HIV-1 Vpr Reprograms CLR4DCAF1 E3 Ubiquitin Ligase to Antagonize Exonuclease 1-Mediated Restriction of HIV-1 Infection

Multilayered and versatile inhibition of cellular antiviral factors by HIV and SIV accessory proteins

(2018) Daniel Sauter et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Vpr Targets TET2 for Degradation by CRL4 VprBP E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication

(2018) Lei Lv et al.   MOLECULAR CELL

Large-Scale Arrayed Analysis of Protein Degradation Reveals Cellular Targets for HIV-1 Vpu

(2018) Prashant Jain et al.   Cell Reports

DNA-damage-induced degradation of EXO1 exonuclease limits DNA end resection to ensure accurate DNA repair

(2017) Nozomi Tomimatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Vpr protein directly loads helicase-like transcription factor (HLTF) onto the CRL4-DCAF1 E3 ubiquitin ligase

(2017) Xiaohong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exonuclease 1 and its versatile roles in DNA repair

(2016) Guido Keijzers et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

SLX4-SLX1 Protein-independent Down-regulation of MUS81-EME1 Protein by HIV-1 Viral Protein R (Vpr)

(2016) Xiaohong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DDB1–DCAF1–Vpr–UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction

(2016) Ying Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages

(2016) Hichem Lahouassa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 and HIV-2 exhibit divergent interactions with HLTF and UNG2 DNA repair proteins

(2016) Kasia Hrecka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DDB1–DCAF1–Vpr–UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction

(2016) Ying Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

5-Hydroxymethylcytosine Marks Sites of DNA Damage and Promotes Genome Stability

(2016) Georgia Rose Kafer et al.   Cell Reports

HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4 + T Cells

(2016) Jolien Vermeire et al.   Cell Reports

Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells

(2016) Erik C Hansen et al.   eLife

DNA2 drives processing and restart of reversed replication forks in human cells

(2015) Saravanabhavan Thangavel et al.   JOURNAL OF CELL BIOLOGY

Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response

(2015) Andrew E.H. Elia et al.   MOLECULAR CELL

Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing

(2014) Nadine Laguette et al.   CELL

DNA end resection is needed for the repair of complex lesions in G1-phase human cells

(2014) Nicole B Averbeck et al.   CELL CYCLE

Holliday junction resolution: Regulation in space and time

(2014) Joao Matos et al.   DNA REPAIR

HIV-1 Vpr—a still “enigmatic multitasker”

(2014) Carolin A. Guenzel et al.   Frontiers in Microbiology

Multiple APOBEC3 Restriction Factors for HIV-1 and One Vif to Rule Them All

(2013) Belete A. Desimmie et al.   JOURNAL OF MOLECULAR BIOLOGY

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

(2013) Caroline Goujon et al.   NATURE

Base Excision Repair

(2013) H. E. Krokan et al.   Cold Spring Harbor Perspectives in Biology

An Optimized microRNA Backbone for Effective Single-Copy RNAi

(2013) Christof Fellmann et al.   Cell Reports

Cyclin F-Mediated Degradation of Ribonucleotide Reductase M2 Controls Genome Integrity and DNA Repair

(2012) Vincenzo D'Angiolella et al.   CELL

HIV/Simian Immunodeficiency Virus (SIV) Accessory Virulence Factor Vpx Loads the Host Cell Restriction Factor SAMHD1 onto the E3 Ubiquitin Ligase Complex CRL4DCAF1

(2012) Jinwoo Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lentivirus Vpr and Vpx accessory proteins usurp the cullin4–DDB1 (DCAF1) E3 ubiquitin ligase

(2012) Bizhan Romani et al.   Current Opinion in Virology

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

(2011) A. V. Nimonkar et al.   GENES & DEVELOPMENT

Abundant Non-canonical dUTP Found in Primary Human Macrophages Drives Its Frequent Incorporation by HIV-1 Reverse Transcriptase

(2011) Edward M. Kennedy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

Viral hijacking of the host ubiquitin system to evade interferon responses

(2010) Kasinath Viswanathan et al.   CURRENT OPINION IN MICROBIOLOGY

Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks

(2010) Sascha E. Liberti et al.   DNA REPAIR

HIV-1 Vpr Loads Uracil DNA Glycosylase-2 onto DCAF1, a Substrate Recognition Subunit of a Cullin 4A-RING E3 Ubiquitin Ligase for Proteasome-dependent Degradation

(2010) Jinwoo Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The evolution of HIV-1 and the origin of AIDS

(2010) P. M. Sharp et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Formation of Mobile Chromatin-Associated Nuclear Foci Containing HIV-1 Vpr and VPRBP Is Critical for the Induction of G2 Cell Cycle Arrest

(2010) Jean-Philippe Belzile et al.   PLoS Pathogens

Role of Double-Stranded DNA Translocase Activity of Human HLTF in Replication of Damaged DNA

(2009) A. Blastyak et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural and Functional Relationships of the XPF/MUS81 Family of Proteins

(2008) Alberto Ciccia et al.   Annual Review of Biochemistry

Lentiviral Vpx Accessory Factor Targets VprBP/DCAF1 Substrate Adaptor for Cullin 4 E3 Ubiquitin Ligase to Enable Macrophage Infection

(2008) Smita Srivastava et al.   PLoS Pathogens