One-pot chemical synthesis of small ubiquitin-like modifier protein–peptide conjugates using bis(2-sulfanylethyl)amido peptide latent thioester surrogates

A novel PEG-based solid support enables the synthesis of >50 amino-acid peptide thioesters and the total synthesis of a functional SUMO-1 peptide conjugate

(2014) Emmanuelle Boll et al.   Chemical Science

Development of New Thioester Equivalents for Protein Chemical Synthesis

(2013) Ji-Shen Zheng et al.   ACCOUNTS OF CHEMICAL RESEARCH

Convergent Chemical Synthesis of Histone H2B Protein for the Site-Specific Ubiquitination at Lys34

(2013) Peter Siman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total synthesis of biotinylated N domain of human hepatocyte growth factor

(2013) Laurent Raibaut et al.   BIOORGANIC & MEDICINAL CHEMISTRY

SUMOylated RanGAP1 prepared by click chemistry

(2013) Nadine D. van Treel et al.   JOURNAL OF PEPTIDE SCIENCE

Tidbits for the synthesis ofbis(2-sulfanylethyl)amido (SEA) polystyrene resin, SEA peptides and peptide thioesters

(2013) Nathalie Ollivier et al.   JOURNAL OF PEPTIDE SCIENCE

Chemical synthesis of proteins using peptide hydrazides as thioester surrogates

(2013) Ji-Shen Zheng et al.   Nature Protocols

Bis(2-sulfanylethyl)amido Peptides Enable Native Chemical Ligation at Proline and Minimize Deletion Side-Product Formation

(2013) Laurent Raibaut et al.   ORGANIC LETTERS

Highly efficient solid phase synthesis of large polypeptides by iterative ligations of bis(2-sulfanylethyl)amido (SEA) peptide segments

(2013) Laurent Raibaut et al.   Chemical Science

Chemistry and Biology of the Ubiquitin Signal

(2012) Liat Spasser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sequential native peptide ligation strategies for total chemical protein synthesis

(2012) Laurent Raibaut et al.   CHEMICAL SOCIETY REVIEWS

Shedding-Generated Met Receptor Fragments can be Routed to Either the Proteasomal or the Lysosomal Degradation Pathway

(2012) Frédéric Ancot et al.   TRAFFIC

Total Chemical Synthesis of a 304 Amino Acid K48-Linked Tetraubiquitin Protein

(2011) K. S. Ajish Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Synthetic Approach to a Peptide α-Thioester from an Unprotected Peptide through Cleavage and Activation of a Specific Peptide Bond by N-Acetylguanidine

(2011) Ryo Okamoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A One-Pot Three-Segment Ligation Strategy for Protein Chemical Synthesis

(2011) Nathalie Ollivier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expanded Click Conjugation of Recombinant Proteins with Ubiquitin-Like Modifiers Reveals Altered Substrate Preference of SUMO2-Modified Ubc9

(2011) Stefanie Sommer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protein Chemical Synthesis by Ligation of Peptide Hydrazides

(2011) Ge-Min Fang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Sulfanylethylanilide Peptide as a Crypto-Thioester Peptide

(2011) Kohei Sato et al.   CHEMBIOCHEM

Synthesis of Peptide Alkylthioesters Using the IntramolecularN,S-Acyl Shift Properties of Bis(2-sulfanylethyl)amido Peptides

(2011) Julien Dheur et al.   JOURNAL OF ORGANIC CHEMISTRY

Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction

(2011) Beat Fierz et al.   Nature Chemical Biology

Synthesis of Thiazolidine Thioester Peptides and Acceleration of Native Chemical Ligation

(2011) Julien Dheur et al.   ORGANIC LETTERS

Total Chemical Synthesis of Di-ubiquitin Chains

(2010) K. S. Ajish Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Insights into the Finer Issues of Native Chemical Ligation: An Approach to Cascade Ligations

(2010) Zhongping Tan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Synthesis of Ubiquitin, Ubiquitin-Based Probes, and Diubiquitin

(2010) Farid El Oualid et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

9-Fluorenylmethoxycarbonyl-Based Solid-Phase Synthesis of Peptide α-Thioesters

(2010) Franziska Mende et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Protein Synthesis by Kinetically Controlled Ligation of Peptide O-Esters

(2010) Ji-Shen Zheng et al.   CHEMBIOCHEM

Synthesis of K48-linked diubiquitin using dual native chemical ligation at lysine

(2010) Renliang Yang et al.   CHEMICAL COMMUNICATIONS

N-Methylcysteine-mediated total chemical synthesis of ubiquitin thioester

(2010) Lesly A. Erlich et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bis(2-sulfanylethyl)amino Native Peptide Ligation

(2010) Nathalie Ollivier et al.   ORGANIC LETTERS

PeptidylN,N-Bis(2-mercaptoethyl)-amides as Thioester Precursors for Native Chemical Ligation†

(2010) Wen Hou et al.   ORGANIC LETTERS

Dual Native Chemical Ligation at Lysine

(2009) Renliang Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total chemical synthesis of proteins

(2008) Stephen B. H. Kent   CHEMICAL SOCIETY REVIEWS

Application of Dmb-Dipeptides in the Fmoc SPPS of Difficult and Aspartimide-Prone Sequences

(2008) V. Cardona et al.   International Journal of Peptide Research and Therapeutics