The Power of Fish Models to Elucidate Skin Cancer Pathogenesis and Impact the Discovery of New Therapeutic Opportunities

Generation of a double binary transgenic zebrafish model to study myeloid gene regulation in response to oncogene activation in melanocytes

(2018) Amy Kenyon et al.   Disease Models & Mechanisms

Neoadjuvant plus adjuvant dabrafenib and trametinib versus standard of care in patients with high-risk, surgically resectable melanoma: a single-centre, open-label, randomised, phase 2 trial

(2018) Rodabe N Amaria et al.   LANCET ONCOLOGY

Complete mitochondrial genome sequences of five rockfishes (Perciformes: Sebastes)

(2018) Michael W. Sandel et al.   Mitochondrial DNA Part B-Resources

Interleukin 8 mediates bcl-xL-induced enhancement of human melanoma cell dissemination and angiogenesis in a zebrafish xenograft model

(2017) Chiara Gabellini et al.   INTERNATIONAL JOURNAL OF CANCER

Response to “The importance of controlling genetic variation – remarks on ‘Appropriate rearing density in domesticated zebrafish to avoid masculinization: links with the stress response’”

(2017) Laia Ribas et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

(2017) Robert T. Manguso et al.   NATURE

Zebrafish: A Premier Vertebrate Model for Biomedical Research in Indian Scenario

(2017) Sreeja Sarasamma et al.   Zebrafish

mRNA processing in mutant zebrafish lines generated by chemical and CRISPR-mediated mutagenesis produces unexpected transcripts that escape nonsense-mediated decay

(2017) Jennifer L. Anderson et al.   PLoS Genetics

Genome Editing for Cancer Therapy: Delivery of Cas9 Protein/sgRNA Plasmid via a Gold Nanocluster/Lipid Core-Shell Nanocarrier

(2017) Peng Wang et al.   Advanced Science

The Genome of the Trinidadian Guppy, Poecilia reticulata, and Variation in the Guanapo Population

(2017) Axel Künstner et al.   PLoS One

Germ cell and tumor associated piRNAs in the medaka and Xiphophorus melanoma models

(2016) Susanne Kneitz et al.   BMC GENOMICS

Targeting DDR2 in head and neck squamous cell carcinoma with dasatinib

(2016) Anne von Mässenhausen et al.   INTERNATIONAL JOURNAL OF CANCER

CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2- and Regulatory T Cell–like Populations and Diverse Mononuclear Phagocytes

(2016) Christopher T. Dee et al.   JOURNAL OF IMMUNOLOGY

Identification of a small molecule that downregulates MITF expression and mediates antimelanoma activity in vitro

(2016) Chuan Cheng et al.   MELANOMA RESEARCH

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma

(2016) Justin L. Tan et al.   MOLECULAR CELL

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation

(2016) C. K. Kaufman et al.   SCIENCE

Distinct functions of two olfactory marker protein genes derived from teleost-specific whole genome duplication

(2015) Hikoyu Suzuki et al.   BMC EVOLUTIONARY BIOLOGY

15 years of zebrafish chemical screening

(2015) Andrew J Rennekamp et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma

(2015) Robert H.I. Andtbacka et al.   JOURNAL OF CLINICAL ONCOLOGY

Excavating the Genome: Large-Scale Mutagenesis Screening for the Discovery of New Mouse Models

(2015) John P. Sundberg et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

A human laterality disorder caused by a homozygous deleterious mutation inMMP21

(2015) Zeev Perles et al.   JOURNAL OF MEDICAL GENETICS

Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Whole Body Melanoma Transcriptome Response in Medaka

(2015) Manfred Schartl et al.   PLoS One

Cdc6 cooperates with c-Myc to promote genome instability and epithelial to mesenchymal transition (EMT) in zebrafish

(2015) Ching-Hung Chen et al.   Oncotarget

Comparative analysis of melanoma deregulated miRNAs in the medaka and Xiphophorus pigment cell cancer models

(2014) Rasmi R. Mishra et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia

(2014) Alejandro Gutierrez et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014

(2014) L. S. Schneider et al.   JOURNAL OF INTERNAL MEDICINE

A dominant mutation intyrp1Aleads to melanophore death in zebrafish

(2014) Jana Krauss et al.   Pigment Cell & Melanoma Research

Multiple Pigment Cell Types Contribute to the Black, Blue, and Orange Ornaments of Male Guppies (Poecilia reticulata)

(2014) Verena A. Kottler et al.   PLoS One

Evaluating human cancer cell metastasis in zebrafish

(2013) Yong Teng et al.   BMC CANCER

Enhanced Efficiency of Human Pluripotent Stem Cell Genome Editing through Replacing TALENs with CRISPRs

(2013) Qiurong Ding et al.   Cell Stem Cell

Beyond the zebrafish: diverse fish species for modeling human disease

(2013) M. Schartl   Disease Models & Mechanisms

Premature aging in telomerase-deficient zebrafish

(2013) M. Anchelin et al.   Disease Models & Mechanisms

Oxidative stress in melanocyte senescence and melanoma transformation

(2013) Svenja Meierjohann   EUROPEAN JOURNAL OF CELL BIOLOGY

Clinical development of dabrafenib in BRAF mutant melanoma and other malignancies

(2013) Geoffrey T Gibney et al.   Expert Opinion on Drug Metabolism & Toxicology

A Conditional Zebrafish MITF Mutation Reveals MITF Levels Are Critical for Melanoma Promotion vs. Regression In Vivo

(2013) James A. Lister et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Drosophilaas a screening tool to study human neurodegenerative diseases

(2013) Sarah Lenz et al.   JOURNAL OF NEUROCHEMISTRY

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Efficient genome editing in zebrafish using a CRISPR-Cas system

(2013) Woong Y Hwang et al.   NATURE BIOTECHNOLOGY

The genome of the platyfish, Xiphophorus maculatus, provides insights into evolutionary adaptation and several complex traits

(2013) Manfred Schartl et al.   NATURE GENETICS

TALEN-mediated precise genome modification by homologous recombination in zebrafish

(2013) Yao Zu et al.   NATURE METHODS

Coordinated Regulation of Chromatophore Differentiation and Melanogenesis during the Ontogeny of Skin Pigmentation of Solea senegalensis (Kaup, 1858)

(2013) Maria J. Darias et al.   PLoS One

BCL2A1is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition

(2013) Rizwan Haq et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conservation and divergence in the transcriptional programs of the human and mouse immune systems

(2013) T. Shay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developing zebrafish models of autism spectrum disorder (ASD)

(2013) Adam Michael Stewart et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

(2013) Thomas Gaj et al.   TRENDS IN BIOTECHNOLOGY

Frequency of TERT promoter mutations in human cancers

(2013) João Vinagre et al.   Nature Communications

The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models

(2013) Jennifer Yen et al.   GENOME BIOLOGY

Inflammation drives wound hyperpigmentation in zebrafish by recruiting pigment cells to sites of tissue damage

(2012) M. Levesque et al.   Disease Models & Mechanisms

Hooked! Modeling human disease in zebrafish

(2012) Cristina Santoriello et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell cycle arrest associated with anoxia-induced quiescence, anoxic preconditioning, and embryonic diapause in embryos of the annual killifish Austrofundulus limnaeus

(2012) Camie L. Meller et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

Identification of Modulators of Hair Cell Regeneration in the Zebrafish Lateral Line

(2012) P. Namdaran et al.   JOURNAL OF NEUROSCIENCE

Melanoma genome sequencing reveals frequent PREX2 mutations

(2012) Michael F. Berger et al.   NATURE

TALENs: a widely applicable technology for targeted genome editing

(2012) J. Keith Joung et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of two novel small molecules targeting melanocyte development in zebrafish embryogenesis

(2012) Lu Chen et al.   Pigment Cell & Melanoma Research

mTOR Inhibitors Synergize on Regression, Reversal of Gene Expression, and Autophagy in Hepatocellular Carcinoma

(2012) H. E. Thomas et al.   Science Translational Medicine

Akt signalling in health and disease

(2011) Ingeborg Hers et al.   CELLULAR SIGNALLING

Proteomic analyses of the Xiphophorus Gordon–Kosswig melanoma model

(2011) Amy N. Perez et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Prognostic and Clinicopathologic Associations of OncogenicBRAFin Metastatic Melanoma

(2011) Georgina V. Long et al.   JOURNAL OF CLINICAL ONCOLOGY

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset

(2011) Craig J. Ceol et al.   NATURE

Heritable gene targeting in zebrafish using customized TALENs

(2011) Peng Huang et al.   NATURE BIOTECHNOLOGY

Targeted gene disruption in somatic zebrafish cells using engineered TALENs

(2011) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clonal analyses reveal roles of organ founding stem cells, melanocyte stem cells and melanoblasts in establishment, growth and regeneration of the adult zebrafish fin

(2010) S. Tu et al.   DEVELOPMENT

Toxicity and Cytopathogenic Properties Toward Human Melanoma Cells of Activated Cancer Therapeutics in Zebra Fish

(2010) Thomas J. Lewis   INTEGRATIVE CANCER THERAPIES

Parallel amino acid replacements in the rhodopsins of the rockfishes (Sebastes spp.) associated with shifts in habitat depth

(2010) A. SIVASUNDAR et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Selection for a dominant oncogene and large male size as a risk factor for melanoma in the Xiphophorus animal model

(2010) ANDRÉ A. FERNANDEZ et al.   MOLECULAR ECOLOGY

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

(2010) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeted delivery of NRASQ61R and Cre-recombinase to post-natal melanocytes induces melanoma in Ink4a/Arflox/lox mice

(2010) Matthew W. VanBrocklin et al.   Pigment Cell & Melanoma Research

Genetic and environmental melanoma models in fish

(2010) E. Elizabeth Patton et al.   Pigment Cell & Melanoma Research

A Chemical Screen to Identify Novel Inhibitors of Fin Regeneration in Zebrafish

(2010) Douglas Oppedal et al.   Zebrafish

Zebrafish Models of p53 Functions

(2010) N. Y. Storer et al.   Cold Spring Harbor Perspectives in Biology

Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model

(2009) C. Michailidou et al.   Disease Models & Mechanisms

Zebrafish as a Genetic Model in Biological and Behavioral Gerontology: Where Development Meets Aging in Vertebrates – A Mini-Review

(2009) Shuji Kishi et al.   GERONTOLOGY

BRAF Signaling and Targeted Therapies in Melanoma

(2009) Nathalie Dhomen et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

A Mutated EGFR Is Sufficient to Induce Malignant Melanoma with Genetic Background-Dependent Histopathologies

(2009) Manfred Schartl et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Co-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafish

(2009) Bensheng Ju et al.   Molecular Cancer

A medaka model of cancer allowing direct observation of transplanted tumor cells in vivo at a cellular-level resolution

(2009) S. Hasegawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Melanoma Biology and the Promise of Zebrafish

(2009) Craig J. Ceol et al.   Zebrafish

Oncogenic NRAS Cooperates with p53 Loss to Generate Melanoma in Zebrafish

(2009) Michael Dovey et al.   Zebrafish

Melanocytes in Development, Regeneration, and Cancer

(2008) Richard Mark White et al.   Cell Stem Cell

Etiology of MNU-induced melanomas in Xiphophorus hybrids

(2008) Jennifer J. Rahn et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Combined Inhibition of MAPK and mTOR Signaling Inhibits Growth, Induces Cell Death, and Abrogates Invasive Growth of Melanoma Cells

(2008) Konstantinos G. Lasithiotakis et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Role of UV in Cutaneous Melanoma

(2008) Nityanand Maddodi et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Evolutionary mutant models for human disease

(2008) R. Craig Albertson et al.   TRENDS IN GENETICS

Defective Cell Cycle Checkpoint Functions in Melanoma Are Associated with Altered Patterns of Gene Expression

(2007) William K. Kaufmann et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Multiple paternity and maintenance of genetic diversity in the live-bearing rockfishes Sebastes spp.

(2007) JR Hyde et al.   MARINE ECOLOGY PROGRESS SERIES