Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production

Evolutionary relationships among protein lysine deacetylases of parasites causing neglected diseases

(2017) Larissa L.S. Scholte et al.   INFECTION GENETICS AND EVOLUTION

Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives

(2017) Gebremedhin S. Hailu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bromodomains in Protozoan Parasites: Evolution, Function, and Opportunities for Drug Development

(2017) Victoria Jeffers et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Comparative Analysis of Proteome-Wide Lysine Acetylation in Juvenile and Adult Schistosoma japonicum

(2017) Qing Li et al.   Frontiers in Microbiology

Effect of clinically approved HDAC inhibitors on Plasmodium , Leishmania and Schistosoma parasite growth

(2017) Ming Jang Chua et al.   International Journal for Parasitology-Drugs and Drug Resistance

Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs

(2016) Gerard L. Brien et al.   CANCER CELL

Proteome-wide analysis of lysine acetylation in adult Schistosoma japonicum worm

(2016) Yang Hong et al.   Journal of Proteomics

Targeting the cancer epigenome for therapy

(2016) Peter A. Jones et al.   NATURE REVIEWS GENETICS

Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs

(2016) Jesus M. Ontoria et al.   ACS Medicinal Chemistry Letters

Discovery and Characterization of Novel Anti-schistosomal Properties of the Anti-anginal Drug, Perhexiline and Its Impact on Schistosoma mansoni Male and Female Reproductive Systems

(2016) Alessandra Guidi et al.   PLoS Neglected Tropical Diseases

Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives

(2015) Martin Marek et al.   Future Medicinal Chemistry

Development and Validation of a Luminescence-based, Medium-Throughput Assay for Drug Screening in Schistosoma mansoni

(2015) Cristiana Lalli et al.   PLoS Neglected Tropical Diseases

Targeting Lysine Deacetylases (KDACs) in Parasites

(2015) Qi Wang et al.   PLoS Neglected Tropical Diseases

Human schistosomiasis

(2014) Daniel G Colley et al.   LANCET

Schistosoma mansoni: a method for inducing resistance to praziquantel using infected Biomphalaria glabrata snails

(2014) Flávia FB Couto et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Schistosomiasis control: praziquantel forever?

(2014) Donato Cioli et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Praziquantel sensitivity of Kenyan Schistosoma mansoni isolates and the generation of a laboratory strain with reduced susceptibility to the drug

(2014) Ibrahim N. Mwangi et al.   International Journal for Parasitology-Drugs and Drug Resistance

Comparative Study of Transcriptome Profiles of Mechanical- and Skin-Transformed Schistosoma mansoni Schistosomula

(2013) Anna V. Protasio et al.   PLoS Neglected Tropical Diseases

Schistosoma mansoni Sirtuins: Characterization and Potential as Chemotherapeutic Targets

(2013) Julien Lancelot et al.   PLoS Neglected Tropical Diseases

Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni

(2013) Martin Marek et al.   PLoS Pathogens

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni

(2009) Florence Dubois et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Reduced Susceptibility to Praziquantel among Naturally Occurring Kenyan Isolates of Schistosoma mansoni

(2009) Sandra D. Melman et al.   PLoS Neglected Tropical Diseases

Neglected Tropical Diseases in Sub-Saharan Africa: Review of Their Prevalence, Distribution, and Disease Burden

(2009) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases

The class I histone deacetylases of the platyhelminth parasite Schistosoma mansoni

(2008) Frédérik Oger et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis

(2008) Michael J Doenhoff et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Response of Schistosoma mansoni Isolates Having Different Drug Sensitivity to Praziquantel Over Several Life Cycle Passages with and Without Therapeutic Pressure

(2008) Abdel Nasser A. Sabra et al.   JOURNAL OF PARASITOLOGY

Towards an understanding of the mechanism of action of praziquantel

(2008) Anthony D. Aragon et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY