DNA Damage Due to Oxidative Stress in Chronic Obstructive Pulmonary Disease (COPD)

Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD

(2012) Hongwei Yao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

DNA damage as a molecular link in the pathogenesis of COPD in smokers

(2012) Kazutetsu Aoshiba et al.   EUROPEAN RESPIRATORY JOURNAL

Poly(ADP-ribosyl)ation is a survival mechanism in cigarette smoke-induced and hydrogen peroxide-mediated cell death

(2012) Katalin Kovács et al.   FREE RADICAL BIOLOGY AND MEDICINE

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

(2012) Hongwei Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic obstructive pulmonary disease

(2012) Marc Decramer et al.   LANCET

Downregulation of lung mitochondrial prohibitin in COPD

(2012) Nikolaos Soulitzis et al.   RESPIRATORY MEDICINE

Telomere Dysfunction Causes Sustained Inflammation in Chronic Obstructive Pulmonary Disease

(2011) Valerie Amsellem et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Epigenetic Control of Gene Expression in the Lung

(2011) Ivana V. Yang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress

(2011) Nicolas Mercado et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular targets of oxidative stress

(2011) Simon V. Avery   BIOCHEMICAL JOURNAL

The role and therapeutic potential of prohibitin in disease

(2011) Arianne L. Theiss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Oxidative DNA Damage and Somatic Mutations

(2011) Eleni G. Tzortzaki et al.   CHEST

Inflammation, chronic obstructive pulmonary disease and aging

(2011) Mauro Provinciali et al.   CURRENT OPINION IN PULMONARY MEDICINE

New insights into the immunology of chronic obstructive pulmonary disease

(2011) Guy G Brusselle et al.   LANCET

Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer

(2011) G. Caramori et al.   THORAX

Multistudy Fine Mapping of Chromosome 2q IdentifiesXRCC5as a Chronic Obstructive Pulmonary Disease Susceptibility Gene

(2010) Craig P. Hersh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Telomere Length is a Biomarker of Cumulative Oxidative Stress, Biologic Age, and an Independent Predictor of Survival and Therapeutic Treatment Requirement Associated With Smoking Behavior

(2010) Mark A Babizhayev et al.   AMERICAN JOURNAL OF THERAPEUTICS

Molecular mechanisms of oxidative stress in airways and lungs with reference to asthma and chronic obstructive pulmonary disease

(2010) K.F. Chung et al.   Annals of the New York Academy of Sciences

PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity

(2010) Samuel Caito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Smoking and health: association between telomere length and factors impacting on human disease, quality of life and life span in a large population-based cohort under the effect of smoking duration

(2010) Mark A. Babizhayev et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

p300-mediated Acetylation of Histone H3 Lysine 56 Functions in DNA Damage Response in Mammals

(2010) Rahul K. Vempati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

(2010) Kyle M Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate

(2010) F Liu et al.   ONCOGENE

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

DNA Damage Response

(2010) G. Giglia-Mari et al.   Cold Spring Harbor Perspectives in Biology

Epigenetics in asthma and other inflammatory lung diseases

(2010) Andrew Durham et al.   Epigenomics

Shortened Telomeres in Circulating Leukocytes of Patients with Chronic Obstructive Pulmonary Disease

(2009) Laurent Savale et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cigarette Smoke Induces Nucleic-Acid Oxidation in Lung Fibroblasts

(2009) Gaetan Deslee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The role of oxidative stress in the biological responses of lung epithelial cells to cigarette smoke

(2009) Stephen P. Faux et al.   BIOMARKERS

Decreased Small Airway and Alveolar CD83+ Dendritic Cells in COPD

(2009) Maria Tsoumakidou et al.   CHEST

Oxidative Damage to Nucleic Acids in Severe Emphysema

(2009) Gaetan Deslee et al.   CHEST

A hypothesis for the initiation of COPD

(2009) E. G. Tzortzaki et al.   EUROPEAN RESPIRATORY JOURNAL

A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9

(2009) Yuji Nakamaru et al.   FASEB JOURNAL

8-hydroxy-2′ -deoxyguanosine (8-OHdG): A Critical Biomarker of Oxidative Stress and Carcinogenesis

(2009) ATHANASIOS VALAVANIDIS et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Immunologic Aspects of Chronic Obstructive Pulmonary Disease

(2009) Manuel G. Cosio et al.   NEW ENGLAND JOURNAL OF MEDICINE

Somatic DNA alterations in lung epithelial barrier cells in COPD patients

(2009) Katerina D. Samara et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Alveolar Cell Senescence Exacerbates Pulmonary Inflammation in Patients with Chronic Obstructive Pulmonary Disease

(2009) Takao Tsuji et al.   RESPIRATION

DNA demethylation by DNA repair

(2009) Mary Gehring et al.   TRENDS IN GENETICS

SIRT1, an Antiinflammatory and Antiaging Protein, Is Decreased in Lungs of Patients with Chronic Obstructive Pulmonary Disease

(2008) Saravanan Rajendrasozhan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Prohibitin function within mitochondria: Essential roles for cell proliferation and cristae morphogenesis

(2008) Carsten Merkwirth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Microsatellite DNA instability and COPD exacerbations

(2008) D. Makris et al.   EUROPEAN RESPIRATORY JOURNAL

Oxidants and the pathogenesis of lung diseases

(2008) Jonathan Ciencewicki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Aging and induced senescence as factors in the pathogenesis of lung emphysema

(2008) Stefan Karrasch et al.   RESPIRATORY MEDICINE

Telomere shortening in chronic obstructive pulmonary disease

(2008) Joyce M.J. Houben et al.   RESPIRATORY MEDICINE