Article
Immunology
Songji Li, Wenyu Cao, Shifen Zhou, Minhui Ma, Wenjuan Zhang, Fang Li, Changqi Li
Summary: Recent research has found that genetic variants of Cntn1 are linked to major depressive disorders. Overexpression of Cntn1 in the hippocampus triggers anxiety- and depression-like phenotypes, microglia activation, and reduced immature neurons in the hippocampus. These findings suggest that Cntn1 plays a role in regulating anxiety and depression through functional actions in the hippocampus.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Biochemistry & Molecular Biology
Kaitryn E. Ronning, Paul-Alexandre Dechelle-Marquet, Yueshen Che, Xavier Guillonneau, Florian Sennlaub, Cecile Delarasse
Summary: Alzheimer's disease (AD) is characterized by impaired memory, amyloid plaques, and neurofibrillary tangles. The release of ATP and the upregulation of P2X7 receptor in AD patients contribute to the disease's pathological processes. Various pathways involving P2X7 have been identified to influence the development of AD, including modulation of Aβ plaques, Tau protein lesions, and inflammatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Li Ma, Jiancheng Zhang, Yuko Fujita, Hiroyo Shinno-Hashimoto, Jiajing Shan, Xiayun Wan, Youge Qu, Lijia Chang, Xingming Wang, Kenji Hashimoto
Summary: This study found that the splenic nerve plays a role in inflammation-related depression and microglial activation in the hippocampus, and that the gut microbiota may regulate microglial function in the brain via the gut-microbiota-brain axis.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Immunology
Orlando Torres-Rodriguez, Yesenia Rivera-Escobales, Yesenia Castillo-Ocampo, Bethzaly Velazquez, Maria Colon, James T. Porter
Summary: Clinical evidence suggests a link between increased peripheral pro-inflammatory cytokines and post-traumatic stress disorder (PTSD) symptoms. However, it is still unclear whether inflammation contributes to or is a consequence of PTSD. Previous research has shown that stress can activate purinergic P2X7 receptors (P2X7Rs) on microglia to induce inflammation and behavioral changes.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Clinical Neurology
Aimun A. B. Jamjoom, Jonathan Rhodes, Peter J. D. Andrews, Seth G. N. Grant
Summary: Traumatic brain injury (TBI) is a major cause of death and disability worldwide, with potential long-term consequences such as dementia. Recent research has shown that TBI has a significant impact on synapse structure and function, leading to synapse loss. This review highlights the role of synapses in TBI pathophysiology, including the impact of secondary injury processes such as excitotoxicity, inflammation, and oxidative stress. Astrocytes are proposed to play a crucial role in mediating synapse loss and recovery after TBI.
Review
Immunology
Samuel C. Woodburn, Justin L. Bollinger, Eric S. Wohleb
Summary: Microglia are increasingly recognized as critical regulators of neuronal function and behavior in neuroscience. Research has shifted focus from their classical immune functions in pathological contexts to neuro-immune interactions in the absence of disease, injury, or infection. Standard methods to study and define microglial phenotype and function are being developed to facilitate the development of microglia-directed therapeutics in psychiatric and neurological diseases.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Jimeng Li, Lei Tong, Bettina C. Schock, Li-Li Ji
Summary: Post-traumatic stress disorder (PTSD) is closely related to neuroinflammation, which plays a key role in the pathogenesis of PTSD. Activation of immune cells and changes in inflammatory markers in the brain are involved in neuroinflammation. Understanding the mechanisms of neuroinflammation in PTSD is crucial for studying the disorder.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Daiane F. Engel, Licio A. Velloso
Summary: In experimental models, hypothalamic dysfunction is a crucial component in the pathophysiology of diet-induced obesity. Structural and functional changes in neurons, microglia, astrocytes, and tanycytes of the mediobasal hypothalamus, shortly after the introduction of a high-fat diet, impact caloric intake, energy expenditure, and systemic glucose tolerance. Inflammation plays a central role in this response, and there is a temporal sequence of events determining the fate of different cells involved in the central regulation of whole-body energy homeostasis.
Review
Geriatrics & Gerontology
Mingsheng Sun, Jing Rong, Mengdi Zhou, Yi Liu, Shiqi Sun, Lu Liu, Dingjun Cai, Fanrong Liang, Ling Zhao
Summary: Migraine, a prevalent neurological disease, is closely associated with neurogenic inflammation. The interaction between microglia and astrocytes, crucial in the pathology of Alzheimer's disease and other inflammation-related central nervous system diseases, has recently emerged as a novel focus in neuroimmune research. However, the role of this interaction in the pathogenesis and treatment of migraine remains to be explored. By reviewing relevant evidence, we aim to provide new insights for future research and treatment.
Article
Neurosciences
Ying Guo, Jianping Xie, Lanchun Zhang, Lingli Yang, Jiaqing Ma, Yufan Bai, Wenjie Ma, Ling Wang, Haofei Yu, Yueqin Zeng, Haiyun Luo, Rongping Zhang
Summary: Ginsenoside Rb1 has antidepressant effects in mice subjected to chronic restraint stress, possibly through inhibiting inflammation responses and protecting microglia cells.
NEUROSCIENCE LETTERS
(2021)
Article
Pharmacology & Pharmacy
Mariangela Chisari, Michele Barraco, Claudio Bucolo, Lucia Ciranna, Maria Angela Sortino
Summary: Microglia, the resident immune cells in the brain, play a crucial role in neuroinflammation and CNS homeostasis. This study investigated the involvement of two receptor subtypes, purinergic ionotropic P2X7 receptor and metabotropic glutamate mGlu5 receptor, in microglial function. The results showed that these receptors are functionally expressed in microglia and their activation affects ion flux and nitric oxide synthesis. The study suggests an important crosstalk between ATP and glutamate in inflammation and provides potential pharmacological targets for modulating neuroinflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qianqian Liu, Rui Li, Wei Yang, Ranji Cui, Bingjin Li
Summary: This study summarized the role of neuroglia in neuropathic pain and depression, revealing a bridging role of neuroglia in both conditions.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Immunology
Chenhui Ji, Yalin Tang, Yanyan Zhang, Congcong Li, Huazheng Liang, Lu Ding, Xiaohuan Xia, Lize Xiong, Xin-Rui Qi, Jialin C. Zheng
Summary: Glutaminase 1 (GLS1) has been found to play a crucial role in neuroinflammation, particularly in depression. By targeting GLS1 in microglia, it is possible to alleviate neuroinflammation and depression-like behaviors.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Neurosciences
Rino Takei, Mari Nakashima, Mari Gotoh, Misaki Endo, Kei Hashimoto, Yasunori Miyamoto, Kimiko Murakami-Murofushi
Summary: 2-carba-cyclic phosphatidic acid (2ccPA) suppresses microglial and astrocyte inflammation to protect neuronal survival after traumatic brain injury. The study reveals that the behavior of 2ccPA in glial communication involves altering the activation of microglia. Astrocytes play a crucial role in regulating microglial polarization, promoting the M2 phenotype and suppressing cytokine production.
NEUROSCIENCE LETTERS
(2023)
Review
Immunology
Ganggui Zhu, Xiaoyu Wang, Luxi Chen, Cameron Lenahan, Zaixiang Fu, Yuanjian Fang, Wenhua Yu
Summary: This article discusses the adverse consequences of oxidative stress and the role of glial cells in stroke. Glial cells are rapidly activated after stroke, generating large amounts of reactive oxygen species (ROS) that cause oxidative damage. Additionally, ROS regulate the function of glial cells in pathological processes such as neuroinflammation and blood-brain barrier damage. However, glial cells also protect the central nervous system from oxidative damage by synthesizing antioxidants and regulating the Nrf2 pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Psychiatry
Jia-Mei Li, Yi Zhang, Wen-Jun Su, Lin-Lin Liu, Hong Gong, Wei Peng, Chun-Lei Jiang
PSYCHIATRY RESEARCH
(2018)
Article
Neurosciences
Jia-Mei Li, Lin-Lin Liu, Wen-Jun Su, Bo Wang, Ting Zhang, Yi Zhang, Chun-Lei Jiang
Article
Sport Sciences
Hong Gong, Lei Liu, Wen-Jun Su, Zhen Zhu, Yun-Zi Liu, Yong-Jie Lian, Wei Peng, Zhi-Yong Cao, Ting Zhang, Chun-Lei Jiang
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2019)
Article
Oncology
Bo Wang, Yong-Jie Lian, Wen-Jun Su, Lin-Lin Liu, Jia-Mei Li, Chun-Lei Jiang, Yun-Xia Wang
MOLECULAR MEDICINE REPORTS
(2019)
Article
Immunology
Lin-Lin Liu, Jia-Mei Li, Wen-Jun Su, Bo Wang, Chun-Lei Jiang
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Review
Immunology
Wen-Jun Su, Zhi-Yong Cao, Chun-Lei Jiang
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Article
Multidisciplinary Sciences
Yun-zi Liu, Wei Peng, Ji-kuai Chen, Wen-jun Su, Wen-jie Yan, Yun-xia Wang, Chun-lei Jiang
Article
Neurosciences
Ran Wu, Lin-Lin Liu, Hong Zhu, Wen-Jun Su, Zhi-Yong Cao, Shi-Yang Zhong, Xing-Hua Liu, Chun-Lei Jiang
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Clinical Neurology
Zhi-Yong Cao, Yun-Zi Liu, Jia-Mei Li, Yi-Ming Ruan, Wen-Jie Yan, Shi-Yang Zhong, Ting Zhang, Lin-Lin Liu, Ran Wu, Bo Wang, Wei Wang, Xiao-Ying Bi, Yun-Xia Wang, Wen-Jun Su, Chun-Lei Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2020)
Article
Immunology
Bo Wang, Xiao Huang, Xiao Pan, Ting Zhang, Cheng Hou, Wen-Jun Su, Lin-Lin Liu, Jia-Mei Li, Yun-Xia Wang
BRAIN BEHAVIOR AND IMMUNITY
(2020)
Article
Psychiatry
Ran Wu, Shi-Yang Zhong, Guang-Hai Wang, Meng-Yang Wu, Jin-Fang Xu, Hong Zhu, Lin-Lin Liu, Wen-Jun Su, Zhi-Yong Cao, Chun-Lei Jiang
Summary: This study found that brief mindfulness meditation can help reduce suicidal ideation, stress, and sleep disturbances for college students with high suicidal ideation, and may serve as an effective suicide prevention strategy.
ARCHIVES OF SUICIDE RESEARCH
(2023)
Article
Immunology
Jia-Mei Li, Ting Hu, Xiao-Na Zhou, Ting Zhang, Jia-Hui Guo, Min-Yuan Wang, Yi-Lin Wu, Wen-Jun Su, Chun-Lei Jiang
Summary: Inhibiting NLRP3 inflammasome expression can improve depressive-like behaviors in mice and this study aimed to understand its impact on cognitive decline in depression and explore the common neuro-immunological mechanisms of depression and Alzheimer's disease (AD).
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Clinical Neurology
Wen-Jun Su, Jia-Mei Li, Ting Zhang, Zhi-Yong Cao, Ting Hu, Shi-Yang Zhong, Zhang-Yang Xu, Hong Gong, Chun-Lei Jiang
Summary: This study aims to elucidate the neuroimmune mechanism of diabetes-related depression. The activation of NLRP3 inflammasome, mainly in hippocampal microglia, mediates the development of depression-like behaviors in STZ-induced diabetic mice. Targeting the microglial inflammasome is a feasible strategy for the treatment of diabetes-related depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Immunology
Wen-Jie Yan, Chun-Lei Jiang, Wen-Jun Su
Summary: The World Health Organization presented a Mental Health Action Plan in 2013 with a specific goal for suicide prevention, which aims to reduce the suicide rate by 10% in member countries by 2020. Many valuable breakthroughs have emerged in suicide research in recent years, with the potential for inflammatory biomarkers to play a promising role in the future.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2021)