Genetic and Epigenetic Modifiers of Alcoholic Liver Disease

ACG Clinical Guideline: Alcoholic Liver Disease

(2018) Ashwani K Singal et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease

(2018) Abhishek Satishchandran et al.   GASTROENTEROLOGY

Recipient characteristics and morbidity and mortality after liver transplantation

(2018) Sumeet K. Asrani et al.   JOURNAL OF HEPATOLOGY

EASL Clinical Practice Guidelines: Management of alcohol-related liver disease

(2018) Mark Thursz et al.   JOURNAL OF HEPATOLOGY

Decreased expression of microRNA-223 promotes cell proliferation in hepatocellular carcinoma cells via the insulin-like growth factor-1 signaling pathway

(2018) Cheng Zhang et al.   Experimental and Therapeutic Medicine

MicroRNAs in alcoholic liver disease: Recent advances and future applications

(2018) Tao Xu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Estimate of hepatocellular carcinoma incidence in patients with alcoholic cirrhosis

(2018) Nathalie Ganne-Carrié et al.   JOURNAL OF HEPATOLOGY

PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases

(2018) Jie Yang et al.   INTERNATIONAL JOURNAL OF CANCER

PNPLA3, TM6SF2, and MBOAT7 Genotypes and Coronary Artery Disease

(2017) Nynke Simons et al.   GASTROENTEROLOGY

The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation

(2017) Soumik BasuRay et al.   HEPATOLOGY

MicroRNA 181b-3p and its target importin α5 regulate toll-like receptor 4 signaling in Kupffer cells and liver injury in mice in response to ethanol

(2017) Paramananda Saikia et al.   HEPATOLOGY

Epigenetics in non-alcoholic fatty liver disease

(2017) Jooho Lee et al.   MOLECULAR ASPECTS OF MEDICINE

Upregulation of miR-181a impairs hepatic glucose and lipid homeostasis

(2017) Xiliang Du et al.   Oncotarget

Therapeutic miRNA and siRNA: Moving from Bench to Clinic as Next Generation Medicine

(2017) Chiranjib Chakraborty et al.   Molecular Therapy-Nucleic Acids

MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals

(2017) Benedetta Donati et al.   Scientific Reports

Lipid metabolism and signaling in cardiac lipotoxicity

(2016) Kenneth D'Souza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

PNPLA3 rs738409 and TM6SF2 rs58542926 variants increase the risk of hepatocellular carcinoma in alcoholic cirrhosis

(2016) Edmondo Falleti et al.   DIGESTIVE AND LIVER DISEASE

Hepatic Transmembrane 6 Superfamily Member 2 Regulates Cholesterol Metabolism in Mice

(2016) Yanbo Fan et al.   GASTROENTEROLOGY

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

(2016) Rosellina Margherita Mancina et al.   GASTROENTEROLOGY

MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6–p47 phox –oxidative stress pathway in neutrophils

(2016) Man Li et al.   GUT

PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis

(2016) Piero Pingitore et al.   HUMAN MOLECULAR GENETICS

Tiny RNA with great effects: miR-155 in alcoholic liver disease

(2016) Phillipp Hartmann et al.   JOURNAL OF HEPATOLOGY

Treatment of alcohol use disorders in patients with alcoholic liver disease

(2016) Giovanni Addolorato et al.   JOURNAL OF HEPATOLOGY

The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis

(2016) Shashi Bala et al.   JOURNAL OF HEPATOLOGY

Liver Transplantation for Alcoholic Liver Disease

(2016) Giovanni Addolorato et al.   TRANSPLANTATION

Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms

(2016) Fengyuan Li et al.   Gastroenterology Research and Practice

Alcoholic hepatitis accelerates early hepatobiliary cancer by increasing stemness and miR-122-mediated HIF-1α activation

(2016) Aditya Ambade et al.   Scientific Reports

Decompensated alcohol related liver disease: acute management

(2016) Stuart McPherson et al.   BMJ-British Medical Journal

Decompensated alcohol related liver disease: acute management

(2016) Stuart McPherson et al.   BMJ-British Medical Journal

Sexual Dimorphism in Alcohol Induced Adipose Inflammation Relates to Liver Injury

(2016) Melissa A. Fulham et al.   PLoS One

Ethnic Differences in Presentation and Severity of Alcoholic Liver Disease

(2015) Robert E. Levy et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

miR-217 Regulates Ethanol-Induced Hepatic Inflammation by Disrupting Sirtuin 1–Lipin-1 Signaling

