Ning Chen, Nicholas Steudel, Lefei Jiao, Jinggang Lan, Alessio Fasano, W. Allan Walker, Hai Ning Shi
Summary: This study aimed to determine the impact of maternal immunity and microbial factors on the induction and development of obesity in offspring. The results showed that maternal infection with helminths and the resulting changes in gut microbiota composition significantly reduced offspring obesity. Furthermore, supplementation of short-chain fatty acids to the pups of uninfected mothers protected against high-fat diet-induced weight gain.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Peng Wang, Tian Wu, Qinghua Fu, Qichao Liao, Yan Li, Tengda Huang, Yixing Li, Lei Zhou, Ziyi Song
Summary: Excessive fructose intake during pregnancy may adversely affect offspring's metabolic health and impair brown fat development, leading to obesity and metabolic disorders in adulthood.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Mark H. Oliver, Anne L. Jaquiery, Kristin L. Connor, Hui Hui Phua, Jane E. Harding, Eric B. Thorstensen, Frank H. Bloomfield
Summary: Periconceptional undernutrition affects fetal hypothalamic-pituitary-adrenal axis function and placental glucocorticoid metabolism in sheep, but its effects on adult offspring are not known. This study found that PCUN did not significantly affect fetal adrenal development and cortisol regulation in adult offspring.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Yining Xin, Xiaoxiao Sun, Li Ren, Guo Chen, Yingqi Chen, Yingdong Ni, Bin He
Summary: The study found that maternal inflammation can induce phenotypic changes in the next generation. It was discovered that male offspring from inflammatory mothers showed impaired glucose tolerance and hepatic ectopic fat deposition when maintained on a chow diet. These offspring also exhibited anxiety and depressive behaviors, along with elevated serum corticosterone levels and decreased glucocorticoid receptor abundance in the hippocampus. This study expands our understanding of developmental programming and provides a basis for studying metabolic and behavioral alterations in offspring related to maternal inflammation.
Article
Biochemistry & Molecular Biology
You-Lin Tain, Chih-Yao Hou, Guo-Ping Chang-Chien, Sufan Lin, Chien-Ning Hsu
Summary: This study aimed to investigate the protective effects of sodium thiosulfate (STS) in a rat model of maternal CKD-induced hypertension. The results showed that STS treatment could enhance H2S and NO signaling pathways, alter gut microbiota, and protect offspring from maternal CKD-primed hypertension. This suggests that early-life interventions targeting reactive sulfur species (RSS) have potential preventive and therapeutic benefits for CKD-induced hypertension.
Article
Pediatrics
Wei Han, Ya'nan Pan, Ziyao Han, Li Cheng, Li Jiang
Summary: This study aims to evaluate the effects of advanced maternal age (AMA) on the development of myelin sheaths in offspring. The results indicate that AMA impairs memory function and myelin formation in offspring, with the ERK signaling pathway potentially playing a significant role.
FRONTIERS IN PEDIATRICS
(2022)
Review
Endocrinology & Metabolism
Niamh-Maire Mclennan, Jonathan Hazlehurst, Shakila Thangaratinam, Rebecca M. Reynolds
Summary: There is an increase in maternal metabolic burden due to various complications during pregnancy, which is associated with long-term risks for both women and their offspring. Current interventions have shown short-term improvements in metabolic health, but their long-term effects remain uncertain. Early identification and risk assessment strategies are crucial for targeting women and offspring at highest risk for adverse metabolic health.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Purificacion Ros, Jesus Argente, Julie A. Chowen
Summary: Maternal nutritional imbalances, overweight, and obesity can have long-term effects on offspring's metabolic health, increasing the risk of diseases like obesity, diabetes, and cardiovascular issues. Resveratrol, a polyphenolic compound, is believed to provide protective effects against metabolic issues induced by poor dietary habits, although studies on its supplementation during pregnancy are inconclusive. Different responses to metabolic challenges between males and females need further exploration in research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Akiko Mizokami, Satoru Mukai, Jing Gao, Tomoyo Kawakubo-Yasukochi, Takahito Otani, Hiroshi Takeuchi, Eijiro Jimi, Masato Hirata
JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Cell & Tissue Engineering
Daisuke Suzuki, Charlotte Flahou, Norihide Yoshikawa, Ieva Stirblyte, Yoshikazu Hayashi, Akira Sawaguchi, Marina Akasaka, Sou Nakamura, Natsumi Higashi, Huaigeng Xu, Takuya Matsumoto, Kosuke Fujio, Markus G. Manz, Akitsu Hotta, Hitoshi Takizawa, Koji Eto, Naoshi Sugimoto
Article
Pharmacology & Pharmacy
Shohei Yoshimoto, Miho Matsuda, Kenichi Kato, Eijiro Jimi, Hiroshi Takeuchi, Shuji Nakano, Shunichi Kajioka, Etsuko Matsuzaki, Takao Hirofuji, Ryuji Inoue, Masato Hirata, Hiromitsu Morita
