The beneficial health effects of green tea amino acid l -theanine in animal models: Promises and prospects for human trials

l -Theanine prevents ETEC-induced liver damage by reducing intrinsic apoptotic response and inhibiting ERK1/2 and JNK1/2 signaling pathways

(2018) Zhihua Gong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Toxicological effects of Camellia sinensis (green tea): A review

(2018) Zeinab Bedrood et al.   PHYTOTHERAPY RESEARCH

L-Theanine and Caffeine in Combination Affect Human Cognition as Evidenced by Oscillatory alpha-Band Activity and Attention Task Performance

(2018) Simon P. Kelly et al.   JOURNAL OF NUTRITION

Inhibitory effects of l-theanine on airway inflammation in ovalbumin-induced allergic asthma

(2017) Yong Pil Hwang et al.   FOOD AND CHEMICAL TOXICOLOGY

l-Theanine alleviates the neuropathological changes induced by PCB (Aroclor 1254) via inhibiting upregulation of inflammatory cytokines and oxidative stress in rat brain

(2016) Thangarajan Sumathi et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

L-Theanine Improves Immunity by Altering TH2/TH1 Cytokine Balance, Brain Neurotransmitters, and Expression of Phospholipase C in Rat Hearts

(2016) Chengjian Li et al.   MEDICAL SCIENCE MONITOR

Theanine prevents doxorubicin-induced acute hepatotoxicity by reducing intrinsic apoptotic response

(2015) Katsuhito Nagai et al.   FOOD AND CHEMICAL TOXICOLOGY

l-Theanine prevents carbon tetrachloride-induced liver fibrosis via inhibition of nuclear factor κB and down-regulation of transforming growth factor β and connective tissue growth factor

(2015) JE Pérez-Vargas et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Daily oral intake of theanine prevents the decline of 5-bromo-2′-deoxyuridine incorporation in hippocampal dentate gyrus with concomitant alleviation of behavioral abnormalities in adult mice with severe traumatic stress

(2015) Takeshi Takarada et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Effects of melatonin and theanine administration on pentylenetetrazole-inducedseizures and brain tissue oxidative damage in ovariectomized rats

(2015) Shadi CHOOPANKAREH et al.   Turkish Journal Of Medical Sciences

Protective effect of L-Theanine against aluminium induced neurotoxicity in cerebral cortex, hippocampus and cerebellum of rat brain – histopathological, and biochemical approach

(2014) Thangarajan Sumathi et al.   DRUG AND CHEMICAL TOXICOLOGY

l-Theanine healed NSAID-induced gastric ulcer by modulating pro/antioxidant balance in gastric ulcer margin

(2014) Sirshendu Chatterjee et al.   Journal of Natural Medicines

Mitochondrial Toxic Effects of Aβ Through Mitofusins in the Early Pathogenesis of Alzheimer’s Disease

(2014) Zhaofei Wu et al.   MOLECULAR NEUROBIOLOGY

Advantageous effect of theanine intake on cognition

(2014) Haruna Tamano et al.   NUTRITIONAL NEUROSCIENCE

Protective effect of l-theanine on chronic restraint stress-induced cognitive impairments in mice

(2013) Xia Tian et al.   BRAIN RESEARCH

Preventive effect of theanine intake on stress-induced impairments of hippocamapal long-term potentiation and recognition memory

(2013) Haruna Tamano et al.   BRAIN RESEARCH BULLETIN

Beneficial synergistic effects of concurrent treatment with theanine and caffeine against cerebral ischemia–reperfusion injury in rats

(2013) Lingyan Sun et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Neuroprotective activity ofL-theanine on 3-nitropropionic acid-induced neurotoxicity in rat striatum

(2013) Sumathi Thangarajan et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Protective effect of l-theanine on carbon tetrachloride-induced acute liver injury in mice

(2012) Wei Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Enhancement of postoperative recovery by preoperative oral co-administration of the amino acids, cystine and theanine, in a mouse surgical model

(2012) Tetsuro Shibakusa et al.   CLINICAL NUTRITION

Ingestion of theanine, an amino acid in tea, suppresses psychosocial stress in mice

(2012) Keiko Unno et al.   EXPERIMENTAL PHYSIOLOGY

Modulation of irinotecan-induced genomic DNA damage by theanine

(2012) Sabry Attia   FOOD AND CHEMICAL TOXICOLOGY

L-theanine partially counteracts caffeine-induced sleep disturbances in rats

(2012) Hwan-Soo Jang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

l-theanine attenuates abstinence signs in morphine-dependent rhesus monkeys and elicits anxiolytic-like activity in mice

(2012) Laura E. Wise et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

L-theanine Administration Results in Neuroprotection and Prevents Glutamate Receptor Agonist-Mediated Injury in the Rat Model of Cerebral Ischemia-Reperfusion

(2012) Mavdzhuda Zukhurova et al.   PHYTOTHERAPY RESEARCH

Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses

(2012) Ai Yoto et al.   Journal of Physiological Anthropology

Theanine is a candidate amino acid for pharmacological stabilization of mast cells

(2011) N. H. Kim et al.   AMINO ACIDS

l-Theanine prevents alcoholic liver injury through enhancing the antioxidant capability of hepatocytes

(2011) Guilan Li et al.   FOOD AND CHEMICAL TOXICOLOGY

L-Theanine: properties, synthesis and isolation from tea

(2011) Quan V Vuong et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Tea and cardiovascular disease

(2011) Apranta Deka et al.   PHARMACOLOGICAL RESEARCH

Antidepressant-like Effects of L-theanine in the Forced Swim and Tail Suspension Tests in Mice

(2011) Cui Yin et al.   PHYTOTHERAPY RESEARCH

Behavioral and molecular evidence for psychotropic effects in l-theanine

(2011) Chisato Wakabayashi et al.   PSYCHOPHARMACOLOGY

Enzymatic synthesis of theanine from glutamic acid γ-methyl ester and ethylamine by immobilized Escherichia coli cells with γ-glutamyltranspeptidase activity

(2010) Fei Zhang et al.   AMINO ACIDS

Combined Administration of L-Cystine and L-Theanine Enhances Immune Functions and Protects against Influenza Virus Infection in Aged Mice

(2010) Yasuhiro TAKAGI et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

l-theanine protects the APP (Swedish mutation) transgenic SH-SY5Y cell against glutamate-induced excitotoxicity via inhibition of the NMDA receptor pathway

(2010) X. Di et al.   NEUROSCIENCE

l-Theanine, an amino acid in green tea, attenuates β-amyloid-induced cognitive dysfunction and neurotoxicity: Reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-κB pathways

(2009) Tae Il Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Green tea inhibits Helicobacter growth in vivo and in vitro

(2009) Calin Stoicov et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The potential role of green tea catechins in the prevention of the metabolic syndrome – A review

(2009) Frank Thielecke et al.   PHYTOCHEMISTRY

Theanine, γ-glutamylethylamide, a unique amino acid in tea leaves, modulates neurotransmitter concentrations in the brain striatum interstitium in conscious rats

(2008) T. Yamada et al.   AMINO ACIDS

Altered Levels of Oxidation and Phospholipase C Isozyme Expression in the Brains of Theanine-Administered Rats

(2008) Kentaro Nishida et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Tumorigenicity study of l-theanine administrated orally to mice

(2008) S. Fujii et al.   FOOD CHEMISTRY

A calculated response: control of inflammation by the innate immune system

(2008) Gregory M. Barton   JOURNAL OF CLINICAL INVESTIGATION

Protective effect of the green tea component, l-theanine on environmental toxins-induced neuronal cell death

(2008) Hong-Suk Cho et al.   NEUROTOXICOLOGY

L-theanine intervention enhances human γδ T lymphocyte function

(2008) Jack F Bukowski et al.   NUTRITION REVIEWS