Endoplasmic Reticulum Stress and Unfolded Protein Response in Cartilage Pathophysiology; Contributing Factors to Apoptosis and Osteoarthritis

Unfolded protein response gene GADD34 is overexpressed in rheumatoid arthritis and related to the presence of circulating anti-citrullinated protein antibodies

(2016) Giovanna Clavarino et al.   AUTOIMMUNITY

Ziploc-ing the structure: Triple helix formation is coordinated by rough endoplasmic reticulum resident PPIases

(2015) Yoshihiro Ishikawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mechanisms for exporting large-sized cargoes from the endoplasmic reticulum

(2015) Kota Saito et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation

(2015) E. Kozhemyakina et al.   DEVELOPMENT

Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization

(2015) T.L. Cameron et al.   OSTEOARTHRITIS AND CARTILAGE

Increased Classical Endoplasmic Reticulum Stress Is Sufficient to Reduce Chondrocyte Proliferation Rate in the Growth Plate and Decrease Bone Growth

(2015) Louise H. W. Kung et al.   PLoS One

Sp7/Osterix induces the mouse pro-α2(I) collagen gene (Col1a2) expression via the proximal promoter in osteoblastic cells

(2014) Hiroyuki Yano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transcriptome sequencing of Atlantic salmon (Salmo salar L.) notochord prior to development of the vertebrae provides clues to regulation of positional fate, chordoblast lineage and mineralisation

(2014) Shou Wang et al.   BMC GENOMICS

Mechanisms and models of endoplasmic reticulum stress in chondrodysplasia

(2014) Sara E. Patterson et al.   DEVELOPMENTAL DYNAMICS

Mutations in COL27A1 cause Steel syndrome and suggest a founder mutation effect in the Puerto Rican population

(2014) Claudia Gonzaga-Jauregui et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Master Regulator for Chondrogenesis, Sox9, Regulates Transcriptional Activation of the Endoplasmic Reticulum Stress Transducer BBF2H7/CREB3L2 in Chondrocytes

(2014) Kenta Hino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

XBP1S, a BMP2-inducible transcription factor, accelerates endochondral bone growth by activating GEP growth factor

(2014) Feng-Jin Guo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Endoplasmic reticulum stress plays a role in the advanced glycation end product-induced inflammatory response in endothelial cells

(2014) Lili Wu et al.   LIFE SCIENCES

Endoplasmic reticulum stress-induced apoptosis contributes to articular cartilage degeneration via C/EBP homologous protein

(2014) Y. Uehara et al.   OSTEOARTHRITIS AND CARTILAGE

BMP-2 induces ATF4 phosphorylation in chondrocytes through a COX-2/PGE2 dependent signaling pathway

(2014) T.-F. Li et al.   OSTEOARTHRITIS AND CARTILAGE

Endoplasmic Reticulum Stress-Unfolding Protein Response-Apoptosis Cascade Causes Chondrodysplasia in a col2a1 p.Gly1170Ser Mutated Mouse Model

(2014) Guoyan Liang et al.   PLoS One

Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice

(2014) Jingming Zhou et al.   ARTHRITIS RESEARCH & THERAPY

Association of Reduced Type IX Collagen Gene Expression in Human Osteoarthritic Chondrocytes With Epigenetic Silencing by DNA Hypermethylation

(2014) Kei Imagawa et al.   Arthritis & Rheumatology

Autosomal recessive stickler syndrome due to a loss of function mutation in theCOL9A3gene

(2013) Flavio Faletra et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Osteoarthritis in temporomandibular joint of Col2a1 mutant mice

(2013) M.L. Ricks et al.   ARCHIVES OF ORAL BIOLOGY

A molecular ensemble in the rER for procollagen maturation

(2013) Yoshihiro Ishikawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Advanced glycation end-products induce endoplasmic reticulum stress in human aortic endothelial cells

(2013) Christos Adamopoulos et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Intracellular accumulation of advanced glycation end products induces apoptosis via endoplasmic reticulum stress in chondrocytes

(2013) Soichiro Yamabe et al.   FEBS Journal

Nuclear factor Y (NF-Y) regulates the proximal promoter activity of the mouse collagen α1(XI) gene (Col11a1) in chondrocytes

(2013) Mariko Hida et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Skeletal diseases caused by mutations that affect collagen structure and function

(2013) William V. Arnold et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Radiographic and Tomographic Analysis in Patients with Stickler Syndrome Type I

(2013) Ali Al Kaissi et al.   International Journal of Medical Sciences

Alternative splicing modifies the effect of mutations in COL11A1 and results in recessive type 2 Stickler syndrome with profound hearing loss

(2013) Allan J Richards et al.   JOURNAL OF MEDICAL GENETICS

Chondrocyte Proliferation Regulated by Secreted Luminal Domain of ER Stress Transducer BBF2H7/CREB3L2

(2013) Atsushi Saito et al.   MOLECULAR CELL

The Collagenopathies: Review of Clinical Phenotypes and Molecular Correlations

(2013) Rebekah Jobling et al.   Current Rheumatology Reports

Inflammatory markers associated with osteoarthritis after destabilization surgery in young mice with and without Receptor for Advanced Glycation End-products (RAGE)

(2013) D. Justin Larkin et al.   Frontiers in Physiology

Chondrocyte-specific ablation of Osterix leads to impaired endochondral ossification

(2012) Jung-Hoon Oh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endoplasmic reticulum stress induces the expression of COX-2 through activation of eIF2α, p38-MAPK and NF-κB in advanced glycation end products stimulated human chondrocytes

(2012) Zafar Rasheed et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Comprehensive molecular analysis demonstrates type V collagen mutations in over 90% of patients with classic EDS and allows to refine diagnostic criteria

(2012) Sofie Symoens et al.   HUMAN MUTATION

The Endoplasmic Reticulum Stress Transducer BBF2H7 Suppresses Apoptosis by Activating the ATF5-MCL1 Pathway in Growth Plate Cartilage

(2012) Soutarou Izumi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hearing impairment in Stickler syndrome: a systematic review

(2012) Frederic R E Acke et al.   Orphanet Journal of Rare Diseases

Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage

(2012) F. Wei et al.   OSTEOARTHRITIS AND CARTILAGE

Minor fibrillar collagens, variable regions alternative splicing, intrinsic disorder, and tyrosine sulfation

(2012) Ming Fang et al.   Protein & Cell

D469del-COMP Retention in Chondrocytes Stimulates Caspase-Independent Necroptosis

(2011) Françoise Coustry et al.   AMERICAN JOURNAL OF PATHOLOGY

Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems

(2011) Jeffrey L Brodsky et al.   CURRENT OPINION IN CELL BIOLOGY

The IRE1α–XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix

(2011) Takahide Tohmonda et al.   EMBO REPORTS

The transcription factor c-Jun protects against sustained hepatic endoplasmic reticulum stress thereby promoting hepatocyte survival

(2011) Matthias Fuest et al.   HEPATOLOGY

A novel form of chondrocyte stress is triggered by a COMP mutation causing pseudoachondroplasia

(2011) Farhana Suleman et al.   HUMAN MUTATION

BMP2 Protein Regulates Osteocalcin Expression via Runx2-mediatedAtf6Gene Transcription

(2011) Won-Gu Jang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global defects in collagen secretion in aMia3/TANGO1knockout mouse

(2011) Deanna G. Wilson et al.   JOURNAL OF CELL BIOLOGY

BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development

(2011) B. Shu et al.   JOURNAL OF CELL SCIENCE

Transcriptional Profiling of Chondrodysplasia Growth Plate Cartilage Reveals Adaptive ER-Stress Networks That Allow Survival but Disrupt Hypertrophy

(2011) Trevor L. Cameron et al.   PLoS One

Proteomic analysis of Col11a1-associated protein complexes

(2011) Raquel J. Brown et al.   PROTEOMICS

Stickler syndrome caused by COL2A1 mutations: genotype–phenotype correlation in a series of 100 patients

(2010) Kristien P Hoornaert et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Stickler syndrome and the vitreous phenotype: mutations in COL2A1 and COL11A1

(2010) Allan J. Richards et al.   HUMAN MUTATION

Early-onset progressive osteoarthritis with hereditary progressive ophtalmopathy or Stickler syndrome

(2010) Tifenn Couchouron et al.   JOINT BONE SPINE

In vivo cellular adaptation to ER stress: survival strategies with double-edged consequences

(2010) K. Y. Tsang et al.   JOURNAL OF CELL SCIENCE

Chaperoning osteogenesis: new protein-folding disease paradigms

(2010) Elena Makareeva et al.   TRENDS IN CELL BIOLOGY

Identification of differentially expressed genes between osteoblasts and osteocytes

(2009) Frane Paic et al.   BONE

Evidence of Reduced Bone Turnover and Disturbed Mineralization Process in a Boy with Stickler Syndrome

(2009) A. Al Kaissi et al.   CALCIFIED TISSUE INTERNATIONAL

Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription

(2009) W. Wang et al.   DEVELOPMENT

Osteoblasts derived from osteophytes produce interleukin-6, interleukin-8, and matrix metalloproteinase-13 in osteoarthritis

(2009) Kei Sakao et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Endoplasmic Reticulum Stress-Mediated Autophagy/Apoptosis Induced by Capsaicin (8-Methyl-N-vanillyl-6-nonenamide) and Dihydrocapsaicin is Regulated by the Extent of c-Jun NH2-Terminal Kinase/Extracellular Signal-Regulated Kinase Activation in WI38 Lung Epithelial Fibroblast Cells

(2009) S.-H. Oh et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis

(2009) Atsushi Saito et al.   NATURE CELL BIOLOGY

Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation

(2009) Tomohiko Murakami et al.   NATURE CELL BIOLOGY

Modulating hedgehog signaling can attenuate the severity of osteoarthritis

(2009) Alvin C Lin et al.   NATURE MEDICINE

A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells

(2009) R Kar et al.   ONCOGENE

Subtilase cytotoxin activates PERK, IRE1 and ATF6 endoplasmic reticulum stress-signalling pathways

(2008) Jennifer J. Wolfson et al.   CELLULAR MICROBIOLOGY

BMP2 Regulates Osterix through Msx2 and Runx2 during Osteoblast Differentiation

(2008) Takuma Matsubara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trabecular Bone Deterioration in col9a1+/− Mice Associated With Enlarged Osteoclasts Adhered to Collagen IX-Deficient Bone

(2008) Chiachien Jake Wang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development

(2008) A. K. Townley et al.   JOURNAL OF CELL SCIENCE

Collagen 11a1 is indirectly activated by lymphocyte enhancer-binding factor 1 (Lef1) and negatively regulates osteoblast maturation

(2008) R KAHLER et al.   MATRIX BIOLOGY

ER Stress-Mediated Apoptosis in a New Mouse Model of Osteogenesis imperfecta

(2008) Thomas S. Lisse et al.   PLoS Genetics