Summary: The study found that VRAC is highly functional and associated with proliferation in HST-1 cells, but not in HaCaT cells. The pharmacological profile of VRAC in HST-1 was similar to previous reports, and inhibition of VRAC with DCPIB led to apoptosis in HST-1 cells. Knockdown of TMEM16A and LRRC8A attenuated VRAC activity in HST-1 cells.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Satoru Mukai, Akiko Mizokami, Takahito Otani, Tomomi Sano, Miho Matsuda, Sakura Chishaki, Jing Gao, Tomoyo Kawakubo-Yasukochi, Ronghao Tang, Takashi Kanematsu, Hiroshi Takeuchi, Eijiro Jimi, Masato Hirata
Summary: GPRC6A regulates various physiological processes in response to its interaction with multiple ligands and its constitutive activation in adipocytes plays a key role in adipose lipid handling and the prevention of obesity and related metabolic disorders.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Eika Ando, Sen Higashi, Akiko Mizokami, Seiji Watanabe, Masato Hirata, Hiroshi Takeuchi
Summary: Bone matrix protein osteocalcin (OC) is involved in the development of learning and memory, and the prevention of anxiety-like behaviors in mice. This study found that OC can enhance cell proliferation, differentiation, and survival in neurons by binding to its candidate receptor GPR158.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Hikaru Fukuda, Shinobu Sato, Tingting Zou, Sen Higashi, Osamu Takahashi, Manabu Habu, Masaaki Sasaguri, Kazuhiro Tominaga, Shigeori Takenaka, Hiroshi Takeuchi
Summary: In this study, the interaction of cyclic naphthalene diimide derivatives with G-quartet DNA was investigated under dilute or molecular crowding condition. The results showed that compound 4 exhibited the highest stability towards the TA-core. Additionally, compound 3 demonstrated specific growth inhibition of cancer cell line Ca9-22 at IC50 <0.03 μM, with the highest expression level of telomerase mRNA.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Cell Biology
Jing Gao, Akiko Mizokami, Hiroshi Takeuchi, Aonan Li, Fei Huang, Haruki Nagano, Takashi Kanematsu, Eijiro Jimi, Masato Hirata
Summary: PRIP facilitates insulin signaling by modulating the internalization of insulin receptor (IR) in adipocytes, playing an important regulatory role in insulin signaling.
JOURNAL OF CELL SCIENCE
(2022)
Article
Endocrinology & Metabolism
Kayo Mori, Akiko Mizokami, Tomomi Sano, Satoru Mukai, Fumitaka Hiura, Yasunori Ayukawa, Kiyoshi Koyano, Takashi Kanematsu, Eijiro Jimi
Summary: The study suggests that activation of the non-canonical NF-kappa B pathway through elevation of serum RANKL levels contributes to postmenopausal obesity.
JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maiko Sezaki, Yoshikazu Hayashi, Gaku Nakato, Yuxin Wang, Sayuri Nakata, Subinoy Biswas, Tatsuya Morishima, Md Fakruddin, Jieun Moon, Soyeon Ahn, Pilhan Kim, Yuji Miyamoto, Hideo Baba, Shinji Fukuda, Hitoshi Takizawa
Summary: The study reveals the communication between bone marrow and inflamed sites during gut inflammation, where hematopoietic stem and progenitor cells are activated and directed towards inflamed lymph nodes for expansion and differentiation. This process is mediated by the commensal bacteria Bacteroides and highlights the importance of maintaining immune balance.
Article
Biochemistry & Molecular Biology
Fumitaka Hiura, Yuko Kawabata, Tsukasa Aoki, Akiko Mizokami, Eijiro Jimi
Summary: The study reveals the importance of ATG4/LC3 in osteoclast maturation and bone resorption. By using a specific inhibitor of ATG4B, NSC185058 (NSC), osteoclastogenesis and maturation can be inhibited, leading to a decrease in alveolar bone resorption in a periodontitis model.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Hematology
Koki Nagai, Tetsuya Niihori, Akihiko Muto, Yoshikazu Hayashi, Taiki Abe, Kazuhiko Igarashi, Yoko Aoki
Summary: Radioulnar synostosis with amegakaryocytic thrombocytopenia (RUSAT) is an inherited bone marrow failure syndrome caused by missense mutations in the MECOM gene. Knockin mice harboring RUSAT-associated MECOM mutations recapitulate the bone marrow dysfunction observed in RUSAT patients.
Article
Dentistry, Oral Surgery & Medicine
Mayuka Yamagata, Sen Higashi, Noboru Yaida, Akane Ichihara, Manabu Habu, Masaaki Sasaguri, Kazuhiro Tominaga, Hiroshi Takeuchi
Summary: Metformin reduces the expression of EGFR in cancer cells and inhibits cell proliferation by promoting ligand-induced internalization and degradation of EGFR. This finding suggests that the effect of metformin on EGFR may impact therapeutic outcomes when combined with other cancer treatments.
ORAL SCIENCE INTERNATIONAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Fumiko Aonuma, Sen Higashi, Shintaro Tsuka, Tomoko Ohsumi, Chihiro Masaki, Ryuji Hosokawa, Hiroshi Takeuchi
Summary: The study found that C1q can affect the differentiation of osteoblasts and osteoclasts, depending on the concentration. C1q does not activate the Wnt/beta-catenin signaling pathway, but can upregulate RANKL-induced phosphorylation of Akt.
JOURNAL OF PROSTHODONTIC RESEARCH
(2021)
Article
Multidisciplinary Sciences
Fumio Nakagawa, Sen Higashi, Eika Ando, Tomoko Ohsumi, Seiji Watanabe, Hiroshi Takeuchi