Exploration of a library of triazolothiadiazole and triazolothiadiazine compounds as a highly potent and selective family of cholinesterase and monoamine oxidase inhibitors: design, synthesis, X-ray diffraction analysis and molecular docking studies

Synthetic approaches, functionalization and therapeutic potential of quinazoline and quinazolinone skeletons: The advances continue

(2015) Imtiaz Khan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, anti-HIV activity and molecular modeling study of 3-aryl-6-adamantylmethyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives

(2015) Mahmood-ul-Hassan Khan et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES

Active compounds from a diverse library of triazolothiadiazole and triazolothiadiazine scaffolds: Synthesis, crystal structure determination, cytotoxicity, cholinesterase inhibitory activity, and binding mode analysis

(2014) Imtiaz Khan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, crystal structure and biological evaluation of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines

(2014) Imtiaz Khan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in the structural library of functionalized quinazoline and quinazolinone scaffolds: Synthetic approaches and multifarious applications

(2014) Imtiaz Khan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Untangling Amyloid-β, Tau, and Metals in Alzheimer’s Disease

(2013) Masha G. Savelieff et al.   ACS Chemical Biology

Oxadiazoles as Privileged Motifs for Promising Anticancer Leads: Recent Advances and Future Prospects

(2013) Imtiaz Khan et al.   ARCHIV DER PHARMAZIE

Structurally Diversified Heterocycles and Related Privileged Scaffolds as Potential Urease Inhibitors: A Brief Overview

(2013) Aliya Ibrar et al.   ARCHIV DER PHARMAZIE

Aromatase and glycosyl transferase inhibiting acridone alkaloids from fruits of Cameroonian Zanthoxylum species

(2013) Vyry NA Wouatsa et al.   Chemistry Central Journal

Triazolothiadiazoles and triazolothiadiazines – Biologically attractive scaffolds

(2013) Imtiaz Khan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dual Targeting of Adenosine A2A Receptors and Monoamine Oxidase B by 4H-3,1-Benzothiazin-4-ones

(2013) Anne Stößel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of functionalised 4H-quinolizin-4-ones via tandem Horner–Wadsworth–Emmons olefination/cyclisation

(2013) Calum W. Muir et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Halogen bonding and other σ-hole interactions: a perspective

(2013) Peter Politzer et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Synthesis, Acetylcholinesterase and Alkaline Phosphatase Inhibition of Some New 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives

(2012) Imtiaz Khan et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Bioinorganic Chemistry of Alzheimer’s Disease

(2012) Kasper P. Kepp   CHEMICAL REVIEWS

A Bioinorganic View of Alzheimer’s Disease: When Misplaced Metal Ions (Re)direct the Electrons to the Wrong Target

(2012) Peter Faller et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis, urease inhibition, antioxidant and antibacterial studies of some 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones and their 3,6-disubstituted 1,2,4-triazolo[3,4-b]1,3,4-thiadiazole derivatives

(2012) Muhammad Hanif et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

Synthesis of some new [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and [1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles starting from 5-nitro-2-furoic acid and evaluation of their antimicrobial activity

(2011) Sahar M.I. Badr et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, crystal structure and β-glucuronidase inhibition activity of some new hydrazinecarboxamides and their 1,2,4-triazole derivatives

(2011) Muhammad Hanif et al.   MEDICINAL CHEMISTRY RESEARCH

The history of the cholinergic hypothesis

(2010) Antonio Contestabile   BEHAVIOURAL BRAIN RESEARCH

Synthesis, antioxidant activities and urease inhibition of some new 1,2,4-triazole and 1,3,4-thiadiazole derivatives

(2010) Imtiaz Khan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins

(2010) Miroslaw Cygler et al.   PROTEIN SCIENCE

6-[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]-3-[(2-naphthyloxy)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole as a potent antioxidant and an anticancer agent induces growth inhibition followed by apoptosis in HepG2 cells

(2010) Dhanya Sunil et al.   Arabian Journal of Chemistry

Studies on Synthesis and Pharmacological Activities of 1,2,4-Triazolo[3,4-b]1,3,4-thiadiazoles and their Dihydro Analogues

(2009) Vinod Mathew et al.   ARCHIV DER PHARMAZIE

Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors

(2009) Amanda P. Skoumbourdis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antitumor activity studies of some new fused 1,2,4-triazole derivatives carrying 2,4-dichloro-5-fluorophenyl moiety

(2009) K. Subrahmanya Bhat et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Comparison of active sites of butyrylcholinesterase and acetylcholinesterase based on inhibition by geometric isomers of benzene-di-N-substituted carbamates

(2009) Shyh-Ying Chiou et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Monoamine oxidase inactivation: From pathophysiology to therapeutics☆

(2008) Marco Bortolato et al.   ADVANCED DRUG DELIVERY REVIEWS

Synthesis, antimicrobial and anti-inflammatory activities of some 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines bearing trichlorophenyl moiety

(2007) Prakash Karegoudar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY