MERS-CoV spike protein: a key target for antivirals

Single-dose treatment with a humanized neutralizing antibody affords full protection of a human transgenic mouse model from lethal Middle East respiratory syndrome (MERS)-coronavirus infection

(2016) Hongjie Qiu et al.   ANTIVIRAL RESEARCH

Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)

(2016) Nan Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection

(2016) Katherine V. Houser et al.   JOURNAL OF INFECTIOUS DISEASES

MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study

(2016) Sun Young Cho et al.   LANCET

3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012

(2016) Reed F. Johnson et al.   VIROLOGY

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) origin and animal reservoir

(2016) Hamzah A. Mohd et al.   Virology Journal

Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus Infection

(2016) Anurodh Shankar Agrawal et al.   Scientific Reports

Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis)

(2016) Vincent J. Munster et al.   Scientific Reports

A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein

(2015) Yan Li et al.   CELL RESEARCH

Estimating the risk of Middle East respiratory syndrome (MERS) death during the course of the outbreak in the Republic of Korea, 2015

(2015) Kenji Mizumoto et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Probable transmission chains of Middle East respiratory syndrome coronavirus and the multiple generations of secondary infection in South Korea

(2015) Shui Shan Lee et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Protective Effect of Intranasal Regimens Containing Peptidic Middle East Respiratory Syndrome Coronavirus Fusion Inhibitor Against MERS-CoV Infection

(2015) Rudragouda Channappanavar et al.   JOURNAL OF INFECTIOUS DISEASES

Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus

(2015) Yang Yang et al.   JOURNAL OF VIROLOGY

Characterization and Demonstration of the Value of a Lethal Mouse Model of Middle East Respiratory Syndrome Coronavirus Infection and Disease

(2015) Xinrong Tao et al.   JOURNAL OF VIROLOGY

Intranasally administered peptidic viral fusion inhibitor protected hDPP4 transgenic mice from MERS-CoV infection

(2015) Shibo Jiang et al.   LANCET

Middle East respiratory syndrome

(2015) Alimuddin Zumla et al.   LANCET

MERS – A cautionary tale

(2015) Sophia Häfner et al.   MICROBES AND INFECTION

Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus

(2015) Davide Corti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection

(2015) Kristen E. Pascal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dromedary Camels and the Transmission of Middle East Respiratory Syndrome Coronavirus (MERS-CoV)

(2015) M. G. Hemida et al.   Transboundary and Emerging Diseases

Bat-to-human: spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond

(2015) Guangwen Lu et al.   TRENDS IN MICROBIOLOGY

An Outbreak of Middle East Respiratory Syndrome Coronavirus Infection in South Korea, 2015

(2015) Jun Yong Choi   YONSEI MEDICAL JOURNAL

Origin and Possible Genetic Recombination of the Middle East Respiratory Syndrome Coronavirus from the First Imported Case in China: Phylogenetics and Coalescence Analysis

(2015) Yanqun Wang et al.   mBio

Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody

(2015) Tianlei Ying et al.   Nature Communications

Evaluation of candidate vaccine approaches for MERS-CoV

(2015) Lingshu Wang et al.   Nature Communications

Lessons to learn from MERS-CoV outbreak in South Korea

(2015) Adnan Khan et al.   Journal of Infection in Developing Countries

Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27

(2015) Xiaojuan Yu et al.   Scientific Reports

Be vigilant: New MERS-CoV outbreaks can occur in the Kingdom of Saudi Arabia

(2015) Payman Salamati et al.   Travel Medicine and Infectious Disease

Urgent development of effective therapeutic and prophylactic agents to control the emerging threat of Middle East respiratory syndrome (MERS)

(2015) Lu Lu et al.   Emerging Microbes & Infections

Bat Origins of MERS-CoV Supported by Bat Coronavirus HKU4 Usage of Human Receptor CD26

(2014) Qihui Wang et al.   Cell Host & Microbe

An Observational, Laboratory-Based Study of Outbreaks of Middle East Respiratory Syndrome Coronavirus in Jeddah and Riyadh, Kingdom of Saudi Arabia, 2014

(2014) C. Drosten et al.   CLINICAL INFECTIOUS DISEASES

Current advancements and potential strategies in the development of MERS-CoV vaccines

(2014) Naru Zhang et al.   Expert Review of Vaccines

Inhibition of Proprotein Convertases Abrogates Processing of the Middle Eastern Respiratory Syndrome Coronavirus Spike Protein in Infected Cells but Does Not Reduce Viral Infectivity

(2014) S. Gierer et al.   JOURNAL OF INFECTIOUS DISEASES

Host Species Restriction of Middle East Respiratory Syndrome Coronavirus through Its Receptor, Dipeptidyl Peptidase 4

(2014) N. van Doremalen et al.   JOURNAL OF VIROLOGY

Receptor Variation and Susceptibility to Middle East Respiratory Syndrome Coronavirus Infection

