Melatonin and its metabolites as chemical agents capable of directly repairing oxidized DNA

Melatonin: A Versatile Protector against Oxidative DNA Damage

(2018) Annia Galano et al.   MOLECULES

Melatonin: A pleiotropic molecule that modulates DNA damage response and repair pathways

(2017) Maryam Majidinia et al.   JOURNAL OF PINEAL RESEARCH

Effect and possible mechanisms of melatonin treatment on the quality and developmental potential of aged bovine oocytes

(2017) Shuang Liang et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Nrf2/HO-1 mediates the neuroprotective effect of mangiferin on early brain injury after subarachnoid hemorrhage by attenuating mitochondria-related apoptosis and neuroinflammation

(2017) Zefeng Wang et al.   Scientific Reports

The anti-inflammatory and antioxidant effects of melatonin on LPS-stimulated bovine mammary epithelial cells

(2017) Guang-Min Yu et al.   PLoS One

Melatonin and its metabolites protect human melanocytes against UVB-induced damage: Involvement of NRF2-mediated pathways

(2017) Zorica Janjetovic et al.   Scientific Reports

Melatonin enhances the developmental competence of porcine somatic cell nuclear transfer embryos by preventing DNA damage induced by oxidative stress

(2017) Shuang Liang et al.   Scientific Reports

Melatonin ameliorates restraint stress-induced oxidative stress and apoptosis in testicular cells via NF-κB/iNOS and Nrf2/ HO-1 signaling pathway

(2017) Ying Guo et al.   Scientific Reports

Melatonin promotes blood-brain barrier integrity in methamphetamine-induced inflammation in primary rat brain microvascular endothelial cells

(2016) Pichaya Jumnongprakhon et al.   BRAIN RESEARCH

WITHDRAWN: Melatonin improves methamphetamine-induced blood brain barrier impairment through NADPH oxidase-2 in primary rat brain microvascular endothelium cells

(2016) Pichaya Jumnongprakhon et al.   BRAIN RESEARCH

Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage

(2016) Yang Yu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Protective effect of melatonin on myenteric neuron damage in experimental colitis in rats

(2016) Boxin Shang et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

DNA Damage and Oxidative DNA Damage in Inflammatory Bowel Disease

(2016) Cristiana Pereira et al.   Journal of Crohns & Colitis

The protective effect of melatonin on smoke-induced vascular injury in rats and humans: a randomized controlled trial

(2016) Zhanqi Wang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin enhances mitochondrial ATP synthesis, reduces reactive oxygen species formation, and mediates translocation of the nuclear erythroid 2-related factor 2 resulting in activation of phase-2 antioxidant enzymes (γ-GCS, HO-1, NQO1) in ultraviolet rad

(2016) Konrad Kleszczyński et al.   JOURNAL OF PINEAL RESEARCH

Elevated Levels of Urinary Markers of Oxidative DNA and RNA Damage in Type 2 Diabetes with Complications

(2016) Xinle Liu et al.   Oxidative Medicine and Cellular Longevity

The key role of the sequential proton loss electron transfer mechanism on the free radical scavenging activity of some melatonin-related compounds

(2016) Ruslán Álvarez-Diduk et al.   THEORETICAL CHEMISTRY ACCOUNTS

Melatonin protects against burn-induced hepatic oxidative injury by inducing HO-1 via the Nrf2 pathway

(2016) G. Bekyarova et al.   VETERINARNI MEDICINA

Food Antioxidants: Chemical Insights at the Molecular Level

(2016) Annia Galano et al.   Annual Review of Food Science and Technology

Melatonin induces the expression of Nrf2-regulated antioxidant enzymes via PKC and Ca2+ influx activation in mouse pancreatic acinar cells

(2015) Patricia Santofimia-Castaño et al.   FREE RADICAL BIOLOGY AND MEDICINE

DFT study on addition reaction mechanism of guanine-cytosine base pair with OH radical

(2015) Minjie Li et al.   JOURNAL OF PHYSICAL ORGANIC CHEMISTRY

Comprehensive Assessment of Oxidatively Induced Modifications of DNA in a Rat Model of Human Wilson's Disease

(2015) Yang Yu et al.   MOLECULAR & CELLULAR PROTEOMICS

Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis-associated colon carcinogenesis

(2015) P.P. Trivedi et al.   MOLECULAR CARCINOGENESIS

Oxidative DNA damage is associated with inflammatory response, insulin resistance and microvascular complications in type 2 diabetes

(2015) Etiane Tatsch et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Melatonin Protects Methamphetamine-Induced Neuroinflammation Through NF-κB and Nrf2 Pathways in Glioma Cell Line

(2015) Pichaya Jumnongprakhon et al.   NEUROCHEMICAL RESEARCH

DNA protective and antioxidative effects of melatonin in streptozotocin-induced diabetic rats

(2015) Selim SEKKİN et al.   TURKISH JOURNAL OF BIOLOGY

Melatonin stimulates antioxidant enzymes and reduces oxidative stress in experimental traumatic brain injury: the Nrf2–ARE signaling pathway as a potential mechanism

(2014) Ke Ding et al.   FREE RADICAL BIOLOGY AND MEDICINE

Kinetics of radical-molecule reactions in aqueous solution: A benchmark study of the performance of density functional methods

(2014) Annia Galano et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Exogenous melatonin supplementation prevents oxidative stress-evoked DNA damage in human spermatozoa

(2014) Ignacio Bejarano et al.   JOURNAL OF PINEAL RESEARCH

Femtosecond Stimulated Raman Spectroscopy of the Cyclobutane Thymine Dimer Repair Mechanism: A Computational Study

(2014) Hideo Ando et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Melatonin Antagonizes Mn-Induced Oxidative Injury Through the Activation of Keap1–Nrf2–ARE Signaling Pathway in the Striatum of Mice

(2014) Yu Deng et al.   NEUROTOXICITY RESEARCH

An experimental and theoretical study of the kinetics and mechanism of hydroxyl radical reaction with 2-aminopyrimidine

(2014) Kavanal P. Prasanthkumar et al.   RSC Advances

Melatonin enhances DNA repair capacity possibly by affecting genes involved in DNA damage responsive pathways

(2013) Ran Liu et al.   BMC CELL BIOLOGY

Effects of melatonin on DNA damage induced by cyclophosphamide in rats

(2013) S.G. Ferreira et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Direct dynamics investigation of the reaction S(3P)+CH4→CH3+SH(2Π)

(2013) Tiago Vinicius Alves et al.   CHEMICAL PHYSICS LETTERS

Mitigative role of melatonin andα-tocopherol against mercury-induced genotoxicity

(2013) Anshita R. Purohit et al.   DRUG AND CHEMICAL TOXICOLOGY

Melatonin attenuates phenytoin sodium-induced DNA damage

(2013) Ufuk Erenberk et al.   DRUG AND CHEMICAL TOXICOLOGY

A Mechanistic and Kinetic Study on the Formation of PBDD/Fs from PBDEs

(2013) Mohammednoor Altarawneh et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Role of oxidative DNA damage in mitochondrial dysfunction and Huntington’s disease pathogenesis

(2013) Sylvette Ayala-Peña   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative Stress, DNA Damage and Repair in Heart Failure Patients after Implantation of Continuous Flow Left Ventricular Assist Devices

(2013) Nandan Kumar Mondal et al.   International Journal of Medical Sciences

A computational methodology for accurate predictions of rate constants in solution: Application to the assessment of primary antioxidant activity

(2013) Annia Galano et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression

(2013) Esther Parada et al.   JOURNAL OF PINEAL RESEARCH

Oxidative damage DNA: 8-oxoGua and 8-oxodG as molecular markers of cancer

(2013) Krzysztof Roszkowski et al.   MEDICAL SCIENCE MONITOR

Comparative Analysis of Four Oxidized Guanine Lesions from Reactions of DNA with Peroxynitrite, Singlet Oxygen, and γ-Radiation

(2012) Liang Cui et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Mechanism of Ketone Allylation with Allylboronates as Catalyzed by Zinc Compounds: A DFT Study

(2012) Weiyi Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Oxidative and non-oxidative DNA damage and cardiovascular disease

(2012) Qudsia Malik et al.   FREE RADICAL RESEARCH

Thermal decomposition of 4-hydroxy-2-butanone in m-xylene solution: Experimental and computational study

(2012) Juliana Murillo et al.   INTERNATIONAL JOURNAL OF CHEMICAL KINETICS

DNA Damage Due to Oxidative Stress in Chronic Obstructive Pulmonary Disease (COPD)

(2012) Eirini Neofytou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Nitrative and Oxidative DNA Damage in Inflammation-Related Carcinogenesis

(2012) Mariko Murata et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

On the Chemical Repair of DNA Radicals by Glutathione: Hydrogen vs Electron Transfer

(2012) Juan Raúl Alvarez-Idaboy et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A computational study of the thermolysis of β-hydroxy ketones in gas phase and inm-xylene solution

(2012) Diana Henao et al.   JOURNAL OF PHYSICAL ORGANIC CHEMISTRY

Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-2'-deoxyguanosine) in ex vivo human skin

(2012) Tobias W. Fischer et al.   JOURNAL OF PINEAL RESEARCH

Ischemic injury promotes Keap1 nitration and disturbance of antioxidative responses in endothelial cells: a potential vasoprotective effect of melatonin

(2012) Rong-rong Tao et al.   JOURNAL OF PINEAL RESEARCH

Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model

(2012) Zhong Wang et al.   JOURNAL OF PINEAL RESEARCH

Association between DNA strand breakage and oxidative, inflammatory and endothelial biomarkers in type 2 diabetes

(2012) Etiane Tatsch et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

On the evolution of one-electron-oxidized deoxyguanosine in damaged DNA under physiological conditions: a DFT and ONIOM study on proton transfer and equilibrium

(2012) Annia Galano et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Solvent effects on electron-driven proton-transfer processes: adenine–thymine base pairs

(2012) Monika Dargiewicz et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Macrophages, Nitric Oxide and microRNAs Are Associated with DNA Damage Response Pathway and Senescence in Inflammatory Bowel Disease

(2012) Jane J. Sohn et al.   PLoS One

Protective effects of melatonin against 12C6+ beam irradiation-induced oxidative stress and DNA injury in the mouse brain

(2011) Z.H. Wu et al.   ADVANCES IN SPACE RESEARCH

Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer's disease: Implications for early intervention and therapeutics

(2011) Peizhong Mao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Nuclear and mitochondrial DNA oxidation in Alzheimer's disease

(2011) Renato X. Santos et al.   FREE RADICAL RESEARCH

Physicochemical Insights on the Free Radical Scavenging Activity of Sesamol: Importance of the Acid/Base Equilibrium

(2011) Annia Galano et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Use of Solution-Phase Vibrational Frequencies in Continuum Models for the Free Energy of Solvation

(2011) Raphael F. Ribeiro et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Nickel exposure induces oxidative damage to mitochondrial DNA in Neuro2a cells: the neuroprotective roles of melatonin

(2011) Shang-Cheng Xu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin enhances endogenous heme oxygenase-1 and represses immune responses to ameliorate experimental murine membranous nephropathy

(2011) Chia-Chao Wu et al.   JOURNAL OF PINEAL RESEARCH

Role of oxidative stress and DNA damage in human carcinogenesis

(2011) Thomas B. Kryston et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Characterization of 2′-deoxyguanosine oxidation products observed in the Fenton-like system Cu(ii)/H2O2/reductant in nucleoside and oligodeoxynucleotide contexts

(2011) Aaron M. Fleming et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Neurotoxins: Free Radical Mechanisms and Melatonin Protection

(2010) Russel J. Reiter et al.   Current Neuropharmacology

Melatonin as a potential tool against oxidative damage and apoptosis in ejaculated human spermatozoa

(2010) Javier Espino et al.   FERTILITY AND STERILITY

Protective effect of melatonin against Opisthorchis viverrini-induced oxidative and nitrosative DNA damage and liver injury in hamsters

(2010) Umawadee Laothong et al.   JOURNAL OF PINEAL RESEARCH

Effect of melatonin on the expression of Nrf2 and NF-κB during cyclophosphamide-induced urinary bladder injury in rat

(2010) D. N. Tripathi et al.   JOURNAL OF PINEAL RESEARCH

Role of Chain Transfer Agents in Free Radical Polymerization Kinetics

(2010) T. Furuncuoğlu et al.   MACROMOLECULES

A Reevaluation of the Ambident Reactivity of the Guanine Moiety Towards Hydroxyl Radicals

(2009) Chryssostomos Chatgilialoglu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Formation of spiroiminodihydantoin nucleoside from 8-oxo-7,8-dihydro-2′-deoxyguanosine by nitric oxide under aerobic conditions

(2009) Toshinori Suzuki   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

8-hydroxy-2′ -deoxyguanosine (8-OHdG): A Critical Biomarker of Oxidative Stress and Carcinogenesis

(2009) ATHANASIOS VALAVANIDIS et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Levels of reduced and oxidized coenzyme Q-10 and 8-hydroxy-2′-deoxyguanosine in the CSF of patients with Alzheimer’s disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurodegenerative process

(2009) Chiaki Isobe et al.   JOURNAL OF NEUROLOGY

Universal Solvation Model Based on Solute Electron Density and on a Continuum Model of the Solvent Defined by the Bulk Dielectric Constant and Atomic Surface Tensions

(2009) Aleksandr V. Marenich et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A computational study of stereospecifity in the thermal elimination reaction of menthyl benzoate in the gas phase

(2009) Ederley Vélez et al.   JOURNAL OF PHYSICAL ORGANIC CHEMISTRY

Levels of reduced and oxidized coenzymeQ-10 and 8-hydroxy-2′-deoxyguanosine in the cerebrospinal fluid of patients with living Parkinson's disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurodegenerative process

(2009) Chiaki Isobe et al.   NEUROSCIENCE LETTERS

Lipid, protein, DNA oxidation and antioxidant status in rheumatoid arthritis

(2008) Arzu Seven et al.   CLINICAL BIOCHEMISTRY

Increased mitochondrial oxidative damage and oxidative DNA damage contributes to the neurodegenerative process in sporadic amyotrophic lateral sclerosis

(2008) Takahiko Murata et al.   FREE RADICAL RESEARCH

How Well Can New-Generation Density Functionals Describe the Energetics of Bond-Dissociation Reactions Producing Radicals?

(2008) Yan Zhao et al.   JOURNAL OF PHYSICAL CHEMISTRY A

A Role for Oxidized DNA Precursors in Huntington's Disease–Like Striatal Neurodegeneration

(2008) Gabriele De Luca et al.   PLoS Genetics

Association between oxidative DNA damage and telomere shortening in circulating endothelial progenitor cells obtained from metabolic syndrome patients with coronary artery disease

(2007) Mamoru Satoh et al.   ATHEROSCLEROSIS

The Chemical Toxicology of 2-Deoxyribose Oxidation in DNA

(2007) Peter C. Dedon   CHEMICAL RESEARCH IN TOXICOLOGY

Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia

(2007) Daniel Gackowski et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES