Beyond a Measure of Liver Function—Bilirubin Acts as a Potential Cardiovascular Protector in Chronic Kidney Disease Patients
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Title
Beyond a Measure of Liver Function—Bilirubin Acts as a Potential Cardiovascular Protector in Chronic Kidney Disease Patients
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 1, Pages 117
Publisher
MDPI AG
Online
2018-12-31
DOI
10.3390/ijms20010117
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Note: Only part of the references are listed.- Bilirubin acts as a multi-potent guardian of cardiovascular integrity: more than just a radical idea
- (2018) Andrew Cameron Bulmer et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Disorders of Lipid Metabolism in Chronic Kidney Disease
- (2018) Mustafa C. Bulbul et al. BLOOD PURIFICATION
- Diagnostic criteria and contributors to Gilbert’s syndrome
- (2018) Karl-Heinz Wagner et al. CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
- Chronic Kidney Disease and Antiplatelet Therapy
- (2018) Iñigo Lozano et al. JACC-Cardiovascular Interventions
- Uremic Solute-Aryl Hydrocarbon Receptor-Tissue Factor Axis Associates with Thrombosis after Vascular Injury in Humans
- (2018) Vijaya B. Kolachalama et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Warfarin accelerated vascular calcification and worsened cardiac dysfunction in remnant kidney mice
- (2018) Ming-Tsun Tsai et al. Journal of the Chinese Medical Association
- Endothelial Progenitor Cells and Kidney Diseases
- (2018) Abdullah Ozkok et al. KIDNEY & BLOOD PRESSURE RESEARCH
- Treatment of rheumatoid arthritis with biologic agents lowers the risk of incident chronic kidney disease
- (2018) Keiichi Sumida et al. KIDNEY INTERNATIONAL
- Hyperbilirubinemia-induced pro-angiogenic activity of infantile endothelial progenitor cells
- (2018) Masoumeh Jabarpour et al. MICROVASCULAR RESEARCH
- Novel treatment strategies for chronic kidney disease: insights from the animal kingdom
- (2018) Peter Stenvinkel et al. Nature Reviews Nephrology
- The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease
- (2018) Tao Yang et al. Nature Reviews Nephrology
- Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine
- (2018) Rafael Radi PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Redox Functions of Heme Oxygenase-1 and Biliverdin Reductase in Diabetes
- (2018) Luc Rochette et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Bilirubin in the Liver–Gut Signaling Axis
- (2018) Abdul-Rizaq Hamoud et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Bilirubin, a new therapeutic for kidney transplant?
- (2018) Vikram L. Sundararaghavan et al. Transplantation Reviews
- Bilirubin Is Inversely Associated With Cardiovascular Disease Among HIV‐Positive and HIV‐Negative Individuals in VACS (Veterans Aging Cohort Study)
- (2018) Vincent C. Marconi et al. Journal of the American Heart Association
- Independent and combined effect of bilirubin and smoking on the progression of chronic kidney disease
- (2018) Jiancheng Wang et al. Clinical Epidemiology
- A causal link between oxidative stress and inflammation in cardiovascular and renal complications of diabetes
- (2018) Jay C. Jha et al. CLINICAL SCIENCE
- Bilirubin, a Cardiometabolic Signaling Molecule
- (2018) Terry D. Hinds et al. HYPERTENSION
- Naturally Occurring Compounds: New Potential Weapons against Oxidative Stress in Chronic Kidney Disease
- (2017) Lorenzo Signorini et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Association of warfarin with congestive heart failure and peripheral artery occlusive disease in hemodialysis patients with atrial fibrillation
- (2017) Kuo-Hua Lee et al. Journal of the Chinese Medical Association
- The third path of tubulointerstitial fibrosis: aberrant endothelial secretome
- (2017) Mark Lipphardt et al. KIDNEY INTERNATIONAL
- Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy
- (2017) Adeera Levin et al. LANCET
- Chronic Kidney Disease and Disproportionally Increased Cardiovascular Damage: Does Oxidative Stress Explain the Burden?
- (2017) Anila Duni et al. Oxidative Medicine and Cellular Longevity
- Mildly elevated unconjugated bilirubin is associated with reduced platelet activation-related thrombogenesis and inflammation in Gilbert’s syndrome
- (2017) Avinash R. Kundur et al. PLATELETS
- Bilirubin Prevents Atherosclerotic Lesion Formation in Low‐Density Lipoprotein Receptor‐Deficient Mice by Inhibiting Endothelial VCAM‐1 and ICAM‐1 Signaling
- (2017) Megan E. Vogel et al. Journal of the American Heart Association
- Indoxyl Sulfate: A Novel Cardiovascular Risk Factor in Chronic Kidney Disease
- (2017) Szu‐Chun Hung et al. Journal of the American Heart Association
- Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1
- (2017) Xuewei Cheng et al. Acta Pharmaceutica Sinica B
- Total serum bilirubin and 8-year incident type 2 diabetes mellitus: The Korean Genome and Epidemiology Study
- (2017) Y.-J. Kwon et al. DIABETES & METABOLISM
- Elevated bilirubin levels are associated with a better renal prognosis and ameliorate kidney fibrosis
- (2017) Sehoon Park et al. PLoS One
- Effect of bilirubin concentration on the risk of diabetic complications: A meta-analysis of epidemiologic studies
- (2017) Bo Zhu et al. Scientific Reports
- Metabolic Acidosis of CKD: An Update
- (2016) Jeffrey A. Kraut et al. AMERICAN JOURNAL OF KIDNEY DISEASES
- Heme Oxygenase-1 in Kidney Health and Disease
- (2016) Jeremie M. Lever et al. ANTIOXIDANTS & REDOX SIGNALING
- Oxidant Mechanisms in Renal Injury and Disease
- (2016) Brian B. Ratliff et al. ANTIOXIDANTS & REDOX SIGNALING
- Vascular Smooth Muscle Cells in Atherosclerosis
- (2016) Martin R. Bennett et al. CIRCULATION RESEARCH
- The Players: Cells Involved in Glomerular Disease
- (2016) A. R. Kitching et al. Clinical Journal of the American Society of Nephrology
- The Vascular Endothelium in Chronic Kidney Disease
- (2016) Christopher R. Martens et al. EXERCISE AND SPORT SCIENCES REVIEWS
- Role of Oxidative Stress in Drug-Induced Kidney Injury
- (2016) Keiko Hosohata INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α
- (2016) Terry D. Hinds et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hyperbilirubinemia Protects against Aging-Associated Inflammation and Metabolic Deterioration
- (2016) Jaroslav Zelenka et al. Oxidative Medicine and Cellular Longevity
- Heme Oxygenases in Cardiovascular Health and Disease
- (2016) Anita Ayer et al. PHYSIOLOGICAL REVIEWS
- Therapeutics targeting persistent inflammation in chronic kidney disease
- (2016) Anna Machowska et al. Translational Research
- A Novel Perspective on the Biology of Bilirubin in Health and Disease
- (2016) Silvia Gazzin et al. TRENDS IN MOLECULAR MEDICINE
- Longer telomeres in chronic, moderate, unconjugated hyperbilirubinaemia: insights from a human study on Gilbert’s Syndrome
- (2016) Anela Tosevska et al. Scientific Reports
- Platelets in liver and renal disease
- (2016) M. P. Lambert Hematology-American Society of Hematology Education Program
- Thrombosis and anticoagulation in the setting of renal or liver disease
- (2016) C. Ribic et al. Hematology-American Society of Hematology Education Program
- Diagnosis and Management of Cardiovascular Disease in Advanced and End‐Stage Renal Disease
- (2016) Navdeep K. Bhatti et al. Journal of the American Heart Association
- Nanoparticle Delivered Human Biliverdin Reductase-Based Peptide Increases Glucose Uptake by Activating IRK/Akt/GSK3 Axis: The Peptide Is Effective in the Cell and Wild-Type and Diabetic Ob/Ob Mice
- (2016) Peter E. M. Gibbs et al. Journal of Diabetes Research
- Antioxidant Functions of the Aryl Hydrocarbon Receptor
- (2016) Cornelia Dietrich Stem Cells International
- Bilirubin Binding to PPARα Inhibits Lipid Accumulation
- (2016) David E. Stec et al. PLoS One
- Serum Bilirubin Levels Predict Future Development of Metabolic Syndrome in Healthy Middle-aged Nonsmoking Men
- (2015) Shao-Sung Huang et al. AMERICAN JOURNAL OF MEDICINE
- Bilirubin, platelet activation and heart disease: A missing link to cardiovascular protection in Gilbert's syndrome?
- (2015) Avinash R. Kundur et al. ATHEROSCLEROSIS
- Looking to the horizon: the role of bilirubin in the development and prevention of age-related chronic diseases
- (2015) Karl-Heinz Wagner et al. CLINICAL SCIENCE
- Genetic variants and cell-free hemoglobin processing in sickle cell nephropathy
- (2015) S. L. Saraf et al. HAEMATOLOGICA
- Bilirubin exerts pro-angiogenic property through Akt-eNOS-dependent pathway
- (2015) Yasumasa Ikeda et al. HYPERTENSION RESEARCH
- Biliverdin Reductase A (BVRA) Mediates Macrophage Expression of Interleukin-10 in Injured Kidney
- (2015) Zhizhi Hu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Association Between Heme Oxygenase-1 Promoter Polymorphisms and the Development of Albuminuria in Type 2 Diabetes
- (2015) Eun Young Lee et al. MEDICINE
- Association of serum total bilirubin with renal outcome in Japanese patients with stages 3–5 chronic kidney disease
- (2015) Teppei Sakoh et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Inherited disorders of bilirubin clearance
- (2015) Naureen Memon et al. PEDIATRIC RESEARCH
- Biliverdin reductase isozymes in metabolism
- (2015) Luke O’Brien et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Unconjugated Bilirubin exerts Pro-Apoptotic Effect on Platelets via p38-MAPK activation
- (2015) Somanathapura K. NaveenKumar et al. Scientific Reports
- Bilirubin Increases Insulin Sensitivity by Regulating Cholesterol Metabolism, Adipokines and PPARγ Levels
- (2015) Jinfeng Liu et al. Scientific Reports
- Genetic variants and cell-free hemoglobin processing in sickle cell nephropathy
- (2015) S. L. Saraf et al. HAEMATOLOGICA
- Interaction Between Geriatric Nutritional Risk Index and Decoy Receptor 3 Predicts Mortality in Chronic Hemodialysis Patients
- (2014) Ming-Tsun Tsai et al. AMERICAN JOURNAL OF NEPHROLOGY
- A decrease in total bilirubin predicted hyper-LDL cholesterolemia in a health screening population
- (2014) Eiji Oda ATHEROSCLEROSIS
- Low serum bilirubin concentration is a predictor of chronic kidney disease
- (2014) Muhei Tanaka et al. ATHEROSCLEROSIS
- Emerging regulators of vascular smooth muscle cell function in the development and progression of atherosclerosis
- (2014) J. L. Johnson CARDIOVASCULAR RESEARCH
- Endothelial progenitor cells and vascular repair
- (2014) Min Zhang et al. CURRENT OPINION IN HEMATOLOGY
- Bilirubin: A Potential Biomarker and Therapeutic Target for Diabetic Nephropathy
- (2014) T. D. Hull et al. DIABETES
- Unconjugated Bilirubin Mediates Heme Oxygenase-1–Induced Vascular Benefits in Diabetic Mice
- (2014) Jian Liu et al. DIABETES
- Bilirubin and Progression of Nephropathy in Type 2 Diabetes: A Post Hoc Analysis of RENAAL With Independent Replication in IDNT
- (2014) I. J. Riphagen et al. DIABETES
- Bilirubin as a Potential Causal Factor in Type 2 Diabetes Risk: A Mendelian Randomization Study
- (2014) Ali Abbasi et al. DIABETES
- Bilirubin Possesses Powerful Immunomodulatory Activity and Suppresses Experimental Autoimmune Encephalomyelitis
- (2014) Y. Liu et al. JOURNAL OF IMMUNOLOGY
- Length Polymorphism in Heme Oxygenase-1 and Risk of CKD among Patients with Coronary Artery Disease
- (2014) Y.-H. Chen et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Effects of Lowering LDL Cholesterol on Progression of Kidney Disease
- (2014) R. Haynes et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Oxidative DNA Damage and Mortality in Hemodialysis and Peritoneal Dialysis Patients
- (2014) H. Xu et al. PERITONEAL DIALYSIS INTERNATIONAL
- Potential Cardiovascular Risk Protection of Bilirubin in End-Stage Renal Disease Patients under Hemodialysis
- (2014) Maria do Sameiro-Faria et al. Biomed Research International
- Intraperitoneal bilirubin administration decreases infarct area in a rat coronary ischemia/reperfusion model
- (2014) Ron Ben-Amotz et al. Frontiers in Physiology
- Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway
- (2013) Mohammed Qaisiya et al. CELLULAR SIGNALLING
- Length Polymorphism in Heme Oxygenase-1 and Cardiovascular Events and Mortality in Hemodialysis Patients
- (2013) Y.-H. Chen et al. Clinical Journal of the American Society of Nephrology
- Bile cast nephropathy is a common pathologic finding for kidney injury associated with severe liver dysfunction
- (2013) Charles M. van Slambrouck et al. KIDNEY INTERNATIONAL
- Low serum bilirubin concentration is a novel risk factor for the development of albuminuria in patients with type 2 diabetes
- (2013) Hiroshi Okada et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Cytochrome P450 2A5 and bilirubin: Mechanisms of gene regulation and cytoprotection
- (2013) Sangsoo Daniel Kim et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Oxidative stress and endothelial dysfunction: Clinical evidence and therapeutic implications
- (2013) Yukihito Higashi et al. TRENDS IN CARDIOVASCULAR MEDICINE
- Bilirubin attenuates the renal tubular injury by inhibition of oxidative stress and apoptosis
- (2013) Se Won Oh et al. BMC Nephrology
- Hyperbilirubinemia, Augmentation of Endothelial Function, and Decrease in Oxidative Stress in Gilbert Syndrome
- (2012) Tatsuya Maruhashi et al. CIRCULATION
- Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome
- (2012) Ai-Ching Boon et al. FREE RADICAL BIOLOGY AND MEDICINE
- Essential Roles of Raf/Extracellular Signal-regulated Kinase/Mitogen-activated Protein Kinase Pathway, YY1, and Ca2+Influx in Growth Arrest of Human Vascular Smooth Muscle Cells by Bilirubin
- (2012) Marlon Stoeckius et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Bilirubin and beyond: A review of lipid status in Gilbert’s syndrome and its relevance to cardiovascular disease protection
- (2012) A.C. Bulmer et al. PROGRESS IN LIPID RESEARCH
- Plasma bilirubin and late graft failure in renal transplant recipients
- (2012) Petronella E. Deetman et al. TRANSPLANT INTERNATIONAL
- Bilirubin Inhibits Neointima Formation and Vascular Smooth Muscle Cell Proliferation and Migration
- (2012) Kelly J. Peyton et al. Frontiers in Pharmacology
- Serum Bilirubin Links UGT1A1*28 Polymorphism and Predicts Long-Term Cardiovascular Events and Mortality in Chronic Hemodialysis Patients
- (2011) Y.-H. Chen et al. Clinical Journal of the American Society of Nephrology
- The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial
- (2011) Colin Baigent et al. LANCET
- Risk Factors for Neurotoxicity in Newborns With Severe Neonatal Hyperbilirubinemia
- (2011) R. Gamaleldin et al. PEDIATRICS
- Vanin-1; a potential biomarker for nephrotoxicant-induced renal injury
- (2011) Keiko Hosohata et al. TOXICOLOGY
- The Bilirubin-Increasing Drug Atazanavir Improves Endothelial Function in Patients With Type 2 Diabetes Mellitus
- (2010) Douwe Dekker et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Bilirubin Promotes De Novo Generation of T Regulatory Cells
- (2010) Fredy Rocuts et al. CELL TRANSPLANTATION
- Serum Bilirubin and Genes Controlling Bilirubin Concentrations as Biomarkers for Cardiovascular Disease
- (2010) J.-P. Lin et al. CLINICAL CHEMISTRY
- Improved renal function after kidney transplantation is associated with heme oxygenase-1 polymorphism
- (2010) K.S. Ozaki et al. CLINICAL TRANSPLANTATION
- Low serum bilirubin concentration in haemodialysis patients with Type 2 diabetes
- (2010) M. Fukui et al. DIABETIC MEDICINE
- Chronic kidney disease stages 1-3 increase the risk of venous thrombosis
- (2010) G. OCAK et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Bilirubin and biliverdin protect rodents against diabetic nephropathy by downregulating NAD(P)H oxidase
- (2010) Masakazu Fujii et al. KIDNEY INTERNATIONAL
- Rosuvastatin and Cardiovascular Events in Patients Undergoing Hemodialysis
- (2009) Bengt C. Fellström et al. NEW ENGLAND JOURNAL OF MEDICINE
- Bilirubin and glutathione have complementary antioxidant and cytoprotective roles
- (2009) T. W. Sedlak et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Serum bilirubin levels, UGT1A1 polymorphisms and risk for coronary artery disease
- (2008) Arno Lingenhel et al. EXPERIMENTAL GERONTOLOGY
- Pharmacological and Clinical Aspects of Heme Oxygenase
- (2008) N. G. Abraham et al. PHARMACOLOGICAL REVIEWS
- Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling
- (2008) N. Lerner-Marmarosh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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