Translating GWAS findings into therapies for depression and anxiety disorders: gene-set analyses reveal enrichment of psychiatric drug classes and implications for drug repositioning

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

(2018) Naomi R. Wray et al.   NATURE GENETICS

Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry

(2017) Hon-Cheong So et al.   NATURE NEUROSCIENCE

Genetic effects influencing risk for major depressive disorder in China and Europe

(2017) T B Bigdeli et al.   Translational Psychiatry

Drug enrichment and discovery from schizophrenia genome-wide association results: an analysis and visualisation approach

(2017) H. A. Gaspar et al.   Scientific Reports

The Effect of Concomitant Treatment With SSRIs and Statins: A Population-Based Study

(2016) Ole Köhler et al.   AMERICAN JOURNAL OF PSYCHIATRY

Combining dependentP-values with an empirical adaptation of Brown’s method

(2016) William Poole et al.   BIOINFORMATICS

Statins for the treatment of depression: A meta-analysis of randomized, double-blind, placebo-controlled trials

(2016) Estela Salagre et al.   JOURNAL OF AFFECTIVE DISORDERS

Gene-set analysis based on the pharmacological profiles of drugs to identify repurposing opportunities in schizophrenia

(2016) Simone de Jong et al.   JOURNAL OF PSYCHOPHARMACOLOGY

A systematic review of calcium channel antagonists in bipolar disorder and some considerations for their future development

(2016) A Cipriani et al.   MOLECULAR PSYCHIATRY

Erratum: Meta-analysis of genome-wide association studies of anxiety disorders

(2016) T Otowa et al.   MOLECULAR PSYCHIATRY

Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci

(2016) D J Smith et al.   MOLECULAR PSYCHIATRY

Meta-analysis of genome-wide association studies of anxiety disorders

(2016) T Otowa et al.   MOLECULAR PSYCHIATRY

Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses

(2016) Aysu Okbay et al.   NATURE GENETICS

The statistical properties of gene-set analysis

(2016) Christiaan A. de Leeuw et al.   NATURE REVIEWS GENETICS

Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank

(2016) C R Gale et al.   Translational Psychiatry

Fast set-based association analysis using summary data from GWAS identifies novel gene loci for human complex traits

(2016) Andrew Bakshi et al.   Scientific Reports

DSigDB: drug signatures database for gene set analysis: Fig. 1.

(2015) Minjae Yoo et al.   BIOINFORMATICS

Propranolol for the treatment of anxiety disorders: Systematic review and meta-analysis

(2015) Serge A Steenen et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Sparse whole-genome sequencing identifies two loci for major depressive disorder

(2015) Na Cai et al.   NATURE

PubChem Substance and Compound databases

(2015) Sunghwan Kim et al.   NUCLEIC ACIDS RESEARCH

Failed drug discovery in psychiatry: time for human genome-guided solutions

(2015) Andreas Papassotiropoulos et al.   TRENDS IN COGNITIVE SCIENCES

Valproate augmentation in a subgroup of patients with treatment-resistant unipolar depression

(2015) Maykel F. Ghabrash et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Anxious and non-anxious major depressive disorder in the World Health Organization World Mental Health Surveys

(2015) R. C. Kessler et al.   Epidemiology and Psychiatric Sciences

MAGMA: Generalized Gene-Set Analysis of GWAS Data

(2015) Christiaan A. de Leeuw et al.   PLoS Computational Biology

The heterogeneity of “major depression”

(2015) DAVID GOLDBERG   World Psychiatry

DrugComboRanker: drug combination discovery based on target network analysis

(2014) L. Huang et al.   BIOINFORMATICS

A Review of the Use of Stimulants and Stimulant Alternatives in Treating Bipolar Depression and Major Depressive Disorder

(2014) Stephanie A. Corp et al.   JOURNAL OF CLINICAL PSYCHIATRY

Polypharmacology: Challenges and Opportunities in Drug Discovery

(2014) Andrew Anighoro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antidepressant and Antioxidative Effect of Ibuprofen in the Rotenone Model of Parkinson’s Disease

(2014) Tiago Zaminelli et al.   NEUROTOXICITY RESEARCH

Antidepressant-like activity of ellagic acid in unstressed and acute immobilization-induced stressed mice

(2014) Dinesh Dhingra et al.   Pharmacological Reports

Effects of Race and Ethnicity on Depression Treatment Outcomes: The CO-MED Trial

(2014) Ira M. Lesser et al.   PSYCHIATRIC SERVICES

Pilot investigation of isradipine in the treatment of bipolar depression motivated by genome-wide association

(2013) Michael J Ostacher et al.   BIPOLAR DISORDERS

Gene set analysis methods: statistical models and methodological differences

(2013) H. Maciejewski   BRIEFINGS IN BIOINFORMATICS

Involvement of the GABAergic system in the anxiolytic-like effect of the flavonoid ellagic acid in mice

(2013) Chandrashekaran Girish et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The relationship between statins and depression: a review of the literature

(2013) Hong You et al.   EXPERT OPINION ON PHARMACOTHERAPY

Development and evaluation of an ensemble resource linking medications to their indications

(2013) Wei-Qi Wei et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

(2013) S Hong Lee et al.   NATURE GENETICS

Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs

(2013) Erich Gulbins et al.   NATURE MEDICINE

Race, Genetic Ancestry and Response to Antidepressant Treatment for Major Depression

(2013) Eleanor Murphy et al.   NEUROPSYCHOPHARMACOLOGY

BDNF signaling is necessary for the antidepressant-like effect of naringenin

(2013) Li-Tao Yi et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Assessing the Roles of Stimulants/Stimulant-like Drugs and Dopamine-agonists in the Treatment of Bipolar Depression

(2013) Bernardo Dell’Osso et al.   Current Psychiatry Reports

Adjunctive Atypical Antipsychotic Treatment for Major Depressive Disorder: A Meta-Analysis of Depression, Quality of Life, and Safety Outcomes

(2013) Glen I. Spielmans et al.   PLOS MEDICINE

Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression

(2012) F Lamers et al.   MOLECULAR PSYCHIATRY

Use of genome-wide association studies for drug repositioning

(2012) Philippe Sanseau et al.   NATURE BIOTECHNOLOGY

Effects of Genetic Variants Previously Associated with Fasting Glucose and Insulin in the Diabetes Prevention Program

(2012) Jose C. Florez et al.   PLoS One

Identification of short-acting κ-opioid receptor antagonists with anxiolytic-like activity

(2011) Matthew F. Peters et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Meta-review of depressive subtyping models

(2011) Baumeister Harald et al.   JOURNAL OF AFFECTIVE DISORDERS

Epilogue: Lessons from the CONVERGE study of major depressive disorder in China

(2011) Jonathan Flint et al.   JOURNAL OF AFFECTIVE DISORDERS

Comorbidity Patterns of Anxiety and Depressive Disorders in a Large Cohort Study

(2011) Femke Lamers et al.   JOURNAL OF CLINICAL PSYCHIATRY

Treating Generalized Anxiety Disorder With Second Generation Antipsychotics

(2011) Carlos D. Lalonde et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Migraine and psychiatric comorbidity: a review of clinical findings

(2011) Fabio Antonaci et al.   JOURNAL OF HEADACHE AND PAIN

Microinjection of sanguinarine into the ventrolateral orbital cortex inhibits Mkp-1 and exerts an antidepressant-like effect in rats

(2011) Yunchun Chen et al.   NEUROSCIENCE LETTERS

ChEMBL: a large-scale bioactivity database for drug discovery

(2011) A. Gaulton et al.   NUCLEIC ACIDS RESEARCH

Oxotremorine treatment restores hippocampal neurogenesis and ameliorates depression-like behaviour in chronically stressed rats

(2011) J. Veena et al.   PSYCHOPHARMACOLOGY

Depression and Hypothalamic-Pituitary-Adrenal Activation: A Quantitative Summary of Four Decades of Research

(2011) Cinnamon Stetler et al.   PSYCHOSOMATIC MEDICINE

A Versatile Gene-Based Test for Genome-wide Association Studies

(2010) Jimmy Z. Liu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Issues for DSM-5: Whither Melancholia? The Case for Its Classification as a Distinct Mood Disorder

(2010) Gordon Parker et al.   AMERICAN JOURNAL OF PSYCHIATRY

Efficacy and safety of treatments for refractory generalized anxiety disorder

(2010) Miny Samuel et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

Antidepressant Drug Effects and Depression Severity

(2010) Jay C. Fournier et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Personality Change During Depression Treatment

(2009) Tony Z. Tang et al.   ARCHIVES OF GENERAL PSYCHIATRY

Ethnic differences in antidepressant response: a prospective multi-site clinical trial

(2009) Ira M. Lesser et al.   DEPRESSION AND ANXIETY

Valproate for the treatment of acute bipolar depression: Systematic review and meta-analysis

(2009) L.A. Smith et al.   JOURNAL OF AFFECTIVE DISORDERS

Response to a Selective Serotonin Reuptake Inhibitor (Citalopram) in Major Depressive Disorder With Melancholic Features

(2009) Patrick J. McGrath et al.   JOURNAL OF CLINICAL PSYCHIATRY

Antidepressant properties of the 5-HT4 receptor partial agonist, SL65.0155: Behavioral and neurochemical studies in rats

(2009) Alessandra Tamburella et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Role of GSK3  in behavioral abnormalities induced by serotonin deficiency

(2008) J.-M. Beaulieu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration

(2008) Irving Kirsch et al.   PLOS MEDICINE