Scutellariae Radix and Coptidis Rhizoma Improve Glucose and Lipid Metabolism in T2DM Rats via Regulation of the Metabolic Profiling and MAPK/PI3K/Akt Signaling Pathway

Scutellaria baicalensis and Cancer Treatment: Recent Progress and Perspectives in Biomedical and Clinical Studies

(2018) Chien-Shan Cheng et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Baicalin alleviates IL-1β-induced inflammatory injury via down-regulating miR-126 in chondrocytes

(2018) Xirui Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Coptisine from Rhizoma coptidis exerts an anti-cancer effect on hepatocellular carcinoma by up-regulating miR-122

(2018) Fang-Ni Chai et al.   BIOMEDICINE & PHARMACOTHERAPY

Evaluation of novel TGR5 agonist in combination with Sitagliptin for possible treatment of type 2 diabetes

(2018) Sameer Agarwal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Procyanidin B2 protects against d -galactose-induced mimetic aging in mice: Metabolites and microbiome analysis

(2018) Ying Xiao et al.   FOOD AND CHEMICAL TOXICOLOGY

Anti-inflammatory effect of Apo-9′-fucoxanthinone via inhibition of MAPKs and NF-kB signaling pathway in LPS-stimulated RAW 264.7 macrophages and zebrafish model

(2018) Eun-A Kim et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Lipidome as a predictive tool in progression to type 2 diabetes in Finnish men

(2018) Tommi Suvitaival et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Helminth infection in mice improves insulin sensitivity via modulation of gut microbiota and fatty acid metabolism

(2018) Fernanda Pace et al.   PHARMACOLOGICAL RESEARCH

Anti-inflammatory activity of Khayandirobilide A from Khaya senegalensis via NF-κB, AP-1 and p38 MAPK/Nrf2/HO-1 signaling pathways in lipopolysaccharide-stimulated RAW 264.7 and BV-2 cells

(2018) Miao-Miao Zhou et al.   PHYTOMEDICINE

Combined intervention of swimming plus metformin ameliorates the insulin resistance and impaired lipid metabolism in murine gestational diabetes mellitus

(2018) Liping Huang et al.   PLoS One

Glucose challenge metabolomics implicates medium-chain acylcarnitines in insulin resistance

(2018) Christoph Nowak et al.   Scientific Reports

Reduction in hepatic secondary bile acids caused by short-term antibiotic-induced dysbiosis decreases mouse serum glucose and triglyceride levels

(2018) Takuya Kuno et al.   Scientific Reports

Plasma bile acid changes in type 2 diabetes correlated with insulin secretion in two-step hyperglycemic clamp

(2018) Shujie Wang et al.   Journal of Diabetes

Possible therapeutic potential of berberine in the treatment of STZ plus HFD-induced diabetic osteoporosis

(2018) Huanguang Xie et al.   BIOMEDICINE & PHARMACOTHERAPY

Association of serum metabolites with impaired fasting glucose/diabetes and traditional risk factors for metabolic disease in Chinese adults

(2018) Siming Wang et al.   CLINICA CHIMICA ACTA

Rethinking Bile Acid Metabolism and Signaling for Type 2 Diabetes Treatment

(2018) Karolina E. Zaborska et al.   Current Diabetes Reports

Antimicrobial Potential of Silver Nanoparticles Synthesized Using Medicinal Herb Coptidis rhizome

(2018) Garima Sharma et al.   MOLECULES

Anti-hyperglycemic and anti-hyperlipidemia effects of the alkaloid-rich extract from barks of Litsea glutinosa in ob/ob mice

(2018) Xiaopo Zhang et al.   Scientific Reports

Luteolin Targets the Toll-Like Receptor Signaling Pathway in Prevention of Hepatic and Adipocyte Fibrosis and Insulin Resistance in Diet-Induced Obese Mice

(2018) Eun-Young Kwon et al.   Nutrients

Betulinic acid improves insulin sensitivity, hyperglycemia, inflammation and oxidative stress in metabolic syndrome rats via PI3K/Akt pathways

(2018) R. A. Ajala-Lawal et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Baicalin and its metabolites suppresses gluconeogenesis through activation of AMPK or AKT in insulin resistant HepG-2 cells

(2017) Tao Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Metabolomics reveal mitochondrial and fatty acid metabolism disorders that contribute to the development of DKD in T2DM patients

(2017) Ling Li et al.   Molecular BioSystems

Ursolic acid activates the TGR5 receptor to enhance GLP-1 secretion in type 1-like diabetic rats

(2017) Shih-Hsiang Lo et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

La protection cardiovasculaire du patient diabétique avec maladie rénale chronique et cas particulier de l’insuffisance rénale chronique terminale du sujet âgé

(2017) P. Zaoui et al.   Nephrologie & Therapeutique

Discovery of Orally Efficacious Tetrahydrobenzimidazoles as TGR5 Agonists for Type 2 Diabetes

(2017) Xuqing Zhang et al.   ACS Medicinal Chemistry Letters

Ginsenoside Rg1 Inhibits Glucagon-Induced Hepatic Gluconeogenesis through Akt-FoxO1 Interaction

(2017) Qun Liu et al.   Theranostics

Cardiac Insulin Signaling Regulates Glycolysis Through Phosphofructokinase 2 Content and Activity

(2017) Lee B. Bockus et al.   Journal of the American Heart Association

Decreasing CB 1 receptor signaling in Kupffer cells improves insulin sensitivity in obese mice

(2017) Tony Jourdan et al.   Molecular Metabolism

JNK at the crossroad of obesity, insulin resistance, and cell stress response

(2017) Giovanni Solinas et al.   Molecular Metabolism

Metabolic Biomarkers for Prognostic Prediction of Pre-diabetes: results from a longitudinal cohort study

(2017) Hailuan Zeng et al.   Scientific Reports

Diabetes, Dementia and Hypoglycemia

(2016) Graydon S. Meneilly et al.   Canadian Journal of Diabetes

The Risk for New-Onset Diabetes Mellitus after Kidney Transplantation in Patients with Autosomal Dominant Polycystic Kidney Disease: A Systematic Review and Meta-Analysis

(2016) Wisit Cheungpasitporn et al.   Canadian Journal of Diabetes

Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Homeostasis

(2016) Eunhee Choi et al.   CELL

Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance

(2016) Kalyana C. Nandipati et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Epigenetic germline inheritance of diet-induced obesity and insulin resistance

(2016) Peter Huypens et al.   NATURE GENETICS

A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

(2016) Cholsoon Jang et al.   NATURE MEDICINE

Skeletal muscle disorders of glycogenolysis and glycolysis

(2016) Richard Godfrey et al.   Nature Reviews Neurology

Berberine activates thermogenesis in white and brown adipose tissue

(2014) Zhiguo Zhang et al.   Nature Communications

The Origins and Drivers of Insulin Resistance

(2013) Andrew M.F. Johnson et al.   CELL

Global estimates of diabetes prevalence for 2013 and projections for 2035

(2013) L. Guariguata et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

TGR5 signalling inhibits the production of pro-inflammatory cytokines byin vitrodifferentiated inflammatory and intestinal macrophages in Crohn's disease

(2013) Kazuaki Yoneno et al.   IMMUNOLOGY

Lysophosphatidylcholine Triggers TLR2- and TLR4-Mediated Signaling Pathways but Counteracts LPS-Induced NO Synthesis in Peritoneal Macrophages by Inhibiting NF-κB Translocation and MAPK/ERK Phosphorylation

(2013) Alan Brito Carneiro et al.   PLoS One

Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells

(2012) Divya P. Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel biomarkers for pre-diabetes identified by metabolomics

(2012) Rui Wang-Sattler et al.   Molecular Systems Biology

Extracts ofScutellaria baicalensisReduced Body Weight and Blood Triglyceride in db/db Mice

(2012) Kwang Hoon Song et al.   PHYTOTHERAPY RESEARCH

Metabolic regulatory effects of licorice: A bile acid metabonomic study by liquid chromatography coupled with tandem mass spectrometry

(2012) Xue Qiao et al.   STEROIDS

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

(2011) Thijs W.H. Pols et al.   Cell Metabolism

Serum Uric Acid Levels and Incident Chronic Kidney Disease in Patients With Type 2 Diabetes and Preserved Kidney Function

(2011) G. Zoppini et al.   DIABETES CARE

Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor γ in hepatic stellate cells for their antifibrotic effect

(2011) Melissa D. Yang et al.   HEPATOLOGY

Mechanisms for anti-inflammatory effects of 1-[15(S)-hydroxyeicosapentaenoyl] lysophosphatidylcholine, administered intraperitoneally, in zymosan A-induced peritonitis

(2010) Nguyen Dang Hung et al.   BRITISH JOURNAL OF PHARMACOLOGY

Importance of lipid rafts for lysophosphatidylcholine-induced caspase-1 activation and reactive oxygen species generation

(2010) Tom Schilling et al.   CELLULAR IMMUNOLOGY

Hepatic Overexpression of a Constitutively Active Form of Liver Glycogen Synthase Improves Glucose Homeostasis

(2010) Susana Ros et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysophosphatidylcholine Containing Docosahexaenoic Acid at the sn-1 Position is Anti-inflammatory

(2010) Long Shuang Huang et al.   LIPIDS

Protective effects of the aqueous extract ofScutellaria baicalensisagainst acrolein-induced oxidative stress in cultured human umbilical vein endothelial cells

(2010) Xing-Wei Zhang et al.   PHARMACEUTICAL BIOLOGY

TNF-α-induced up-regulation of pro-inflammatory cytokines is reduced by phosphatidylcholine in intestinal epithelial cells

(2009) Irina Treede et al.   BMC GASTROENTEROLOGY

Lysophosphatidylcholine Activates Adipocyte Glucose Uptake and Lowers Blood Glucose Levels in Murine Models of Diabetes

(2009) Kyungmoo Yea et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deoxycholic Acid and Selenium Metabolite Methylselenol Exert Common and Distinct Effects on Cell Cycle, Apoptosis, and MAP Kinase Pathway in HCT116 Human Colon Cancer Cells

(2009) Huawei Zeng et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL