Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function

MALT1 Controls Attenuated Rabies Virus by Inducing Early Inflammation and T Cell Activation in the Brain

(2018) E. Kip et al.   JOURNAL OF VIROLOGY

Ancient Origin of the CARD–Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions

(2018) Jens Staal et al.   Frontiers in Immunology

Inhibition of MALT1 decreases neuroinflammation and pathogenicity of virulent rabies virus in mice

(2018) E Kip et al.   JOURNAL OF VIROLOGY

The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition

(2017) Maureen Bardet et al.   IMMUNOLOGY AND CELL BIOLOGY

Mucosa-associated lymphoid tissue lymphoma translocation 1 as a novel therapeutic target for rheumatoid arthritis

(2017) Chang Hoon Lee et al.   Scientific Reports

Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF- B activation

(2016) A. Howes et al.   BIOCHEMICAL JOURNAL

Successful clinical treatment and functional immunological normalization of human MALT1 deficiency following hematopoietic stem cell transplantation

(2016) Jacob Rozmus et al.   CLINICAL IMMUNOLOGY

The paracaspase MALT1 mediates CARD14‐induced signaling in keratinocytes

(2016) Inna S Afonina et al.   EMBO REPORTS

The paracaspase MALT1 cleaves the LUBAC subunit HOIL1 during antigen receptor signaling

(2016) Tiphaine Douanne et al.   JOURNAL OF CELL SCIENCE

A role for MALT1 activity in Kaposi’s sarcoma-associated herpes virus latency and growth of primary effusion lymphoma

(2016) L Bonsignore et al.   LEUKEMIA

Targeting MALT1 Proteolytic Activity in Immunity, Inflammation and Disease: Good or Bad?

(2016) Annelies Demeyer et al.   TRENDS IN MOLECULAR MEDICINE

MALT1 inhibitors prevent the development of DSS-induced experimental colitis in mice via inhibiting NF-κB and NLRP3 inflammasome activation

(2016) Wen Liu et al.   Oncotarget

MALT1 is not alone after all: identification of novel paracaspases

(2015) Paco Hulpiau et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MALT1 - a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression

(2015) Inna S. Afonina et al.   FEBS Journal

MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-κB signaling

(2015) Lynn Elton et al.   FEBS Journal

Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss

(2015) Ulrike Harre et al.   Nature Communications

Combinatorial BTK and MALT1 inhibition augments killing of CD79 mutant diffuse large B cell lymphoma

(2015) Daniel Nagel et al.   Oncotarget

Crosstalk among IL-23 and DNAX Activating Protein of 12 kDa–Dependent Pathways Promotes Osteoclastogenesis

(2014) Hyun-Seock Shin et al.   JOURNAL OF IMMUNOLOGY

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis

(2014) Conor Mc Guire et al.   Journal of Neuroinflammation

Chemical structure of phenothiazines and their biological activity

(2014) Agata Jaszczyszyn et al.   Pharmacological Reports

Structural Analysis of Phenothiazine Derivatives as Allosteric Inhibitors of the MALT1 Paracaspase

(2013) Florian Schlauderer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Combined immunodeficiency associated with homozygous MALT1 mutations

(2013) Margaret L. McKinnon et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CMV promoter is repressed by p53 and activated by JNK pathway

(2013) Marianna Rodova et al.   PLASMID

Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL

(2012) Daniel Nagel et al.   CANCER CELL

New insights into osteoclastogenic signaling mechanisms

(2012) Tomoki Nakashima et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1

(2011) Jens Staal et al.   EMBO JOURNAL

Osteoclast Activity and Subtypes as a Function of Physiology and Pathology—Implications for Future Treatments of Osteoporosis

(2011) K. Henriksen et al.   ENDOCRINE REVIEWS

Dephosphorylation of Bcl-10 by calcineurin is essential for canonical NF-κB activation in Th cells

(2011) Stefan Frischbutter et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Recent progress in biological activities of synthesized phenothiazines

(2011) Krystian Pluta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

(2011) Alexander David Barrow et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibitory Effect of Chlorpromazine on RANKL-Induced Osteoclastogenesis in Mouse Bone Marrow Cells

(2011) Hiroharu Kawamura et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

CaMKII targets Bcl10 in T-cell receptor induced activation of NF-κB

(2011) Sreenivasa Rao Oruganti et al.   MOLECULAR IMMUNOLOGY

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

(2011) Mourad Matmati et al.   NATURE GENETICS

Malt1-dependent RelB cleavage promotes canonical NF- B activation in lymphocytes and lymphoma cell lines

(2011) S. Hailfinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased bone density and resistance to ovariectomy-induced bone loss in FoxP3-transgenic mice based on impaired osteoclast differentiation

(2010) Mario M. Zaiss et al.   ARTHRITIS AND RHEUMATISM

The expanding roles of ITAM adapters FcRγ and DAP12 in myeloid cells

(2009) Jessica A. Hamerman et al.   IMMUNOLOGICAL REVIEWS

Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice

(2008) Wei Jin et al.   JOURNAL OF CLINICAL INVESTIGATION

T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

(2008) Beatrice Coornaert et al.   NATURE IMMUNOLOGY

RelB is the NF- B subunit downstream of NIK responsible for osteoclast differentiation

(2008) S. Vaira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA