Tumour necrosis factor α induces neuroinflammation and insulin resistance in immortalised hypothalamic neurones through independent pathways

Palmitate induces neuroinflammation, ER stress, and Pomc mRNA expression in hypothalamic mHypoA-POMC/GFP neurons through novel mechanisms that are prevented by oleate

(2018) Erika K. Tse et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

CXCL1 and CXCL2 Regulate NLRP3 Inflammasome Activation via G-Protein–Coupled Receptor CXCR2

(2017) Monoranjan Boro et al.   JOURNAL OF IMMUNOLOGY

The clinical significance of CXCL5 in non-small cell lung cancer

(2017) Kongju Wu et al.   OncoTargets and Therapy

Metabolic Effects of High Glycaemic Index Diets: A Systematic Review and Meta-Analysis of Feeding Studies in Mice and Rats

(2017) Grace Campbell et al.   Nutrients

High fat induces acute and chronic inflammation in the hypothalamus: effect of high-fat diet, palmitate and TNF-α on appetite-regulating NPY neurons

(2016) P S Dalvi et al.   INTERNATIONAL JOURNAL OF OBESITY

Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance

(2016) Max C. Petersen et al.   JOURNAL OF CLINICAL INVESTIGATION

60 YEARS OF POMC: Regulation of feeding and energy homeostasis by α-MSH

(2016) Erica J P Anderson et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Tollip, an early regulator of the acute inflammatory response in the substantia nigra

(2016) Marie Humbert-Claude et al.   Journal of Neuroinflammation

Diet-induced cellular neuroinflammation in the hypothalamus: Mechanistic insights from investigation of neurons and microglia

(2016) Dean Q. Tran et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Signaling via the NFκB system

(2016) Simon Mitchell et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Tumor necrosis factor-α regulates interleukin-33 expression through extracellular signal-regulated kinase, p38, and nuclear factor-κB pathways in airway epithelial cells

(2016) Il-Ho Park et al.   International Forum of Allergy & Rhinology

Beneficial Effects of Metformin and/or Salicylate on Palmitate- or TNFα-Induced Neuroinflammatory Marker and Neuropeptide Gene Regulation in Immortalized NPY/AgRP Neurons

(2016) Wenqing Ye et al.   PLoS One

Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity

(2015) Rebecca J. Ford et al.   BIOCHEMICAL JOURNAL

Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cellsex vivothrough inhibition ofde novolipogenesis

(2015) Andrew J. O’Brien et al.   BIOCHEMICAL JOURNAL

Saturated lipids decrease mitofusin 2 leading to endoplasmic reticulum stress activation and insulin resistance in hypothalamic cells

(2015) Brenda Diaz et al.   BRAIN RESEARCH

Delineating the regulation of energy homeostasis using hypothalamic cell models

(2015) Leigh Wellhauser et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Tollip is a critical mediator of cerebral ischaemia-reperfusion injury

(2015) Mingchang Li et al.   JOURNAL OF PATHOLOGY

Regulation of energy homeostasis by the NPY system

(2015) Kim Loh et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hypothalamic inflammation and gliosis in obesity

(2015) Mauricio D. Dorfman et al.   Current Opinion in Endocrinology Diabetes and Obesity

Low-grade chronic inflammation perpetuated by modern diet as a promoter of obesity and osteoporosis

(2014) Jasminka Z. Ilich et al.   Arhiv za Higijenu Rada i Toksikologiju-Archives of Industrial Hygiene and Toxicology

Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells

(2014) Bumsup Kwon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

Fractalkine (CX3CL1) Is Involved in the Early Activation of Hypothalamic Inflammation in Experimental Obesity

(2014) Joseane Morari et al.   DIABETES

Insulin and Metabolic Stress Stimulate Multisite Serine/Threonine Phosphorylation of Insulin Receptor Substrate 1 and Inhibit Tyrosine Phosphorylation

(2014) Nancy J. Hançer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the omega-3 fatty acid receptor GPR120 mediates anti-inflammatory actions in immortalized hypothalamic neurons

(2014) Leigh Wellhauser et al.   Journal of Neuroinflammation

Hypothalamic Inflammation: Marker or Mechanism of Obesity Pathogenesis?

(2013) Joshua P. Thaler et al.   DIABETES

Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing

(2013) Isin Çakir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of inflammasomes in adipose tissue of women with gestational diabetes

(2013) Martha Lappas   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Palmitate alters the rhythmic expression of molecular clock genes and orexigenic neuropeptide Y mRNA levels within immortalized, hypothalamic neurons

(2011) Laura J. Fick et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TNFα increases hypothalamic PTP1B activity via the NFκB pathway in rat hypothalamic organotypic cultures

(2011) Yoshihiro Ito et al.   REGULATORY PEPTIDES

The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation

(2009) H. Kolb et al.   DIABETOLOGIA

Central Insulin Signaling Is Attenuated by Long-Term Insulin Exposure via Insulin Receptor Substrate-1 Serine Phosphorylation, Proteasomal Degradation, and Lysosomal Insulin Receptor Degradation

(2009) Christopher M. Mayer et al.   ENDOCRINOLOGY

Palmitate Attenuates Insulin Signaling and Induces Endoplasmic Reticulum Stress and Apoptosis in Hypothalamic Neurons: Rescue of Resistance and Apoptosis through Adenosine 5′ Monophosphate-Activated Protein Kinase Activation

(2009) Christopher M. Mayer et al.   ENDOCRINOLOGY

Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents

(2009) Stephen C. Benoit et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin directly regulates NPY and AgRP gene expression via the MAPK MEK/ERK signal transduction pathway in mHypoE-46 hypothalamic neurons

(2009) Christopher M. Mayer et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Metabolic fate of saturated and monounsaturated dietary fats: The Mediterranean diet revisited from epidemiological evidence to cellular mechanisms

(2009) Audrey Bergouignan et al.   PROGRESS IN LIPID RESEARCH

Phosphorylation of IRS proteins, insulin action, and insulin resistance

(2008) Sigalit Boura-Halfon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF-α Signaling through IKK2

(2008) Jin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY