Looking to the horizon: the role of bilirubin in the development and prevention of age-related chronic diseases

Circulating Total Bilirubin and Risk of Incident Cardiovascular Disease in the General PopulationSignificance

(2015) Setor K. Kunutsor et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bilirubin, platelet activation and heart disease: A missing link to cardiovascular protection in Gilbert's syndrome?

(2015) Avinash R. Kundur et al.   ATHEROSCLEROSIS

UGT1A1*28 Polymorphism in Chronic Lymphocytic Leukemia: The First Investigation of the Polymorphism in Disease Susceptibility and Its Specific Cytogenetic Abnormalities

(2014) Maria Karakosta et al.   ACTA HAEMATOLOGICA

Bilirubin Levels and Their Association with Carotid Intima Media Thickness and High-Sensitivity C-reactive Protein in Patients with Psoriasis Vulgaris

(2014) Sevket Balta et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Hyperbilirubinemia modulates myocardial function, aortic ejection, and ischemic stress resistance in the Gunn rat

(2014) Bhavisha Bakrania et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A decrease in total bilirubin predicted hyper-LDL cholesterolemia in a health screening population

(2014) Eiji Oda   ATHEROSCLEROSIS

The inverse association of incident cardiovascular disease with plasma bilirubin is unaffected by adiponectin

(2014) Robin P.F. Dullaart et al.   ATHEROSCLEROSIS

Differential Body Composition Effects of Protease Inhibitors Recommended for Initial Treatment of HIV Infection: A Randomized Clinical Trial

(2014) Esteban Martinez et al.   CLINICAL INFECTIOUS DISEASES

Association of bilirubin with coronary artery calcification and cardiovascular events in the general population without known liver disease: the Heinz Nixdorf Recall study

(2014) Amir A. Mahabadi et al.   Clinical Research in Cardiology

A Critical and Comprehensive Insight on Heme Oxygenase and Related Products Including Carbon Monoxide, Bilirubin, Biliverdin and Ferritin in Type-1 and Type-2 Diabetes

(2014) Manish Mishra et al.   CURRENT PHARMACEUTICAL DESIGN

Serum bilirubin as a predictor of incident metabolic syndrome: A 4-year retrospective longitudinal study of 6205 initially healthy Korean men

(2014) M.J. Lee et al.   DIABETES & METABOLISM

Bilirubin Increases Insulin Sensitivity in Leptin-Receptor Deficient and Diet-Induced Obese Mice Through Suppression of ER Stress and Chronic Inflammation

(2014) Huansheng Dong et al.   ENDOCRINOLOGY

The Relationship Between Serum Bilirubin and Crohn’s Disease

(2014) Martin Leníček et al.   INFLAMMATORY BOWEL DISEASES

Mean platelet volume and coronary artery disease: a systematic review and meta-analysis

(2014) Nakarin Sansanayudh et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Platelet Volume Indices are Associated with High Residual Platelet Reactivity after Antiplatelet Therapy in Patients Undergoing Percutaneous Coronary Intervention

(2014) Yun Gi Kim et al.   Journal of Atherosclerosis and Thrombosis

The Relationship of the Anti-Oxidant Bilirubin with Free Thyroxine Is Modified by Insulin Resistance in Euthyroid Subjects

(2014) Petronella E. Deetman et al.   PLoS One

Body Fat Percentage Is a Major Determinant of Total Bilirubin Independently of UGT1A1*28 Polymorphism in Young Obese

(2014) Luís Belo et al.   PLoS One

The Relationship between Total Bilirubin Levels and Total Mortality in Older Adults: The United States National Health and Nutrition Examination Survey (NHANES) 1999-2004

(2014) Kwok-Leung Ong et al.   PLoS One

Circular dichroism study of the interaction between mutagens and bilirubin bound to different binding sites of serum albumins

(2014) Sergey Orlov et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Statins alter the hepatobiliary transport of unconjugated and conjugated bilirubin in sandwich-cultured rat hepatocytes

(2014) Mónika Szabó et al.   TOXICOLOGY IN VITRO

Using genetic variation for establishing causality of cardiovascular risk factors: overcoming confounding and reverse causality

(2014) R. A. J. Smit et al.   Netherlands Heart Journal

Intraperitoneal bilirubin administration decreases infarct area in a rat coronary ischemia/reperfusion model

(2014) Ron Ben-Amotz et al.   Frontiers in Physiology

Cardiovascular Risk and Psoriasis: Beyond the Traditional Risk Factors

(2013) Ann G. Coumbe et al.   AMERICAN JOURNAL OF MEDICINE

Decreased Serum Bilirubin Is Associated With Silent Cerebral Infarction

(2013) Rui-Yan Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study

(2013) Amanda J. Cox et al.   ATHEROSCLEROSIS

Measures of cardiovascular risk and subclinical atherosclerosis in a cohort of women with a remote history of preeclampsia

(2013) Sarah D. McDonald et al.   ATHEROSCLEROSIS

Elevated serum bilirubin levels are inversely associated with coronary artery atherosclerosis

(2013) Seung Joo Kang et al.   ATHEROSCLEROSIS

The effects of Gilbertʼs syndrome on the mean platelet volume and other hematological parameters

(2013) Medine C. Cure et al.   BLOOD COAGULATION & FIBRINOLYSIS

Anti-Genotoxic Potential of Bilirubin In Vivo: Damage to DNA in Hyperbilirubinemic Human and Animal Models

(2013) M. Wallner et al.   Cancer Prevention Research

Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway

(2013) Mohammed Qaisiya et al.   CELLULAR SIGNALLING

Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome

(2013) Marlies Wallner et al.   CLINICAL SCIENCE

Plasma total bilirubin levels predict amputation events in type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study

(2013) K. H. Chan et al.   DIABETOLOGIA

Endothelial dysfunction over the course of coronary artery disease

(2013) E. Gutierrez et al.   EUROPEAN HEART JOURNAL

Haem catabolism: a novel modulator of inflammation in Gilbert's syndrome

(2013) Marlies Wallner et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Bilirubin influences the clinical presentation of pre-eclampsia

(2013) Eamonn Breslin et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Serum bilirubin levels and risk of prediabetes in young and healthy adults

(2013) Matthias Bossard et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Relationship between serum bilirubin and uric acid to oxidative stress markers in Italian and Czech populations

(2013) Libor Vítek et al.   Journal of Applied Biomedicine

Effects of total bilirubin on the prevalence of osteoporosis in postmenopausal women without potential liver disease

(2013) Lu-Qin Bian et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Unconjugated bilirubin, a potent endogenous antioxidant, is decreased in patients with non-alcoholic steatohepatitis and advanced fibrosis

(2013) Federico Salomone et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Bilirubin and Related Tetrapyrroles Inhibit Food-Borne Mutagenesis: A Mechanism for Antigenotoxic Action against a Model Epoxide

(2013) Christine Mölzer et al.   JOURNAL OF NATURAL PRODUCTS

Serum Bilirubin Level Is Inversely Associated With Nonalcoholic Steatohepatitis in Children

(2013) Kanika Puri et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Interaction between TNFone and tetrapyrroles may account for their anti-genotoxic effects — a novel mechanism for DNA-protection

(2013) Christine Mölzer et al.   JOURNAL OF PORPHYRINS AND PHTHALOCYANINES

Higher serum bilirubin level as a protective factor for the development of diabetes in healthy Korean men: A 4year retrospective longitudinal study

(2013) Chang Hee Jung et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: It's time for reconciliation

(2013) Eugenio Barone et al.   NEUROBIOLOGY OF DISEASE

Bilirubin-Induced Neurologic Damage — Mechanisms and Management Approaches

(2013) Jon F. Watchko et al.   NEW ENGLAND JOURNAL OF MEDICINE

Unconjugated bilirubin inhibits collagen induced platelet activation

(2013) Avinash R. Kundur et al.   PLATELETS

Detection of subclinical atherosclerosis and diastolic dysfunction in patients with schizophrenia

(2013) Cüneyt Ünsal et al.   Neuropsychiatric Disease and Treatment

Amyloid β-Peptide (1–42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression

(2012) D. Allan Butterfield et al.   ANTIOXIDANTS & REDOX SIGNALING

Serum Total Bilirubin Concentration Is Inversely Correlated with Framingham Risk Score in Koreans

(2012) Kwang-Min Kim et al.   ARCHIVES OF MEDICAL RESEARCH

Effects of statin treatments and polymorphisms in UGT1A1 and SLCO1B1 on serum bilirubin levels in Chinese patients with hypercholesterolaemia

(2012) Miao Hu et al.   ATHEROSCLEROSIS

Heme modulates smooth muscle cell proliferation and migration via NADPH oxidase: A counter-regulatory role for heme oxygenase system

(2012) J.A. Moraes et al.   ATHEROSCLEROSIS

Increased Cardiovascular Risk in Patients With Chronic Obstructive Pulmonary Disease and the Potential Mechanisms Linking the Two Conditions

(2012) Kuldeepa Ghoorah et al.   Cardiology in Review

Cardiovascular Events as a Function of Serum Bilirubin Levels in a Large, Statin-Treated Cohort

(2012) Laura J. Horsfall et al.   CIRCULATION

Association between serum total bilirubin level and leukoaraiosis in Korean adults

(2012) Byoung-Jin Park et al.   CLINICAL BIOCHEMISTRY

Evaluation of Early Atherosclerosis in Patients with Inflammatory Bowel Disease

(2012) Hasan Kayahan et al.   DIGESTIVE DISEASES AND SCIENCES

In vitro DNA-damaging effects of intestinal and related tetrapyrroles in human cancer cells

(2012) Christine Mölzer et al.   EXPERIMENTAL CELL RESEARCH

Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome

(2012) Ai-Ching Boon et al.   FREE RADICAL BIOLOGY AND MEDICINE

In vitroantioxidant capacity and antigenotoxic properties of protoporphyrin and structurally related tetrapyrroles

(2012) Christine Mölzer et al.   FREE RADICAL RESEARCH

Serum total bilirubin is inversely associated with brachial-ankle pulse wave velocity in men with hypertension

(2012) Zheng-Yun Zhang et al.   HEART AND VESSELS

Association of Arterial Stiffness with Serum Bilirubin Levels in Established Coronary Artery Disease

(2012) Cansheng Zhu et al.   INTERNAL MEDICINE

Increased Serum Bilirubin Level is Related to Good Collateral Development in Patients with Chronic Total Coronary Occlusion

(2012) Turan Erdogan et al.   INTERNAL MEDICINE

Essential Roles of Raf/Extracellular Signal-regulated Kinase/Mitogen-activated Protein Kinase Pathway, YY1, and Ca2+Influx in Growth Arrest of Human Vascular Smooth Muscle Cells by Bilirubin

(2012) Marlon Stoeckius et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of PTEN expression and activity by angiotensin II induces proliferation and migration of vascular smooth muscle cells

(2012) Xue Dong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Liver function from Y to Z

(2012) Irwin M. Arias   JOURNAL OF CLINICAL INVESTIGATION

Triglycerides: How Much Credit Do They Deserve?

(2012) Payal Kohli et al.   MEDICAL CLINICS OF NORTH AMERICA

Unconjugated Bilirubin Restricts Oligodendrocyte Differentiation and Axonal Myelination

(2012) Andreia Barateiro et al.   MOLECULAR NEUROBIOLOGY

Effects of unconjugated bilirubin on chromosomal damage in individuals with Gilbert`s syndrome measured with the micronucleus cytome assay

(2012) M. Wallner et al.   MUTAGENESIS

Bilirubin and beyond: A review of lipid status in Gilbert’s syndrome and its relevance to cardiovascular disease protection

(2012) A.C. Bulmer et al.   PROGRESS IN LIPID RESEARCH

Leukoaraiosis Is a Chronic Atherosclerotic Disease

(2012) Einor Ben-Assayag et al.   TheScientificWorldJOURNAL

Extracellular and intracellular anti-mutagenic effects of bile pigments in the Salmonella typhimurium reverse mutation assay

(2012) C. Mölzer et al.   TOXICOLOGY IN VITRO

Promoter length polymorphism in UGT1A1 and the risk of sporadic colorectal cancer

(2012) Marija Hiljadnikova Bajro et al.   Cancer Genetics

The Role of Bilirubin in Diabetes, Metabolic Syndrome, and Cardiovascular Diseases

(2012) Libor Vítek   Frontiers in Pharmacology

Usefulness of Serum Bilirubin and Cardiorespiratory Fitness as Predictors of Mortality in Men

(2011) Rahma Ajja et al.   AMERICAN JOURNAL OF CARDIOLOGY

Mean platelet volume (MPV) is associated with leukoaraiosis in the apparently healthy elderly

(2011) Seong-Jin Kang et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Statin use and serum bilirubin levels

(2011) Libor Vítek et al.   ATHEROSCLEROSIS

Association of lower total bilirubin level with statin usage: The United States National Health and Nutrition Examination Survey 1999–2008

(2011) Kwok Leung Ong et al.   ATHEROSCLEROSIS

Bilirubin Attenuates Bufadienolide-Induced Ventricular Arrhythmias and Cardiac Dysfunction in Guinea-Pigs by Reducing Elevated Intracellular Na+ Levels

(2011) Hongyue Ma et al.   Cardiovascular Toxicology

Serum Bilirubin Links UGT1A1*28 Polymorphism and Predicts Long-Term Cardiovascular Events and Mortality in Chronic Hemodialysis Patients

(2011) Y.-H. Chen et al.   Clinical Journal of the American Society of Nephrology

Association of serum bilirubin and promoter variations in HMOX1 and UGT1A1 genes with sporadic colorectal cancer

(2011) Alena Jirásková et al.   INTERNATIONAL JOURNAL OF CANCER

Serum Bilirubin and Risk of Respiratory Disease and Death

(2011) Laura J. Horsfall   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Relationship Between Bilirubin Concentration, Coronary Endothelial Function, and Inflammatory Stress in Overweight Patients

(2011) Satoshi Yoshino et al.   Journal of Atherosclerosis and Thrombosis

Serum bilirubin concentrations and multiple sclerosis

(2011) Fuhua Peng et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Serum bilirubin levels in familial hypercholesterolemia: a new risk marker for cardiovascular disease?

(2011) Pernette R.W. de Sauvage Nolting et al.   JOURNAL OF LIPID RESEARCH

Inverse Association Between Total Bilirubin and Metabolic Syndrome in Rural Korean Women

(2011) Kyung-Min Kwon et al.   JOURNAL OF WOMENS HEALTH

Decreased serum bilirubin is associated with arterial stiffness in men

(2011) Y. Li et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

A global view on the development of non communicable diseases

(2011) Karl-Heinz Wagner et al.   PREVENTIVE MEDICINE

Moderate hyperbilirubinemia improves renal hemodynamics in ANG II-dependent hypertension

(2010) Trinity Vera et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The Bilirubin-Increasing Drug Atazanavir Improves Endothelial Function in Patients With Type 2 Diabetes Mellitus

(2010) Douwe Dekker et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Associations between Polymorphisms in Glucuronidation and Sulfation Enzymes and Mammographic Breast Density in Premenopausal Women in the United States

(2010) M. Yong et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Bilirubin Promotes De Novo Generation of T Regulatory Cells

(2010) Fredy Rocuts et al.   CELL TRANSPLANTATION

Decreased small dense LDL levels in Gilbert's syndrome

(2010) Serkan Tapan et al.   CLINICAL BIOCHEMISTRY

Serum Bilirubin and Genes Controlling Bilirubin Concentrations as Biomarkers for Cardiovascular Disease

(2010) J.-P. Lin et al.   CLINICAL CHEMISTRY

Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women

(2010) Keizo Ohnaka et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

The novel antidote Bezoar Bovis prevents the cardiotoxicity of Toad (Bufo bufo gargarizans Canto) Venom in mice

(2010) Hongyue Ma et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Genetic polymorphism in the conjugating enzyme UGT1A1 and the risk of head and neck cancer

(2010) Martin Lacko et al.   INTERNATIONAL JOURNAL OF CANCER

Micronuclei frequency in peripheral blood lymphocytes and cancer risk: evidence from human studies

(2010) S. Bonassi et al.   MUTAGENESIS

Risk of Arterial Cardiovascular Diseases in Patients with Multiple Sclerosis: A Population-Based Cohort Study

(2010) Christian Fynbo Christiansen et al.   NEUROEPIDEMIOLOGY

Serum bilirubin levels and UGT1A1 promoter variations in patients with schizophrenia

(2010) Libor Vítek et al.   PSYCHIATRY RESEARCH

Association of systemic lupus erythematosus with low serum bilirubin levels

(2010) L Vítek et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Low serum bilirubin concentration is associated with coronary artery calcification (CAC)

(2009) Muhei Tanaka et al.   ATHEROSCLEROSIS

Bilirubin inhibits the TNFα-related induction of three endothelial adhesion molecules

(2009) Graciela Luján Mazzone et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Soluble CD40 ligand and soluble P-selectin levels in Gilbert's syndrome: A link to protection against atherosclerosis?

(2009) Serkan Tapan et al.   CLINICAL BIOCHEMISTRY

Complement activation and disease: protective effects of hyperbilirubinaemia

(2009) Cecilia L. BASIGLIO et al.   CLINICAL SCIENCE

Bilirubin Chemistry and Metabolism; Harmful and Protective Aspects

(2009) Libor Vitek et al.   CURRENT PHARMACEUTICAL DESIGN

Inflammation in Atherosclerosis

(2009) Peter Libby et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Acute effect of weight loss on levels of total bilirubin in obese, cardiovascular high-risk patients: an analysis from the lead-in period of the Sibutramine Cardiovascular Outcome trial

(2009) Charlotte Andersson et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Gene Knockdowns in Adult Animals: PPMOs and Vivo-Morpholinos

(2009) Jon Moulton et al.   MOLECULES

Sensitive Troponin I Assay in Early Diagnosis of Acute Myocardial Infarction

(2009) Till Keller et al.   NEW ENGLAND JOURNAL OF MEDICINE

Serum Total Bilirubin Level, Prevalent Stroke, and Stroke Outcomes: NHANES 1999–2004

(2008) Todd S. Perlstein et al.   AMERICAN JOURNAL OF MEDICINE

Cardiovascular disease risk awareness in systemic lupus erythematosus patients

(2008) Lisabeth V. Scalzi et al.   ARTHRITIS AND RHEUMATISM

Improved resistance to serum oxidation in Gilbert's syndrome: A mechanism for cardiovascular protection

(2008) Andrew C. Bulmer et al.   ATHEROSCLEROSIS

Gilbert syndrome, UGT1A1*28 allele, and cardiovascular disease risk: Possible protective effects and therapeutic applications of bilirubin

(2008) Harvey A. Schwertner et al.   ATHEROSCLEROSIS

Vivo-Morpholinos: A non-peptide transporter delivers Morpholinos into a wide array of mouse tissues

(2008) Paul A. Morcos et al.   BIOTECHNIQUES

Use of conventional and -omics based methods for health claims of dietary antioxidants: a critical overview

(2008) Siegfried Knasmüller et al.   BRITISH JOURNAL OF NUTRITION

Impact of Triglyceride Levels Beyond Low-Density Lipoprotein Cholesterol After Acute Coronary Syndrome in the PROVE IT-TIMI 22 Trial

(2008) Michael Miller et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Atherosclerosis and osteoporosis: age-dependent degenerative processes or related entities?

(2008) P. Anagnostis et al.   OSTEOPOROSIS INTERNATIONAL

Serum Total Bilirubin Level and Prevalent Lower-Extremity Peripheral Arterial Disease

(2007) Todd S. Perlstein et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY