The RES domain toxins of RES-Xre toxin-antitoxin modules induce cell stasis by degrading NAD+

Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology

(2018) Alexander Harms et al.   MOLECULAR CELL

Diverse NADase effector families mediate interbacterial antagonism via the type VI secretion system

(2017) Jenny Y. Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TADB 2.0: an updated database of bacterial type II toxin–antitoxin loci

(2017) Yingzhou Xie et al.   NUCLEIC ACIDS RESEARCH

Toxin-antitoxin systems in bacterial growth arrest and persistence

(2016) Rebecca Page et al.   Nature Chemical Biology

VapCs of Mycobacterium tuberculosis cleave RNAs essential for translation

(2016) Kristoffer Winther et al.   NUCLEIC ACIDS RESEARCH

Toxin-Antitoxin Modules Are Pliable Switches Activated by Multiple Protease Pathways

(2016) Meenakumari Muthuramalingam et al.   Toxins

An Interbacterial NAD(P)+ Glycohydrolase Toxin Requires Elongation Factor Tu for Delivery to Target Cells

(2015) John C. Whitney et al.   CELL

The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD

(2015) Jim Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Growth-regulating Mycobacterium tuberculosis VapC-mt4 toxin is an isoacceptor-specific tRNase

(2015) Jonathan W. Cruz et al.   Nature Communications

The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD

(2015) Jim Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distinct type I and type II toxin-antitoxin modules control Salmonella lifestyle inside eukaryotic cells

(2015) Damián Lobato-Márquez et al.   Scientific Reports

Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology

(2015) Alexander Harms et al.   Cell Reports

Novel bacterial ADP-ribosylating toxins: structure and function

(2014) Nathan C. Simon et al.   NATURE REVIEWS MICROBIOLOGY

Internalization of Salmonella by Macrophages Induces Formation of Nonreplicating Persisters

(2014) S. Helaine et al.   SCIENCE

Cell Growth Inhibition upon Deletion of Four Toxin-Antitoxin Loci from the Megaplasmids of Sinorhizobium meliloti

(2013) B. Milunovic et al.   JOURNAL OF BACTERIOLOGY

Structure of theProteus vulgarisHigB-(HigA)2-HigB Toxin-Antitoxin Complex

(2013) Marc A. Schureck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VapC20 of Mycobacterium tuberculosis cleaves the Sarcin–Ricin loop of 23S rRNA

(2013) Kristoffer S. Winther et al.   Nature Communications

Comprehensive comparative-genomic analysis of Type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes

(2012) Kira S Makarova et al.   Biology Direct

Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics

(2012) Dapeng Zhang et al.   Biology Direct

Growth and Translation Inhibition through Sequence-specific RNA Binding byMycobacterium tuberculosisVapC Toxin

(2012) Jared D. Sharp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determining the Extremes of the Cellular NAD(H) Level by Using an Escherichia coli NAD+-Auxotrophic Mutant

(2011) Yongjin Zhou et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Diversity of bacterial type II toxin–antitoxin systems: a comprehensive search and functional analysis of novel families

(2011) Raphaël Leplae et al.   NUCLEIC ACIDS RESEARCH

Enteric virulence associated protein VapC inhibits translation by cleavage of initiator tRNA

(2011) K. S. Winther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Streptococcus pyogenes Immunity to Its NAD+ Glycohydrolase Toxin

(2011) Craig L. Smith et al.   STRUCTURE

Experimental phasing withSHELXC/D/E: combining chain tracing with density modification

(2010) George M. Sheldrick   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Photox, a Novel Actin-targeting Mono-ADP-ribosyltransferase fromPhotorhabdus luminescens

(2010) Danielle D. Visschedyk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dali server: conservation mapping in 3D

(2010) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

Photorhabdus luminescens Toxins ADP-Ribosylate Actin and RhoA to Force Actin Clustering

(2010) A. E. Lang et al.   SCIENCE

Toward a unified nomenclature for mammalian ADP-ribosyltransferases

(2010) Michael O. Hottiger et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE

(2009) Cajetan Neubauer et al.   CELL

Characterization ofStreptococcus pyogenesβ-NAD+Glycohydrolase

(2009) Joydeep Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Pfam protein families database

(2009) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

Comprehensive Functional Analysis of Mycobacterium tuberculosis Toxin-Antitoxin Systems: Implications for Pathogenesis, Stress Responses, and Evolution

(2009) Holly R. Ramage et al.   PLoS Genetics

Photorhabdus: a model for the analysis of pathogenicity and mutualism

(2008) David J. Clarke   CELLULAR MICROBIOLOGY

HicA of Escherichia coli Defines a Novel Family of Translation-Independent mRNA Interferases in Bacteria and Archaea

(2008) M. G. Jorgensen et al.   JOURNAL OF BACTERIOLOGY

Structural basis of actin recognition and arginine ADP-ribosylation by Clostridium perfringens  -toxin

(2008) H. Tsuge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA