Unravelling the Interplay between Extracellular Acidosis and Immune Cells

Acidosis exacerbates in vivo IL-1-dependent inflammatory responses and neutrophil recruitment during pulmonary Pseudomonas aeruginosa infection

(2018) Iviana M. Torres et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

(2018) Zandra E. Walton et al.   CELL

Human dendritic cell subsets: an update

(2018) Matthew Collin et al.   IMMUNOLOGY

Hypoxia and acidosis: immune suppressors and therapeutic targets

(2018) Sultan Damgaci et al.   IMMUNOLOGY

Gating mechanisms of acid-sensing ion channels

(2018) Nate Yoder et al.   NATURE

Reversal of tumor acidosis by systemic buffering reactivates NK cells to express IFN-γ and induces NK cell-dependent lymphoma control without other immunotherapies

(2017) Johann Pötzl et al.   INTERNATIONAL JOURNAL OF CANCER

Extracellular Acidification Inhibits the ROS-Dependent Formation of Neutrophil Extracellular Traps

(2017) Martina Behnen et al.   Frontiers in Immunology

The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na+ channel (ENaC): IUPHAR Review 19

(2016) Emilie Boscardin et al.   BRITISH JOURNAL OF PHARMACOLOGY

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Acidic microenvironments induce lymphangiogenesis and IL-8 production via TRPV1 activation in human lymphatic endothelial cells

(2016) Masako Nakanishi et al.   EXPERIMENTAL CELL RESEARCH

Lactic acid in tumor microenvironments causes dysfunction of NKT cells by interfering with mTOR signaling

(2016) Di Xie et al.   Science China-Life Sciences

Fever-range hyperthermia improves the anti-apoptotic effect induced by low pH on human neutrophils promoting a proangiogenic profile

(2016) Fernando Erra Díaz et al.   Cell Death & Disease

Abstract 3213: Extracellular acidosis alters polarization of macrophages

(2015) Asmaa E. El-Kenawi et al.   CANCER RESEARCH

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

(2015) Shari Pilon-Thomas et al.   CANCER RESEARCH

Regulation of T cells by mTOR: the known knowns and the known unknowns

(2015) Kristen N. Pollizzi et al.   TRENDS IN IMMUNOLOGY

Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions

(2015) Robert Haas et al.   PLOS BIOLOGY

Effect of low extracellular pH on NF-κB activation in macrophages

(2014) A.B. Gerry et al.   ATHEROSCLEROSIS

Novel immune function for the TRPV1 channel in T lymphocytes

(2014) Samuel Bertin et al.   Channels

Acidosis Potentiates the Host Proinflammatory Interleukin-1β Response to Pseudomonas aeruginosa Infection

(2014) Iviana M. Torres et al.   INFECTION AND IMMUNITY

Tumor-Secreted Lactic Acid Promotes IL-23/IL-17 Proinflammatory Pathway

(2014) H. Shime et al.   JOURNAL OF IMMUNOLOGY

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

(2013) V. Estrella et al.   CANCER RESEARCH

Extracellular acidosis modulates the endocytosis and maturation of macrophages

(2013) Xiaoling Kong et al.   CELLULAR IMMUNOLOGY

Extracellular Acidosis Is a Novel Danger Signal Alerting Innate Immunity via the NLRP3 Inflammasome

(2013) Kristiina Rajamäki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dendritic Cell Reprogramming by Endogenously Produced Lactic Acid

(2013) A. Nasi et al.   JOURNAL OF IMMUNOLOGY

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

Acid-sensing ion channels in pain and disease

(2013) John A. Wemmie et al.   NATURE REVIEWS NEUROSCIENCE

Acidosis Activation of the Proton-Sensing GPR4 Receptor Stimulates Vascular Endothelial Cell Inflammatory Responses Revealed by Transcriptome Analysis

(2013) Lixue Dong et al.   PLoS One

An Acidic Microenvironment Increases NK Cell Killing of Cryptococcus neoformans and Cryptococcus gattii by Enhancing Perforin Degranulation

(2013) Anowara Islam et al.   PLoS Pathogens

Low pH Environmental Stress Inhibits LPS and LTA-Stimulated Proinflammatory Cytokine Production in Rat Alveolar Macrophages

(2013) Stanley F. Fernandez et al.   Biomed Research International

pH sensing and regulation in cancer

(2013) Mehdi Damaghi et al.   Frontiers in Physiology

The functions of TRPA1 and TRPV1: moving away from sensory nerves

(2012) ES Fernandes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chronic Autophagy Is a Cellular Adaptation to Tumor Acidic pH Microenvironments

(2012) Jonathan W. Wojtkowiak et al.   CANCER RESEARCH

Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes

(2012) A. Calcinotto et al.   CANCER RESEARCH

Functional distinction of rat liver natural killer cells from spleen natural killer cells under normal and acidic conditions in vitro

(2012) Li-Hong Lv et al.   Hepatobiliary & Pancreatic Diseases International

The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors

(2012) Matteo Bellone et al.   OncoImmunology

Tumor-Associated Neutrophils: New Targets for Cancer Therapy

(2011) A. D. Gregory et al.   CANCER RESEARCH

Low extracellular pH stimulates the production of IL-1β by human monocytes

(2011) Carolina Cristina Jancic et al.   CYTOKINE

The biophysical and molecular basis of TRPV1 proton gating

(2011) Eduardo Aneiros et al.   EMBO JOURNAL

Acid-Sensing Ion Channels Contribute to the Effect of Acidosis on the Function of Dendritic Cells

(2011) J. Tong et al.   JOURNAL OF IMMUNOLOGY

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Regulation of mTORC1 Signaling by pH

(2011) Aruna D. Balgi et al.   PLoS One

Activation of GPR4 by Acidosis Increases Endothelial Cell Adhesion through the cAMP/Epac Pathway

(2011) Aishe Chen et al.   PLoS One

Acidosis downregulates platelet haemostatic functions and promotes neutrophil proinflammatory responses mediated by platelets

(2011) J. Etulain et al.   THROMBOSIS AND HAEMOSTASIS

Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways

(2010) Jin-Peng Liu et al.   PHARMACOLOGICAL RESEARCH

Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases

(2009) I. F. Robey et al.   CANCER RESEARCH

The Potential Role of Systemic Buffers in Reducing Intratumoral Extracellular pH and Acid-Mediated Invasion

(2009) A. S. Silva et al.   CANCER RESEARCH

Extracellular acidosis suppresses endothelial function by inhibiting store-operated Ca2+ entry via non-selective cation channels

(2009) Masayoshi Asai et al.   CARDIOVASCULAR RESEARCH

In contrast to anti-tumor activity, YT cell and primary NK cell cytotoxicity for Cryptococcus neoformans bypasses LFA-1

(2009) Gareth J. Jones et al.   INTERNATIONAL IMMUNOLOGY

Presence of Intratumoral Neutrophils Is an Independent Prognostic Factor in Localized Renal Cell Carcinoma

(2009) Hanne Krogh Jensen et al.   JOURNAL OF CLINICAL ONCOLOGY

Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes

(2009) K. Dietl et al.   JOURNAL OF IMMUNOLOGY

Protons make tumor cells move like clockwork

(2009) Christian Stock et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL