Maternal genotype determines kynurenic acid levels in the fetal brain: Implications for the pathophysiology of schizophrenia

Preferential Disruption of Prefrontal GABAergic Function by Nanomolar Concentrations of the α7nACh Negative Modulator Kynurenic Acid

(2017) Eden Flores-Barrera et al.   JOURNAL OF NEUROSCIENCE

Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review

(2017) Błażej Misiak et al.   MOLECULAR NEUROBIOLOGY

Association of Genetic Risk for Schizophrenia With Nonparticipation Over Time in a Population-Based Cohort Study

(2016) Joanna Martin et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Restraint Stress during Pregnancy Rapidly Raises Kynurenic Acid Levels in Mouse Placenta and Fetal Brain

(2016) Francesca M. Notarangelo et al.   DEVELOPMENTAL NEUROSCIENCE

Schizophrenia

(2016) Michael J Owen et al.   LANCET

Repeated LPS Injection Induces Distinct Changes in the Kynurenine Pathway in Mice

(2016) M. K. Larsson et al.   NEUROCHEMICAL RESEARCH

Prenatal kynurenine exposure in rats: age-dependent changes in NMDA receptor expression and conditioned fear responding

(2016) Michelle L. Pershing et al.   PSYCHOPHARMACOLOGY

Maternal immune activation: Implications for neuropsychiatric disorders

(2016) M. L. Estes et al.   SCIENCE

Neurotoxic kynurenine metabolism is increased in the dorsal hippocampus and drives distinct depressive behaviors during inflammation

(2016) J M Parrott et al.   Translational Psychiatry

Uncovering the Hidden Risk Architecture of the Schizophrenias: Confirmation in Three Independent Genome-Wide Association Studies

(2015) Javier Arnedo et al.   AMERICAN JOURNAL OF PSYCHIATRY

Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: Implications for schizophrenia

(2015) Michelle L. Pershing et al.   NEUROPHARMACOLOGY

Fetal programming of schizophrenia: Select mechanisms

(2015) Monojit Debnath et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Modified neocortical and cerebellar protein expression and morphology in adult rats following prenatal inhibition of the kynurenine pathway

(2014) Mazura Pisar et al.   BRAIN RESEARCH

Prenatal inhibition of the kynurenine pathway leads to structural changes in the hippocampus of adult rat offspring

(2014) Omari S. Khalil et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Phenotypic effects of maternal immune activation and early postnatal milieu in mice mutant for the schizophrenia risk gene neuregulin-1

(2014) C. O’Leary et al.   NEUROSCIENCE

Continuous kynurenine administration during the prenatal period, but not during adolescence, causes learning and memory deficits in adult rats

(2014) Ana Pocivavsek et al.   PSYCHOPHARMACOLOGY

Prenatal Poly(I:C) Exposure and Other Developmental Immune Activation Models in Rodent Systems

(2013) Urs Meyer   BIOLOGICAL PSYCHIATRY

Prenatal inhibition of the tryptophan–kynurenine pathway alters synaptic plasticity and protein expression in the rat hippocampus

(2013) Caroline M. Forrest et al.   BRAIN RESEARCH

Targeted Deletion of Kynurenine 3-Monooxygenase in Mice

(2013) Flaviano Giorgini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Changes in synaptic transmission and protein expression in the brains of adult offspring after prenatal inhibition of the kynurenine pathway

(2013) C.M. Forrest et al.   NEUROSCIENCE

Pre- and postnatal exposure to kynurenine causes cognitive deficits in adulthood

(2012) Ana Pocivavsek et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Prenatal nutrition, epigenetics and schizophrenia risk: can we test causal effects?

(2012) James B Kirkbride et al.   Epigenomics

The Long and the Short of it: Gene and Environment Interactions During Early Cortical Development and Consequences for Long-Term Neurological Disease

(2012) Helen Stolp et al.   Frontiers in Psychiatry

Gas chromatography/tandem mass spectrometry detection of extracellular kynurenine and related metabolites in normal and lesioned rat brain

(2011) Francesca M. Notarangelo et al.   ANALYTICAL BIOCHEMISTRY

Downregulated Kynurenine 3-Monooxygenase Gene Expression and Enzyme Activity in Schizophrenia and Genetic Association With Schizophrenia Endophenotypes

(2011) Ikwunga Wonodi   ARCHIVES OF GENERAL PSYCHIATRY

Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls

(2011) Maria Holtze   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Acute elevations of brain kynurenic acid impair cognitive flexibility: normalization by the alpha7 positive modulator galantamine

(2011) Kathleen S. Alexander et al.   PSYCHOPHARMACOLOGY

Maternal Genetic Mutations as Gestational and Early Life Influences in Producing Psychiatric Disease-Like Phenotypes in Mice

(2011) Georgia Gleason et al.   Frontiers in Psychiatry

Prenatal Interaction of Mutant DISC1 and Immune Activation Produces Adult Psychopathology

(2010) Bagrat Abazyan et al.   BIOLOGICAL PSYCHIATRY

Exposure to Kynurenic Acid During Adolescence Produces Memory Deficits in Adulthood

(2010) C. O. Akagbosu et al.   SCHIZOPHRENIA BULLETIN

Impaired Kynurenine Pathway Metabolism in The Prefrontal Cortex of Individuals With Schizophrenia

(2010) K. V. Sathyasaikumar et al.   SCHIZOPHRENIA BULLETIN

Increased Levels of Kynurenine and Kynurenic Acid in the CSF of Patients With Schizophrenia

(2010) K. R. Linderholm et al.   SCHIZOPHRENIA BULLETIN

Prenatal Exposure to Maternal Infection and Executive Dysfunction in Adult Schizophrenia

(2009) Alan S. Brown et al.   AMERICAN JOURNAL OF PSYCHIATRY

The dynamic effects of nicotine on the developing brain

(2009) Jennifer B. Dwyer et al.   PHARMACOLOGY & THERAPEUTICS

Wild-Type Male Offspring of fmr-1+/− Mothers Exhibit Characteristics of the Fragile X Phenotype

(2008) Bojana Zupan et al.   NEUROPSYCHOPHARMACOLOGY

Gene-Environment Interaction and Covariation in Schizophrenia: The Role of Obstetric Complications

(2008) V. A. Mittal et al.   SCHIZOPHRENIA BULLETIN