Article
Chemistry, Multidisciplinary
Alba Calvo, Esther Moreno, Unai Clemente, Enma Perez, Esther Larrea, Carmen Sanmartin, Juan Manuel Irache, Socorro Espuelas
Summary: In visceral leishmaniasis infection, the uptake and distribution of nanoparticles in organs and cells are specifically affected due to immune cell mobilization and changes in vascular permeability. The liver, spleen, and bone marrow showed decreased cellular uptake of nanoparticles, which could impact their therapeutic efficacy in drug delivery.
Article
Chemistry, Multidisciplinary
Jiayi Zhu, Zhipeng Zhao, Huarui Chen, Xinglin Chen, Jinbin Liu
Summary: This study demonstrates that renal-clearable nanomedicines show a more sensitive response to injection dose and have improved tumor-targeting efficiency compared to nonrenal-clearable nanoparticles.
Article
Engineering, Biomedical
Fei Wang, Ling Sum Liu, Pan Li, Cia Hin Lau, Hoi Man Leung, Y. Rebecca Chin, Chung Tin, Pik Kwan Lo
Summary: Compared with siRNAs or other ASOs, TNA has the advantages of chemical simplicity, DNA/RNA binding capability, folding ability of tertiary structure, and excellent physiological stability, which make it a promising tool in biomedical applications. This study investigates the pharmacokinetics and biosafety of TNAs in living organisms, finding that they exhibit excellent stability, low cytotoxicity, and substantial uptake in living cells without transfection. TNAs also show the ability to efficiently penetrate multicellular spheroids and can be safely administered in mice without causing pathological changes in the kidneys.
MATERIALS TODAY BIO
(2022)
Article
Chemistry, Multidisciplinary
Paul Strasser, Bianca Montsch, Silvia Weiss, Haider Sami, Christoph Kugler, Sonja Hager, Hemma Schueffl, Robert Mader, Oliver Brueggemann, Christian R. R. Kowol, Manfred Ogris, Petra Heffeter, Ian Teasdale
Summary: The design and synthesis of novel bottlebrush polymers (PPz-g-PGA) with exceptional control over their structure and molecular dimensions have been reported. These polymers show outstanding aqueous solubility, ultra-high multivalency, and biodegradability, making them ideal as nanomedicines. They exhibit enhanced cellular uptake, pharmacokinetics, and tumor accumulation, offering valuable insights into the influence of architecture on the in vivo performance of nanomedicines.
Review
Immunology
Ramon Gonzalez-Rioja, Vivian A. Salazar, Neus G. Bastus, Victor Puntes
Summary: Researchers have developed ionizable lipid nanoparticles (iLNPs) as a universal carrier for efficient drug delivery. These iLNPs are formed by electrostatic aggregation of surfactants, therapeutic agents, and lipids, resulting in nanoparticles stabilized with lipid polymers. They have overcome previous limitations and offer advantages such as low toxicity and entry into cells via endocytosis. iLNPs have the potential to greatly improve disease management and are widely available for clinical use.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Andrew Kerr, Erny Sagita, Edward D. H. Mansfield, Tri-Hung Nguyen, Orlagh M. Feeney, Colin W. Pouton, Christopher J. H. Porter, Joaquin Sanchis, Sebastien Perrier
Summary: In this study, the behavior of molecular bottle-brush and cyclic peptide self-assembled nanotubes was investigated in vitro and in vivo. The results showed that the molecular bottle-brush had the longest circulation time, while the cyclic peptide nanotubes were able to avoid organ accumulation.
Article
Biotechnology & Applied Microbiology
Rita M. Pinto, Saleh Yazdani, Catarina Leal Seabra, Martine De Jonge, Mukaddes Izci, Rebeca Cruz, Susana Casal, Stefaan J. Soenen, Salette Reis, Claudia Nunes, Patrick Van Dijck
Summary: Staphylococcus aureus is a high priority pathogen due to its prevalence and ability to form biofilms. Current treatments do not target the matrix that contributes to antimicrobial tolerance. This study proposes the use of lipid nanoparticles encapsulating caspofungin to disrupt the matrix, and combining them with moxifloxacin-loaded nanoparticles to reduce biofilms. In vitro and in vivo studies showed promising results, with reduced biofilm formation and no bacterial dissemination into vital organs.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Article
Agriculture, Multidisciplinary
Paula S. Ferreira, John A. Manthey, Marina S. Nery, Thais B. Cesar
Summary: The study demonstrated the metabolism and distribution of orally administered eriocitrin in rats for the first time, identifying multiple metabolites in rat urine and tissues, with homoeriodictyol and homoeriodictyol-7-O-glucuronide as the major metabolites. The half-lives of metabolites in plasma were approximately 3 to 3.2 hours, and the total bioavailability of eriocitrin was less than 1%.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Qing Yu, Megan G. Roberts, Loujin Houdaihed, Yang Liu, Kuan Ho, Gilbert Walker, Christine Allen, Raymond M. Reilly, Ian Manners, Mitchell A. Winnik
Summary: The physicochemical properties of drug nanocarriers, such as size, shape, and surface chemistry, play a crucial role in their efficient penetration into tumor tissues. Rigid rod-like micelles with uniform width and varied lengths were found to exhibit significant cell uptake and penetration into multicellular tumor spheroids, with elongated micelles showing deeper penetration. However, the extent and depth of tumor penetration decreased with increasing aspect ratio of the rod-like micelles, indicating a shape-dependent effect on cellular uptake and penetration.
Article
Chemistry, Multidisciplinary
Vincent Mittelheisser, Pierre Coliat, Eric Moeglin, Lilian Goepp, Jacky G. Goetz, Loic J. Charbonniere, Xavier Pivot, Alexandre Detappe
Summary: Tumor-targeted antibody/fragment-conjugated nanoparticles show promise in improving local delivery of small molecules. A meta-analysis of 161 studies confirmed that targeted nanoparticles had significantly higher tumor uptake compared to naked nanoparticles. The study also found that the choice of nanoparticle type, size, and antibody moiety affected tumor uptake.
ADVANCED MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Hideo Takakusa, Norihiko Iwazaki, Makiya Nishikawa, Tokuyuki Yoshida, Satoshi Obika, Takao Inoue
Summary: Oligonucleotide therapeutics have become popular as a new treatment option for diseases that were previously difficult to target. However, there is a need to develop efficient methods for evaluating the metabolism and drug interactions of these therapeutics. The distribution and metabolism mechanisms of oligonucleotide therapeutics differ from small molecule drugs, and there are also challenges regarding experimental approaches in the evaluation of these therapeutics. This review summarizes the DMPK characteristics of antisense oligonucleotide (ASO) therapeutics and discusses how to optimize their evaluation and prediction.
NUCLEIC ACID THERAPEUTICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jens M. Debacker, Luna Maris, Fleur Cordier, David Creytens, Philippe Deron, Benedicte Descamps, Yves D'Asseler, Kathia De Man, Vincent Keereman, Sasha Libbrecht, Vanessa Schelfhout, Koen van de Vijver, Christian Vanhove, Wouter Huvenne
Summary: Recent advancements in PET imaging have improved sensitivity and resolution, presenting previously unseen resolution in clinical nuclear medicine. In order to better understand the distribution of [F-18]FDG at submillimetric scale, a direct correlation between radionuclide imaging and histopathology is necessary. This study successfully co-registered autoradiography with histopathology, revealing uncharted heterogeneity in [F-18]FDG uptake in gastrointestinal tissue.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Pharmacology & Pharmacy
Imran Rather, Nusrat Shafiq, Jaya Shukla, Gurvinder Kaur, Somit Pandey, Ritika Kondel Bhandari, Avaneesh Kumar Pandey, B. R. Mittal, G. K. Khuller, Navneet Sharma, Samir Malhotra
Summary: This study explores the pharmacokinetics and biodistribution of poly(lactic-co-glycolic) acid (PLGA) nanoparticles in healthy human volunteers. The results show significant differences in pharmacokinetic parameters between the nanoparticle and conventional groups, with the nanoparticles mainly distributed in the distal portions of the intestine, making them potentially advantageous for the treatment of intestinal or lymph node tuberculosis.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yu-Chuen Huang, Pei-Ying Hsieh, Li-Ying Wang, Tung-Hu Tsai, Yu-Jen Chen, Chen-Hsi Hsieh
Summary: The aim of this study was to evaluate the radiotherapy (RT)-pharmacokinetics (PK) effect of cabozantinib in concurrent or sequential regimens with external beam radiotherapy (EBRT) or stereotactic body radiation therapy (SBRT). The RT-drug interactions of cabozantinib under RT were confirmed in a free-moving rat model. The biodistribution of cabozantinib in the heart is modulated by off-target irradiation and SBRT doses simultaneously.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Anna Maria Tolomeo, Gaia Zuccolotto, Ricardo Malvicini, Giada De Lazzari, Alessandro Penna, Chiara Franco, Federico Caicci, Fabio Magarotto, Santina Quarta, Michela Pozzobon, Antonio Rosato, Maurizio Muraca, Federica Collino
Summary: This study aimed to evaluate the biodistribution of MSC-EVs after different routes of administration in mice. Results showed that local administration could increase the concentration of EVs in selective organs, limiting their systemic distribution and potentially reducing extra-organ effects. Biodistribution studies can help in selecting the most appropriate way of administering MSC-EVs for treating different diseases.
Article
Biochemistry & Molecular Biology
Mohammed F. Aldawsari, Ahmed Alalaiwe, El-Sayed Khafagy, Ahmed Al Saqr, Saad M. Alshahrani, Bader B. Alsulays, Sultan Alshehri, Amr S. Abu Lila, Syed Mohd Danish Rizvi, Wael A. H. Hegazy
Summary: Alveolar macrophages are crucial in immune defense, and schizophyllan nanoparticles can effectively stimulate inflammatory responses through TLR-9, promoting a shift from M2 to M1 phenotype in the immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Ahmed Alalaiwe
Summary: Nanometals can enhance drug solubility and target specificity, while conjugation processes can improve treatment efficiency and targeting. Nanomedicine contributes to the development of personalized cancer therapy.
Article
Pharmacology & Pharmacy
Amer S. AlAli, Mohammed F. Aldawsari, Ahmed Alalaiwe, Bjad K. Almutairy, Ramadan Al-Shdefat, Ismail A. Walbi, Mohamed H. Fayed
Summary: The study successfully designed and optimized fast-disintegrating tablets for sublingual delivery of sildenafil citrate using a design-of-experiment approach. The optimized formulation showed improved mechanical strength, fast disintegration and dissolution, as well as significantly increased C-max and AUC(0)-infinity compared to the market product. Overall, the design approach ensured a high level of product quality and performance for the fast-disintegrating tablets.
Article
Biochemistry & Molecular Biology
Ahmed Alalaiwe, Jia-You Fang, Hsien-Ju Lee, Chun-Hui Chiu, Ching-Yun Hsu
Summary: This study compared the anti-adipogenic activity and mechanisms of curcumin, demethoxycurcumin, and bisdemethoxycurcumin, finding that they all reduce lipid accumulation by downregulating the expression of adipogenic genes.
Article
Infectious Diseases
Mohammed F. Aldawsari, El-Sayed Khafagy, Ahmed Al Saqr, Ahmed Alalaiwe, Hisham A. Abbas, Moataz A. Shaldam, Wael A. H. Hegazy, Reham M. Goda
Summary: Sotolon exhibits anti-virulence activities against Pseudomonas aeruginosa by reducing biofilm and virulence factor production, modulating quorum sensing gene expression, and protecting mice from infection. It could be a potential therapeutic agent for combating bacterial infections and addressing antibiotic resistance issues.
Article
Medicine, Research & Experimental
Chwan-Fwu Lin, Shih-Yi Chuang, Tse-Hung Huang, Thi My Huyen Nguyen, Pei-Wen Wang, Ahmed Alalaiwe, Jia-You Fang
Summary: This study evaluated the topical application of rhubarb anthraquinone aglycones for psoriasis treatment. The anti-inflammatory effects of five anthraquinones were compared in cell-based studies, showing reduction in cytokines and inhibition of MAPK and NF-kappa B signaling. Both rhein and chrysophanol were effective in improving psoriasis symptoms in a mouse model, demonstrating multifunctional inhibition of psoriasiform inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ahmed Alalaiwe, Chi-Yuan Chen, Zi-Yu Chang, Jui-Tai Sung, Shih-Yi Chuang, Jia-You Fang
Summary: Research suggests that activated macrophages and mitochondrial fission factor GDAP1L1 play important roles in the development of psoriasis by regulating cytokine release and inflammatory mediators. Mitochondrial fission could potentially be a target for treating psoriatic inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Mohammed Muqtader Ahmed, Md. Khalid Anwer, Farhat Fatima, Mohammed F. Aldawsari, Ahmed Alalaiwe, Amer S. Alali, Abdulrahman I. Alharthi, Mohd Abul Kalam
Summary: In this study, lipid-polymer hybrid nanoparticles (LPHNPs) were fabricated using lipoid-90H and chitosan, and loaded with the anticancer drug sunitinib malate (SM). The optimized formulation, SLPN4, showed suitable size, stability, and drug release rate. It exhibited potent cytotoxicity against MCF-7 breast cancer cells and could be a promising therapy option for breast cancer.
Article
Pharmacology & Pharmacy
Mohamed H. Fayed, Ahmed Alalaiwe, Ziyad S. Almalki, Doaa A. Helal
Summary: In this study, a quality-by-design (QbD) approach using design-of-experiment (DoE) was implemented to optimize the key process variables in the green fluidized bed granulation (GFBG) process. The results showed that by optimizing the water amount and spray rate, the GFBG process can enhance the disintegration and dissolution of tablets containing a poorly water-soluble drug.
Article
Engineering, Chemical
Md Khalid Anwer, Essam A. Ali, Muzaffar Iqbal, Mohammed Muqtader Ahmed, Mohammed F. Aldawsari, Ahmed Al Saqr, Ahmed Alalaiwe, Gamal A. Soliman
Summary: In this study, OLP-loaded PLGA nanoparticles and OLP-CS-PLGA nanoparticles were successfully prepared to improve the dissolution rate and bioavailability of Olaparib. The results showed that OLP-CS-PLGA nanoparticles could be an effective approach for enhancing the bioavailability of Olaparib.
Review
Biochemistry & Molecular Biology
Shih-Chun Yang, Ahmed Alalaiwe, Zih-Chan Lin, Yu-Chih Lin, Ibrahim A. Aljuffali, Jia-You Fang
Summary: miRNA plays a critical role in regulating skin inflammation and has anti-inflammatory features. miRNA-based therapies could be potential candidates for treating skin inflammation.
Article
Materials Science, Multidisciplinary
Mohammad Javed Ansari, Najeeb Ur Rehman, Elmoatasim Ibnouf, Ahmed Alalaiwe, Majid Ahmad Ganaie, Ameeduzzafar Zafar
Summary: This research article presents the development, characterization, stability, antimicrobial activity, antispasmodic activity, and antidiarrheal activity of silver nanoparticles synthesized and stabilized by a polymeric coating of gum tragacanth solution. The study found that the silver nanoparticles exhibited good stability and significant antimicrobial, antispasmodic, and antidiarrheal activities.
