Enhanced protection in mice induced by immunization with inactivated whole viruses compare to spike protein of middle east respiratory syndrome coronavirus

The recombinant N-terminal domain of spike proteins is a potential vaccine against Middle East respiratory syndrome coronavirus (MERS-CoV) infection

(2017) Lan Jiaming et al.   VACCINE

MERS-CoV spike nanoparticles protect mice from MERS-CoV infection

(2017) Christopher M. Coleman et al.   VACCINE

DNA vaccine encoding Middle East respiratory syndrome coronavirus S1 protein induces protective immune responses in mice

(2017) Hang Chi et al.   VACCINE

Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches

(2017) Nisreen MA Okba et al.   Current Opinion in Virology

A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein

(2017) Yingzhu Chen et al.   Emerging Microbes & Infections

MERS-CoV spike protein: a key target for antivirals

(2016) Lanying Du et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus–Derived CD8+T Cell Epitopes and Host MHC

(2016) William J. Liu et al.   JOURNAL OF IMMUNOLOGY

A roadmap for MERS-CoV research and product development: report from a World Health Organization consultation

(2016) Kayvon Modjarrad et al.   NATURE MEDICINE

A recombinant receptor-binding domain of MERS-CoV in trimeric form protects human dipeptidyl peptidase 4 (hDPP4) transgenic mice from MERS-CoV infection

(2016) Wanbo Tai et al.   VIROLOGY

Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus

(2016) Anurodh Shankar Agrawal et al.   Human Vaccines & Immunotherapeutics

Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus

(2015) Naru Zhang et al.   Cellular & Molecular Immunology

Middle East Respiratory Syndrome Coronavirus: Another Zoonotic Betacoronavirus Causing SARS-Like Disease

(2015) Jasper F. W. Chan et al.   CLINICAL MICROBIOLOGY REVIEWS

Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus

(2015) Xiaojuan Guo et al.   IMMUNOLOGY

An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels

(2015) B. L. Haagmans et al.   SCIENCE

A synthetic consensus anti–spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates

(2015) Karuppiah Muthumani et al.   Science Translational Medicine

Recombinant Receptor Binding Domain Protein Induces Partial Protective Immunity in Rhesus Macaques Against Middle East Respiratory Syndrome Coronavirus Challenge

(2015) Jiaming Lan et al.   EBioMedicine

Prior Immunization with Severe Acute Respiratory Syndrome (SARS)-Associated Coronavirus (SARS-CoV) Nucleocapsid Protein Causes Severe Pneumonia in Mice Infected with SARS-CoV

(2014) F. Yasui et al.   JOURNAL OF IMMUNOLOGY

Effects of Toll-Like Receptor Stimulation on Eosinophilic Infiltration in Lungs of BALB/c Mice Immunized with UV-Inactivated Severe Acute Respiratory Syndrome-Related Coronavirus Vaccine

(2014) N. Iwata-Yoshikawa et al.   JOURNAL OF VIROLOGY

Severe Acute Respiratory Syndrome-Associated Coronavirus Vaccines Formulated with Delta Inulin Adjuvants Provide Enhanced Protection while Ameliorating Lung Eosinophilic Immunopathology

(2014) Yoshikazu Honda-Okubo et al.   JOURNAL OF VIROLOGY

Tailoring Subunit Vaccine Immunity with Adjuvant Combinations and Delivery Routes Using the Middle East Respiratory Coronavirus (MERS-CoV) Receptor-Binding Domain as an Antigen

(2014) Jiaming Lan et al.   PLoS One

Rapid generation of a mouse model for Middle East respiratory syndrome

(2014) Jincun Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent progress concerning CpG DNA and its use as a vaccine adjuvant

(2013) Hidekazu Shirota et al.   Expert Review of Vaccines

Evaluation of Serologic and Antigenic Relationships Between Middle Eastern Respiratory Syndrome Coronavirus and Other Coronaviruses to Develop Vaccine Platforms for the Rapid Response to Emerging Coronaviruses

(2013) Sudhakar Agnihothram et al.   JOURNAL OF INFECTIOUS DISEASES

Middle East Respiratory Syndrome Coronavirus Spike Protein Delivered by Modified Vaccinia Virus Ankara Efficiently Induces Virus-Neutralizing Antibodies

(2013) F. Song et al.   JOURNAL OF VIROLOGY

Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26

(2013) Guangwen Lu et al.   NATURE

Poly(I:C)/Alum Mixed Adjuvant Priming Enhances HBV Subunit Vaccine-Induced Immunity in Mice When Combined with Recombinant Adenoviral-Based HBV Vaccine Boosting

(2013) Xia Chuai et al.   PLoS One

The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS-CoV) are potent interferon antagonists

(2013) Yang Yang et al.   Protein & Cell

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

(2012) Chien-Te Tseng et al.   PLoS One

Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans

(2012) S. van Boheemen et al.   mBio

A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

(2011) M. Bolles et al.   JOURNAL OF VIROLOGY

The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Acts as a Dominant Immunogen Revealed by a Clustering Region of Novel Functionally and Structurally Defined Cytotoxic T‐Lymphocyte Epitopes

(2010) Jun Liu et al.   JOURNAL OF INFECTIOUS DISEASES

Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion Channel

(2009) Konstantin Pervushin et al.   PLoS Pathogens