The anticancer effects and mechanisms of fucoxanthin combined with other drugs

Cytotoxic activity of fucoxanthin, alone and in combination with the cancer drugs imatinib and doxorubicin, in CML cell lines

(2018) Tânia Patrícia Almeida et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Low-dose doxorubicin with carotenoids selectively alters redox status and upregulates oxidative stress-mediated apoptosis in breast cancer cells

(2018) Kariyappa Vijay et al.   FOOD AND CHEMICAL TOXICOLOGY

Polymeric chitosan-glycolipid nanocarriers for an effective delivery of marine carotenoid fucoxanthin for induction of apoptosis in human colon cancer cells (Caco-2 cells)

(2018) Hindupur Ravi et al.   Materials Science & Engineering C-Materials for Biological Applications

Fucoxanthin and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Synergistically Promotes Apoptosis of Human Cervical Cancer Cells by Targeting PI3K/Akt/NF-κB Signaling Pathway

(2018) Ye Jin et al.   MEDICAL SCIENCE MONITOR

A marine bio-functional lipid, fucoxanthinol, attenuates human colorectal cancer stem-like cell tumorigenicity and sphere formation

(2017) Masaru Terasaki et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Antitumor Effects of Laminaria Extract Fucoxanthin on Lung Cancer

(2017) ChengHan Mei et al.   Marine Drugs

Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathways

(2017) Li Zhang et al.   Scientific Reports

Fucoxanthin Activates Apoptosis via Inhibition of PI3K/Akt/mTOR Pathway and Suppresses Invasion and Migration by Restriction of p38-MMP-2/9 Pathway in Human Glioblastoma Cells

(2016) Yugang Liu et al.   NEUROCHEMICAL RESEARCH

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Fucoxanthin and Its Metabolite Fucoxanthinol in Cancer Prevention and Treatment

(2015) Luc Martin   Marine Drugs

Anticancer effects of fucoxanthin and fucoxanthinol on colorectal cancer cell lines and colorectal cancer tissues

(2015) KAZUTO TAKAHASHI et al.   Oncology Letters

Trailing TRAIL Resistance: Novel Targets for TRAIL Sensitization in Cancer Cells

(2015) Rachana Trivedi et al.   Frontiers in Oncology

Inhibitory effects of fucoxanthinol on the viability of human breast cancer cell lines MCF-7 and MDA-MB-231 are correlated with modulation of the NF-kappaB pathway

(2014) Arlette Rwigemera et al.   CELL BIOLOGY AND TOXICOLOGY

Getting TRAIL back on track for cancer therapy

(2014) J Lemke et al.   CELL DEATH AND DIFFERENTIATION

The Molecular Mechanisms of TRAIL Resistance in Cancer Cells: Help in Designing New Drugs

(2014) Feng Wang et al.   CURRENT PHARMACEUTICAL DESIGN

Essential role of autophagy in fucoxanthin-induced cytotoxicity to human epithelial cervical cancer HeLa cells

(2013) Li-li Hou et al.   ACTA PHARMACOLOGICA SINICA

Leukaemias into the 21st century - part 2: the chronic leukaemias

(2013) J. Gibson et al.   INTERNAL MEDICINE JOURNAL

Fucoxanthin Enhances Cisplatin-Induced Cytotoxicity via NFκB-Mediated Pathway and Downregulates DNA Repair Gene Expression in Human Hepatoma HepG2 Cells

(2013) Cheng-Ling Liu et al.   Marine Drugs

Epigenetic Regulation of SOX9 by the NF-κB Signaling Pathway in Pancreatic Cancer Stem Cells

(2013) Lei Sun et al.   STEM CELLS

Transcriptional Up-Regulation of Sox9 by NF-κB in Endometrial Carcinoma Cells, Modulating Cell Proliferation Through Alteration in the p14 ARF /p53/p21 WAF1 Pathway

(2012) Makoto Saegusa et al.   AMERICAN JOURNAL OF PATHOLOGY

CaMKII  , a critical regulator of CML stem/progenitor cells, is a target of the natural product berbamine

(2012) Y. Gu et al.   BLOOD

Oncogenicity of the Developmental Transcription Factor Sox9

(2012) A. Matheu et al.   CANCER RESEARCH

Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells

(2012) Kil-Nam Kim et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Fucoxanthin Attenuates Rifampin-Induced Cytochrome P450 3A4 (CYP3A4) and Multiple Drug Resistance 1 (MDR1) Gene Expression Through Pregnane X Receptor (PXR)-Mediated Pathways in Human Hepatoma HepG2 and Colon Adenocarcinoma LS174T Cells

(2012) Cheng-Ling Liu et al.   Marine Drugs

In Vivo Induction of Apoptosis by Fucoxanthin, a Marine Carotenoid, Associated with Down-Regulating STAT3/EGFR Signaling in Sarcoma 180 (S180) Xenografts-Bearing Mice

(2012) Jun Wang et al.   Marine Drugs

Fucoxanthin promotes translocation and induction of glucose transporter 4 in skeletal muscles of diabetic/obese KK-Ay mice

(2012) Sho Nishikawa et al.   PHYTOMEDICINE

Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters

(2012) Safaa Yehia Eid et al.   PHYTOMEDICINE

Single and 13-Week Oral Toxicity Study of Fucoxanthin Oil from Microalgae in Rats

(2011) Kumiko IIO et al.   Food Hygiene and Safety Science

Fucoxanthin and its deacetylated product, fucoxanthinol, induce apoptosis of primary effusion lymphomas

(2010) Kei Yamamoto et al.   CANCER LETTERS

Fucoxanthin inhibits the inflammatory response by suppressing the activation of NF-κB and MAPKs in lipopolysaccharide-induced RAW 264.7 macrophages

(2010) Kil-Nam Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Doxorubicin pathways

(2010) Caroline F. Thorn et al.   Pharmacogenetics and Genomics

Fucoxanthin induces apoptosis in human leukemia HL-60 cells through a ROS-mediated Bcl-xL pathway

(2010) Kil-Nam Kim et al.   TOXICOLOGY IN VITRO

Implication of mitogen-activated protein kinase in the induction of G1 cell cycle arrest and gadd45 expression by the carotenoid fucoxanthin in human cancer cells

(2009) Yoshiko Satomi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Inhibition of proliferation of a hepatoma cell line by fucoxanthin in relation to cell cycle arrest and enhanced gap junctional intercellular communication

(2009) Cheng-Ling Liu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Single and repeated oral dose toxicity study of fucoxanthin (FX), a marine carotenoid, in mice

(2009) Fumiaki Beppu et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

In vitro and in vivo evaluation of mutagenicity of fucoxanthin (FX) and its metabolite fucoxanthinol (FXOH)

(2009) Fumiaki Beppu et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Bioavailability and metabolism of fucoxanthin in rats: structural characterization of metabolites by LC-MS (APCI)

(2009) Ravi Kumar Sangeetha et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Cancer prevention by carotenoids

(2008) Hoyoku Nishino et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Growth inhibition of human hepatic carcinoma HepG2 cells by fucoxanthin is associated with down-regulation of cyclin D

(2008) Swadesh K. Das et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Novel Orphan Nuclear Receptors-Coregulator Interactions Controlling Anti-Cancer Drug Metabolism

(2008) Radharani Gollamudi et al.   CURRENT DRUG METABOLISM

Antiadult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol

(2008) Chie Ishikawa et al.   INTERNATIONAL JOURNAL OF CANCER