Monoamine oxidase-B inhibitors as potential neurotherapeutic agents: An overview and update

Proposing Novel MAO-B Hit Inhibitors Using Multidimensional Molecular Modeling Approaches and Application of Binary QSAR Models for Prediction of Their Therapeutic Activity, Pharmacokinetic and Toxicity Properties

(2018) Yusuf Serhat Is et al.   ACS Chemical Neuroscience

Novel indanone derivatives as MAO B/H 3 R dual-targeting ligands for treatment of Parkinson’s disease

(2018) Anna Affini et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

MAO inhibitors and their wider applications: a patent review

(2018) Simone Carradori et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Tight-Binding Inhibition of Human Monoamine Oxidase B by Chromone Analogs: A Kinetic, Crystallographic, and Biological Analysis

(2018) Joana Reis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Contilisant, a Tetratarget Small Molecule for Alzheimer’s Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile

(2018) Óscar M. Bautista-Aguilera et al.   JOURNAL OF MEDICINAL CHEMISTRY

Why does the Y326I mutant of monoamine oxidase B decompose an endogenous amphetamine at a slower rate than the wild type enzyme? Reaction step elucidated by multiscale molecular simulations

(2018) Domen Pregeljc et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Selenazolyl-hydrazones as Novel Selective MAO Inhibitors With Antiproliferative and Antioxidant Activities: Experimental and In-silico Studies

(2018) Hana Elshaflu et al.   Frontiers in Chemistry

Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease

(2017) Jacques Joubert et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and structure-activity relationship study of novel 3-heteroarylcoumarins based on pyridazine scaffold as selective MAO-B inhibitors

(2017) María Carmen Costas-Lago et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Crystal structures, binding interactions, and ADME evaluation of brain penetrant N -substituted indazole-5-carboxamides as subnanomolar, selective monoamine oxidase B and dual MAO-A/B inhibitors

(2017) Nikolay T. Tzvetkov et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multiscale simulation of monoamine oxidase catalyzed decomposition of phenylethylamine analogs

(2017) Gabriel Oanca et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Recognition dynamics of dopamine to human Monoamine oxidase B: role of Leu171/Gln206 and conserved water molecules in the active site cavity

(2017) Subrata Dasgupta et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Subnanomolar indazole-5-carboxamide inhibitors of monoamine oxidase B (MAO-B) continued: indications of iron binding, experimental evidence for optimised solubility and brain penetration

(2017) Nikolay T. Tzvetkov et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Through scaffold modification to 3,5-diaryl-4,5-dihydroisoxazoles: new potent and selective inhibitors of monoamine oxidase B

(2017) Rita Meleddu et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Design, synthesis, and pharmacological evaluation of 2-amino-5-nitrothiazole derived semicarbazones as dual inhibitors of monoamine oxidase and cholinesterase: effect of the size of aryl binding site

(2017) Rati K. P. Tripathi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

In-vitroandin-vivoevaluation of the modulatory effects of the multitarget compound ASS234 on the monoaminergic system

(2017) Gerard Esteban et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Pharmacophore-Based 3D-QSAR Analysis of Thienyl Chalcones as a New Class of Human MAO-B Inhibitors: Investigation of Combined Quantum Chemical and Molecular Dynamics Approach

(2017) Bijo Mathew et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease

(2017) Mari Paz Serrano et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Synthesis and Evaluation of Phenylxanthine Derivatives as Potential Dual A2AR Antagonists/MAO-B Inhibitors for Parkinson’s Disease

(2017) et al.   MOLECULES

How fast monoamine oxidases decompose adrenaline? Kinetics of isoenzymes A and B evaluated by empirical valence bond simulation

(2017) Gabriel Oanca et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

MAO inhibitory activity of bromo-2-phenylbenzofurans: synthesis, in vitro study, and docking calculations

(2017) G. L. Delogu et al.   MedChemComm

Synthesis and pharmacological evaluation of multi-functional homoisoflavonoid derivatives as potent inhibitors of monoamine oxidase B and cholinesterase for the treatment of Alzheimer's disease

(2017) Qiao-Hong Liu et al.   MedChemComm

Pyrazolobenzothiazine-based carbothioamides as new structural leads for the inhibition of monoamine oxidases: design, synthesis, in vitro bioevaluation and molecular docking studies

(2017) Syed Mobasher Ali Abid et al.   MedChemComm

Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels

(2017) Sophia Schedin-Weiss et al.   Alzheimers Research & Therapy

Characterization of Thienylchalcones as hMAO-B Inhibitors: Synthesis, Biochemistry and Molecular Dynamics Studies

(2017) Bijo Mathew et al.   ChemistrySelect

Comparative Analysis of the Neurochemical Profile and MAO Inhibition Properties of N-(Furan-2-ylmethyl)-N-methylprop-2-yn-1-amine

(2016) Philippe De Deurwaerdère et al.   ACS Chemical Neuroscience

Novel tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6H)-one: Design, synthesis, model and use as hMAO-B inhibitors

(2016) Rui Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer’s disease

(2016) Yan Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of novel donepezil–coumarin hybrids as multi-target agents for the treatment of Alzheimer’s disease

(2016) Sai-Sai Xie et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of N -methyl- N -[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors

(2016) Ornella Di Pietro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition of monoamine oxidase by benzoxathiolone analogues

(2016) Samantha Mostert et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2-Benzylidene-1-indanone derivatives as inhibitors of monoamine oxidase

(2016) Magdalena S. Nel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An evaluation of synthetic indole derivatives as inhibitors of monoamine oxidase

(2016) Zhanna V. Chirkova et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2-Heteroarylidene-1-indanone derivatives as inhibitors of monoamine oxidase

(2016) Magdalena S. Nel et al.   BIOORGANIC CHEMISTRY

2-Azolylchromone Derivatives as Potent and Selective Inhibitors of Monoamine Oxidases A and B

(2016) Koichi Takao et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Rapid synthesis of flavone-based monoamine oxidase (MAO) inhibitors targeting two active sites using click chemistry

(2016) Wei Zhen Jia et al.   Chemical Biology & Drug Design

Evaluation of Natural and Synthetic 1,4-naphthoquinones as Inhibitors of Monoamine Oxidase

(2016) Samantha Mostert et al.   Chemical Biology & Drug Design

Exploration of a Library of 3,4-(Methylenedioxy)aniline-Derived Semicarbazones as Dual Inhibitors of Monoamine Oxidase and Acetylcholinesterase: Design, Synthesis, and Evaluation

(2016) Rati K. P. Tripathi et al.   ChemMedChem

Design, Synthesis, and Evaluation of 2-Amino-6-nitrobenzothiazole-Derived Hydrazones as MAO Inhibitors: Role of the Methylene Spacer Group

(2016) Rati K. P. Tripathi et al.   ChemMedChem

Upregulation of Antioxidant Enzymes by ASS234, a Multitarget Directed Propargylamine for Alzheimer's Disease Therapy

(2016) Eva Ramos et al.   CNS Neuroscience & Therapeutics

( E )-3-Heteroarylidenechroman-4-ones as potent and selective monoamine oxidase-B inhibitors

(2016) Nicoletta Desideri et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Drug design, synthesis, in vitro and in silico evaluation of selective monoaminoxidase B inhibitors based on 3-acetyl-2-dichlorophenyl-5-aryl-2,3-dihydro-1,3,4-oxadiazole chemical scaffold

(2016) Simona Distinto et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of novel chalcones as potent selective monoamine oxidase-B inhibitors

(2016) Arwa Hammuda et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation

(2016) Ming-Yu Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Exploration of chlorinated thienyl chalcones: A new class of monoamine oxidase-B inhibitors

(2016) Bijo Mathew et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Monoamino Oxidase Inhibitors Activities of Some Synthesized 2,6-bis (Tetracarboxamide)-pyridine and Macrocyclic Octacarboxamide Derivatives

(2016) Mohamed M. Abdalla et al.   International Journal of Pharmacology

Synthesis of some novel 2-substituted benzothiazole derivatives containing benzylamine moiety as monoamine oxidase inhibitory agents

(2016) Betül Kaya et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors

(2016) Joana Reis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Searching for Multi-Targeting Neurotherapeutics against Alzheimer’s: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif

(2016) Leonardo Pisani et al.   MOLECULES

ONIOM calculations on serotonin degradation by monoamine oxidase B: insight into the oxidation mechanism and covalent reversible inhibition

(2016) Kubra Cakir et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Why p-OMe- and p-Cl-β-Methylphenethylamines Display Distinct Activities upon MAO-B Binding

(2016) Angélica Fierro et al.   PLoS One

Molecular aspects of monoamine oxidase B

(2016) Rona R. Ramsay   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The Use of Multiscale Molecular Simulations in Understanding a Relationship between the Structure and Function of Biological Systems of the Brain: The Application to Monoamine Oxidase Enzymes

(2016) Robert Vianello et al.   Frontiers in Neuroscience

ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy

(2016) José Marco-Contelles et al.   Frontiers in Neuroscience

Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease

(2016) Mercedes Unzeta et al.   Frontiers in Neuroscience

Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology

(2016) John P. M. Finberg et al.   Frontiers in Pharmacology

Monoamine Oxidase Inhibitory Activity of Novel Pyrazoline Analogues: Curcumin Based Design and Synthesis-II

(2016) Vishnu Nayak Badavath et al.   ChemistrySelect

Synthesis and Screening of Human Monoamine Oxidase-A Inhibitor Effect of New 2-Pyrazoline and Hydrazone Derivatives

(2015) Begüm Evranos-Aksöz et al.   ARCHIV DER PHARMAZIE

Monoamine Oxidase Inhibitory Activity of Ferulic Acid Amides: Curcumin-Based Design and Synthesis

(2015) Vishnu N. Badavath et al.   ARCHIV DER PHARMAZIE

Design and synthesis of novel 2-pyrazoline-1-ethanone derivatives as selective MAO inhibitors

(2015) Xu Tong et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation of selegiline derivatives as monoamine oxidase inhibitor, antioxidant and metal chelator against Alzheimer’s disease

(2015) Shishun Xie et al.   BIOORGANIC & MEDICINAL CHEMISTRY

α-Ketoamino acid ester derivatives as promising MAO inhibitors

(2015) Ayman El-Faham et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of monoamine oxidase by indole-5,6-dicarbonitrile derivatives

(2015) Zhanna V. Chirkova et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The synthesis and evaluation of sesamol and benzodioxane derivatives as inhibitors of monoamine oxidase

(2015) Idalet Engelbrecht et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Multifunctional coumarin derivatives: Monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer’s disease

(2015) Ming Huang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development of fluorinated methoxylated chalcones as selective monoamine oxidase-B inhibitors: Synthesis, biochemistry and molecular docking studies

(2015) Bijo Mathew et al.   BIOORGANIC CHEMISTRY

Monoamine oxidase inhibitory activity of 2-aryl-4H-chromen-4-ones

(2015) Vishnu Nayak Badavath et al.   BIOORGANIC CHEMISTRY

The Synthesis and Evaluation of C7-Substitutedα-Tetralone Derivatives as Inhibitors of Monoamine Oxidase

(2015) Lesetja J. Legoabe et al.   Chemical Biology & Drug Design

Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry

(2015) F. Cagide et al.   CHEMICAL COMMUNICATIONS

Discovery of 3-Hydroxy-3-phenacyloxindole Analogues of Isatin as Potential Monoamine Oxidase Inhibitors

(2015) Rati K. P. Tripathi et al.   ChemMedChem

Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease

(2015) Ondrej Benek et al.   ChemMedChem

Indanones As High-Potency Reversible Inhibitors of Monoamine Oxidase

(2015) Samantha Mostert et al.   ChemMedChem

In silico design of novel 2H-chromen-2-one derivatives as potent and selective MAO-B inhibitors

(2015) Leonardo Pisani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives

(2015) Oludotun A. Phillips et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multi-target tacrine-coumarin hybrids: Cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease

(2015) Sai-Sai Xie et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of the monoamine oxidases inhibitory activity of a small series of 5-(azole)methyl oxazolidinones

(2015) Oludotun A. Phillips et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

cis-cyclopropylamines as mechanism-based inhibitors of monoamine oxidases

(2015) Thomas Malcomson et al.   FEBS Journal

Purine homo-N-nucleoside+coumarin hybrids as pleiotropic agents for the potential treatment of Alzheimer's disease

(2015) Michael G Kallitsakis et al.   Future Medicinal Chemistry

Revealing Monoamine Oxidase B Catalytic Mechanisms by Means of the Quantum Chemical Cluster Approach

(2015) Gerald Zapata-Torres et al.   Journal of Chemical Information and Modeling

(Thiazol-2-yl)hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: synthesis, biological evaluation and molecular modeling studies

(2015) Melissa D’Ascenzio et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Novel Arylalkenylpropargylamines as Neuroprotective, Potent, and Selective Monoamine Oxidase B Inhibitors for the Treatment of Parkinson’s Disease

(2015) Paul B. Huleatt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases

(2015) Roberta Farina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders

(2015) Robert Otto et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Frontiers in Selective Human MAO-B Inhibitors

(2015) Simone Carradori et al.   JOURNAL OF MEDICINAL CHEMISTRY

Influence of the Environment on the Oxidative Deamination of p-Substituted Benzylamines in Monoamine Oxidase

(2015) Roland K. Zenn et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Development of Fluorinated Thienylchalcones as Monoamine Oxidase-B Inhibitors: Design, Synthesis, Biological Evaluation and Molecular Docking Studies

(2015) Bijo Mathew et al.   LETTERS IN ORGANIC CHEMISTRY

Quinolinyl-Thienyl Chalcones as Monoamine Oxidase Inhibitors and their In Silico Modeling Studies

(2015) Sumera Zaib et al.   Medicinal Chemistry

Acetophenone derivatives: novel and potent small molecule inhibitors of monoamine oxidase B

(2015) Zhi-Min Wang et al.   MedChemComm

Chromanones: selective and reversible monoamine oxidase B inhibitors with nanomolar potency

(2015) Jin-Shuai Lan et al.   MedChemComm

Synthesis and evaluation of 6-methylcoumarin derivatives as potent and selective monoamine oxidase B inhibitors

(2015) Jin-Shuai Lan et al.   MedChemComm

Monoamine Oxidase Inhibitory Activity of Novel Pyrazoline Analogues: Curcumin Based Design and Synthesis

(2015) Vishnu Nayak Badavath et al.   ACS Medicinal Chemistry Letters

2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors

(2015) Lesetja Legoabe et al.   Drug Design Development and Therapy

Synthesis and evaluation of 6-substituted 3-arylcoumarin derivatives as multifunctional acetylcholinesterase/monoamine oxidase B dual inhibitors for the treatment of Alzheimer’s disease

(2015) Zhi-Min Wang et al.   RSC Advances

Exploration of a library of triazolothiadiazole and triazolothiadiazine compounds as a highly potent and selective family of cholinesterase and monoamine oxidase inhibitors: design, synthesis, X-ray diffraction analysis and molecular docking studies

(2015) Imtiaz Khan et al.   RSC Advances

Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease

(2014) Gerard Esteban et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

N-(furan-2-ylmethyl)-N-methylprop-2-yn-1-amine (F2MPA): A Potential Cognitive Enhancer with MAO Inhibitor Properties

(2014) Giuseppe Di Giovanni et al.   CNS Neuroscience & Therapeutics

Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease

(2014) Li Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil–indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

(2014) Oscar M. Bautista-Aguilera et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel monoamine oxidase inhibitors: a patent review (2012 – 2014)

(2014) Simone Carradori et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual Inhibitor

(2014) Oscar M. Bautista-Aguilera et al.   JOURNAL OF MEDICINAL CHEMISTRY

Monoamine oxidases as sources of oxidants in the heart

(2014) Nina Kaludercic et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Update on the pharmacology of selective inhibitors of MAO-A and MAO-B: Focus on modulation of CNS monoamine neurotransmitter release

(2014) John P.M. Finberg   PHARMACOLOGY & THERAPEUTICS

Design, Synthesis, in vitro MAO-B Inhibitory Evaluation, and Computational Studies of Some 6-Nitrobenzothiazole-Derived Semicarbazones

(2013) Rati K. P. Tripathi et al.   ChemMedChem

A comparative computational investigation on the proton and hydride transfer mechanisms of monoamine oxidase using model molecules

(2013) Vildan Enisoğlu Atalay et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Multipotent, Permeable Drug ASS234 Inhibits Aβ Aggregation, Possesses Antioxidant Properties and Protects from Aβ-induced Apoptosis In Vitro

(2013) Irene Bolea et al.   Current Alzheimer Research

Exploring 4-substituted-2-thiazolylhydrazones from 2-, 3-, and 4-acetylpyridine as selective and reversible hMAO-B inhibitors

(2013) Paola Chimenti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Do MAO A and MAO B utilize the same mechanism for the C–H bond cleavage step in catalysis? Evidence suggesting differing mechanisms

(2013) R. Orru et al.   JOURNAL OF NEURAL TRANSMISSION

Computational modeling of the direct hydride transfer mechanism for the MAO catalyzed oxidation of phenethylamine and benzylamine: ONIOM (QM/QM) calculations

(2013) Mehmet Ali Akyüz et al.   JOURNAL OF NEURAL TRANSMISSION

Reaction Mechanism of Monoamine Oxidase from QM/MM Calculations

(2013) Enrique Abad et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Effect of diet on serotonergic neurotransmission in depression

(2013) Faisal Shabbir et al.   NEUROCHEMISTRY INTERNATIONAL

Sulfanylphthalonitrile analogues as selective and potent inhibitors of monoamine oxidase B

(2012) Mietha M. Van der Walt et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selected chromone derivatives as inhibitors of monoamine oxidase

(2012) Lesetja J. Legoabe et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Opportunities for reversible inhibitors of monoamine oxidase-A (RIMAs) in the treatment of depression

(2012) Christopher T. Lum et al.   CNS SPECTRUMS

Recent advances in the development of selective human MAO-B inhibitors: (Hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines

(2012) Daniela Secci et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

How are Biogenic Amines Metabolized by Monoamine Oxidases?

(2012) Robert Vianello et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Safety of Selegiline Transdermal System in Clinical Practice

(2012) Chi-Un Pae et al.   JOURNAL OF CLINICAL PSYCHIATRY

Dietary Restrictions and Drug Interactions With Monoamine Oxidase Inhibitors

(2012) David A. Flockhart   JOURNAL OF CLINICAL PSYCHIATRY

2H Kinetic Isotope Effects and pH Dependence of Catalysis as Mechanistic Probes of Rat Monoamine Oxidase A: Comparisons with the Human Enzyme

(2011) Jin Wang et al.   BIOCHEMISTRY

Steered Molecular Dynamics Simulations Reveal Important Mechanisms in Reversible Monoamine Oxidase B Inhibition

(2011) William J. Allen et al.   BIOCHEMISTRY

Exploration of new scaffolds as potential MAO-A inhibitors using pharmacophore and 3D-QSAR based in silico screening

(2011) Suhas M. Shelke et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Monoamine oxidase inhibition by C4-substituted phthalonitriles

(2011) Clarina I. Manley-King et al.   BIOORGANIC CHEMISTRY

Monoamine oxidase inhibition by selected anilide derivatives

(2011) Lesetja Legoabe et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Irreversible Inhibition of Monoamine Oxidase B by the Antiparkinsonian Medicines Rasagiline and Selegiline: A Computational Study

(2011) Rok Borštnar et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The ‘gating’ residues Ile199 and Tyr326 in human monoamine oxidase B function in substrate and inhibitor recognition

(2011) Erika M. Milczek et al.   FEBS Journal

Evaluation of the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to toxic pyridinium cations by monoamine oxidase (MAO) enzymes and its use to search for new MAO inhibitors and protective agents

(2011) Tomás Herraiz   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

3-Acetyl-2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoles: A New Scaffold for the Selective Inhibition of Monoamine Oxidase B

(2011) Elias Maccioni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil andN-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s Disease

(2011) Irene Bolea et al.   JOURNAL OF MEDICINAL CHEMISTRY

Computational investigation on the structure–activity relationship of the biradical mechanism for monoamine oxidase

(2011) Safiye S. Erdem et al.   JOURNAL OF NEURAL TRANSMISSION

Nitrogen Kinetic Isotope Effects for the Monoamine Oxidase B-Catalyzed Oxidation of Benzylamine and (1,1-2H2)Benzylamine: Nitrogen Rehybridization and CH Bond Cleavage Are Not Concerted

(2011) Susanna MacMillar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Associations of MAOA-VNTR or 5HTT-LPR alleles with attention-deficit hyperactivity disorder symptoms are moderated by platelet monoamine oxidase B activity

(2011) Hanna-Linn Wargelius et al.   PSYCHIATRIC GENETICS

Tyrosyl Radical Formation and Propagation in Flavin Dependent Monoamine Oxidases

(2010) Rachel V. Dunn et al.   CHEMBIOCHEM

On the formation and nature of the imidazoline I2 binding site on human monoamine oxidase-B

(2010) G. Reid McDonald et al.   PHARMACOLOGICAL RESEARCH

Oxidation of amines by flavoproteins

(2009) Paul F. Fitzpatrick   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Molecular and Mechanistic Properties of the Membrane-Bound Mitochondrial Monoamine Oxidases

(2009) Dale E. Edmondson et al.   BIOCHEMISTRY

Recent advances in our understanding of neurodegeneration

(2009) Kurt A. Jellinger   JOURNAL OF NEURAL TRANSMISSION

Platelet monoamine oxidase activity in children with attention-deficit/hyperactivity disorder

(2009) Gordana Nedic et al.   PSYCHIATRY RESEARCH

Novel Druggable Hot Spots in Avian Influenza Neuraminidase H5N1 Revealed by Computational Solvent Mapping of a Reduced and Representative Receptor Ensemble

(2008) Melissa R. Landon et al.   Chemical Biology & Drug Design

Structure of human monoamine oxidase A at 2.2-A resolution: The control of opening the entry for substrates/inhibitors

(2008) S.-Y. Son et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA