Neutralizing Monoclonal Antibodies as Promising Therapeutics against Middle East Respiratory Syndrome Coronavirus Infection

Prophylactic and therapeutic efficacy of mAb treatment against MERS-CoV in common marmosets

(2018) Emmie de Wit et al.   ANTIVIRAL RESEARCH

Ultrapotent Human Neutralizing Antibody Repertoires Against Middle East Respiratory Syndrome Coronavirus From a Recovered Patient

(2018) Peihua Niu et al.   JOURNAL OF INFECTIOUS DISEASES

A Novel Nanobody Targeting Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Receptor-Binding Domain Has Potent Cross-Neutralizing Activity and Protective Efficacy against MERS-CoV

(2018) Guangyu Zhao et al.   JOURNAL OF VIROLOGY

Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape

(2018) Lingshu Wang et al.   JOURNAL OF VIROLOGY

Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission

(2018) David S Hui et al.   LANCET INFECTIOUS DISEASES

Experimental infection of dromedaries with Middle East respiratory syndrome-Coronavirus is accompanied by massive ciliary loss and depletion of the cell surface receptor dipeptidyl peptidase 4

(2018) Ann-Kathrin Haverkamp et al.   Scientific Reports

Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein

(2018) Senyan Zhang et al.   Cell Reports

A novel human mAb (MERS-GD27) provides prophylactic and postexposure efficacy in MERS-CoV susceptible mice

(2018) Peihua Niu et al.   Science China-Life Sciences

Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection

(2018) V. Stalin Raj et al.   Science Advances

Application of camelid heavy-chain variable domains (VHHs) in prevention and treatment of bacterial and viral infections

(2017) Lucas Wilken et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset

(2017) Zhe Chen et al.   JOURNAL OF INFECTIOUS DISEASES

Nanobodies® † †Nanobody is a registered trademark of Ablynx NV. as inhaled biotherapeutics for lung diseases

(2017) Gino Van Heeke et al.   PHARMACOLOGY & THERAPEUTICS

A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein

(2017) Yingzhu Chen et al.   Emerging Microbes & Infections

Human monoclonal antibodies as candidate therapeutics against emerging viruses

(2017) Yujia Jin et al.   Frontiers of Medicine

MERS-CoV spike protein: a key target for antivirals

(2016) Lanying Du et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Evidence for zoonotic origins of Middle East respiratory syndrome coronavirus

(2016) Hui-Ju Han et al.   JOURNAL OF GENERAL VIROLOGY

Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection

(2016) Katherine V. Houser et al.   JOURNAL OF INFECTIOUS DISEASES

3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012

(2016) Reed F. Johnson et al.   VIROLOGY

Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus Infection

(2016) Anurodh Shankar Agrawal et al.   Scientific Reports

Rapid generation of a human monoclonal antibody to combat Middle East respiratory syndrome

(2016) Davide Corti et al.   Journal of Infection and Public Health

Generation and Characterization of ALX-0171, a Potent Novel Therapeutic Nanobody for the Treatment of Respiratory Syncytial Virus Infection

(2015) Laurent Detalle et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein

(2015) Yan Li et al.   CELL RESEARCH

Probable transmission chains of Middle East respiratory syndrome coronavirus and the multiple generations of secondary infection in South Korea

(2015) Shui Shan Lee et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Asymptomatic Middle East Respiratory Syndrome Coronavirus Infection in Rabbits

(2015) Bart L. Haagmans et al.   JOURNAL OF VIROLOGY

Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus

(2015) Davide Corti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection

(2015) Kristen E. Pascal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multi-Organ Damage in Human Dipeptidyl Peptidase 4 Transgenic Mice Infected with Middle East Respiratory Syndrome-Coronavirus

(2015) Guangyu Zhao et al.   PLoS One

Exceptionally Potent Neutralization of Middle East Respiratory Syndrome Coronavirus by Human Monoclonal Antibodies

(2014) Tianlei Ying et al.   JOURNAL OF VIROLOGY

A Conformation-Dependent Neutralizing Monoclonal Antibody Specifically Targeting Receptor-Binding Domain in Middle East Respiratory Syndrome Coronavirus Spike Protein

(2014) L. Du et al.   JOURNAL OF VIROLOGY

Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution

(2014) X.-C. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid generation of a mouse model for Middle East respiratory syndrome

(2014) Jincun Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potent Neutralization of MERS-CoV by Human Neutralizing Monoclonal Antibodies to the Viral Spike Glycoprotein

(2014) L. Jiang et al.   Science Translational Medicine

Identification of residues on human receptor DPP4 critical for MERS-CoV binding and entry

(2014) Wenfei Song et al.   VIROLOGY

Infection with MERS-CoV Causes Lethal Pneumonia in the Common Marmoset

(2014) Darryl Falzarano et al.   PLoS Pathogens

Nanobodies: Natural Single-Domain Antibodies

(2013) Serge Muyldermans   Annual Review of Biochemistry

Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4

(2013) Nianshuang Wang et al.   CELL RESEARCH

Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus

(2013) C. M. Coleman et al.   JOURNAL OF GENERAL VIROLOGY

An Animal Model of MERS Produced by Infection of Rhesus Macaques With MERS Coronavirus

(2013) Y. Yao et al.   JOURNAL OF INFECTIOUS DISEASES

Adenosine Deaminase Acts as a Natural Antagonist for Dipeptidyl Peptidase 4-Mediated Entry of the Middle East Respiratory Syndrome Coronavirus

(2013) V. S. Raj et al.   JOURNAL OF VIROLOGY

Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26

(2013) Guangwen Lu et al.   NATURE

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Does Not Replicate in Syrian Hamsters

(2013) Emmie de Wit et al.   PLoS One

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans

(2012) S. van Boheemen et al.   mBio