Curcumin ameliorates PRMT5-MEP50 arginine methyltransferase expression by decreasing the Sp1 and NF-YA transcription factors in the A549 and MCF-7 cells

Identification of a novel selective small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) by virtual screening, resynthesis and biological evaluations

(2018) Kongkai Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Protein arginine methyltransferase 5 promotes lung cancer metastasis via the epigenetic regulation of miR-99 family/FGFR3 signaling

(2018) Pengyu Jing et al.   CANCER LETTERS

Specificity Protein Transcription Factors and Cancer: Opportunities for Drug Development

(2018) Stephen Safe et al.   Cancer Prevention Research

Protein kinase C: perfectly balanced

(2018) Alexandra C. Newton   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Curcumin: A Natural Pan-HDAC Inhibitor in Cancer

(2018) Sara Saffar Soflaei et al.   CURRENT PHARMACEUTICAL DESIGN

Identification of Selective, Cell Active Inhibitors of Protein Arginine Methyltransferase 5 through Structure-Based Virtual Screening and Biological Assays

(2018) Fei Ye et al.   Journal of Chemical Information and Modeling

Expression of protein arginine methyltransferase-5 in oral squamous cell carcinoma and its significance in epithelial-to-mesenchymal transition

(2018) Yusuke Amano et al.   PATHOLOGY INTERNATIONAL

Protein kinase C (PKC) isoforms in cancer, tumor promotion and tumor suppression

(2018) Noah Isakov   SEMINARS IN CANCER BIOLOGY

PRMT5 promotes cell proliferation by inhibiting BTG2 expression via the ERK signaling pathway in hepatocellular carcinoma

(2018) Hai Jiang et al.   Cancer Medicine

Targeting protein arginine methyltransferase 5 in disease

(2017) André Richters   Future Medicinal Chemistry

The protein arginine methyltransferase 5 promotes malignant phenotype of hepatocellular carcinoma cells and is associated with adverse patient outcomes after curative hepatectomy

(2017) Dai Shimizu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization

(2017) Ruifeng Mao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Arginine Methylation: The Coming of Age

(2017) Roméo S. Blanc et al.   MOLECULAR CELL

Selective small-chemical inhibitors of protein arginine methyltransferase 5 with anti-lung cancer activity

(2017) Gui-Mei Kong et al.   PLoS One

Targeting multiple pro-apoptotic signaling pathways with curcumin in prostate cancer cells

(2017) Mariela Rivera et al.   PLoS One

Biochemistry and regulation of the protein arginine methyltransferases (PRMTs)

(2016) Yalemi Morales et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Polyphenol compounds and PKC signaling

(2016) Joydip Das et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Protein arginine methyltransferase 5 regulates multiple signaling pathways to promote lung cancer cell proliferation

(2016) Xiumei Sheng et al.   BMC CANCER

Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations

(2016) Sen Ji et al.   Chemical Biology & Drug Design

A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression

(2016) H Chen et al.   ONCOGENE

Protein arginine methyltransferase 5 functions as an epigenetic activator of the androgen receptor to promote prostate cancer cell growth

(2016) X Deng et al.   ONCOGENE

Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells

(2016) Erik Hedrick et al.   Oncotarget

The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond

(2015) Nicole Stopa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Sp1 and the ‘hallmarks of cancer’

(2015) Kate Beishline et al.   FEBS Journal

Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)

(2015) GEORGE MIHAI NITULESCU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Histone H2A and H4 N-terminal Tails Are Positioned by the MEP50 WD Repeat Protein for Efficient Methylation by the PRMT5 Arginine Methyltransferase

(2015) Emmanuel S. Burgos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PI3K/AKT signaling pathway and cancer: an updated review

(2014) Miriam Martini et al.   ANNALS OF MEDICINE

Transcriptional activation of PRMT5 by NF-Y is required for cell growth and negatively regulated by the PKC/c-Fos signaling in prostate cancer cells

(2014) Huan-Tian Zhang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Sequence-Specific Transcription Factor NF-Y Displays Histone-like DNA Binding and H2B-like Ubiquitination

(2013) Marco Nardini et al.   CELL

Overexpression of PRMT5 Promotes Tumor Cell Growth and Is Associated with Poor Disease Prognosis in Epithelial Ovarian Cancer

(2013) Xiangxiang Bao et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Curcumin Down-Regulates DNA Methyltransferase 1 and Plays an Anti-Leukemic Role in Acute Myeloid Leukemia

(2013) Jianhua Yu et al.   PLoS One

PRMT5 Is Upregulated in Malignant and Metastatic Melanoma and Regulates Expression of MITF and p27Kip1

(2013) Courtney Nicholas et al.   PLoS One

Concurrent inhibition of enzymatic activity and NF-Y-mediated transcription of Topoisomerase-IIα by bis-DemethoxyCurcumin in cancer cells

(2013) S Belluti et al.   Cell Death & Disease

Protein arginine methyltransferase 5 is essential for growth of lung cancer cells

(2012) Zhongping Gu et al.   BIOCHEMICAL JOURNAL

HOXA9 Methylation by PRMT5 Is Essential for Endothelial Cell Expression of Leukocyte Adhesion Molecules

(2012) S. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation

(2011) Tin Oo Khor et al.   BIOCHEMICAL PHARMACOLOGY

Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation

(2011) Jung-Mao Hsu et al.   NATURE CELL BIOLOGY

Specific inhibition of NF-Y subunits triggers different cell proliferation defects

(2011) Paolo Benatti et al.   NUCLEIC ACIDS RESEARCH

Protein Arginine Methyltransferase 5 Regulates ERK1/2 Signal Transduction Amplitude and Cell Fate Through CRAF

(2011) P. Andreu-Perez et al.   Science Signaling

Versatility of PRMT5-induced methylation in growth control and development

(2011) Vrajesh Karkhanis et al.   TRENDS IN BIOCHEMICAL SCIENCES

Specificity protein, Sp1-mediated increased expression of Prdx6 as a curcumin-induced antioxidant defense in lens epithelial cells against oxidative stress

(2011) B Chhunchha et al.   Cell Death & Disease

PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130

(2010) Zhongwei Zhou et al.   CELL RESEARCH

Curcumin induces down-regulation of EZH2 expression through the MAPK pathway in MDA-MB-435 human breast cancer cells

(2010) Wen-Feng Hua et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of NFκB and Pancreatic Cancer Cell and Tumor Growth by Curcumin Is Dependent on Specificity Protein Down-regulation

(2010) Indira Jutooru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Curcumin induces apoptosis-independent death in oesophageal cancer cells

(2009) G O'Sullivan-Coyne et al.   BRITISH JOURNAL OF CANCER

Expression levels of NF-Y target genes changed by CDKN1B correlate with clinical prognosis in multiple cancers

(2009) Kazunori Yamanaka et al.   GENOMICS

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing

(2009) Quan Zhao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Curcumin is a potent DNA hypomethylation agent

(2008) Zhongfa Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Curcumin Decreases Specificity Protein Expression in Bladder Cancer Cells

(2008) G. Chadalapaka et al.   CANCER RESEARCH

The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5

(2008) Matthieu Lacroix et al.   EMBO REPORTS

Protein Arginine Methyltransferase 5 Suppresses the Transcription of the RB Family of Tumor Suppressors in Leukemia and Lymphoma Cells

(2008) L. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Curcumin: Preventive and Therapeutic Properties in Laboratory Studies and Clinical Trials

(2007) Alexios S. Strimpakos et al.   ANTIOXIDANTS & REDOX SIGNALING