Article
Pharmacology & Pharmacy
Ahmed Alalaiwe, Mohammad A. Alsenaidy, Ziyad S. Almalki, Mohamed H. Fayed
Summary: This study developed and optimized sildenafil orodispersible mini-tablets (ODMTs) for the treatment of pediatric pulmonary hypertension. Microcrystalline cellulose and partially pre-gelatinized starch were found to significantly influence the quality attributes of sildenafil ODMTs. By optimizing the formulation, the study achieved the optimal sildenafil ODMTs that meet the USP acceptance criteria.
Article
Polymer Science
El-Sayed Khafagy, Amr S. Abu Lila, Nahed Mohamed Sallam, Rania Abdel-Basset Sanad, Mahgoub Mohamed Ahmed, Mamdouh Mostafa Ghorab, Hadil Faris Alotaibi, Ahmed Alalaiwe, Mohammed F. Aldawsari, Saad M. Alshahrani, Abdullah Alshetaili, Bjad K. Almutairy, Ahmed Al Saqr, Shadeed Gad
Summary: This study aimed to investigate the efficacy of bilosomes-based mucoadhesive carvedilol nanosponge for enhancing the oral bioavailability of carvedilol. The bilosomes were prepared, optimized and characterized, and then incorporated into a composite mixture to obtain buccal nanosponge enriched with bilosomes. The optimized bilosome formula showed minimum vesicle size, maximum entrapment, and highest cumulative in vitro release, exhibiting sustained drug release for up to 24 h. In vivo assessment in rats indicated that the carvedilol-loaded nanosponge efficiently enhanced blood pressure, decreased oxidative stress, improved lipid profile, and exhibited a potent cardio-protective effect.
Article
Polymer Science
Vaibhav Gupta, Sradhanjali Mohapatra, Harshita Mishra, Uzma Farooq, Keshav Kumar, Mohammad Javed Ansari, Mohammed F. Aldawsari, Ahmed S. Alalaiwe, Mohd Aamir Mirza, Zeenat Iqbal
Summary: Nanotechnology has the potential to improve cosmetic formulations and enhance their effectiveness. The use of nanomaterials in cosmetics has been found to overcome certain limitations and improve consumer satisfaction. However, concerns have been raised regarding the potential health hazards of nanocosmetics due to their ability to penetrate the skin. This article provides an overview of nanotechnology-based approaches in cosmetics, discusses the benefits and risks associated with nanocosmetics, and highlights the regulatory status of cosmeceuticals in different regions.
Article
Nanoscience & Nanotechnology
Daniela Rubanova, Svitlana Skoroplyas, Alena Libanska, Eva Randarova, Josef Bryja, Michaela Chorvatova, Tomas Etrych, Lukas Kubala
Summary: This study explored the use of nanocarriers to deliver dexamethasone for treating rheumatoid arthritis. The results showed that this method increased the accumulation of dexamethasone in the arthritic area, had a dose-dependent healing effect, and reduced the accumulation of the RA mediator RANKL. This study provides a feasible strategy for improving rheumatoid arthritis therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Article
Nanoscience & Nanotechnology
Thanpisit Lomphithak, Apiwit Sae-Fung, Simone Sprio, Anna Tampieri, Siriporn Jitkaew, Bengt Fadeel
Summary: In this study, iron-doped hydroxyapatite (FeHA) was evaluated as a potential nanomedicine approach for treating PDAC. The results showed that FeHA, in combination with a sublethal dose of the GPX4 inhibitor RSL3, could trigger ferroptosis in KRAS mutant PANC-1 cells while sparing normal human cells. The induction of ferroptosis by FeHA plus RSL3 was found to be dependent on the metalloreductase STEAP3 in PDAC cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Review
Nanoscience & Nanotechnology
Marco Felipe Salas-Orozco, Ana Cecilia Lorenzo-Leal, Idania de Alba Montero, Nuria Patino Marin, Miguel Angel Casillas Santana, Horacio Bach
Summary: The emergence of antibiotic-resistant bacteria in severe infections is a growing concern, particularly in hospital environments. Metal-based nanomaterials have shown potential as an alternative to combat these bacteria, but there is a risk of bacterial resistance and environmental accumulation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
