Novel positioning from obesity to cancer: FTO, an m6A RNA demethylase, regulates tumour progression

FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling

(2018) Huajie Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m 6 A/MYC/CEBPA Signaling

(2018) Rui Su et al.   CELL

FTO, m6 Am , and the hypothesis of reversible epitranscriptomic mRNA modifications

(2018) Jan Mauer et al.   FEBS LETTERS

Differential distribution and association of FTO rs9939609 gene polymorphism with obesity: A cross-sectional study among two tribal populations of India with East-Asian ancestry

(2018) Somorjit Singh Ningombam et al.   GENE

FTO reduces mitochondria and promotes hepatic fat accumulation through RNA demethylation

(2018) Huifang Kang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Ubiquitination Regulates the Proteasomal Degradation and Nuclear Translocation of the Fat Mass and Obesity-Associated (FTO) Protein

(2018) Tianyi Zhu et al.   JOURNAL OF MOLECULAR BIOLOGY

FTO regulates the chemo-radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β-catenin through mRNA demethylation

(2018) Shun Zhou et al.   MOLECULAR CARCINOGENESIS

YTH Domain: A Family of N 6 -methyladenosine (m 6 A) Readers

(2018) Shanhui Liao et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm

(2018) Jiangbo Wei et al.   MOLECULAR CELL

Protein kinase Cβ activates fat mass and obesity-associated protein by influencing its ubiquitin/proteasome degradation

(2017) Haoran Tai et al.   FASEB JOURNAL

Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia

(2017) Chau-To Kwok et al.   Journal of Hematology & Oncology

N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing

(2017) Marek Bartosovic et al.   NUCLEIC ACIDS RESEARCH

FTO Gene Affects Obesity and Breast Cancer Through Similar Mechanisms: A New Insight into the Molecular Therapeutic Targets

(2017) M. E. Akbari et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

FTO expression is associated with the occurrence of gastric cancer and prognosis

(2017) Dong Xu et al.   ONCOLOGY REPORTS

Is FTO gene variant related to cancer risk independently of adiposity? An updated meta-analysis of 129,467 cases and 290,633 controls

(2017) Yu Kang et al.   Oncotarget

m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

(2017) Qi Cui et al.   Cell Reports

Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy

(2017) Aleksander Aas et al.   PLoS One

AMPK regulates lipid accumulation in skeletal muscle cells through FTO-dependent demethylation of N6-methyladenosine

(2017) Weiche Wu et al.   Scientific Reports

Obesity, Inflammation, and Cancer

(2016) Tuo Deng et al.   Annual Review of Pathology-Mechanisms of Disease

Association between FTO gene polymorphism (rs9939609 T/A) and cancer risk: a meta-analysis

(2016) Xiaoyi Huang et al.   EUROPEAN JOURNAL OF CANCER CARE

Reversible methylation of m6Am in the 5′ cap controls mRNA stability

(2016) Jan Mauer et al.   NATURE

Post-transcriptional gene regulation by mRNA modifications

(2016) Boxuan Simen Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Estrogen promotes fat mass and obesity-associated protein nuclear localization and enhances endometrial cancer cell proliferation via the mTOR signaling pathway

(2016) YAPING ZHU et al.   ONCOLOGY REPORTS

N6-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5

(2016) Shui Zou et al.   Scientific Reports

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

(2015) Xiao Wang et al.   CELL

Birth weight is associated with placental fat mass- and obesity-associated gene expression and promoter methylation in a Chinese population

(2015) Zi-Wei Liu et al.   Journal of Maternal-Fetal & Neonatal Medicine

Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases

(2015) Bodo C. Melnik   Journal of Translational Medicine

N6-methyladenosine marks primary microRNAs for processing

(2015) Claudio R. Alarcón et al.   NATURE

N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

(2015) Nian Liu et al.   NATURE

m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

(2015) Shay Geula et al.   SCIENCE

Premature aging of leukocyte DNA methylation is associated with type 2 diabetes prevalence

(2015) Gidon Toperoff et al.   Clinical Epigenetics

Fat mass and obesity-related (FTO) shuttles between the nucleus and cytoplasm

(2014) Pawan Gulati et al.   BIOSCIENCE REPORTS

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

Fat Mass and Obesity-Associated Gene (FTO) Is Linked to Higher Plasma Levels of the Hunger Hormone Ghrelin and Lower Serum Levels of the Satiety Hormone Leptin in Older Adults

(2014) Christian Benedict et al.   DIABETES

Diabetes mellitus and the risk of prostate cancer: an update and cumulative meta-analysis

(2014) Pan Jian Gang et al.   ENDOCRINE RESEARCH

Crystal structure of the RNA demethylase ALKBH5 from zebrafish

(2014) Weizhong Chen et al.   FEBS LETTERS

Structures of Human ALKBH5 Demethylase Reveal a Unique Binding Mode for Specific Single-strandedN6-Methyladenosine RNA Demethylation

(2014) Chao Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single nucleotide polymorphisms of the FTO gene and cancer risk: an overview

(2014) Marta Elena Hernández-Caballero et al.   MOLECULAR BIOLOGY REPORTS

N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells

(2014) Yang Wang et al.   NATURE CELL BIOLOGY

Unique features of the m6A methylome in Arabidopsis thaliana

(2014) Guan-Zheng Luo et al.   Nature Communications

High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis

(2013) Schraga Schwartz et al.   CELL

RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock

(2013) Jean-Michel Fustin et al.   CELL

The biology of FTO: from nucleic acid demethylase to amino acid sensor

(2013) Pawan Gulati et al.   DIABETOLOGIA

Preliminary findings on the influence of FTO rs9939609 and MC4R rs17782313 polymorphisms on resting energy expenditure, leptin and thyrotropin levels in obese non-morbid premenopausal women

(2013) María Arrizabalaga et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

Genome-wide association studies identify four ER negative–specific breast cancer risk loci

(2013) Montserrat Garcia-Closas et al.   NATURE GENETICS

Role for the obesity-related FTO gene in the cellular sensing of amino acids

(2013) P. Gulati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA

(2013) Ye Fu et al.   Nature Communications

Association of Type 2 Diabetes Susceptibility Variants With Advanced Prostate Cancer Risk in the Breast and Prostate Cancer Cohort Consortium

(2012) M. J. Machiela et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Estrogen induces endometrial cancer cell proliferation and invasion by regulating the fat mass and obesity-associated gene via PI3K/AKT and MAPK signaling pathways

(2012) Zhenbo Zhang et al.   CANCER LETTERS

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Prospective Identification of Glioblastoma Cells Generating Dormant Tumors

(2012) Ronit Satchi-Fainaro et al.   PLoS One

“Is obesity linked to aging?”

(2011) Irene P. Tzanetakou et al.   AGEING RESEARCH REVIEWS

Association of Obesity-related Genetic Variants With Endometrial Cancer Risk: A Report From the Shanghai Endometrial Cancer Genetics Study

(2011) R. J. Delahanty et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

The role of the fat mass and obesity associated gene (FTO) in breast cancer risk

(2011) Virginia Kaklamani et al.   BMC Medical Genetics

Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood

(2011) Gidon Toperoff et al.   HUMAN MOLECULAR GENETICS

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

The Obesity-Associated Polymorphisms FTO rs9939609 and MC4R rs17782313 and Endometrial Cancer Risk in Non-Hispanic White Women

(2011) Galina Lurie et al.   PLoS One

FTO Is Expressed in Neurones throughout the Brain and Its Expression Is Unaltered by Fasting

(2011) James S. McTaggart et al.   PLoS One

Variant rs9939609 in the FTO gene is associated with body mass index among Chinese children

(2010) Hongyun Fang et al.   BMC Medical Genetics

The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels

(2010) Tea Berulava et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Crystal structure of the FTO protein reveals basis for its substrate specificity

(2010) Zhifu Han et al.   NATURE

Common SNPs in FTO Gene Are Associated with Obesity Related Anthropometric Traits in an Island Population from the Eastern Adriatic Coast of Croatia

(2010) Ge Zhang et al.   PLoS One

Associations between an Obesity Related Genetic Variant (FTO rs9939609) and Prostate Cancer Risk

(2010) Sarah J. Lewis et al.   PLoS One

Cancer stem cells in glioblastoma—molecular signaling and therapeutic targeting

(2010) Zhi Huang et al.   Protein & Cell

The Fat Mass and Obesity-Associated (FTO) Gene is Associated with Intramuscular Fat Content and Growth Rate in the Pig

(2009) Bin Fan et al.   ANIMAL BIOTECHNOLOGY

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia

(2009) J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute promyelocytic leukemia: from highly fatal to highly curable

(2008) Z.-Y. Wang et al.   BLOOD

Variant rs9939609 in theFTOgene is associated with obesity in an adult population from Spain

(2008) José L. González-Sánchez et al.   CLINICAL ENDOCRINOLOGY

Fat Mass-and Obesity-Associated (FTO) Gene Variant Is Associated With Obesity: Longitudinal Analyses in Two Cohort Studies and Functional Test

(2008) L. Qi et al.   DIABETES

Common Variation in the Fat Mass and Obesity-Associated (FTO) Gene Confers Risk of Obesity and Modulates BMI in the Chinese Population

(2008) Y.-C. Chang et al.   DIABETES

Genetic Variants of FTO Influence Adiposity, Insulin Sensitivity, Leptin Levels, and Resting Metabolic Rate in the Quebec Family Study

(2008) R. Do et al.   DIABETES

Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO

(2008) Guifang Jia et al.   FEBS LETTERS

Variations in the FTO gene are associated with severe obesity in the Japanese

(2008) Kikuko Hotta et al.   JOURNAL OF HUMAN GENETICS

Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

(2008) Andrew G Renehan et al.   LANCET

Association Analysis of the FTO Gene with Obesity in Children of Caucasian and African Ancestry Reveals a Common Tagging SNP

(2008) Struan F. A. Grant et al.   PLoS One

Obesity and cancer

(2008) Tobias Pischon et al.   PROCEEDINGS OF THE NUTRITION SOCIETY