Understanding the Bone in Cancer Metastasis

Where Hematopoietic Stem Cells Live: The Bone Marrow Niche

(2018) Krzysztof Szade et al.   ANTIOXIDANTS & REDOX SIGNALING

Incidence of bone metastases in patients with solid tumors: analysis of oncology electronic medical records in the United States

(2018) Rohini K. Hernandez et al.   BMC CANCER

The hematopoietic stem cell niche: What's so special about bone?

(2018) Benjamin J. Frisch   BONE

CD150 high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine

(2018) Yuichi Hirata et al.   Cell Stem Cell

Adjuvant zoledronic acid reduces fractures in breast cancer patients; an AZURE (BIG 01/04) study

(2018) C. Wilson et al.   EUROPEAN JOURNAL OF CANCER

Mechanical regulation of breast cancer migration and apoptosis via direct and indirect osteocyte signaling

(2018) Yu-Heng V. Ma et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy

(2018) Jordan A. Krall et al.   Science Translational Medicine

Adipocyte-activated oxidative and ER stress pathways promote tumor survival in bone via upregulation of Heme Oxygenase 1 and Survivin

(2018) Mackenzie K. Herroon et al.   Scientific Reports

Adipogenic niches for melanoma cell colonization and growth in bone marrow

(2017) Juan Wang et al.   LABORATORY INVESTIGATION

Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain

(2017) Andrew S Gdowski et al.   Nanomedicine

20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years

(2017) Hongchao Pan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis

(2017) Kenneth G. Saag et al.   NEW ENGLAND JOURNAL OF MEDICINE

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhighneutrophils

(2017) Camilla Engblom et al.   SCIENCE

RON kinase: A target for treatment of cancer-induced bone destruction and osteoporosis

(2017) Kelsi Andrade et al.   Science Translational Medicine

The fat and the bad: Mature adipocytes, key actors in tumor progression and resistance

(2017) Minh Ngoc Duong et al.   Oncotarget

The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression

(2017) János Kappelmayer et al.   Biomed Research International

Targeted delivery to bone and mineral deposits using bisphosphonate ligands

(2016) Lisa E. Cole et al.   ADVANCED DRUG DELIVERY REVIEWS

Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma

(2016) J. Delgado-Calle et al.   CANCER RESEARCH

Angiopoietin-2 promotes ER+ breast cancer cell survival in bone marrow niche

(2016) Hyun Ho Han et al.   ENDOCRINE-RELATED CANCER

Osteocyte Apoptosis Caused by Hindlimb Unloading is Required to Trigger Osteocyte RANKL Production and Subsequent Resorption of Cortical and Trabecular Bone in Mice Femurs

(2016) Pamela Cabahug-Zuckerman et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inflammatory Osteoclasts Prime TNFα-Producing CD4+T Cells and Express CX3CR1

(2016) Lidia Ibáñez et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Annual Hazard Rates of Recurrence for Breast Cancer During 24 Years of Follow-Up: Results From the International Breast Cancer Study Group Trials I to V

(2016) Marco Colleoni et al.   JOURNAL OF CLINICAL ONCOLOGY

Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer

(2016) Lucia D’Amico et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Early dissemination seeds metastasis in breast cancer

(2016) Hedayatollah Hosseini et al.   NATURE

Mechanism of early dissemination and metastasis in Her2+ mammary cancer

(2016) Kathryn L. Harper et al.   NATURE

Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow

(2016) Rachelle W. Johnson et al.   NATURE CELL BIOLOGY

Osteocytic connexin hemichannels suppress breast cancer growth and bone metastasis

(2016) J Z Zhou et al.   ONCOGENE

Parathyroid Hormone-Related Protein, Its Regulation of Cartilage and Bone Development, and Role in Treating Bone Diseases

(2016) T. John Martin   PHYSIOLOGICAL REVIEWS

Pre-Osteoblasts Stimulate Migration of Breast Cancer Cells via the HGF/MET Pathway

(2016) Sonia Vallet et al.   PLoS One

Femoral Bone Marrow Insulin Sensitivity Is Increased by Resistance Training in Elderly Female Offspring of Overweight and Obese Mothers

(2016) Ville Huovinen et al.   PLoS One

Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone

(2016) Trevor T. Price et al.   Science Translational Medicine

Bone marrow adipocytes promote the Warburg phenotype in metastatic prostate tumors via HIF-1α activation

(2016) Jonathan D. Diedrich et al.   Oncotarget

Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development

(2016) Xianmin Luo et al.   Cell Reports

The Bone Microenvironment: a Fertile Soil for Tumor Growth

(2016) Denise Buenrostro et al.   Current Osteoporosis Reports

Bone Marrow Adipose Tissue: A New Player in Cancer Metastasis to Bone

(2016) Emma V. Morris et al.   Frontiers in Endocrinology

The dynamics of adult haematopoiesis in the bone and bone marrow environment

(2015) Miriel S. H. Ho et al.   BRITISH JOURNAL OF HAEMATOLOGY

The Osteogenic Niche Promotes Early-Stage Bone Colonization of Disseminated Breast Cancer Cells

(2015) Hai Wang et al.   CANCER CELL

Tumor-Induced Pressure in the Bone Microenvironment Causes Osteocytes to Promote the Growth of Prostate Cancer Bone Metastases

(2015) Joseph L. Sottnik et al.   CANCER RESEARCH

Marrow adipocyte-derived CXCL1 and CXCL2 contribute to osteolysis in metastatic prostate cancer

(2015) Aimalie L. Hardaway et al.   CLINICAL & EXPERIMENTAL METASTASIS

Prevention of Bone Metastases in Patients with High-risk Nonmetastatic Prostate Cancer Treated with Zoledronic Acid: Efficacy and Safety Results of the Zometa European Study (ZEUS)

(2015) Manfred Wirth et al.   EUROPEAN UROLOGY

Inhibition of Osteocyte Apoptosis Prevents the Increase in Osteocytic Receptor Activator of Nuclear Factor κB Ligand (RANKL) but Does Not Stop Bone Resorption or the Loss of Bone Induced by Unloading

(2015) Lilian I. Plotkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Randomized, Double-Blind Phase 2 Clinical Trial of Blosozumab, a Sclerostin Antibody, in Postmenopausal Women with Low Bone Mineral Density

(2015) Robert R. Recker et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Gut-derived serotonin induced by depression promotes breast cancer bone metastasis through the RUNX2/PTHrP/RANKL pathway in mice

(2015) JIAN-CHUN ZONG et al.   ONCOLOGY REPORTS

Radium-223 Dichloride for Metastatic Castration-resistant Prostate Cancer: The Urologist's Perspective

(2015) Neal D. Shore   UROLOGY

Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues

(2015) Erica L. Scheller et al.   Nature Communications

NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes

(2015) Maria Soledad Sosa et al.   Nature Communications

Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche

(2015) Michelle A. Lawson et al.   Nature Communications

Breast Cancer Cell Colonization of the Human Bone Marrow Adipose Tissue Niche

(2015) Zach S. Templeton et al.   NEOPLASIA

Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone

(2015) Jinhu Xiong et al.   PLoS One

Bone marrow adipocytes promote tumor growth in bone via FABP4-dependent mechanisms

(2015) Mackenzie Herroon et al.   Oncotarget

Notch signaling drives multiple myeloma induced osteoclastogenesis

(2015) Michela Colombo et al.   Oncotarget

What's the matter with MAT? Marrow adipose tissue, metabolism, and skeletal health

(2014) Erica L. Scheller et al.   Annals of the New York Academy of Sciences

Osteocyte apoptosis is required for production of osteoclastogenic signals following bone fatigue in vivo

(2014) Oran D. Kennedy et al.   BONE

Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction

(2014) William P. Cawthorn et al.   Cell Metabolism

Zoledronic Acid Has Differential Antitumor Activity in the Pre- and Postmenopausal Bone Microenvironment In Vivo

(2014) P. D. Ottewell et al.   CLINICAL CANCER RESEARCH

Castration-induced bone loss triggers growth of disseminated prostate cancer cells in bone

(2014) P. D. Ottewell et al.   ENDOCRINE-RELATED CANCER

Age-related Marrow Adipogenesis Is Linked to Increased Expression of RANKL

(2014) Sunao Takeshita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Review of Osteocyte Function and the Emerging Importance of Sclerostin

(2014) Jocelyn T Compton et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo

(2014) M. K. Chang et al.   JOURNAL OF IMMUNOLOGY

Effect of radium-223 dichloride on symptomatic skeletal events in patients with castration-resistant prostate cancer and bone metastases: results from a phase 3, double-blind, randomised trial

(2014) Oliver Sartor et al.   LANCET ONCOLOGY

Adjuvant zoledronic acid in patients with early breast cancer: final efficacy analysis of the AZURE (BIG 01/04) randomised open-label phase 3 trial

(2014) Robert Coleman et al.   LANCET ONCOLOGY

Direct measurement of local oxygen concentration in the bone marrow of live animals

(2014) Joel A. Spencer et al.   NATURE

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

(2014) Anjali P. Kusumbe et al.   NATURE

Hypoxia promotes stem cell-like phenotype in multiple myeloma cells

(2014) B Muz et al.   Blood Cancer Journal

Dysregulated B Cell Expression of RANKL and OPG Correlates with Loss of Bone Mineral Density in HIV Infection

(2014) Kehmia Titanji et al.   PLoS Pathogens

Apoptotic Osteocytes and the Control of Targeted Bone Resorption

(2014) Lilian I. Plotkin   Current Osteoporosis Reports

Osteoclast-induced Foxp3+ CD8 T-cells limit bone loss in mice

(2013) Zachary S. Buchwald et al.   BONE

Tumor-Induced Osteoclast miRNA Changes as Regulators and Biomarkers of Osteolytic Bone Metastasis

(2013) Brian Ell et al.   CANCER CELL

Osteocytes Regulate Primary Lymphoid Organs and Fat Metabolism

(2013) Mari Sato et al.   Cell Metabolism

Monocyte chemoattractant protein-1 is a mediator of the anabolic action of parathyroid hormone on bone

(2013) Joseph A Tamasi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The perivascular niche regulates breast tumour dormancy

(2013) Cyrus M. Ghajar et al.   NATURE CELL BIOLOGY

Alpha Emitter Radium-223 and Survival in Metastatic Prostate Cancer

(2013) C. Parker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting tumor–stromal interactions in bone metastasis

(2013) Mark Esposito et al.   PHARMACOLOGY & THERAPEUTICS

GAS6 Receptor Status Is Associated with Dormancy and Bone Metastatic Tumor Formation

(2013) Russell S. Taichman et al.   PLoS One

Myeloid-Derived Suppressor Cells Function as Novel Osteoclast Progenitors Enhancing Bone Loss in Breast Cancer

(2012) A. Sawant et al.   CANCER RESEARCH

The multifaceted actions of PTHrP in skeletal metastasis

(2012) Fabiana N Soki et al.   Future Oncology

Increased presence of capillaries next to remodeling sites in adult human cancellous bone

(2012) Helene Bjoerg Kristensen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Depletion of Plasmacytoid Dendritic Cells Inhibits Tumor Growth and Prevents Bone Metastasis of Breast Cancer Cells

(2012) Anandi Sawant et al.   JOURNAL OF IMMUNOLOGY

Development of Novel Bisphosphonate Prodrugs of Doxorubicin for Targeting Bone Metastases That Are Cleaved pH Dependently or by Cathepsin B: Synthesis, Cleavage Properties, and Binding Properties to Hydroxyapatite As Well As Bone Matrix

(2012) Katrin Hochdörffer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Increased osteocyte death in multiple myeloma patients: role in myeloma-induced osteoclast formation

(2012) N Giuliani et al.   LEUKEMIA

Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape

(2012) Bradley N Bidwell et al.   NATURE MEDICINE

Osteoclast Activated FoxP3+ CD8+ T-Cells Suppress Bone Resorption in vitro

(2012) Zachary S. Buchwald et al.   PLoS One

Stimulation of Host Bone Marrow Stromal Cells by Sympathetic Nerves Promotes Breast Cancer Bone Metastasis in Mice

(2012) J. Preston Campbell et al.   PLOS BIOLOGY

Myeloid-derived suppressor cells expand during breast cancer progression and promote tumor-induced bone destruction

(2012) Sabrina Danilin et al.   OncoImmunology

Host-derived adiponectin is tumor-suppressive and a novel therapeutic target for multiple myeloma and the associated bone disease

(2011) J. A. Fowler et al.   BLOOD

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells

(2011) Nilay Sethi et al.   CANCER CELL

CD8+ T Cells Regulate Bone Tumor Burden Independent of Osteoclast Resorption

(2011) K. Zhang et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Osteoclast activity modulates B-cell development in the bone marrow

(2011) Anna Mansour et al.   CELL RESEARCH

Primary human bone marrow adipocytes support TNF-α-induced osteoclast differentiation and function through RANKL expression

(2011) Hisataka Goto et al.   CYTOKINE

Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice

(2011) Moshe Elkabets et al.   JOURNAL OF CLINICAL INVESTIGATION

Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow

(2011) Yusuke Shiozawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study

(2011) Karim Fizazi et al.   LANCET

In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche

(2011) Joji Fujisaki et al.   NATURE

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Three-Dimensional Characterization of the Vascular Bed in Bone Metastasis of the Rat by Microcomputed Tomography (MicroCT)

(2011) Hervé Nyangoga et al.   PLoS One

The Cathepsin K Inhibitor Odanacatib Suppresses Bone Resorption in Women With Breast Cancer and Established Bone Metastases: Results of a 4-Week, Double-Blind, Randomized, Controlled Trial

(2010) Anders Bonde Jensen et al.   Clinical Breast Cancer

Caloric restriction leads to high marrow adiposity and low bone mass in growing mice

(2010) Maureen J Devlin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The amazing osteocyte

(2010) Lynda F Bonewald   JOURNAL OF BONE AND MINERAL RESEARCH

High-Resolution Peripheral Quantitative Computed Tomographic Imaging of Cortical and Trabecular Bone Microarchitecture in Patients with Type 2 Diabetes Mellitus

(2010) Andrew J. Burghardt et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Denosumab Compared With Zoledronic Acid for the Treatment of Bone Metastases in Patients With Advanced Breast Cancer: A Randomized, Double-Blind Study

(2010) Alison T. Stopeck et al.   JOURNAL OF CLINICAL ONCOLOGY

Low bone marrow oxygen tension and hypoxia-inducible factor-1α overexpression characterize patients with multiple myeloma: role on the transcriptional and proangiogenic profiles of CD138+ cells

(2010) S Colla et al.   LEUKEMIA

Bone marrow adipocytes support dexamethasone-induced osteoclast differentiation

(2009) Akira Hozumi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of differentially expressed genes between osteoblasts and osteocytes

(2009) Frane Paic et al.   BONE

Osteocyte apoptosis and control of bone resorption following ovariectomy in mice

(2009) K.B. Emerton et al.   BONE

Disseminated Tumor Cells in Prostate Cancer Patients after Radical Prostatectomy and without Evidence of Disease Predicts Biochemical Recurrence

(2009) T. M. Morgan et al.   CLINICAL CANCER RESEARCH

Increased Bone Marrow Fat in Anorexia Nervosa

(2009) Miriam A. Bredella et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cross-Presentation by Osteoclasts Induces FoxP3 in CD8+ T Cells

(2009) J. R. Kiesel et al.   JOURNAL OF IMMUNOLOGY

Hypoxia and TGF-β Drive Breast Cancer Bone Metastases through Parallel Signaling Pathways in Tumor Cells and the Bone Microenvironment

(2009) Lauren K. Dunn et al.   PLoS One

A Physical Mechanism for Coupling Bone Resorption and Formation in Adult Human Bone

(2008) Thomas Levin Andersen et al.   AMERICAN JOURNAL OF PATHOLOGY

The effects of surgery on tumor growth: a century of investigations

(2008) R. Demicheli et al.   ANNALS OF ONCOLOGY

Systemic Endocrine Instigation of Indolent Tumor Growth Requires Osteopontin

(2008) Sandra S. McAllister et al.   CELL

Wnt Signaling in the Niche Enforces Hematopoietic Stem Cell Quiescence and Is Necessary to Preserve Self-Renewal In Vivo

(2008) Heather E. Fleming et al.   Cell Stem Cell

Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: Cross talk with the osteoblastogenic program

(2008) S. Muruganandan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease

(2008) Ann E. Kearns et al.   ENDOCRINE REVIEWS

Osteocyte Apoptosis Controls Activation of Intracortical Resorption in Response to Bone Fatigue

(2008) Luis Cardoso et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Biodistribution and Pharmacokinetic Studies of Bone-TargetingN-(2-Hydroxypropyl)methacrylamide Copolymer−Alendronate Conjugates

(2008) Huaizhong Pan et al.   MOLECULAR PHARMACEUTICS

Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes

(2008) Charles A. O'Brien et al.   PLoS One