Histone H2A and H4 N-terminal Tails Are Positioned by the MEP50 WD Repeat Protein for Efficient Methylation by the PRMT5 Arginine Methyltransferase

Protein Arginine Methyltransferase 5 Catalyzes Substrate Dimethylation in a Distributive Fashion

(2014) Min Wang et al.   BIOCHEMISTRY

Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma

(2014) Fengting Yan et al.   CANCER RESEARCH

A Remodeled Protein Arginine Methyltransferase 1 (PRMT1) Generates Symmetric Dimethylarginine

(2014) Shanying Gui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation and arginine methylation mark histone H2A prior to deposition during Xenopus laevis development

(2014) Wei-Lin Wang et al.   Epigenetics & Chromatin

Substrate Specificity, Processivity, and Kinetic Mechanism of Protein Arginine Methyltransferase 5

(2013) Min Wang et al.   BIOCHEMISTRY

Menin Epigenetically Represses Hedgehog Signaling in MEN1 Tumor Syndrome

(2013) B. Gurung et al.   CANCER RESEARCH

Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery

(2013) M. Bezzi et al.   GENES & DEVELOPMENT

Overexpression of PRMT5 Promotes Tumor Cell Growth and Is Associated with Poor Disease Prognosis in Epithelial Ovarian Cancer

(2013) Xiangxiang Bao et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Structure of the Arginine Methyltransferase PRMT5-MEP50 Reveals a Mechanism for Substrate Specificity

(2013) Meng-Chiao Ho et al.   PLoS One

Protein arginine methyltransferase 5 is essential for growth of lung cancer cells

(2012) Zhongping Gu et al.   BIOCHEMICAL JOURNAL

Crystal structure of the human PRMT5:MEP50 complex

(2012) S. Antonysamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterizing DNA Methyltransferases With An Ultrasensitive Luciferase-Linked Continuous Assay

(2011) Ivan Hemeon et al.   ANALYTICAL CHEMISTRY

Protein Arginine Methyltransferase Prmt5-Mep50 Methylates Histones H2A and H4 and the Histone Chaperone Nucleoplasmin inXenopus laevisEggs

(2011) Carola Wilczek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone H4 Acetylation Differentially Modulates Arginine Methylation by an inCisMechanism

(2011) You Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PredUs: a web server for predicting protein interfaces using structural neighbors

(2011) Q. C. Zhang et al.   NUCLEIC ACIDS RESEARCH

Versatility of PRMT5-induced methylation in growth control and development

(2011) Vrajesh Karkhanis et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase

(2010) Priya Aggarwal et al.   CANCER CELL

Histone arginine methylation

(2010) Alessandra Di Lorenzo et al.   FEBS LETTERS

Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency

(2010) W.-W. Tee et al.   GENES & DEVELOPMENT

RioK1, a New Interactor of Protein Arginine Methyltransferase 5 (PRMT5), Competes with pICln for Binding and Modulates PRMT5 Complex Composition and Substrate Specificity

(2010) Gernot Guderian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detecting Ricin: Sensitive Luminescent Assay for Ricin A-Chain Ribosome Depurination Kinetics

(2009) Matthew B. Sturm et al.   ANALYTICAL CHEMISTRY

The protein arginine methyltransferase family: an update about function, new perspectives and the physiological role in humans

(2009) S. S. Wolf   CELLULAR AND MOLECULAR LIFE SCIENCES

Minireview: Protein Arginine Methylation of Nonhistone Proteins in Transcriptional Regulation

(2009) Young-Ho Lee et al.   MOLECULAR ENDOCRINOLOGY

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing

(2009) Quan Zhao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PRMT5 is required for cell-cycle progression and p53 tumor suppressor function

(2009) A. Scoumanne et al.   NUCLEIC ACIDS RESEARCH

The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5

(2008) Matthieu Lacroix et al.   EMBO REPORTS

Analysis of Histones inXenopus laevis

(2008) Joshua J. Nicklay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of Histones inXenopus laevis

(2008) David Shechter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Arginine Methyltransferase 5 Suppresses the Transcription of the RB Family of Tumor Suppressors in Leukemia and Lymphoma Cells

(2008) L. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural Basis for the Recognition of Histone H4 by the Histone-Chaperone RbAp46

(2008) Natalia V. Murzina et al.   STRUCTURE