Article
Oncology
Chenwei Wang, Yadi Liao, Wei He, Hong Zhang, Dinglan Zuo, Wenwu Liu, Zhiwen Yang, Jiliang Qiu, Yichuan Yuan, Kai Li, Yuanping Zhang, Yongjin Wang, Yunxing Shi, Yuxiong Qiu, Song Gao, Yunfei Yuan, Binkui Li
Summary: Elafin, upregulated by Sp1, enhances HCC metastasis via the EGFR/AKT pathway and attenuates the anti-metastatic effects of erlotinib. Its high expression in HCC tissues is correlated with aggressive tumor phenotypes and poor prognosis, suggesting Elafin as a valuable prognostic biomarker and therapeutic target for HCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Yening Xiao, Jiamei Ma, Chunliu Guo, Danni Liu, Jing Pan, Xiaoxi Huang
Summary: This study demonstrates that silencing of the CCNB2 gene can inhibit tumor formation and proliferation in nude mice. CCNB2 may accelerate the proliferation and metastasis of hepatocellular carcinoma cells by increasing JAG1 expression.
Article
Biochemistry & Molecular Biology
Xiaochao Zhang, Yabing Hu, Yonglong Pan, Yixiao Xiong, Yuxin Zhang, Mengzhen Han, Keshuai Dong, Jia Song, Huifang Liang, Zeyang Ding, Xuewu Zhang, He Zhu, Qiumeng Liu, Xun Lu, Yongdong Feng, Xiaoping Chen, Zhanguo Zhang, Bixiang Zhang
Summary: DDR1 is upregulated in hepatocellular carcinoma (HCC) tissues and high expression of DDR1 is associated with poor prognosis. DDR1 promotes HCC metastasis through collagen-induced signaling.
Article
Oncology
Dongbo Chen, Jie Gao, Liying Ren, Pu Chen, Yao Yang, Shaoping She, Yong Xie, Weijia Liao, Hongsong Chen
Summary: In this study, a predictive signature based on NKG2D ligands (MICA, ULBP3, and ULBP5) was developed to predict HCC recurrence. The effectiveness of this signature was validated in multiple datasets and patient cohorts. Additionally, high-risk patients had lower levels of infiltrated NK-activated cells and NKG2D expression compared to low-risk patients.
Article
Medicine, Research & Experimental
Yue Li, Xiaoqin He, Xiaoyu Zhang, Yangtao Xu, Wenliang Chen, Xin Liu, Ximing Xu
Summary: The study found that RMI2 is overexpressed in HCC tissues, correlating with poor prognosis. Overexpression of RMI2 promotes proliferation and inhibits apoptosis of HCC cells, while reducing the protein expression of key effector molecules in the p53 signaling pathway.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Oncology
Qian Xie, Huiling Guo, Peirong He, Huan Deng, Yanjun Gao, Ningning Dong, Wenbo Niu, Tiancai Liu, Ming Li, Suihai Wang, Yingsong Wu, Ji-Liang Li
Summary: High expression of Tspan5 is significantly associated with clinicopathological features and poor survival in HCC patients, promoting cell migration and tumour metastasis. Mechanistically, Tspan5 enhances ADAM10 enzymatic activity, activates Notch signaling, and induces epithelial-mesenchymal transition in tumour cells. These findings highlight the pivotal role of Tspan5 in regulating Notch signaling, EMT, and tumour metastasis in HCC.
MOLECULAR ONCOLOGY
(2021)
Article
Oncology
Yunzheng Li, Binghua Li, Yanchao Xu, Liyuan Qian, Tiancheng Xu, Gang Meng, Huan Li, Ye Wang, Laizhu Zhang, Xiang Jiang, Qi Liu, Yuanyuan Xie, Chunxiao Cheng, Beicheng Sun, Decai Yu
Summary: The study reveals that low expression of GOT2 is associated with advanced progression and poor prognosis of HCC. Knock down of GOT2 promotes proliferation, migration, and invasion of HCC cells, and loss of GOT2 promotes tumor growth and metastasis in mouse models. Mechanistically, silencing of GOT2 reprograms glutamine metabolism to support the cellular antioxidant system and activates the PI3K/AKT/mTOR pathway, promoting HCC progression. HCC with low expression of GOT2 is highly sensitive to the glutaminase inhibitor CB-839.
Article
Oncology
Shi Xiaoyun, Zi Yuyuan, Xing Jie, Nie Yingjie, Xie Qing, Deng Yuezhen, Xin Haiguang
Summary: This study reveals that the short isoform of PHF19 interacts with beta-TrCP, the E3 ligase of Gli1, promoting the growth of HCC cells. Knocking out PHF19 inhibits tumorigenesis and improves survival in a HCC mouse model, demonstrating that PHF19 activates the Hedgehog signaling pathway to promote HCC cell growth.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Bao Wang, Hui Zhang, Ya F. Chen, Long Q. Hu, Yi Y. Tian, Hong W. Tong, Gang Wang, Chong Chen, Peng Yuan
Summary: ACOT9 plays an oncogenic role in promoting tumor growth and metastasis in HCC by reprogramming lipid metabolism.
LIVER INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
Hongjin Chen, Fubing Wu, Haojun Xu, Guanqun Wei, Min Ding, Fanggui Xu, Amudha Deivasigamani, Guoren Zhou, Kam M. Hui, Hongping Xia
Summary: Hepatocellular carcinoma (HCC) is a deadly cancer type, with overexpression of centromere proteins (CENPs) playing a critical role in its progression. Specifically, overexpression of CENPF is associated with poor survival in HCC patients, promoting cell migration and EMT progression. Silencing CENPF inhibits cell growth both in vitro and in vivo, suggesting its potential as a biomarker for tackling HCC progression.
CANCER GENE THERAPY
(2022)
Article
Medicine, Research & Experimental
Da Man, Yifan Jiang, Deguo Zhang, Jingjing Wu, Bo Ding, Hanqing Liu, Guangming Xu, Jiahua Lu, Junnan Ru, Rongliang Tong, Shusheng Zheng, Diyu Chen, Jian Wu
Summary: Hepatocellular carcinoma (HCC) is a lethal tumor type. This study investigated the glycosylation status of HCC and its molecular mechanisms. High glycosylation levels were found to correlate with tumor progression and poor prognosis. The key molecular mechanism involved ST6GALNAC4, which induced abnormal glycosylation and contributed to proliferation, migration, and invasion in HCC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Anna Kan, Shuang Liu, Minke He, Dongsheng Wen, Haijing Deng, Lichang Huang, Zhicheng Lai, Yexing Huang, Ming Shi
Summary: This study reveals the correlation between the transcription factor MZF1 and the immune checkpoint molecule PD-L1 in hepatocellular carcinoma (HCC). The overexpression of MZF1 is associated with an immunosuppressive environment and decreased T-cell infiltration in HCC. Mechanistically, MZF1 accelerates PD-L1 ubiquitination via the CDK4 pathway. Inhibition of CDK4 may restore PD-L1 expression and enhance the efficacy of anti-PD-L1 antibodies.
Article
Cell Biology
Yuling Liu, Yuanzhou Zhang, Bowen Xiao, Ning Tang, Jingying Hu, Shunshun Liang, Yechun Pang, Huili Xu, Junping Ao, Juan Yang, Xiaofei Liang, Lin Wei, Yunfeng Wang, Xiaoying Luo
Summary: This study revealed that miR-103a may act as a key mediator in the progression of HCC, with its high expression associated with poor prognosis and promoting HCC cell growth and mobility by promoting glucose metabolism and inhibiting cell death. The findings suggest that miR-103a could be a potential therapeutic target for HCC.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Asli Kurden-Pekmezci, Ece Cakiroglu, Sude Eris, Fatma Aybuke Mazi, Ozlem Silan Coskun-Deniz, Ertugrul Dalgic, Ozden Oz, Serif Senturk
Summary: This study shows that MALT1 expression is elevated in human HCC tumors and cell lines, and is correlated with tumor grade and differentiation state. Ectopic expression of MALT1 promotes cell proliferation, clonogenic growth, and spheroid formation in well differentiated HCC cell lines, while silencing of MALT1 attenuates aggressive cancer cell phenotypes in poorly differentiated HCC cell lines. The study also suggests that MALT1 is positively correlated with NF-kB activation in HCC tissues, indicating its potential involvement in tumor promotion through the NF-kB signaling pathway.
Article
Multidisciplinary Sciences
Seiga Komiyama, Takahiro Yamada, Nobuyuki Takemura, Norihiro Kokudo, Koji Hase, Yuki Kawamura
Summary: Liver cancer is the fourth leading cause of cancer-related death, with patients exhibiting distinct tumor microbiota composition that may play a role in the pathogenesis of HCC.
SCIENTIFIC REPORTS
(2021)
Article
Surgery
Sam E. Mason, Eftychios Manoli, James L. Alexander, Liam Poynter, Lauren Ford, Petra Paizs, Afeez Adebesin, James S. McKenzie, Francesca Rosini, Rob Goldin, Ara Darzi, Zoltan Takats, James M. Kinross
Summary: This study used REIMS to analyze the lipid composition of colorectal tissues and evaluate its accuracy for real-time tissue recognition and risk stratification. The results showed that REIMS can differentiate samples of carcinoma, adenoma, and normal mucosa with 93.1% accuracy and 96.1% negative predictive value for carcinoma. It can also predict the presence of neoplasia (carcinoma or adenoma) with 96.0% accuracy and 91.8% negative predictive value. In addition, the study identified unique lipidomic features associated with colorectal carcinogenesis, such as the progressive increase in relative abundance of phosphatidylglycerols, sphingomyelins, and monounsaturated fatty acid-containing phospholipids.
Article
Pathology
Clare McGenity, Rebecca Randell, Christopher Bellamy, Alastair Burt, Alyn Cratchley, Robert Goldin, Stefan G. Hubscher, Desley A. H. Neil, Alberto Quaglia, Dina Tiniakos, Judy Wyatt, Darren Treanor
Summary: This study surveyed members of the UK Liver Pathology Group to understand their attitudes and priorities towards digital pathology and artificial intelligence in liver disease. The majority of liver pathologists in the UK are in favor of using digital pathology and AI in clinical practice, research, and education.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Cell Biology
Elliot H. H. Akama-Garren, Paul Miller, Thomas M. M. Carroll, Michael Tellier, Gopinath Sutendra, Ludovico Buti, Justyna Zaborowska, Robert D. D. Goldin, Elizabeth Slee, Francis G. G. Szele, Shona Murphy, Xin Lu
Summary: Maintaining a balance between tolerance and autoimmunity is crucial for preventing human diseases. The protein p53 and its regulator iASPP play important roles in immunological tolerance and tumorigenesis. Deficiency in iASPP promotes tumor development but reduces susceptibility to autoimmune diseases. Furthermore, iASPP-deficient tumors exhibit immunosuppression characteristics, suggesting potential therapeutic opportunities for targeting the iASPP/p53 axis in autoimmune diseases and cancer.
CELL DEATH & DISEASE
(2023)
Article
Gastroenterology & Hepatology
Karl King Yong, Yun He, Hoi Ching Annie Cheung, Ramya Sriskandarajah, William Jenkins, Robert Goldin, Sabina Beg
Summary: This study aimed to determine if combining multiple small colorectal polyps in a single specimen pot can reduce carbon footprint without negatively impacting clinical outcomes. Results showed that consolidating small polyps could decrease carbon footprint, but may also result in missing advanced lesions. Therefore, changing practice at a national level could amplify the reduction in carbon footprint from judicious use of specimen pots.
FRONTLINE GASTROENTEROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Paul Miller, Elliot H. Akama-Garren, Richard P. Owen, Constantinos Demetriou, Thomas M. Carroll, Elizabeth Slee, Khatoun Al Moussawi, Michael Ellis, Robert Goldin, Eric O'Neill, Xin Lu
Summary: iASPP is an inhibitor of p53 that suppresses inflammation and oncogenic KRAS-driven pancreatic cancer tumorigenesis.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Nila Jambulingam, Roberta Forlano, Benjamin Preston, Benjamin H. Mullish, Greta Portone, Yama Baheer, Michael Yee, Robert D. Goldin, Mark R. Thursz, Pinelopi Manousou
Summary: Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease worldwide, and fibrosis stage is an important predictor for clinical outcomes. This study investigates the metabolic profile of NAFLD patients in relation to fibrosis progression. The results show that a combination of metabolites and lipoproteins can accurately identify fast fibrosis progressors and perform better than noninvasive markers. These specific metabolic profiles can predict fibrosis progression in patients with NAFLD, and algorithms combining metabolites and lipids could be used for risk stratification of these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Emma Rose McGlone, Matthieu Siebert, Marian Dore, David C. D. Hope, Iona Davies, Bryn Owen, Bernard Khoo, Rob Goldin, Dave Carling, Stephen Bloom, Maude Le Gall, Tricia M-M. Tan
Summary: The study investigated the effects of sleeve gastrectomy on weight-independent improvements in liver steatosis in mice with diet-induced obesity. It was found that VSG not only improves liver fat content but also enhances insulin and glucagon sensitivity.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Diego Calvisi, Luke Boulter, Javier Vaquero, Anna Saborowski, Luca M. Fabris, Pedro Rodrigues, Cedric E. Coulouarn, Rui Castro, Oreste Segatto, Chiara Raggi, Luc J. W. van der Laan, Guido Carpino, Benjamin Goeppert, Stephanie J. Roessler, Timothy Kendall, Matthias Evert, Ester W. Gonzalez-Sanchez, Juan Valle, Arndt Vogel, John J. Bridgewater, Mitesh J. Borad, Gregory R. Gores, Lewis Roberts, Jose J. G. B. Marin, Jesper Andersen, Domenico Alvaro, Alejandro M. Forner, Jesus Banales, Vincenzo Cardinale, Rocio I. R. Macias, Silve Vicent, Xin Chen, Chiara Braconi, Monique M. A. Verstegen, Laura Fouassier, Lewis Roberts, Alexander Scheiter, Florin M. Selaru, Katja Evert, Kirsten Utpatel, Laura Broutier, Massimiliano Cadamuro, Meritxell Huch, Robert Goldin, Sergio A. Gradilone, Yoshimasa Saito
Summary: In this Consensus Statement, experts provide recommendations on the criteria for preclinical models of cholangiocarcinoma (CCA) to increase disease understanding and develop novel therapeutic approaches.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Multidisciplinary Sciences
Jonathan W. Lo, Domenico Cozzetto, James L. Alexander, Nathan P. Danckert, Matthew Madgwick, Naomi Knox, Jillian Yong Xin Sieh, Marton Olbei, Zhigang Liu, Hajir Ibraheim, Jesus Miguens Blanco, Hiromi Kudo, Rocio Castro Seoane, Lucia A. Possamai, Robert Goldin, Julian Marchesi, Tamas Korcsmaros, Graham M. Lord, Nick Powell
Summary: Immune checkpoint inhibitors (CPIs) are a new cancer treatment that can potentially cure previously untreatable diseases. However, they can also cause off-target immune-mediated tissue injury. Researchers found that CPI-colitis in mice depends on the composition of the intestinal microbiota and the expression of certain immune molecules. Targeting these factors may hold the key to reversing CPI-colitis.
NATURE COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
David J. Pinato, Takahiro Kaneko, Antonio D'Alessio, Alejandro Forner, Petros Fessas, Beatriz Minguez, Edoardo G. Giannini, Federica Grillo, Alba Diaz, Francesco A. Mauri, Claudia A. M. Fulgenzi, Alessia Dalla Pria, Robert D. Goldin, Giulia Pieri, Pierluigi Toniutto, Claudio Avellini, Maria Corina Plaz Torres, Ayse U. Akarca, Teresa Marafioti, Sherrie Bhoori, Jose Maria Miro, Mark Bower, Norbert Brau, Vincenzo Mazzaferro
Summary: The aim of this study was to evaluate the impact of HIV infection on the functional characteristics of T cell infiltrate in hepatocellular carcinoma (HCC). Results showed that HIV infection was associated with increased immune exhaustion and higher expression of PD-L1 in tumor tissue. Therefore, prospective testing of immunotherapy in HIV-associated HCC is warranted.
Meeting Abstract
Gastroenterology & Hepatology
Jonathan W. Lo, Domenico Cozzetto, Matthew Madgwick, Jillian Y. Sieh, Marton Olbei, James L. Alexander, Jesus Miguens Blanco, Hiromi Kudo, Hajir Ibraheim, Zhigang Liu, Rocio Castro Seoane, Robert Goldin, Julian Marchesi, Tamas Korcsmaros, Graham Lord, Nick Powell
Meeting Abstract
Gastroenterology & Hepatology
Nikhil Vergis, Vishal C. Patel, Karolina Bogdanowicz, Justyna Czyzewska-Khan, Rosemary Keshinro, Francesca Fiorentino, Emily Day, Paul Middleton, Stephen Atkinson, Mary Cross, Daphne Babalis, Neil Foster, Alberto Quaglia, Josephine Lloyd, Robert D. Goldin, William Rosenberg, Richard Parker, Paul Richardson, Steven Masson, Gavin Whitehouse, Cyril Sieberhagen, David Patch, Ashwin Dhanda, Emma Lord, Ewan Forrest, Nikolai Naoumov, Mark Thursz
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Nikhil Vergis, Isabelle Hall, Callum Arthurs, Hiromi Kudo, Stephen Atkinson, David Shapiro, Michael Lutz, Birgit Jung, Markus Weissbach, Wolfgang Albrecht, Luke D. Tyson, Tong Liu, Emma Lord, Lars Zender, Mark Thursz, Robert D. Goldin
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Antonio D'Alessio, Madhava Pai, Duncan Spalding, Poyyamozhi Rajagopal, Thomas Talbot, Robert Goldin, Claudia Angela Maria Fulgenzi, Caroline Ward, Vincent Yip, Tony Dhillon, Sarah Slater, Mikael Sodergren, Paul Tait, Nagy Habib, Robert Thomas, Alessio Cortellini, Rohini Sharma, David J. Pinato
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
J. Lo, D. Cozzetto, M. Madgwick, J. Y. X. S. Sieh, M. Olbei, J. L. Alexander, J. Miguens Blanco, H. Kudo, H. Ibraheim, Z. Liu, R. Castro Seoane, R. Goldin, J. Marchesi, T. Korcsmaros, G. Lord, N. Powell
JOURNAL OF CROHNS & COLITIS
(2022)
