RON kinase: A target for treatment of cancer-induced bone destruction and osteoporosis

Excess TGF-β mediates muscle weakness associated with bone metastases in mice

(2015) David L Waning et al.   NATURE MEDICINE

Matrix protein CCN1 induced by bacterial DNA and CpG ODN limits lung inflammation and contributes to innate immune homeostasis

(2014) H-G Moon et al.   Mucosal Immunology

The Role of Denosumab for Prevention of Skeletal-Related Complications in Multiple Myeloma

(2013) Kelly Hageman et al.   ANNALS OF PHARMACOTHERAPY

Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases

(2013) Arno G. Steinig et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors

(2013) Christel Vérollet et al.   FASEB JOURNAL

Inhibition of Ron Kinase Blocks Conversion of Micrometastases to Overt Metastases by Boosting Antitumor Immunity

(2013) H. Eyob et al.   Cancer Discovery

Impact of Docosahexaenoic Acid on Gene Expression during Osteoclastogenesis in Vitro—A Comprehensive Analysis

(2013) Masako Akiyama et al.   Nutrients

Patient-derived luminal breast cancer xenografts retain hormone receptor heterogeneity and help define unique estrogen-dependent gene signatures

(2012) Peter Kabos et al.   BREAST CANCER RESEARCH AND TREATMENT

Elucidating Prognosis and Biology of Breast Cancer Arising in Young Women Using Gene Expression Profiling

(2012) Hatem A. Azim et al.   CLINICAL CANCER RESEARCH

Superiority of denosumab to zoledronic acid for prevention of skeletal-related events: A combined analysis of 3 pivotal, randomised, phase 3 trials

(2012) Allan Lipton et al.   EUROPEAN JOURNAL OF CANCER

Efficacy and Safety of Denosumab for the Treatment of Bone Metastases in Patients with Advanced Cancer

(2012) T. Kurata et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

c-Src Links a RANK/ v 3 Integrin Complex to the Osteoclast Cytoskeleton

(2012) T. Izawa et al.   MOLECULAR AND CELLULAR BIOLOGY

New developments in osteoimmunology

(2012) Hiroshi Takayanagi   Nature Reviews Rheumatology

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells

(2011) Nilay Sethi et al.   CANCER CELL

Five years of denosumab exposure in women with postmenopausal osteoporosis: Results from the first two years of the FREEDOM extension

(2011) Socrates Papapoulos et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Src Kinase Mediates Productive Endocytic Sorting of Reovirus during Cell Entry

(2011) B. A. Mainou et al.   JOURNAL OF VIROLOGY

Combined therapy with the RANKL inhibitor RANK-Fc and rhApo2L/TRAIL/dulanermin reduces bone lesions and skeletal tumor burden in a model of breast cancer skeletal metastasis

(2010) Pamela M. Holland et al.   CANCER BIOLOGY & THERAPY

Metastasis and bone loss: Advancing treatment and prevention

(2010) Robert E. Coleman et al.   CANCER TREATMENT REVIEWS

The Macrophage Stimulating Protein/Ron Pathway as a Potential Therapeutic Target to Impede Multiple Mechanisms Involved in Breast Cancer Progression

(2010) Kelsi L. Kretschmann et al.   CURRENT DRUG TARGETS

Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee

(2010) A. Michael Parfitt et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Fyn promotes proliferation, differentiation, survival and function of osteoclast lineage cells

(2010) Hyun-Ju Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Denosumab Compared With Zoledronic Acid for the Treatment of Bone Metastases in Patients With Advanced Breast Cancer: A Randomized, Double-Blind Study

(2010) Alison T. Stopeck et al.   JOURNAL OF CLINICAL ONCOLOGY

Lyn inhibits osteoclast differentiation by interfering with PLCγ1-mediated Ca2+signaling

(2009) Soo-Hyun Yoon et al.   FEBS LETTERS

Discovery ofN-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily

(2009) Gretchen M. Schroeder et al.   JOURNAL OF MEDICINAL CHEMISTRY

Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis

(2009) Steven R. Cummings et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo

(2009) H.-J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional grouping of osteoclast genes revealed through microarray analysis

(2007) Guozhe Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS