Gene-set analysis based on the pharmacological profiles of drugs to identify repurposing opportunities in schizophrenia

The Chemical Space Project

(2015) Jean-Louis Reymond   ACCOUNTS OF CHEMICAL RESEARCH

Genetic analysis of schizophrenia and bipolar disorder reveals polygenicity but also suggests new directions for molecular interrogation

(2015) Benjamin M Neale et al.   CURRENT OPINION IN NEUROBIOLOGY

Computational and Experimental Advances in Drug Repositioning for Accelerated Therapeutic Stratification

(2015) Khader Shameer et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Learning from the past and looking to the future: Emerging perspectives for improving the treatment of psychiatric disorders

(2015) Mark J. Millan et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Schizophrenia drug discovery and development in an evolving era: Are new drug targets fulfilling expectations?

(2015) John Dunlop et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Targeting the schizophrenia genome: a fast track strategy from GWAS to clinic

(2015) T Lencz et al.   MOLECULAR PSYCHIATRY

Know your target, know your molecule

(2015) Mark E Bunnage et al.   Nature Chemical Biology

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

(2015)   NATURE NEUROSCIENCE

Pioneering government-sponsored drug repositioning collaborations: progress and learning

(2015) Donald E. Frail et al.   NATURE REVIEWS DRUG DISCOVERY

Nicotinic ACh receptors as therapeutic targets in CNS disorders

(2015) Kelly T. Dineley et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Identification of novel therapeutics for complex diseases from genome-wide association data

(2014) Mani P Grover et al.   BMC Medical Genomics

Where now for schizophrenia research?

(2014) David J. Nutt et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Recent Advances in Drug Repositioning for the Discovery of New Anticancer Drugs

(2014) Joong Sup Shim et al.   International Journal of Biological Sciences

Recent genetic findings in schizophrenia and their therapeutic relevance

(2014) Paul J Harrison   JOURNAL OF PSYCHOPHARMACOLOGY

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Functional and genomic context in pathway analysis of GWAS data

(2014) Michael A. Mooney et al.   TRENDS IN GENETICS

Overcoming obstacles to repurposing for neurodegenerative disease

(2014) Diana W. Shineman et al.   Annals of Clinical and Translational Neurology

Recent Trends and Future Prospects in Computational GPCR Drug Discovery: From Virtual Screening to Polypharmacology

(2013) Antonio Carrieri et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The ChEMBL bioactivity database: an update

(2013) A. Patrícia Bento et al.   NUCLEIC ACIDS RESEARCH

Varenicline modulates spatial working memory deficits in smokers with schizophrenia

(2013) Victoria C. Wing et al.   SCHIZOPHRENIA RESEARCH

INRICH: interval-based enrichment analysis for genome-wide association studies

(2012) Phil H. Lee et al.   BIOINFORMATICS

Common Genetic Variants and Gene-Expression Changes Associated with Bipolar Disorder Are Over-Represented in Brain Signaling Pathway Genes

(2012) Inti Pedroso et al.   BIOLOGICAL PSYCHIATRY

Use of genome-wide association studies for drug repositioning

(2012) Philippe Sanseau et al.   NATURE BIOTECHNOLOGY

Revolution Stalled

(2012) S. E. Hyman   Science Translational Medicine

Effects of Moderate-Dose Treatment With Varenicline on Neurobiological and Cognitive Biomarkers in Smokers and Nonsmokers With Schizophrenia or Schizoaffective Disorder

(2011) L. Elliot Hong   ARCHIVES OF GENERAL PSYCHIATRY

Using Inverted Indices for Accelerating LINGO Calculations

(2011) Thomas G. Kristensen et al.   Journal of Chemical Information and Modeling

Mining for therapeutic gold

(2011) Francis S. Collins   NATURE REVIEWS DRUG DISCOVERY

The productivity crisis in pharmaceutical R&D

(2011) Fabio Pammolli et al.   NATURE REVIEWS DRUG DISCOVERY

Extended-Connectivity Fingerprints

(2010) David Rogers et al.   Journal of Chemical Information and Modeling

The effectiveness of multi-target agents in schizophrenia and mood disorders: Relevance of receptor signature to clinical action

(2010) Erik H.F. Wong et al.   PHARMACOLOGY & THERAPEUTICS

Chemical space as a source for new drugs

(2010) Jean-Louis Reymond et al.   MedChemComm

Drug Discovery in a Multidimensional World: Systems, Patterns, and Networks

(2010) Joel T. Dudley et al.   Journal of Cardiovascular Translational Research

Drug repositioning usingin silicocompound profiling

(2009) Elodie Dubus et al.   Future Medicinal Chemistry

A critical evaluation of genomic control methods for genetic association studies

(2008) Tony Dadd et al.   GENETIC EPIDEMIOLOGY

Rare chromosomal deletions and duplications increase risk of schizophrenia

(2008) Jennifer L. Stone et al.   NATURE

Large recurrent microdeletions associated with schizophrenia

(2008) Hreinn Stefansson et al.   NATURE

Use of antihypertensives and the risk of Parkinson disease

(2008) C. Becker et al.   NEUROLOGY