Endo-lysosomal sorting of G-protein-coupled receptors by ubiquitin: Diverse pathways for G-protein-coupled receptor destruction and beyond

Horizontal transfer of exosomal CXCR4 promotes murine hepatocarcinoma cell migration, invasion and lymphangiogenesis

(2018) Min Li et al.   GENE

β-Adrenergic Receptor Trafficking, Degradation, and Cell Surface Expression Are Altered in Dermal Fibroblasts from Hypertrophic Scars

(2018) Amina El Ayadi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?

(2018) Krishna Sriram et al.   MOLECULAR PHARMACOLOGY

Exosomes in cancer: Small transporters with big functions

(2018) Xi Li et al.   CANCER LETTERS

A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling

(2018) Neil J. Grimsey et al.   Cell Reports

Isopeptide and ester bond ubiquitination both regulate degradation of the human dopamine receptor 4

(2017) Jennifer C. Peeler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of Gβγ subunits of Giprotein coupled with S1P receptor on multivesicular endosomes in F-actin formation and cargo sorting into exosomes

(2017) Taketoshi Kajimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis

(2016) Pierre-Michaël Coly et al.   Autophagy

Post-endocytotic Deubiquitination and Degradation of the Metabotropic γ-Aminobutyric Acid Receptor by the Ubiquitin-specific Protease 14

(2016) Nicolas Lahaie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor

(2016) Xufan Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

(2016) Lori Buetow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis

(2016) Xiaonan Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y1 Purinergic Receptor via a YPX3L Motif

(2016) Michael R. Dores et al.   PLoS One

Activation of Adenosine 2A receptor inhibits neutrophil apoptosis in an autophagy-dependent manner in mice with systemic inflammatory response syndrome

(2016) Yang-Wuyue Liu et al.   Scientific Reports

Phosphorylation of the Deubiquitinase USP20 by Protein Kinase A Regulates Post-endocytic Trafficking of β2Adrenergic Receptors to Autophagosomes during Physiological Stress

(2015) Reddy Peera Kommaddi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins

(2015) Neil J. Grimsey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes

(2015) Neil J. Grimsey et al.   JOURNAL OF CELL BIOLOGY

The α-arrestin ARRDC3 mediates ALIX ubiquitination and G protein–coupled receptor lysosomal sorting

(2015) Michael R. Dores et al.   MOLECULAR BIOLOGY OF THE CELL

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

(2015) Yanyong Kang et al.   NATURE

The demographics of the ubiquitin system

(2015) Michael J. Clague et al.   TRENDS IN CELL BIOLOGY

The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein–coupled receptor CXCR4

(2014) Justine Holleman et al.   MOLECULAR BIOLOGY OF THE CELL

Beclin 2 Functions in Autophagy, Degradation of G Protein-Coupled Receptors, and Metabolism

(2013) Congcong He et al.   CELL

ARF6 and GASP-1 are post-endocytic sorting proteins selectively involved in the intracellular trafficking of dopamine D2receptors mediated by GRK and PKC in transfected cells

(2012) DI Cho et al.   BRITISH JOURNAL OF PHARMACOLOGY

ALIX Is a Lys63-Specific Polyubiquitin Binding Protein that Functions in Retrovirus Budding

(2012) Dara P. Dowlatshahi et al.   DEVELOPMENTAL CELL

Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking

(2012) Sang-Oh Han et al.   EMBO REPORTS

ALIX binds a YPX3L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting

(2012) Michael R. Dores et al.   JOURNAL OF CELL BIOLOGY

AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway

(2012) Michael R. Dores et al.   MOLECULAR BIOLOGY OF THE CELL

The E3 Ubiquitin LigaseMahoguninUbiquitinates the Melanocortin 2 Receptor

(2011) Sadani N. Cooray et al.   ENDOCRINOLOGY

Ubiquitination in the First Cytoplasmic Loop of μ-Opioid Receptors Reveals a Hierarchical Mechanism of Lysosomal Down-regulation

(2011) James N. Hislop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adaptor Protein Complex-2 (AP-2) and Epsin-1 Mediate Protease-activated Receptor-1 Internalization via Phosphorylation- and Ubiquitination-dependent Sorting Signals

(2011) Buxin Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β2-Adrenergic Receptor Lysosomal Trafficking Is Regulated by Ubiquitination of Lysyl Residues in Two Distinct Receptor Domains

(2011) Kunhong Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Agonist-directed Interactions with Specific β-Arrestins Determine μ-Opioid Receptor Trafficking, Ubiquitination, and Dephosphorylation

(2011) Chad E. Groer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt

(2010) Akiko Mukai et al.   EMBO JOURNAL

Arrestin-2 Interacts with the Endosomal Sorting Complex Required for Transport Machinery to Modulate Endosomal Sorting of CXCR4

(2010) Rohit Malik et al.   MOLECULAR BIOLOGY OF THE CELL

Dysbindin Promotes the Post-Endocytic Sorting of G Protein-Coupled Receptors to Lysosomes

(2010) Aaron Marley et al.   PLoS One

The deubiquitinases USP33 and USP20 coordinate β2 adrenergic receptor recycling and resensitization

(2009) Magali Berthouze et al.   EMBO JOURNAL

Endosomal Deubiquitinating Enzymes Control Ubiquitination and Down-regulation of Protease-activated Receptor 2

(2009) Burcu Hasdemir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological functions of the HECT family of ubiquitin ligases

(2009) Daniela Rotin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

 -Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2

(2009) S. K. Shenoy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Function of Yeast Epsin and Ede1 Ubiquitin-Binding Domains During Receptor Internalization

(2009) Michael R. Dores et al.   TRAFFIC

ALG-2 interacting protein AIP1: a novel link between D1 and D3 signalling

(2008) Lingping Zhan et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Deubiquitination of CXCR4 by USP14 Is Critical for Both CXCL12-induced CXCR4 Degradation and Chemotaxis but Not ERK Activation

(2008) Marjelo A. Mines et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nedd4 Mediates Agonist-dependent Ubiquitination, Lysosomal Targeting, and Degradation of the β2-Adrenergic Receptor

(2008) Sudha K. Shenoy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells

(2008) Hewang Li et al.   JOURNAL OF CLINICAL INVESTIGATION

The E3 Ubiquitin Ligase Atrophin Interacting Protein 4 Binds Directly To The Chemokine Receptor CXCR4 Via a Novel WW Domain-mediated Interaction

(2008) Deepali Bhandari et al.   MOLECULAR BIOLOGY OF THE CELL

Agonist-Promoted Lys63-Linked Polyubiquitination of the Human  -Opioid Receptor Is Involved in Receptor Down-Regulation

(2008) J.-G. Li et al.   MOLECULAR PHARMACOLOGY