- Home
- Publications
- Publication Search
- Publication Details
Title
Design of Hedgehog pathway inhibitors for cancer treatment
Authors
Keywords
-
Journal
MEDICINAL RESEARCH REVIEWS
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2018-11-29
DOI
10.1002/med.21555
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Synthesis and evaluation of novel dimethylpyridazine derivatives as hedgehog signaling pathway inhibitors
- (2018) Chenglin Wang et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Design, synthesis and biological evaluation of deuterated Vismodegib for improving pharmacokinetic properties
- (2018) Fangying Wang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Hedgehog Antagonist Pyrimidine-Indole Hybrid Molecule Inhibits Ciliogenesis through Microtubule Destabilisation
- (2018) Harleen Khatra et al. CHEMBIOCHEM
- Structure-Activity Relationship Studies of Vitamin D3 Analogues Containing an Ether or Thioether Linker as Hedgehog Pathway Inhibitors
- (2018) Jiachen Wen et al. ChemMedChem
- Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates
- (2018) Eamon FX Byrne et al. CURRENT OPINION IN CELL BIOLOGY
- Overcoming the resistance mechanisms of Smoothened inhibitors
- (2018) Xiaochun Dong et al. DRUG DISCOVERY TODAY
- Discovery and characterization of a potent Wnt and hedgehog signaling pathways dual inhibitor
- (2018) Haikuo Ma et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold
- (2018) Simone Berardozzi et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of potent and novel smoothened antagonists via structure-based virtual screening and biological assays
- (2018) Wenfeng Lu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Dehydroeffusol inhibits viability and epithelial-mesenchymal transition through the Hedgehog and Akt/mTOR signaling pathways in neuroblastoma cells
- (2018) Kang He et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Discovery of a potent hedgehog pathway inhibitor capable of activating caspase8-dependent apoptosis
- (2018) Qin Chen et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Strategies to target the Hedgehog signaling pathway for cancer therapy
- (2018) Minhang Xin et al. MEDICINAL RESEARCH REVIEWS
- Probing seco-steroid inhibition of the hedgehog signaling pathway
- (2018) Evrett N. Thompson et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo
- (2018) Loredana Vesci et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, synthesis, and biological evaluation of optimized phthalazine derivatives as hedgehog signaling pathway inhibitors
- (2017) Xiuhong Lu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, synthesis, and biological evaluation of structurally modified isoindolinone and quinazolinone derivatives as hedgehog pathway inhibitors
- (2017) Deepak Bhattarai et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of 1-(3-aryl-4-chlorophenyl)-3-( p -aryl)urea derivatives against breast cancer by inhibiting PI3K/Akt/mTOR and Hedgehog signalings
- (2017) Wenlu Li et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Novel Macrocyclic Hedgehog Pathway Inhibitors Acting by Suppressing the Gli-Mediated Transcription
- (2017) Gang Liu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Combination therapy of paclitaxel and cyclopamine polymer-drug conjugates to treat advanced prostate cancer
- (2017) Ruinan Yang et al. Nanomedicine-Nanotechnology Biology and Medicine
- Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer
- (2017) Vinod Kumar et al. Scientific Reports
- Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells
- (2016) Ursula R. Rodgers et al. ACS Chemical Biology
- The Organocatalytic Approach to Enantiopure 2H- and 3H-Pyrroles: Inhibitors of the Hedgehog Signaling Pathway
- (2016) Lisa Kötzner et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Co-delivery of small molecule hedgehog inhibitor and miRNA for treating liver fibrosis
- (2016) Virender Kumar et al. BIOMATERIALS
- Synthesis and pharmacological evaluation of trifluoromethyl containing 4-(2-pyrimidinylamino)benzamides as Hedgehog signaling pathway inhibitors
- (2016) Minhang Xin et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Three new alkaloids from Veratrum grandiflorum Loes with inhibition activities on Hedgehog pathway
- (2016) Lijuan Gao et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Development of thieno- and benzopyrimidinone inhibitors of the Hedgehog signaling pathway reveals PDE4-dependent and PDE4-independent mechanisms of action
- (2016) Jonathan E. Hempel et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis and evaluation of novel benzylphthalazine derivatives as hedgehog signaling pathway inhibitors
- (2016) Xiaolong Bao et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Piperazic acid derivatives inhibit Gli1 in Hedgehog signaling pathway
- (2016) Harleen Khatra et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery of novel 4-(2-pyrimidinylamino)benzamide derivatives as highly potent and orally available hedgehog signaling pathway inhibitors
- (2016) Minhang Xin et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic
- (2016) Jennifer R. Pace et al. JOURNAL OF MEDICINAL CHEMISTRY
- Micelle Mixtures for Coadministration of Gemcitabine and GDC-0449 To Treat Pancreatic Cancer
- (2016) Melek Karaca et al. MOLECULAR PHARMACEUTICS
- Structural basis of Smoothened regulation by its extracellular domains
- (2016) Eamon F. X. Byrne et al. NATURE
- Quinolone-1-(2H)-ones as hedgehog signalling pathway inhibitors
- (2016) Trieu N. Trinh et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Pharmacokinetics and Biodistribution of GDC-0449 Loaded Micelles in Normal and Liver Fibrotic Mice
- (2016) Rinku Dutta et al. PHARMACEUTICAL RESEARCH
- Design, synthesis and evaluation of novel tetrahydrothieno[3,2-c]pyridine derivatives as potent smoothened antagonists
- (2016) Xiaofeng Chen et al. MedChemComm
- Inhibition of the CyclinD1 promoter in response to sonic hedgehog signaling pathway transduction is mediated by Gli1
- (2016) Zhongxiao Lin et al. Experimental and Therapeutic Medicine
- Hedgehog inhibitors from Artocarpus communis and Hyptis suaveolens
- (2015) Midori A. Arai et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis and evaluation of hedgehog signaling inhibitor with novel core system
- (2015) Tomohiro Ohashi et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Design, synthesis, and evaluation of hybrid vitamin D3 side chain analogues as hedgehog pathway inhibitors
- (2015) Upasana Banerjee et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Discovery of a 6-(pyridin-3-yl)benzo[d]thiazole template for optimization of hedgehog and PI3K/AKT/mTOR dual inhibitors
- (2015) Zhaohui Yang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Hedgehog inhibitors from Withania somnifera
- (2015) Tatsuro Yoneyama et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Oxidative regioselective amination of chromones exposes potent inhibitors of the hedgehog signaling pathway
- (2015) Rajarshi Samanta et al. CHEMICAL COMMUNICATIONS
- SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer
- (2015) C. M. Della Corte et al. CLINICAL CANCER RESEARCH
- Targeting the Hedgehog Signaling Pathway with Small Molecules from Natural Sources
- (2015) E. Petricci et al. CURRENT MEDICINAL CHEMISTRY
- Vitamin D3 analogues that contain modified A- and seco-B-rings as hedgehog pathway inhibitors
- (2015) Albert M. DeBerardinis et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, synthesis, and structure–activity-relationship of tetrahydrothiazolopyridine derivatives as potent smoothened antagonists
- (2015) Haikuo Ma et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor
- (2015) Lucile Hoch et al. FASEB JOURNAL
- Targeting hedgehog signalling by arsenic trioxide reduces cell growth and induces apoptosis in rhabdomyosarcoma
- (2015) KAREN A. BOEHME et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Modulation of Amide Bond Rotamers in 5-Acyl-6,7-dihydrothieno[3,2-c]pyridines
- (2015) Thomas Lanyon-Hogg et al. JOURNAL OF ORGANIC CHEMISTRY
- Codelivery of Small Molecule Hedgehog Inhibitor and miRNA for Treating Pancreatic Cancer
- (2015) Virender Kumar et al. MOLECULAR PHARMACEUTICS
- Regulation of the oncoprotein Smoothened by small molecules
- (2015) Hayley J Sharpe et al. Nature Chemical Biology
- Twist1 and Snail Link Hedgehog Signaling to Tumor-Initiating Cell-Like Properties and Acquired Chemoresistance Independently of ABC Transporters
- (2015) Ying Kong et al. STEM CELLS
- Targeting GLI factors to inhibit the Hedgehog pathway
- (2015) Paola Infante et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Synthesis and evaluation of novel N-3-benzimidazolephenylbisamide derivatives for antiproliferative and Hedgehog pathway inhibitory activity
- (2015) Chiyu Sun et al. MedChemComm
- Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened
- (2015) Annelies Gonnissen et al. Oncotarget
- An In Vivo Chemical Genetic Screen Identifies Phosphodiesterase 4 as a Pharmacological Target for Hedgehog Signaling Inhibition
- (2015) Charles H. Williams et al. Cell Reports
- Design, synthesis, and evaluation of pyrrolo[2,1-f][1,2,4]triazine derivatives as novel hedgehog signaling pathway inhibitors
- (2014) Minhang Xin et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Five-membered heteroaromatic ring fused-pyrimidine derivatives: Design, synthesis, and hedgehog signaling pathway inhibition study
- (2014) Liandi Zhang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Scaffold hopping approach to a new series of smoothened antagonists
- (2014) Wenfeng Lu et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Smoothened Goes Molecular: New Pieces in the Hedgehog Signaling Puzzle
- (2014) Jacqueline M. McCabe et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure–Activity Relationships for Vitamin D3-Based Aromatic A-Ring Analogues as Hedgehog Pathway Inhibitors
- (2014) Albert M. DeBerardinis et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Fast Entry to Furanoditerpenoid-Based Hedgehog Signaling Inhibitors: Identifying Essential Structural Features
- (2014) Maria Chatzopoulou et al. ORGANIC LETTERS
- Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs
- (2014) Chong Wang et al. Nature Communications
- Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography
- (2014) Uwe Weierstall et al. Nature Communications
- Catalytic Enantioselective Synthesis of Functionalized Tropanes Reveals Novel Inhibitors of Hedgehog Signaling
- (2013) Rishikesh Narayan et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Cyclopamine analogs bearing exocyclic methylenes are highly potent and acid-stable inhibitors of hedgehog signaling
- (2013) Johann Moschner et al. Beilstein Journal of Organic Chemistry
- The discovery of novel N-(2-pyrimidinylamino) benzamide derivatives as potent hedgehog signaling pathway inhibitors
- (2013) Minhang Xin et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis and evaluation of 4-(2-pyrimidinylamino) benzamides inhibitors of hedgehog signaling pathway
- (2013) Minhang Xin et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Itraconazole and Arsenic Trioxide Inhibit Hedgehog Pathway Activation and Tumor Growth Associated with Acquired Resistance to Smoothened Antagonists
- (2013) James Kim et al. CANCER CELL
- Targeting Sonic Hedgehog-Associated Medulloblastoma through Inhibition of Aurora and Polo-like Kinases
- (2013) S. L. Markant et al. CANCER RESEARCH
- Discovery of NVP-LEQ506, a Second-Generation Inhibitor of Smoothened
- (2013) Stefan Peukert et al. ChemMedChem
- Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors
- (2013) A. Jimeno et al. CLINICAL CANCER RESEARCH
- Hedgehog pathway inhibitors: a patent review (2009 – present)
- (2013) Matthew Kyle Hadden EXPERT OPINION ON THERAPEUTIC PATENTS
- Discovery of Small-Molecule Modulators of the Sonic Hedgehog Pathway
- (2013) Giannina I. Schaefer et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Hh signaling inhibitors from Vitex negundo; naturally occurring inhibitors of the GLI1–DNA complex
- (2013) Midori A. Arai et al. Molecular BioSystems
- Structure of the human smoothened receptor bound to an antitumour agent
- (2013) Chong Wang et al. NATURE
- Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling
- (2013) Elissaveta Petrova et al. Nature Chemical Biology
- Unraveling the therapeutic potential of the Hedgehog pathway in cancer
- (2013) Dereck Amakye et al. NATURE MEDICINE
- Nanomedicines of Hedgehog Inhibitor and PPAR-γ Agonist for Treating Liver Fibrosis
- (2013) Virender Kumar et al. PHARMACEUTICAL RESEARCH
- Identification of Vitamin D3-Based Hedgehog Pathway Inhibitors That Incorporate an Aromatic A-Ring Isostere
- (2013) Albert M. DeBerardinis et al. ACS Medicinal Chemistry Letters
- Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling
- (2013) Rajashree Rana et al. Nature Communications
- Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
- (2013) Sigrid Nachtergaele et al. eLife
- Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors
- (2012) Tomohiro Ohashi et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: Modification of the core skeleton for improved solubility
- (2012) Tomohiro Ohashi et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Probing the structural requirements for vitamin D3 inhibition of the hedgehog signaling pathway
- (2012) Albert M. DeBerardinis et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO
- (2012) Bin Yang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Attenuation of early liver fibrosis by pharmacological inhibition of smoothened receptor signaling
- (2012) Akshay Pratap et al. JOURNAL OF DRUG TARGETING
- Acylthiourea, Acylurea, and Acylguanidine Derivatives with Potent Hedgehog Inhibiting Activity
- (2012) Antonio Solinas et al. JOURNAL OF MEDICINAL CHEMISTRY
- Micellar Delivery of Cyclopamine and Gefitinib for Treating Pancreatic Cancer
- (2012) Deepak Chitkara et al. MOLECULAR PHARMACEUTICS
- Chemoresistance in Prostate Cancer Cells Is Regulated by miRNAs and Hedgehog Pathway
- (2012) Saurabh Singh et al. PLoS One
- Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies
- (2012) Chris Dockendorff et al. ACS Medicinal Chemistry Letters
- Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor
- (2011) Guillaume Guerlet et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydroimid azo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 1
- (2011) Savina Malancona et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitors
- (2011) Jesus M. Ontoria et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- N-(2-alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl)piperazine-1-carboxamides as highly potent smoothened antagonists
- (2011) Ester Muraglia et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Evaluation of vitamin D3 A-ring analogues as Hedgehog pathway inhibitors
- (2011) Upasana Banerjee et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Small Molecule Antagonists in Distinct Binding Modes Inhibit Drug-Resistant Mutant of Smoothened
- (2011) Haiyan Tao et al. CHEMISTRY & BIOLOGY
- Itraconazole Side Chain Analogues: Structure–Activity Relationship Studies for Inhibition of Endothelial Cell Proliferation, Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Glycosylation, and Hedgehog Signaling
- (2011) Wei Shi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Cyclopamine Attenuates Acute Warm Ischemia Reperfusion Injury in Cholestatic Rat Liver: Hope for Marginal Livers
- (2011) Akshay Pratap et al. MOLECULAR PHARMACEUTICS
- Studies Directed toward the Elucidation of the Pharmacophore of Steroid-Based Sonic Hedgehog Signaling Inhibitors
- (2011) André K. Isaacs et al. ORGANIC LETTERS
- Stereoselective Synthesis of F-Ring Saturated Estrone-Derived Inhibitors of Hedgehog Signaling Based on Cyclopamine
- (2011) Zhihui Zhang et al. ORGANIC LETTERS
- Design, synthesis, and biological evaluation of estrone-derived hedgehog signaling inhibitors
- (2011) Jeffrey D. Winkler et al. TETRAHEDRON
- Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened
- (2011) Michael J. Munchhof et al. ACS Medicinal Chemistry Letters
- Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway
- (2010) Neeraj Mahindroo et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Modulators of the hedgehog signaling pathway
