Invited Review: From nose to gut – the role of the microbiome in neurological disease

The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases

(2018) Nolwen L. Rey et al.   NEUROBIOLOGY OF DISEASE

Determining the Presence of Periodontopathic Virulence Factors in Short-Term Postmortem Alzheimer's Disease Brain Tissue

(2018) Sophie Poole et al.   JOURNAL OF ALZHEIMERS DISEASE

Bacterial Infection and Alzheimer's Disease: A Meta-Analysis

(2018) Priya Maheshwari et al.   JOURNAL OF ALZHEIMERS DISEASE

Oral Inflammation, Tooth Loss, Risk Factors, and Association with Progression of Alzheimer's Disease

(2018) Sim K. Singhrao et al.   JOURNAL OF ALZHEIMERS DISEASE

The Microbiome and Disease: Reviewing the Links between the Oral Microbiome, Aging, and Alzheimer's Disease

(2018) Deborah K. Shoemark et al.   JOURNAL OF ALZHEIMERS DISEASE

Lung Homeostasis: Influence of Age, Microbes, and the Immune System

(2017) Clare M. Lloyd et al.   IMMUNITY

An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells

(2017) Anthony J. St. Leger et al.   IMMUNITY

Alzheimer’s Disease Histological and Behavioral Manifestations in Transgenic Mice Correlate with Specific Gut Microbiome State

(2017) Liang Shen et al.   JOURNAL OF ALZHEIMERS DISEASE

Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer’s Mouse Model

(2017) Carolin Brandscheid et al.   JOURNAL OF ALZHEIMERS DISEASE

Injected Amyloid Beta in the Olfactory Bulb Transfers to Other Brain Regions via Neural Connections in Mice

(2017) Baixuan He et al.   MOLECULAR NEUROBIOLOGY

Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome

(2017) Erin M. Hill-Burns et al.   MOVEMENT DISORDERS

The commensal lifestyle of Staphylococcus aureus and its interactions with the nasal microbiota

(2017) Bernhard Krismer et al.   NATURE REVIEWS MICROBIOLOGY

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

(2017) Annamaria Cattaneo et al.   NEUROBIOLOGY OF AGING

Oral and nasal microbiota in Parkinson's disease

(2017) Pedro A.B. Pereira et al.   PARKINSONISM & RELATED DISORDERS

Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

(2017) Kerstin Berer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease

(2017) Ashutosh Mangalam et al.   Cell Reports

16S rRNA Next Generation Sequencing Analysis Shows Bacteria in Alzheimer’s Post-Mortem Brain

(2017) David C. Emery et al.   Frontiers in Aging Neuroscience

Association of Delirium With Cognitive Decline in Late Life

(2017) Daniel H. J. Davis et al.   JAMA Psychiatry

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

(2017) T. Harach et al.   Scientific Reports

Temporal Stability and Composition of the Ocular Surface Microbiome

(2017) Jerome Ozkan et al.   Scientific Reports

Urinary Incontinence in Alzheimer’s Disease

(2016) Hsiang-Ying Lee et al.   American Journal of Alzheimers Disease and Other Dementias

The Microbiome and the Respiratory Tract

(2016) Robert P. Dickson et al.   Annual Review of Physiology

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

The sinonasal bacterial microbiome in health and disease

(2016) Vijay R. Ramakrishnan et al.   Current Opinion in Otolaryngology & Head and Neck Surgery

Urinary incontinence in multiple sclerosis: prevalence, severity and impact on patients’ quality of life

(2016) C. Zecca et al.   EUROPEAN JOURNAL OF NEUROLOGY

The potential role of subclinical Bordetella Pertussis colonization in the etiology of multiple sclerosis

(2016) Keith Rubin et al.   IMMUNOBIOLOGY

Lung inflammation stalls Th17-cell migrationen routeto the central nervous system during the development of experimental autoimmune encephalomyelitis

(2016) Masashi Kanayama et al.   INTERNATIONAL IMMUNOLOGY

Back on the scent: the olfactory system in CNS demyelinating diseases

(2016) Albert Joseph et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

Emerging pathogenic links between microbiota and the gut–lung axis

(2016) Kurtis F. Budden et al.   NATURE REVIEWS MICROBIOLOGY

Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls

(2016) Marcus M. Unger et al.   PARKINSONISM & RELATED DISORDERS

Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins

(2016) Simone M. Brändle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alterations of the human gut microbiome in multiple sclerosis

(2016) Sushrut Jangi et al.   Nature Communications

Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial

(2016) Elmira Akbari et al.   Frontiers in Aging Neuroscience

Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype

(2016) Leopoldo N. Segal et al.   Nature Microbiology

Periodontitis and Cognitive Decline in Alzheimer’s Disease

(2016) Mark Ide et al.   PLoS One

Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls

(2016) Jun Chen et al.   Scientific Reports

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease

(2016) Myles R. Minter et al.   Scientific Reports

Brain microbiota disruption within inflammatory demyelinating lesions in multiple sclerosis