(2015) Huquan Yin et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study

(2015) Martina Goffredo et al.   HEPATOLOGY

Transmembrane 6 superfamily member 2 gene E167K variant impacts on steatosis and liver damage in chronic hepatitis C patients

(2015) Marta Milano et al.   HEPATOLOGY

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

(2015) Paola Dongiovanni et al.   HEPATOLOGY

Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity

(2015) Silvia Sookoian et al.   HEPATOLOGY

Trends in the management and burden of alcoholic liver disease

(2015) Philippe Mathurin et al.   JOURNAL OF HEPATOLOGY

A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis

(2015) Stephan Buch et al.   NATURE GENETICS

Genetics of Alcoholic Liver Disease

(2015) Ann Daly et al.   SEMINARS IN LIVER DISEASE

MicroRNAs in Alcoholic Liver Disease

(2015) Abhishek Satishchandran et al.   SEMINARS IN LIVER DISEASE

A metabolic stress-inducible miR-34a-HNF4α pathway regulates lipid and lipoprotein metabolism

(2015) Yang Xu et al.   Nature Communications

Alcohol-Attributable Mortality Among American Indians and Alaska Natives in the United States, 1999–2009

(2014) Michael Landen et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Regulation of the Extrinsic Apoptotic Pathway by MicroRNA-21 in Alcoholic Liver Injury

(2014) Heather Francis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PNPLA3in end-stage liver disease: Alcohol consumption, hepatocellular carcinoma development, and transplantation-free survival

(2014) Kilian Friedrich et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

A common polymorphism in the NCAN gene is associated with hepatocellular carcinoma in alcoholic liver disease

(2014) Hans Dieter Nischalke et al.   JOURNAL OF HEPATOLOGY

Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma

(2014) Y.-L. Liu et al.   JOURNAL OF HEPATOLOGY

Prevalence of the TM6SF2 variant and non-alcoholic fatty liver disease in Chinese

(2014) Vincent Wai-Sun Wong et al.   JOURNAL OF HEPATOLOGY

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

(2014) Julia Kozlitina et al.   NATURE GENETICS

The heritability of alcohol use disorders: a meta-analysis of twin and adoption studies

(2014) B. Verhulst et al.   PSYCHOLOGICAL MEDICINE

Clinical differences between alcoholic liver disease and nonalcoholic fatty liver disease

(2014) Nobuyuki Toshikuni   WORLD JOURNAL OF GASTROENTEROLOGY

TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease

(2014) Yang-Lin Liu et al.   Nature Communications

Prevalence of Nonalcoholic Fatty Liver Disease in the United States: The Third National Health and Nutrition Examination Survey, 1988–1994

(2013) Mariana Lazo et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Cardiovascular risk, lipidemic phenotype and steatosis. A comparative analysis of cirrhotic and non-cirrhotic liver disease due to varying etiology

(2013) P. Loria et al.   ATHEROSCLEROSIS

Dynamic expression of miR-126∗and its effects on proliferation and contraction of hepatic stellate cells

(2013) Can-Jie Guo et al.   FEBS LETTERS

Deletion of SIRT1 From Hepatocytes in Mice Disrupts Lipin-1 Signaling and Aggravates Alcoholic Fatty Liver

(2013) Huquan Yin et al.   GASTROENTEROLOGY

Association between thePNPLA3(rs738409 C>G) variant and hepatocellular carcinoma: Evidence from a meta-analysis of individual participant data

(2013) Eric Trépo et al.   HEPATOLOGY

Global burden of alcoholic liver diseases

(2013) Jürgen Rehm et al.   JOURNAL OF HEPATOLOGY

Treatment of HCV Infection by Targeting MicroRNA

(2013) Harry L.A. Janssen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Roles of Cytochrome P4502E1 Gene Polymorphisms and the Risks of Alcoholic Liver Disease: A Meta-Analysis

(2013) Tao Zeng et al.   PLoS One

Chronic Ethanol Feeding Alters miRNA Expression Dynamics During Liver Regeneration

(2012) Rachael P. Dippold et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Cirrhosis and mortality risks of biopsy-verified alcoholic pure steatosis and steatohepatitis: a nationwide registry-based study

(2012) T. Deleuran et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Epigenetic Regulation of miR-34a Expression in Alcoholic Liver Injury

(2012) Fanyin Meng et al.   AMERICAN JOURNAL OF PATHOLOGY

Chronic ethanol feeding enhances miR-21 induction during liver regeneration while inhibiting proliferation in rats

(2012) Rachael P. Dippold et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Prevalence and Natural History of Alcoholic Liver Disease

(2012) Jonathan M. Schwartz et al.   Clinics in Liver Disease

Genetic variants of TNFα, IL10, IL1β, CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population

(2012) Neelanjana Roy et al.   GENE

A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration

(2012) Raymond Ng et al.   JOURNAL OF CLINICAL INVESTIGATION

Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro

(2012) Carlo Pirazzi et al.   JOURNAL OF HEPATOLOGY

PNPLA3 rs738409, hepatocellular carcinoma occurrence and risk model prediction in patients with cirrhosis

(2012) Erwan Guyot et al.   JOURNAL OF HEPATOLOGY

Multicausality in fatty liver disease: Is there a rationale to distinguish between alcoholic and non-alcoholic origin?

(2012) Henry Völzke   WORLD JOURNAL OF GASTROENTEROLOGY

Gut-Liver Axis and Sensing Microbes

(2011) Gyongyi Szabo et al.   DIGESTIVE DISEASES

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

Genetic determinants of alcoholic liver disease

(2011) Felix Stickel et al.   GUT

Circulating microRNAs as potential markers of human drug-induced liver injury

(2011) Philip J. Starkey Lewis et al.   HEPATOLOGY

Regulation of placenta growth factor by microRNA-125b in hepatocellular cancer

(2011) Gianfranco Alpini et al.   JOURNAL OF HEPATOLOGY

PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence

(2011) Edmondo Falleti et al.   LIVER INTERNATIONAL

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

(2011) Elizabeth K. Speliotes et al.   PLoS Genetics

Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians

(2010) Felix Stickel et al.   HEPATOLOGY

Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis

(2010) Christoph Roderburg et al.   HEPATOLOGY

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease

(2010) Luca Valenti et al.   HEPATOLOGY

Up-regulation of MicroRNA-155 in Macrophages Contributes to Increased Tumor Necrosis Factor α (TNFα) Production via Increased mRNA Half-life in Alcoholic Liver Disease

(2010) Shashi Bala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Pathway Involving Farnesoid X Receptor and Small Heterodimer Partner Positively Regulates Hepatic Sirtuin 1 Levels via MicroRNA-34a Inhibition

(2010) Jiyoung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Predictive Factors for Pure Steatosis in Alcoholic Patients

(2009) Sylvie Naveau et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

MicroRNA Expression Profile in Lieber-DeCarli Diet-Induced Alcoholic and Methionine Choline Deficient Diet-Induced Nonalcoholic Steatohepatitis Models in Mice

(2009) Angela Dolganiuc et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Age, alcohol metabolism and liver disease

(2009) Patrick Meier et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis

(2009) Shaoqing He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity

(2009) Silvia Sookoian et al.   JOURNAL OF LIPID RESEARCH

Variant in PNPLA3 is associated with alcoholic liver disease

(2009) Chao Tian et al.   NATURE GENETICS

Emerging role of microRNAs in liver diseases

(2009) Shashi Bala et al.   WORLD JOURNAL OF GASTROENTEROLOGY

No Role of Matrixmetalloproteinase-3 Genetic Promoter Polymorphism 1171 as a Risk Factor for Cirrhosis in Alcoholic Liver Disease

(2008) Felix Stickel et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Effect of Alcohol on miR-212 Expression in Intestinal Epithelial Cells and Its Potential Role in Alcoholic Liver Disease

(2008) Yueming Tang et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Evaluation of the transforming growth factor β1 codon 25 (Arg→Pro) polymorphism in alcoholic liver disease

(2008) Christoph H. Österreicher et al.   CYTOKINE

GlutathioneS-transferase m1 and t1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury

(2008) M. Isabel Lucena et al.   HEPATOLOGY

The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88

(2008) Istvan Hritz et al.   HEPATOLOGY

MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations

(2008) Yannick Ladeiro et al.   HEPATOLOGY

Lysophospholipid Acyltransferases and Arachidonate Recycling in Human Neutrophils

(2008) Miguel A. Gijón et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS