Review
Agriculture, Dairy & Animal Science
Baishuang Yin, Wei Li, Hongyu Qin, Jinyan Yun, Xuezhao Sun
Summary: Scutellaria baicalensis, a common Chinese medicinal herb, contains bioactive compounds such as baicalein and baicalin with multiple biological functions. It has been used in animal production to effectively improve production performance, reduce stress and inflammation, and treat diseases caused by pathogens. Natural products like medicinal herbs, including S. baicalensis, have become increasingly popular due to their safety and lack of drug resistance.
Article
Engineering, Chemical
Tseng-Ting Kao, Ming-Chao Wang, Yi-Hsuan Chen, Yu-Tung Chung, Pai-An Hwang
Summary: The study found that more than 80% of the components in the 20% propylene glycol (PG) solvent were retained after storage for two months, while only some components were retained in water solvent. Additionally, the relative antibacterial activities, antioxidant properties, and anti-inflammatory activities of the 20% PG solvent group were better than those of the water solvent group.
Article
Food Science & Technology
Minting Chen, Haitao Xiao, Baisen Chen, Zhaoxiang Bian, Hiu Yee Kwan
Summary: Scutellaria baicalensis and its flavonoids exhibit potential advantages in managing non-viral hepatocellular carcinoma by possessing anti-cancer effects and alleviating associated pathogenic conditions. This review comprehensively summarizes the clinical application, therapeutic effects, mode of action at molecular levels and the safety of Scutellaria baicalensis and its flavonoids in HCC treatment.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Chemistry, Medicinal
Vafa Baradaran Rahimi, Vahid Reza Askari, Hossein Hosseinzadeh
Summary: Studies have shown that Scutellaria baicalensis and its active constituents, baicalin and baicalein, have promising effects on controlling metabolic syndrome and related disorders such as obesity, hyperlipidemia, atherosclerosis, diabetes, and their subsequent complications by regulating key signaling pathways in glucose and lipid metabolism.
PHYTOTHERAPY RESEARCH
(2021)
Article
Nutrition & Dietetics
Yoon-Young Sung, Seung-Hyung Kim, Dong-Seon Kim
Summary: This study found that BS21 has anti-obesity and antihyperlipidemic activities in high-fat diet-induced obese mice by increasing thermogenesis and energy expenditure, and regulating lipid metabolism.
Article
Plant Sciences
Li Xiang, Yue Gao, Shiyu Chen, Jiayi Sun, Jiasi Wu, Xianli Meng
Summary: This review summarizes the pharmacological effects and molecular mechanisms of Scutellaria baicalensis in lung cancer therapy. Scutellaria baicalensis and its constituents exhibit multiple anti-cancer mechanisms against lung cancer and show high antitumor efficacy and safety in animal models.
Article
Plant Sciences
Huan He, Jianling Deng, Maochun Yang, Linjing An, Xiaoli Ye, Xuegang Li
Summary: JAT from RC has an effect on treating obesity, and its anti-obesity effect may be exerted via the IRS1/PI3K/AKT signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Suying Hu, Donghao Wang, Wentao Wang, Caijuan Zhang, Yunyun Li, Yueyue Wang, Wen Zhou, Junfeng Niu, Shiqiang Wang, Yi Qiang, Xiaoyan Cao, Zhezhi Wang
Summary: Scutellaria baicalensis is a medicinal plant with high levels of flavonoids in its roots. A chromosome-level genome was assembled, and comparative analysis revealed its relationship with other species. Structural genes involved in flavonoid synthesis were identified, and the transcription factor S.baiMYB was found to regulate flavonoid production. These findings provide valuable genetic resources for understanding flavonoid biosynthesis in S. baicalensis.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Medicine, Research & Experimental
Nova Syafni, Seema Devi, Amy M. Zimmermann-Klemd, Jakob K. Reinhardt, Ombeline Danton, Carsten Gruendemann, Matthias Hamburger
Summary: This study identified immunosuppressant compounds in the roots of Scutellaria baicalensis, including flavonoids that inhibited T-cell proliferation at non-cytotoxic concentrations. These findings support the potential use of S. baicalensis in disorders where modulation of the cellular immune response is desirable.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Integrative & Complementary Medicine
Peng Yu, Jingyang Li, Yanqing Luo, Jiayi Sun, Yingfan Hu, Bo Lin, Xianli Meng, Li Xiang
Summary: Breast cancer is a common and deadly malignancy in women. Traditional Chinese medicine, especially Scutellaria baicalensis, has shown promising activity against breast cancer through multiple mechanisms, including proliferation inhibition, apoptosis induction, and modulation of signaling pathways.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Review
Plant Sciences
Tianlin Pei, Mengxiao Yan, Yanbo Huang, Yukun Wei, Cathie Martin, Qing Zhao
Summary: Scutellaria baicalensis, a traditional medicinal plant, is widely used in traditional Chinese medicine for its anti-tumor, antioxidant, and antiviral properties. Its specialized flavones have been found to inhibit the replication of the COVID-19 virus. This review focuses on the 4'-deoxyflavones in S. baicalensis and their pharmacological properties, as well as the evolutionary pathway of the genes involved in the biosynthesis of baicalein and wogonin.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Yumin Fang, Jie Liu, Minmin Zheng, Sanming Zhu, Tianlin Pei, Mengying Cui, Lijing Chang, Hanwen Xiao, Jun Yang, Cathie Martin, Qing Zhao
Summary: This study elucidated the biosynthetic pathways of flavones in Scutellaria baicalensis and identified the transcription factor SbMYB3 as a key regulator. SbMYB3 was found to activate the expression of SbFNSII-2 gene, leading to enhanced flavone production. This research provides a potential target for metabolic engineering of flavones in S. baicalensis.
HORTICULTURE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Joanna Oracz, Stanislaw Kowalski, Dorota Zyzelewicz, Gabriela Kowalska, Dorota Gumul, Kamila Kulbat-Warycha, Justyna Rosicka-Kaczmarek, Anna Brzozowska, Aleksandra Grzegorczyk, Anna Areczuk
Summary: The aim of this study was to investigate the effects of different microwave-assisted extraction (MAE) conditions on the efficiency of phenolic compounds extraction from Scutellaria species. The extracts were examined for total phenolic content, antioxidant and anti-inflammatory activity. The phenolic profile of the extracts was characterized using UHPLC-DAD/ESI-HRMS/MS. The results showed that the extraction conditions significantly influenced the phenolic content and biological activity of the extracts.
Article
Chemistry, Multidisciplinary
Xinliang Zhu, Wenzhen An, Xu Li, Bo Zhou, Huixia Li
Summary: In this study, the anti-inflammatory mechanisms of Huang Qin in LPS-induced macrophages were investigated using an untargeted metabolomics approach. The results showed that Huang Qin could exert anti-inflammatory effects by regulating multiple fatty acid metabolism pathways and inhibiting the secretion of inflammatory cytokines and VEGFR. These findings provide evidence for the development of natural and effective anti-inflammatory products.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Plant Sciences
Hoai Thu Thi Do, Thanh Huong Nguyen, Trong Duc Nghiem, Huu Tung Nguyen, Gyung Ja Choi, Cuong Tu Ho, Quang Le Dang
Summary: The methanol extract from the roots of Scutellaria baicalensis showed significant antimicrobial efficacy against various fungal plant diseases and phytopathogenic bacteria. Bioactive flavonoids and oligosaccharides were identified from the extract, which exhibited in vitro and in vivo antifungal activities. Compounds like wogonin and baicalein were found to have promising potential in developing botanical fungicides to control plant diseases.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)