(2014) A. Barlan et al.   JOURNAL OF VIROLOGY

Receptor Recognition Mechanisms of Coronaviruses: a Decade of Structural Studies

(2014) Fang Li   JOURNAL OF VIROLOGY

Exceptionally Potent Neutralization of Middle East Respiratory Syndrome Coronavirus by Human Monoclonal Antibodies

(2014) Tianlei Ying et al.   JOURNAL OF VIROLOGY

A Conformation-Dependent Neutralizing Monoclonal Antibody Specifically Targeting Receptor-Binding Domain in Middle East Respiratory Syndrome Coronavirus Spike Protein

(2014) L. Du et al.   JOURNAL OF VIROLOGY

Evidence for Camel-to-Human Transmission of MERS Coronavirus

(2014) Esam I. Azhar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein

(2014) Jean Kaoru Millet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution

(2014) X.-C. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid generation of a mouse model for Middle East respiratory syndrome

(2014) Jincun Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus

(2014) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soaring MERS Cases in Saudi Arabia Raise Alarms

(2014) K. Kupferschmidt   SCIENCE

Potent Neutralization of MERS-CoV by Human Neutralizing Monoclonal Antibodies to the Viral Spike Glycoprotein

(2014) L. Jiang et al.   Science Translational Medicine

Middle East respiratory syndrome coronavirus (MERS-CoV) entry inhibitors targeting spike protein

(2014) Shuai Xia et al.   VIRUS RESEARCH

IFITM Proteins Inhibit Entry Driven by the MERS-Coronavirus Spike Protein: Evidence for Cholesterol-Independent Mechanisms

(2014) Florian Wrensch et al.   Viruses-Basel

Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor

(2014) Lu Lu et al.   Nature Communications

Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4

(2013) Nianshuang Wang et al.   CELL RESEARCH

Evolution and Emergence of Therapeutic Monoclonal Antibodies

(2013) Ian N. Foltz et al.   CIRCULATION

Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease

(2013) X. Yang et al.   JOURNAL OF GENERAL VIROLOGY

Adenosine Deaminase Acts as a Natural Antagonist for Dipeptidyl Peptidase 4-Mediated Entry of the Middle East Respiratory Syndrome Coronavirus

(2013) V. S. Raj et al.   JOURNAL OF VIROLOGY

Middle East Respiratory Syndrome Coronavirus Infection Mediated by the Transmembrane Serine Protease TMPRSS2

(2013) Kazuya Shirato et al.   JOURNAL OF VIROLOGY

Inhibition of Middle East Respiratory Syndrome Coronavirus Infection by Anti-CD26 Monoclonal Antibody

(2013) K. Ohnuma et al.   JOURNAL OF VIROLOGY

Structure of the Fusion Core and Inhibition of Fusion by a Heptad Repeat Peptide Derived from the S Protein of Middle East Respiratory Syndrome Coronavirus

(2013) J. Gao et al.   JOURNAL OF VIROLOGY

Identification of a Receptor-Binding Domain in the S Protein of the Novel Human Coronavirus Middle East Respiratory Syndrome Coronavirus as an Essential Target for Vaccine Development

(2013) L. Du et al.   JOURNAL OF VIROLOGY

Crystal Structure of the Receptor-Binding Domain from Newly Emerged Middle East Respiratory Syndrome Coronavirus

(2013) Y. Chen et al.   JOURNAL OF VIROLOGY

The Spike Protein of the Emerging Betacoronavirus EMC Uses a Novel Coronavirus Receptor for Entry, Can Be Activated by TMPRSS2, and Is Targeted by Neutralizing Antibodies

(2013) S. Gierer et al.   JOURNAL OF VIROLOGY

Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission

(2013) Benoit Guery et al.   LANCET

Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation

(2013) Bart L Haagmans et al.   LANCET INFECTIOUS DISEASES

Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26

(2013) Guangwen Lu et al.   NATURE

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Role of the Spike Glycoprotein of Human Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Virus Entry and Syncytia Formation

(2013) Zhaohui Qian et al.   PLoS One

Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus

(2013) T. Scobey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering a Replication-Competent, Propagation-Defective Middle East Respiratory Syndrome Coronavirus as a Vaccine Candidate

(2013) F. Almazan et al.   mBio

Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?

(2012) Jasper F.W. Chan et al.   JOURNAL OF INFECTION

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5

(2012) Patrick CY Woo et al.   Emerging Microbes & Infections

The safety and side effects of monoclonal antibodies

(2010) Trevor T. Hansel et al.   NATURE REVIEWS DRUG DISCOVERY

Therapeutic antibodies: successes, limitations and hopes for the future

(2009) Patrick Chames et al.   BRITISH JOURNAL OF PHARMACOLOGY

The spike protein of SARS-CoV — a target for vaccine and therapeutic development

(2009) Lanying Du et al.   NATURE REVIEWS MICROBIOLOGY