Hepatokines—a novel group of exercise factors

Heat Shock Protein 72 Regulates Hepatic Lipid Accumulation

(2018) Ashley E. Archer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The influence of adiposity and acute exercise on circulating hepatokines in normal-weight and overweight/obese men

(2018) Jack A. Sargeant et al.   Applied Physiology Nutrition and Metabolism

FGF21 gene therapy as treatment for obesity and insulin resistance

(2018) Veronica Jimenez et al.   EMBO Molecular Medicine

Inactivating hepatic follistatin alleviates hyperglycemia

(2018) Rongya Tao et al.   NATURE MEDICINE

Follistatin inactivation improves glucose tolerance

(2018) Ivone Leong   Nature Reviews Endocrinology

Inhibin βE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples

(2018) Masakazu Sugiyama et al.   PLoS One

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

(2018) Viktoria Gusarova et al.   Nature Communications

Exercise increases circulating GDF15 in humans

(2018) Maximilian Kleinert et al.   Molecular Metabolism

Fasting exacerbates hepatic growth differentiation factor 15 to promote fatty acid β-oxidation and ketogenesis via activating XBP1 signaling in liver

(2018) Meiyuan Zhang et al.   Redox Biology

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

(2017) Linda Yang et al.   NATURE MEDICINE

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

(2017) Paul J Emmerson et al.   NATURE MEDICINE

Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle

(2017) Hirofumi Misu et al.   NATURE MEDICINE

Angptl4 does not control hyperglucagonemia or α-cell hyperplasia following glucagon receptor inhibition

(2017) Haruka Okamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skeletal Muscle as an Endocrine Organ: The Role of Myokines in Exercise Adaptations

(2017) Christoph Hoffmann et al.   Cold Spring Harbor Perspectives in Medicine

Angiopoietin-like protein 4 is an exercise-induced hepatokine in humans, regulated by glucagon and cAMP

(2017) Bodil Ingerslev et al.   Molecular Metabolism

Global mRNA sequencing of human skeletal muscle: Search for novel exercise-regulated myokines

(2017) S. Pourteymour et al.   Molecular Metabolism

Liver glycogen metabolism during and after prolonged endurance-type exercise

(2016) Javier T. Gonzalez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects

(2016) Saswata Talukdar et al.   Cell Metabolism

FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver

(2016) Stephanie von Holstein-Rathlou et al.   Cell Metabolism

Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding

(2016) Christine Loyd et al.   JOURNAL OF APPLIED PHYSIOLOGY

Loss of Interdependent Binding by the FoxO1 and FoxA1/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin-sensitive Genes

(2016) Akua Yalley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circulating Follistatin Is Liver-Derived and Regulated by the Glucagon-to-Insulin Ratio

(2016) Jakob S. Hansen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Exercise-Induced Secretion of FGF21 and Follistatin Are Blocked by Pancreatic Clamp and Impaired in Type 2 Diabetes

(2016) Jakob Schiøler Hansen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes

(2016) Wieneke Dijk et al.   JOURNAL OF LIPID RESEARCH

Circulating follistatin in relation to energy metabolism

(2016) Jakob Schiøler Hansen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption

(2015) Xunde Wang et al.   Cell Metabolism

FGF21 and the late adaptive response to starvation in humans

(2015) Pouneh K. Fazeli et al.   JOURNAL OF CLINICAL INVESTIGATION

A Phase 1/2a Follistatin Gene Therapy Trial for Becker Muscular Dystrophy

(2015) Jerry R Mendell et al.   MOLECULAR THERAPY

Attenuated fibroblast growth factor 21 response to acute aerobic exercise in obese individuals

(2015) A.L. Slusher et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy

(2015) Savalan Babapoor-Farrokhran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angptl4 links α-cell proliferation following glucagon receptor inhibition with adipose tissue triglyceride metabolism

(2015) Danny Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases

(2015) B. K. Pedersen et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

FGF21 Revolutions: Recent Advances Illuminating FGF21 Biology and Medicinal Properties

(2015) Alexei Kharitonenkov et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Acute exercise does not decrease liver fat in men with overweight or NAFLD

(2015) L. Bilet et al.   Scientific Reports

Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans

(2015) Jakob Schiøler Hansen et al.   Molecular Metabolism

Changes in Serum Levels of Myokines and Wnt-Antagonists after an Ultramarathon Race

(2015) Katharina Kerschan-Schindl et al.   PLoS One

Metabolic and hormonal responses to isoenergetic high-intensity interval exercise and continuous moderate-intensity exercise

(2014) Jonathan M. Peake et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss

(2014) Bryn M. Owen et al.   Cell Metabolism

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

(2014) K. R. Markan et al.   DIABETES

Identification of human exercise-induced myokines using secretome analysis

(2014) Milène Catoire et al.   PHYSIOLOGICAL GENOMICS

Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise

(2014) M. Catoire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GDF15 Is a Novel Biomarker for Impaired Fasting Glucose

(2014) Jun Hwa Hong et al.   Diabetes & Metabolism Journal

Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

(2013) Brendan Egan et al.   Cell Metabolism

The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes

(2013) Gregory Gaich et al.   Cell Metabolism

Plasma follistatin is elevated in patients with type 2 diabetes: relationship to hyperglycemia, hyperinsulinemia, and systemic low-grade inflammation

(2013) J. Hansen et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

The role of hepatokines in metabolism

(2013) Norbert Stefan et al.   Nature Reviews Endocrinology

FOXOs: signalling integrators for homeostasis maintenance

(2013) Astrid Eijkelenboom et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Systemic administration of Follistatin288 increases muscle mass and reduces fat accumulation in mice

(2013) Samudra S. Gangopadhyay   Scientific Reports

Glucagon increases circulating fibroblast growth factor 21 independently of endogenous insulin levels: a novel mechanism of glucagon-stimulated lipolysis?

(2012) A. M. Arafat et al.   DIABETOLOGIA

A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise

(2012) Wataru Aoi et al.   GUT

Production of Selenoprotein P (Sepp1) by Hepatocytes Is Central to Selenium Homeostasis

(2012) Kristina E. Hill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transgenic overexpression of heat shock protein 72 in mouse muscle protects against exhaustive exercise-induced skeletal muscle damage

(2012) Chieh-Chung Liu et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Hsp72 preserves muscle function and slows progression of severe muscular dystrophy

(2012) Stefan M. Gehrig et al.   NATURE

Refeeding with a high-protein diet after a 48 h fast causes acute hepatocellular injury in mice

(2011) Motoko Oarada et al.   BRITISH JOURNAL OF NUTRITION

Energy Deprivation Alters in a Leptin- and Cortisol-Independent Manner Circulating Levels of Activin A and Follistatin But Not Myostatin in Healthy Males

(2011) Maria T. Vamvini et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Testosterone inhibits transforming growth factor-β signaling during myogenic differentiation and proliferation of mouse satellite cells: Potential role of follistatin in mediating testosterone action

(2011) Melissa Braga et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A Liver-Derived Secretory Protein, Selenoprotein P, Causes Insulin Resistance

(2010) Hirofumi Misu et al.   Cell Metabolism

Activation of the mitogen-activated protein kinase (MAPK) signalling pathway in the liver of mice is related to plasma glucose levels after acute exercise

(2010) M. Hoene et al.   DIABETOLOGIA

Exercise Induces a Marked Increase in Plasma Follistatin: Evidence That Follistatin Is a Contraction-Induced Hepatokine

(2010) Jakob Hansen et al.   ENDOCRINOLOGY

Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease

(2010) Jody Dushay et al.   GASTROENTEROLOGY

Follistatin induces muscle hypertrophy through satellite cell proliferation and inhibition of both myostatin and activin

(2009) Hélène Gilson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Free Fatty Acids Link Metabolism and Regulation of the Insulin-Sensitizing Fibroblast Growth Factor-21

(2009) K. Mai et al.   DIABETES

Circulating Fibroblast Growth Factor 21 Is Induced by Peroxisome Proliferator-Activated Receptor Agonists But Not Ketosis in Man

(2009) Constantinos Christodoulides et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Antioxidants prevent health-promoting effects of physical exercise in humans

(2009) M. Ristow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Follistatin Gene Delivery Enhances Muscle Growth and Strength in Nonhuman Primates

(2009) J. Kota et al.   Science Translational Medicine

The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man

(2008) Cecilia Gälman et al.   Cell Metabolism

Decreased hepatic RBP4 secretion is correlated with reduced hepatic glucose production but is not associated with insulin resistance in patients with liver cirrhosis

(2008) Matthias J. Bahr et al.   CLINICAL ENDOCRINOLOGY

Plasma Fetuin-A Levels and the Risk of Type 2 Diabetes

(2008) N. Stefan et al.   DIABETES

Exercise-induced changes in insulin-like growth factors and their low molecular weight binding protein in healthy subjects and patients with growth hormone deficiency

(2008) P. BANG et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

HSP72 protects against obesity-induced insulin resistance

(2008) J. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heat Shock Protein 72 Response to Exercise in Humans

(2008) Paulette Yamada et al.   SPORTS MEDICINE