The biology of FTO: from nucleic acid demethylase to amino acid sensor

Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake

(2013) Toshiko Tanaka et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Role for the obesity-related FTO gene in the cellular sensing of amino acids

(2013) P. Gulati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adult Onset Global Loss of the Fto Gene Alters Body Composition and Metabolism in the Mouse

(2013) Fiona McMurray et al.   PLoS Genetics

Genetic determinants of common obesity and their value in prediction

(2012) Ruth J.F. Loos   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Kinetic analysis of FTO (fat mass and obesity-associated) reveals that it is unlikely to function as a sensor for 2-oxoglutarate

(2012) Marcella Ma et al.   BIOCHEMICAL JOURNAL

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

(2012) Jung Min Han et al.   CELL

FTO, obesity and the adolescent brain

(2012) Melkaye G. Melka et al.   HUMAN MOLECULAR GENETICS

FTO expression is regulated by availability of essential amino acids

(2012) M K Cheung et al.   INTERNATIONAL JOURNAL OF OBESITY

Leucyl-tRNA Synthetase Controls TORC1 via the EGO Complex

(2012) Grégory Bonfils et al.   MOLECULAR CELL

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

FTO genotype is associated with phenotypic variability of body mass index

(2012) Jian Yang et al.   NATURE

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Unraveling the brain regulation of appetite: lessons from genetics

(2012) Giles S H Yeo et al.   NATURE NEUROSCIENCE

Genetic Variants in the Fat and Obesity Associated (FTO) Gene and Risk of Alzheimer's Disease

(2012) Christiane Reitz et al.   PLoS One

Where next for GWAS?

(2011) G. S. H. Yeo   Briefings in Functional Genomics

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children

(2011) Tuomas O. Kilpeläinen et al.   PLOS MEDICINE

Prioritizing GWAS Results: A Review of Statistical Methods and Recommendations for Their Application

(2010) Rita M. Cantor et al.   AMERICAN JOURNAL OF HUMAN GENETICS

FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth

(2010) Gaifen Liu et al.   BMC Medical Genetics

Crystal structure of the FTO protein reveals basis for its substrate specificity

(2010) Zhifu Han et al.   NATURE

Overexpression of Fto leads to increased food intake and results in obesity

(2010) Chris Church et al.   NATURE GENETICS

Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats

(2010) Yi-Chun Loraine Tung et al.   PLoS One

The Fat Mass and Obesity Associated Gene FTO Functions in the Brain to Regulate Postnatal Growth in Mice

(2010) Xue Gao et al.   PLoS One

A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly

(2010) A. J. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The genetics of obesity: FTO leads the way

(2010) Katherine A. Fawcett et al.   TRENDS IN GENETICS

Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO

(2009) Marcel den Hoed et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The FTO gene rs9939609 obesity-risk allele and loss of control over eating

(2009) Marian Tanofsky-Kraff et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Loss-of-Function Mutation in the Dioxygenase-Encoding FTO Gene Causes Severe Growth Retardation and Multiple Malformations

(2009) Sarah Boissel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults

(2009) A. Jonsson et al.   DIABETOLOGIA

Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB Study

(2009) G H Goossens et al.   INTERNATIONAL JOURNAL OF OBESITY

FTO Genotype Is Associated with Body Mass Index after the Age of Seven Years But Not with Energy Intake or Leisure-Time Physical Activity

(2009) Maarit Hakanen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Inactivation of the Fto gene protects from obesity

(2009) Julia Fischer et al.   NATURE

Obesity,FTOGene Variant, and Energy Intake in Children

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of Fto/Ftm gene expression in mice and humans

(2008) George Stratigopoulos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Genetic Variants of FTO Influence Adiposity, Insulin Sensitivity, Leptin Levels, and Resting Metabolic Rate in the Quebec Family Study

(2008) R. Do et al.   DIABETES

Variation in the FTO Gene Influences Food Intake but not Energy Expenditure

(2008) A. Haupt et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO

(2008) Guifang Jia et al.   FEBS LETTERS

The FTO gene and measured food intake in children

(2008) J Wardle et al.   INTERNATIONAL JOURNAL OF OBESITY

Lack of Association of Fatness-Related FTO Gene Variants with Energy Expenditure or Physical Activity

(2008) T. Berentzen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Obesity Associated Genetic Variation inFTOIs Associated with Diminished Satiety

(2008) Jane Wardle et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Common nonsynonymous variants in PCSK1 confer risk of obesity

(2008) Michael Benzinou et al.   NATURE GENETICS

Common variants near MC4R are associated with fat mass, weight and risk of obesity

(2008) Ruth J F Loos et al.   NATURE GENETICS

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

(2008) Gudmar Thorleifsson et al.   NATURE GENETICS

Common genetic variation near MC4R is associated with waist circumference and insulin resistance

(2008) John C Chambers et al.   NATURE GENETICS

Brain-Derived Neurotrophic Factor and Obesity in the WAGR Syndrome

(2008) Joan C. Han et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Obesity-AssociatedFTOGene Variant and Increased Energy Intake in Children

(2008) Joanne E. Cecil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Polymorphisms of theFTOGene Are Associated With Variation in Energy Intake, but not Energy Expenditure

(2008) John R. Speakman et al.   Obesity