- (2010) Philipp Heretsch et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonists
- (2010) Brian S. Lucas et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway
- (2010) Georgette M. Castanedo et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- New Hedgehog/GLI signaling inhibitors from Excoecaria agallocha
- (2010) Yusnita Rifai et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Gli3 mediates cell survival and sensitivity to cyclopamine in pancreatic cancer
- (2010) Adam Steg et al. CANCER BIOLOGY & THERAPY
- Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth
- (2010) James Kim et al. CANCER CELL
- Small-Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics
- (2010) Stefan Peukert et al. ChemMedChem
- New developments in the discovery of small molecule Hedgehog pathway antagonists
- (2010) Martin R Tremblay et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site
- (2010) Henry R. Maun et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Bisindole Alkaloid with Hedgehog Signal Inhibitory Activity from the MyxomycetePerichaena chrysosperma
- (2010) Akinori Shintani et al. JOURNAL OF NATURAL PRODUCTS
- Terpenoids and a Flavonoid Glycoside fromAcacia pennataLeaves as Hedgehog/GLI-Mediated Transcriptional Inhibitors
- (2010) Yusnita Rifai et al. JOURNAL OF NATURAL PRODUCTS
- New hedgehog/GLI-signaling inhibitors from Adenium obesum
- (2010) Midori A. Arai et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- International Union of Basic and Clinical Pharmacology. LXXX. The Class Frizzled Receptors
- (2010) G. Schulte PHARMACOLOGICAL REVIEWS
- Hedgehog signaling is essential for normal wound healing
- (2010) Huong Le et al. WOUND REPAIR AND REGENERATION
- Context-dependent Regulation of the GLI Code in Cancer by HEDGEHOG and Non-HEDGEHOG Signals
- (2010) B. Stecca et al. Journal of Molecular Cell Biology
- Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist
- (2010) Shifeng Pan et al. ACS Medicinal Chemistry Letters
- Review: Targeting the Hedgehog pathway in cancer
- (2010) Sachin Gupta et al. Therapeutic Advances in Medical Oncology
- Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway
- (2009) Anita Büttner et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog
- (2009) Lee F. Peng et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- GDC-0449—A potent inhibitor of the hedgehog pathway
- (2009) Kirk D. Robarge et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Hedgehog Target Genes: Mechanisms of Carcinogenesis Induced by Aberrant Hedgehog Signaling Activation
- (2009) Y. Katoh et al. CURRENT MOLECULAR MEDICINE
- Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)
- (2009) Martin R. Tremblay et al. JOURNAL OF MEDICINAL CHEMISTRY
- 1-Amino-4-benzylphthalazines as Orally Bioavailable Smoothened Antagonists with Antitumor Activity
- (2009) Karen Miller-Moslin et al. JOURNAL OF MEDICINAL CHEMISTRY
- Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer
- (2009) Motoko Seto et al. MOLECULAR CARCINOGENESIS
- Design and Synthesis of Inhibitors of Hedgehog Signaling Based on the Alkaloid Cyclopamine
- (2009) Jeffrey D. Winkler et al. ORGANIC LETTERS
- Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
- (2009) K. P. Olive et al. SCIENCE
- Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
- (2009) Suzie J. Scales et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana
- (2008) Midori A. Arai et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Identification and structure–activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway
- (2008) Stefan Peukert et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Naturally Occurring Small-Molecule Inhibitors of Hedgehog/GLI-Mediated Transcription
- (2008) Takahiro Hosoya et al. CHEMBIOCHEM
- Semisynthetic Cyclopamine Analogues as Potent and Orally Bioavailable Hedgehog Pathway Antagonists
- (2008) Martin R. Tremblay et al. JOURNAL OF MEDICINAL CHEMISTRY
- Potent Inhibitors of the Hedgehog Signaling Pathway
- (2008) Shirley A. Brunton et al. JOURNAL OF MEDICINAL CHEMISTRY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started