Enkephalinase inhibitors, potential therapeutics for the future treatment of diarrhea predominant functional gastrointestinal disorders

Antinociceptive potency of enkephalins and enkephalinase inhibitors in the mouse model of colorectal distension-proof-of-concept

(2018) Adam Fabisiak et al.   Chemical Biology & Drug Design

Preventive and alleviative effects of the dual enkephalinase inhibitor (Denki) PL265 in a murine model of neuropathic pain

(2016) Elisabeth Bonnard et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Review: The Role of MOP and DOP Receptors in Treatment of Diarrheapredominant Irritable Bowel Syndrome

(2016) Agata Jarmu| et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Eluxadoline for Irritable Bowel Syndrome with Diarrhea

(2016) Anthony J. Lembo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Current and emergent pharmacologic treatments for irritable bowel syndrome with diarrhea: evidence-based treatment in practice

(2016) Susan Lucak et al.   Therapeutic Advances in Gastroenterology

Racecadotril for acute diarrhoea in children: systematic review and meta-analyses

(2015) Morris Gordon et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Su1378 Robustness of Eluxadoline for the Treatment of Irritable Bowel Syndrome With Diarrhea: Results From Phase 3 Composite Endpoint Assessments

(2015) Brian E. Lacy et al.   GASTROENTEROLOGY

316 Eluxadoline Demonstrates Sustained Efficacy for the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome in Phase 3 Clinical Trials

(2015) William D. Chey et al.   GASTROENTEROLOGY

Immune derived opioidergic inhibition of viscerosensory afferents is decreased in Irritable Bowel Syndrome patients

(2014) Patrick A. Hughes et al.   BRAIN BEHAVIOR AND IMMUNITY

Anxiety, Depression, and Catecholamine Levels After Self-Management Intervention in Irritable Bowel Syndrome

(2014) Wimon Deechakawan et al.   Gastroenterology Nursing

Orally administered novel cyclic pentapeptide P-317 alleviates symptoms of diarrhoea-predominant irritable bowel syndrome

(2014) Marta Zielińska et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Immune Activation in Irritable Bowel Syndrome: Can Neuroimmune Interactions Explain Symptoms?

(2013) Patrick A Hughes et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives

(2013) Marta Sobczak et al.   JOURNAL OF GASTROENTEROLOGY

Opioid receptor expression in human brain and peripheral tissues using absolute quantitative real-time RT-PCR

(2012) Jinsong Peng et al.   DRUG AND ALCOHOL DEPENDENCE

Sensory neuro-immune interactions differ between Irritable Bowel Syndrome subtypes

(2012) Patrick A Hughes et al.   GUT

The genetics of the opioid system and specific drug addictions

(2012) Orna Levran et al.   HUMAN GENETICS

Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain

(2012) Bernard P. Roques et al.   NATURE REVIEWS DRUG DISCOVERY

A Comprehensive Review of the Pharmacodynamics, Pharmacokinetics, and Clinical Effects of the Neutral Endopeptidase Inhibitor Racecadotril

(2012) Marion Eberlin et al.   Frontiers in Pharmacology

The Efficacy and Safety of Rifaximin for the Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis

(2011) Stacy B Menees et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Localization and Regulation of Fluorescently Labeled Delta Opioid Receptor, Expressed in Enteric Neurons of Mice

(2011) Daniel P. Poole et al.   GASTROENTEROLOGY

Bowel Disorders

(2010) Robin C Spiller et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Asimadoline in the treatment of irritable bowel syndrome

(2010) Allen W Mangel et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Opioids and anxiety

(2010) A Colasanti et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Coexpression of  - and  -opioid receptors in nociceptive sensory neurons

(2010) H.-B. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

A Molecular Analysis of Fecal and Mucosal Bacterial Communities in Irritable Bowel Syndrome

(2009) Caroline Codling et al.   DIGESTIVE DISEASES AND SCIENCES

Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes

(2009) Luca Gallelli et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Fecal proteases from diarrheic-IBS and ulcerative colitis patients exert opposite effect on visceral sensitivity in mice

(2009) Anita Annaházi et al.   PAIN

Antinociceptive and anti-allodynic effects of oral PL37, a complete inhibitor of enkephalin-catabolizing enzymes, in a rat model of peripheral neuropathic pain induced by vincristine

(2008) Karine Thibault et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Challenges to the Therapeutic Pipeline for Irritable Bowel Syndrome: End Points and Regulatory Hurdles

(2008) Michael Camilleri et al.   GASTROENTEROLOGY

The involvement of the μ-opioid receptor in gastrointestinal pathophysiology: Therapeutic opportunities for antagonism at this receptor

(2007) Diane L. DeHaven-Hudkins et al.   PHARMACOLOGY & THERAPEUTICS