(2016) W. G. Branton et al.   Scientific Reports

Vagotomy and subsequent risk of Parkinson's disease

(2015) Elisabeth Svensson et al.   ANNALS OF NEUROLOGY

Respiratory infection with a bacterial pathogen attenuates CNS autoimmunity through IL-10 induction

(2015) Sarah C. Edwards et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Increased Risk of Dementia in Patients With Chronic Obstructive Pulmonary Disease

(2015) Kuang-Ming Liao et al.   MEDICINE

Colonic bacterial composition in Parkinson's disease

(2015) Ali Keshavarzian et al.   MOVEMENT DISORDERS

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Cancer and the microbiota

(2015) W. S. Garrett   SCIENCE

Protein misfolding and dysregulated protein homeostasis in autoinflammatory diseases and beyond

(2015) Amma F. Agyemang et al.   Seminars in Immunopathology

Role of the normal gut microbiota

(2015) Sai Manasa Jandhyala   WORLD JOURNAL OF GASTROENTEROLOGY

Application of a Neutral Community Model To Assess Structuring of the Human Lung Microbiome

(2015) Arvind Venkataraman et al.   mBio

The Lung Microbiome: New Principles for Respiratory Bacteriology in Health and Disease

(2015) Robert P. Dickson et al.   PLoS Pathogens

Review: Microbiome in Inflammatory Arthritis and Human Rheumatic Diseases

(2015) Jose U. Scher et al.   Arthritis & Rheumatology

Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters

(2015) Sachiko Miyake et al.   PLoS One

Intestinal Dysbiosis and Lowered Serum Lipopolysaccharide-Binding Protein in Parkinson’s Disease

(2015) Satoru Hasegawa et al.   PLoS One

Olfactory bulb involvement in neurodegenerative diseases

(2014) Johannes Attems et al.   ACTA NEUROPATHOLOGICA

Olfactory Pathology in Central Nervous System Demyelinating Diseases

(2014) Gabriele C. DeLuca et al.   BRAIN PATHOLOGY

Anatomical localization of commensal bacteria in immune cell homeostasis and disease

(2014) Thomas C. Fung et al.   IMMUNOLOGICAL REVIEWS

Gut microbiota are related to Parkinson's disease and clinical phenotype

(2014) Filip Scheperjans et al.   MOVEMENT DISORDERS

Dynamics and associations of microbial community types across the human body

(2014) Tao Ding et al.   NATURE

Changes in the Bacterial Microbiota in Gut, Blood, and Lungs following Acute LPS Instillation into Mice Lungs

(2014) Marc A. Sze et al.   PLoS One

The gut microbiota influences blood-brain barrier permeability in mice

(2014) V. Braniste et al.   Science Translational Medicine

Role of the gut microbiota in inflammatory bowel disease pathogenesis: What have we learnt in the past 10 years?

(2014) Georgina L Hold   WORLD JOURNAL OF GASTROENTEROLOGY

An intestinal commensal symbiosis factor controls neuroinflammation via TLR2-mediated CD39 signalling

(2014) Yan Wang et al.   Nature Communications

Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson’s disease

(2013) David Hilton et al.   ACTA NEUROPATHOLOGICA

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice

(2013) Nolwen L. Rey et al.   ACTA NEUROPATHOLOGICA

Comparison of the Respiratory Microbiome in Healthy Nonsmokers and Smokers

(2013) Alison Morris et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Casting light on multiple sclerosis heterogeneity: the role of HLA-DRB1 on spinal cord pathology

(2013) Gabriele C. DeLuca et al.   BRAIN

Nasal Microenvironments and Interspecific Interactions Influence Nasal Microbiota Complexity and S. aureus Carriage

(2013) Miling Yan et al.   Cell Host & Microbe

The role of inflammation in sporadic and familial Parkinson’s disease

(2013) Michela Deleidi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Prevalence and resistance of commensal Staphylococcus aureus, including meticillin-resistant S aureus, in nine European countries: a cross-sectional study

(2013) Casper DJ den Heijer et al.   LANCET INFECTIOUS DISEASES

Respiratory infection promotes T cell infiltration and amyloid-β deposition in APP/PS1 mice

(2013) Róisín M. McManus et al.   NEUROBIOLOGY OF AGING

Brain Microbial Populations in HIV/AIDS: α-Proteobacteria Predominate Independent of Host Immune Status

(2013) William G. Branton et al.   PLoS One

The Microbiome of the Middle Meatus in Healthy Adults

(2013) Vijay R. Ramakrishnan et al.   PLoS One

Cause of death in Alzheimer's disease: a cohort study

(2013) S. Todd et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Staphylococcal immune complexes and myelinolytic toxin in early acute multiple sclerosis lesions—An immunohistological study supported by multifactorial cluster analysis and antigen-imprint isoelectric focusing

(2013) Frederick Gay   Multiple Sclerosis and Related Disorders

Vaginal Microbiome: Rethinking Health and Disease

(2012) Bing Ma et al.   Annual Review of Microbiology

Cortical lesion load associates with progression of disability in multiple sclerosis

(2012) M. Calabrese et al.   BRAIN

The microbiome as a human organ

(2012) F. Baquero et al.   CLINICAL MICROBIOLOGY AND INFECTION

T cells become licensed in the lung to enter the central nervous system

(2012) Francesca Odoardi et al.   NATURE

Olfactory Dysfunction in Different Subtypes of Multiple Sclerosis and in Neuromyelitis Optica (P07.065)

(2012) F. Schmidt et al.   NEUROLOGY

Defining the human microbiome

(2012) Luke K Ursell et al.   NUTRITION REVIEWS

Microbiota of male genital tract: Impact on the health of man and his partner

(2012) Reet Mändar   PHARMACOLOGICAL RESEARCH

Chapter 12: Human Microbiome Analysis

(2012) Xochitl C. Morgan et al.   PLoS Computational Biology

Alzheimer's disease and co-morbidity: Increased prevalence and possible risk factors of excess mortality in a naturalistic 7-year follow-up

(2011) R. Heun et al.   EUROPEAN PSYCHIATRY

Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease

(2011) Kathleen M. Shannon et al.   MOVEMENT DISORDERS

Staphylococcus aureus harbouring Enterotoxin A as a possible risk factor for multiple sclerosis exacerbations

(2011) Michael R Mulvey et al.   Multiple Sclerosis Journal

Olfactory dysfunction in multiple sclerosis: association with secondary progression

(2011) Ana Martins Silva et al.   Multiple Sclerosis Journal

Olfactory threshold is impaired in early, active multiple sclerosis

(2011) A Lutterotti et al.   Multiple Sclerosis Journal

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

The skin microbiome

(2011) Elizabeth A. Grice et al.   NATURE REVIEWS MICROBIOLOGY

Olfaction in Parkinson's disease and related disorders

(2011) Richard L. Doty   NEUROBIOLOGY OF DISEASE

Inflammatory Cortical Demyelination in Early Multiple Sclerosis

(2011) Claudia F. Lucchinetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Faecal transplant eases symptoms of Parkinson's disease

(2011) Anil Ananthaswamy   NEW SCIENTIST

A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis

(2010) Roberta Magliozzi et al.   ANNALS OF NEUROLOGY

Central trigeminal involvement in multiple sclerosis using high-resolution MRI at 3 T

(2010) R J Mills et al.   BRITISH JOURNAL OF RADIOLOGY

Is there a ‘gut-brain-skin axis’?

(2010) Petra Arck et al.   EXPERIMENTAL DERMATOLOGY

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

The Human Oral Microbiome

(2010) F. E. Dewhirst et al.   JOURNAL OF BACTERIOLOGY

A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease

(2010) J Ochoa-Repáraz et al.   Mucosal Immunology

Clinico-pathological evidence that axonal loss underlies disability in progressive multiple sclerosis

(2010) Emma C Tallantyre et al.   Multiple Sclerosis Journal

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

(2010) Y. K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unique Lipids from a Common Human Bacterium Represent a New Class of Toll-Like Receptor 2 Ligands Capable of Enhancing Autoimmunity

(2009) Frank C. Nichols et al.   AMERICAN JOURNAL OF PATHOLOGY

Live imaging of Toll-like receptor 2 response in cerebral ischaemia reveals a role of olfactory bulb microglia as modulators of inflammation

(2009) M. Lalancette-Hébert et al.   BRAIN

The relation between inflammation and neurodegeneration in multiple sclerosis brains

(2009) Josa M. Frischer et al.   BRAIN

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

TNF-α and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects

(2009) Angela R. Kamer et al.   JOURNAL OF NEUROIMMUNOLOGY

Periodontitis is associated with cognitive impairment among older adults: analysis of NHANES-III

(2009) J M Noble et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Medical records documentation of constipation preceding Parkinson disease: A case-control study

(2009) R. Savica et al.   NEUROLOGY

The olfactory vector hypothesis of neurodegenerative disease: Is it viable?

(2008) Richard L. Doty   ANNALS OF NEUROLOGY

Toll-like receptors in neurodegeneration

(2008) Eitan Okun et al.   BRAIN RESEARCH REVIEWS

Effects ofBifidobacterium animalisadministered during lactation on allergic and autoimmune responses in rodents

(2008) J. Ezendam et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Urinary dysfunction in Parkinson's disease: A review

(2008) Helen Blackett et al.   PARKINSONISM & RELATED DISORDERS

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY

Association of olfactory dysfunction with risk for future Parkinson's disease

(2007) G. Webster Ross et al.   ANNALS OF NEUROLOGY

Reduced olfactory bulb and tract volume in early Alzheimer's disease—A MRI study

(2007) Philipp A. Thomann et al.   NEUROBIOLOGY OF AGING