Impact of Tryptophan Oxidation in Complementarity-Determining Regions of Two Monoclonal Antibodies on Structure-Function Characterized by Hydrogen-Deuterium Exchange Mass Spectrometry and Surface Plasmon Resonance

The Use of a 2,2'-Azobis (2-Amidinopropane) Dihydrochloride Stress Model as an Indicator of Oxidation Susceptibility for Monoclonal Antibodies

(2018) Michelle Z. Dion et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Understanding the Increased Aggregation Propensity of a Light-Exposed IgG1 Monoclonal Antibody Using Hydrogen Exchange Mass Spectrometry, Biophysical Characterization, and Structural Analysis

(2018) Rupesh Bommana et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Antibodies to watch in 2018

(2018) Hélène Kaplon et al.   mAbs

Hydrogen deuterium exchange mass spectrometry in biopharmaceutical discovery and development – A review

(2016) Bin Deng et al.   ANALYTICA CHIMICA ACTA

Understanding the Impact of Methionine Oxidation on the Biological Functions of IgG1 Antibodies Using Hydrogen/Deuterium Exchange Mass Spectrometry

(2016) Jingjie Mo et al.   ANALYTICAL CHEMISTRY

Isomerization and Oxidation in the Complementarity-Determining Regions of a Monoclonal Antibody: A Study of the Modification–Structure–Function Correlations by Hydrogen–Deuterium Exchange Mass Spectrometry

(2016) Yuetian Yan et al.   ANALYTICAL CHEMISTRY

Antibodies to watch in 2017

(2016) Janice M. Reichert   mAbs

Oxidation in the complementarity-determining regions differentially influences the properties of therapeutic antibodies

(2016) Tetyana Dashivets et al.   mAbs

Selective Oxidation of Methionine and Tryptophan Residues in a Therapeutic IgG1 Molecule

(2015) Emilien folzer et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Hydrogen-Deuterium Exchange Mass Spectrometry as an Emerging Analytical Tool for Stabilization and Formulation Development of Therapeutic Monoclonal Antibodies

(2015) Ranajoy Majumdar et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Understanding the Conformational Impact of Chemical Modifications on Monoclonal Antibodies with Diverse Sequence Variation Using Hydrogen/Deuterium Exchange Mass Spectrometry and Structural Modeling

(2014) Aming Zhang et al.   ANALYTICAL CHEMISTRY

Characterization of the Degradation Products of a Color-Changed Monoclonal Antibody: Tryptophan-Derived Chromophores

(2014) Yiming Li et al.   ANALYTICAL CHEMISTRY

Origins of specificity and affinity in antibody–protein interactions

(2014) Hung-Pin Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

(2014) Vikas K. Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications

(2013) Hui Wei et al.   DRUG DISCOVERY TODAY

Investigating Monoclonal Antibody Aggregation Using a Combination of H/DX-MS and Other Biophysical Measurements

(2013) Roxana E. Iacob et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences

(2013) Riccardo Torosantucci et al.   PHARMACEUTICAL RESEARCH

Molecular engineering of antibodies for therapeutic and diagnostic purposes

(2012) Frédéric Ducancel et al.   mAbs

Protein dynamics viewed by hydrogen exchange

(2012) John J. Skinner et al.   PROTEIN SCIENCE

Classification and Characterization of Therapeutic Antibody Aggregates

(2011) Marisa K. Joubert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical Modifications in Therapeutic Protein Aggregates Generated under Different Stress Conditions

(2011) Quanzhou Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Aggregation Mechanisms of Monoclonal Antibody Under Thermal and Freeze-Thaw Stresses Revealed by Hydrogen Exchange

(2011) Aming Zhang et al.   PHARMACEUTICAL RESEARCH

Identification of Potential Sites for Tryptophan Oxidation in Recombinant Antibodies Using tert-Butylhydroperoxide and Quantitative LC-MS

(2011) Miriam Hensel et al.   PLoS One

Stability of Protein Pharmaceuticals: An Update

(2010) Mark Cornell Manning et al.   PHARMACEUTICAL RESEARCH

Conformational changes in oxidatively stressed monoclonal antibodies studied by hydrogen exchange mass spectrometry

(2010) William Burkitt et al.   PROTEIN SCIENCE

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody

(2009) Josef Vlasak et al.   ANALYTICAL BIOCHEMISTRY

Characterization of IgG1 Conformation and Conformational Dynamics by Hydrogen/Deuterium Exchange Mass Spectrometry

(2009) Damian Houde et al.   ANALYTICAL CHEMISTRY

Human IgG1 Hinge Fragmentation as the Result of H2O2-mediated Radical Cleavage

(2009) Boxu Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methionine, tryptophan, and histidine oxidation in a model protein, PTH: Mechanisms and stabilization

(2009) Junyan A. Ji et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Impact of methionine oxidation on the binding of human IgG1 to FcRn and Fcγ receptors

(2009) Andrea Bertolotti-Ciarlet et al.   MOLECULAR IMMUNOLOGY

Structure and Stability Changes of Human IgG1 Fc as a Consequence of Methionine Oxidation

(2008) Dingjiang Liu et al.   BIOCHEMISTRY

Structural effect of deglycosylation and methionine oxidation on a recombinant monoclonal antibody

(2007) Hongcheng Liu et al.   MOLECULAR IMMUNOLOGY