Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape

Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset

(2017) Zhe Chen et al.   JOURNAL OF INFECTIOUS DISEASES

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen

(2017) Jesper Pallesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

(2017) Ling Xu et al.   SCIENCE

Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains

(2017) Yuan Yuan et al.   Nature Communications

A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein

(2017) Yingzhu Chen et al.   Emerging Microbes & Infections

Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding

(2016) Miao Gui et al.   CELL RESEARCH

Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection

(2016) Katherine V. Houser et al.   JOURNAL OF INFECTIOUS DISEASES

Pre-fusion structure of a human coronavirus spike protein

(2016) Robert N. Kirchdoerfer et al.   NATURE

Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo

(2016) Thomas Luke et al.   Science Translational Medicine

3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012

(2016) Reed F. Johnson et al.   VIROLOGY

Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability

(2016) Rosemarie D. Mason et al.   PLoS Pathogens

Animal models of Middle East respiratory syndrome coronavirus infection

(2015) Neeltje van Doremalen et al.   ANTIVIRAL RESEARCH

A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein

(2015) Yan Li et al.   CELL RESEARCH

Passive Immunotherapy with Dromedary Immune Serum in an Experimental Animal Model for Middle East Respiratory Syndrome Coronavirus Infection

(2015) Jincun Zhao et al.   JOURNAL OF VIROLOGY

Generation of a Transgenic Mouse Model of Middle East Respiratory Syndrome Coronavirus Infection and Disease

(2015) Anurodh Shankar Agrawal et al.   JOURNAL OF VIROLOGY

Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus

(2015) Davide Corti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection

(2015) Kristen E. Pascal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody

(2015) Tianlei Ying et al.   Nature Communications

Evaluation of candidate vaccine approaches for MERS-CoV

(2015) Lingshu Wang et al.   Nature Communications

History of passive antibody administration for prevention and treatment of infectious diseases

(2015) Barney S. Graham et al.   Current Opinion in HIV and AIDS

Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27

(2015) Xiaojuan Yu et al.   Scientific Reports

Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein

(2015) Morgan S. A. Gilman et al.   PLoS Pathogens

Improving Neutralization Potency and Breadth by Combining Broadly Reactive HIV-1 Antibodies Targeting Major Neutralization Epitopes

(2014) Rui Kong et al.   JOURNAL OF VIROLOGY

Effects of Human Anti-Spike Protein Receptor Binding Domain Antibodies on Severe Acute Respiratory Syndrome Coronavirus Neutralization Escape and Fitness

(2014) J. Sui et al.   JOURNAL OF VIROLOGY

Exceptionally Potent Neutralization of Middle East Respiratory Syndrome Coronavirus by Human Monoclonal Antibodies

(2014) Tianlei Ying et al.   JOURNAL OF VIROLOGY

A Conformation-Dependent Neutralizing Monoclonal Antibody Specifically Targeting Receptor-Binding Domain in Middle East Respiratory Syndrome Coronavirus Spike Protein

(2014) L. Du et al.   JOURNAL OF VIROLOGY

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp

(2014) Xiangguo Qiu et al.   NATURE

Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution

(2014) X.-C. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potent Neutralization of MERS-CoV by Human Neutralizing Monoclonal Antibodies to the Viral Spike Glycoprotein

(2014) L. Jiang et al.   Science Translational Medicine

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4

(2013) Nianshuang Wang et al.   CELL RESEARCH

The Receptor Binding Domain of the New Middle East Respiratory Syndrome Coronavirus Maps to a 231-Residue Region in the Spike Protein That Efficiently Elicits Neutralizing Antibodies

(2013) H. Mou et al.   JOURNAL OF VIROLOGY

Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk

(2013) Romulus Breban et al.   LANCET

Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study

(2013) Abdullah Assiri et al.   LANCET INFECTIOUS DISEASES

Middle East respiratory syndrome coronavirus: quantification of the extent of the epidemic, surveillance biases, and transmissibility

(2013) Simon Cauchemez et al.   LANCET INFECTIOUS DISEASES

Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26

(2013) Guangwen Lu et al.   NATURE

Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia

(2013) Masashi Shingai et al.   NATURE

Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus

(2013) Abdullah Assiri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus

(2013) T. Scobey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation of antibody V(D)J sequences from single cell sorted rhesus macaque B cells

(2012) Christopher Sundling et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Epitope Mapping of Broadly Neutralizing HIV-2 Human Monoclonal Antibodies

(2012) R. Kong et al.   JOURNAL OF VIROLOGY

Structural and genetic basis for development of broadly neutralizing influenza antibodies

(2012) Daniel Lingwood et al.   NATURE

HIV therapy by a combination of broadly neutralizing antibodies in humanized mice

(2012) Florian Klein et al.   NATURE

Human Monoclonal Antibodies against Highly Conserved HR1 and HR2 Domains of the SARS-CoV Spike Protein Are More Broadly Neutralizing

(2012) Hatem A. Elshabrawy et al.   PLoS One

Origin, diversity, and maturation of human antiviral antibodies analyzed by high-throughput sequencing

(2012) Ponraj Prabakaran et al.   Frontiers in Microbiology

iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM

(2011) T. Geoff G. Battye et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Neutralizing human monoclonal antibodies to severe acute respiratory syndrome coronavirus: target, mechanism of action, and therapeutic potential

(2011) Melissa M. Coughlin et al.   REVIEWS IN MEDICAL VIROLOGY

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

(2011) X. Wu et al.   SCIENCE

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

(2010) X. Wu et al.   SCIENCE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis

(2008) X. Brochet et al.   NUCLEIC ACIDS RESEARCH