Emerging roles of lymphatic endothelium in regulating adaptive immunity

Human Lymphatic Endothelial Cells Express Multiple Functional TLRs

(2014) A. Pegu et al.   JOURNAL OF IMMUNOLOGY

An analysis of the function and expression of D6 on lymphatic endothelial cells

(2013) C. S. McKimmie et al.   BLOOD

IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia

(2013) Corey N. Miller et al.   INTERNATIONAL IMMUNOLOGY

Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses

(2013) Suvendu Das et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Normal Dendritic Cell Mobilization to Lymph Nodes under Conditions of Severe Lymphatic Hypoplasia

(2013) A. M. Platt et al.   JOURNAL OF IMMUNOLOGY

An Immunological Fingerprint Differentiates Muscular Lymphatics from Arteries and Veins

(2013) Eric A. Bridenbaugh et al.   Lymphatic Research and Biology

The intestinal micro-environment imprints stromal cells to promote efficient Treg induction in gut-draining lymph nodes

(2013) S Cording et al.   Mucosal Immunology

IL-7-producing stromal cells are critical for lymph node remodeling

(2012) L. Onder et al.   BLOOD

Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells

(2012) E. F. Tewalt et al.   BLOOD

Lymph node-derived lymphatic endothelial cells express functional costimulatory molecules and impair dendritic cell-induced allogenic T-cell proliferation

(2012) Miriam Nörder et al.   FASEB JOURNAL

Identification of IL-7-Producing Cells in Primary and Secondary Lymphoid Organs Using IL-7-GFP Knock-In Mice

(2012) T. Hara et al.   JOURNAL OF IMMUNOLOGY

Expansion of Cortical and Medullary Sinuses Restrains Lymph Node Hypertrophy during Prolonged Inflammation

(2012) K. W. Tan et al.   JOURNAL OF IMMUNOLOGY

Impaired Humoral Immunity and Tolerance in K14-VEGFR-3-Ig Mice That Lack Dermal Lymphatic Drainage

(2012) S. N. Thomas et al.   JOURNAL OF IMMUNOLOGY

Protein expression profiles of human lymph and plasma mapped by 2D-DIGE and 1D SDS–PAGE coupled with nanoLC–ESI–MS/MS bottom-up proteomics

(2012) Cristina C. Clement et al.   Journal of Proteomics

Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks

(2012) Deepali Malhotra et al.   NATURE IMMUNOLOGY

Expression and function of interleukin-7 in secondary and tertiary lymphoid organs

(2012) Hsin-Ying Huang et al.   SEMINARS IN IMMUNOLOGY

Lymphoid tissue structure and HIV-1 infection: life or death for T cells

(2012) Ming Zeng et al.   TRENDS IN IMMUNOLOGY

Thymic epithelial cells: working class heroes for T cell development and repertoire selection

(2012) Graham Anderson et al.   TRENDS IN IMMUNOLOGY

VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics

(2012) Amanda W. Lund et al.   Cell Reports

A Long Affair with Renal Tubules

(2011) Gerhard H. Giebisch   Annual Review of Physiology

Tissue inflammation modulates gene expression of lymphatic endothelial cells and dendritic cell migration in a stimulus-dependent manner

(2011) B. Vigl et al.   BLOOD

T Lymphocytes Negatively Regulate Lymph Node Lymphatic Vessel Formation

(2011) Raghu P. Kataru et al.   IMMUNITY

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Afferent lymph–derived T cells and DCs use different chemokine receptor CCR7–dependent routes for entry into the lymph node and intranodal migration

(2011) Asolina Braun et al.   NATURE IMMUNOLOGY

Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes

(2011) Veronika Lukacs-Kornek et al.   NATURE IMMUNOLOGY

Transmural Flow Modulates Cell and Fluid Transport Functions of Lymphatic Endothelium

(2010) Dimana O. Miteva et al.   CIRCULATION RESEARCH

Dendritic cells adhere to and transmigrate across lymphatic endothelium in response to IFN-α

(2010) Ana Rouzaut et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The lymphoid chemokine CCL21 triggers LFA-1 adhesive properties on human dendritic cells

(2010) Christina Eich et al.   IMMUNOLOGY AND CELL BIOLOGY

Lymph node–resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation

(2010) Jarish N. Cohen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions

(2010) Anne L. Fletcher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II

(2010) Hyota Takamatsu et al.   NATURE IMMUNOLOGY

An Expanded Self-Antigen Peptidome Is Carried by the Human Lymph As Compared to the Plasma

(2010) Cristina C. Clement et al.   PLoS One

Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21

(2010) J. D. Shields et al.   SCIENCE

The lymph as a pool of self-antigens

(2010) Cristina C. Clement et al.   TRENDS IN IMMUNOLOGY

D6 and the atypical chemokine receptor family: Novel regulators of immune and inflammatory processes

(2009) Gerard J. Graham   EUROPEAN JOURNAL OF IMMUNOLOGY

The lymphatic system controls intestinal inflammation and inflammation-associated colon cancer through the chemokine decoy receptor D6

(2009) S. Vetrano et al.   GUT

Conduits Mediate Transport of Low-Molecular-Weight Antigen to Lymph Node Follicles

(2009) Ramon Roozendaal et al.   IMMUNITY

Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning

(2009) Trung H.M. Pham et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intestinal Tolerance Is Converted to Autoimmune Enteritis upon PD-1 Ligand Blockade

(2009) E. D. Reynoso et al.   JOURNAL OF IMMUNOLOGY

Fluid Flow Regulates Stromal Cell Organization and CCL21 Expression in a Tissue-Engineered Lymph Node Microenvironment

(2009) A. A. Tomei et al.   JOURNAL OF IMMUNOLOGY

Inflamed Lymphatic Endothelium Suppresses Dendritic Cell Maturation and Function via Mac-1/ICAM-1-Dependent Mechanism

(2009) S. Podgrabinska et al.   JOURNAL OF IMMUNOLOGY

Contractile Physiology of Lymphatics

(2009) David C. Zawieja   Lymphatic Research and Biology

Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes

(2009) Linda Yip et al.   NATURE IMMUNOLOGY

Cell Traffic and the Lymphatic Endothelium

(2008) Louise A. Johnson et al.   Annals of the New York Academy of Sciences

A Novel Gene Expression Profile in Lymphatics Associated with Tumor Growth and Nodal Metastasis

(2008) S. Clasper et al.   CANCER RESEARCH

Leukocyte adhesion molecule and chemokine production through lipoteichoic acid recognition by toll-like receptor 2 in cultured human lymphatic endothelium

(2008) Yoshihiko Sawa et al.   CELL AND TISSUE RESEARCH

Direct Presentation of Antigen by Lymph Node Stromal Cells Protects Against CD8 T-Cell-Mediated Intestinal Autoimmunity

(2008) Fay C. Magnusson et al.   GASTROENTEROLOGY

Systemic antigen cross-presented by liver sinusoidal endothelial cells induces liver-specific CD8 T-cell retention and tolerization

(2008) Nanette von Oppen et al.   HEPATOLOGY

The microanatomy of T-cell responses

(2008) Tim Lämmermann et al.   IMMUNOLOGICAL REVIEWS

The expression of E-selectin and chemokines in the cultured human lymphatic endothelium with lipopolysaccharides

(2008) Yoshihiko Sawa et al.   JOURNAL OF ANATOMY

Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells

(2008) Irina L Grigorova et al.   NATURE IMMUNOLOGY

Immune escape as a fundamental trait of cancer: focus on IDO

(2008) G C Prendergast   ONCOGENE

Deletional Tolerance Mediated by Extrathymic Aire-Expressing Cells

(2008) J. M. Gardner et al.   SCIENCE